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Protein

Epithelial discoidin domain-containing receptor 1

Gene

Ddr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing, but also tumor cell invasion. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Phosphorylates PTPN11 (By similarity). Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing.By similarity1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi213 – 2131Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi232 – 2321Calcium 1By similarity
Metal bindingi232 – 2321Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi235 – 2351Calcium 2By similarity
Metal bindingi237 – 2371Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi255 – 2551Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi257 – 2571Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi362 – 3621Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi363 – 3631Calcium 2By similarity
Binding sitei653 – 6531ATPPROSITE-ProRule annotation
Active sitei764 – 7641Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi614 – 6229ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • collagen binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • protein tyrosine kinase collagen receptor activity Source: UniProtKB

GO - Biological processi

  • branching involved in mammary gland duct morphogenesis Source: MGI
  • collagen-activated tyrosine kinase receptor signaling pathway Source: UniProtKB
  • ear development Source: MGI
  • embryo implantation Source: MGI
  • lactation Source: UniProtKB-KW
  • mammary gland alveolus development Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • peptidyl-tyrosine autophosphorylation Source: UniProtKB
  • peptidyl-tyrosine phosphorylation Source: MGI
  • protein autophosphorylation Source: MGI
  • regulation of cell growth Source: MGI
  • regulation of cell-matrix adhesion Source: MGI
  • regulation of extracellular matrix disassembly Source: UniProtKB
  • smooth muscle cell-matrix adhesion Source: UniProtKB
  • smooth muscle cell migration Source: UniProtKB
  • wound healing, spreading of cells Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Lactation, Pregnancy

Keywords - Ligandi

ATP-binding, Calcium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 3474.
ReactomeiREACT_320075. Non-integrin membrane-ECM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial discoidin domain-containing receptor 1 (EC:2.7.10.1)
Short name:
Epithelial discoidin domain receptor 1
Alternative name(s):
CD167 antigen-like family member A
Cell adhesion kinase
Discoidin receptor tyrosine kinase
Protein-tyrosine kinase MPK-6
Tyrosine kinase DDR
Tyrosine-protein kinase CAK
CD_antigen: CD167a
Gene namesi
Name:Ddr1
Synonyms:Cak, Eddr1, Mpk6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:99216. Ddr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 415394ExtracellularSequence AnalysisAdd
BLAST
Transmembranei416 – 43621HelicalSequence AnalysisAdd
BLAST
Topological domaini437 – 911475CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are born at the expected Mendelian rate, but female mice are dwarfs and most of them are unable to bear offspring, due to defects in blastocyte implantation in the uterus. About one fifth can bear offspring, but for these the mammary gland fails to undergo proper differentiation during pregnancy, with hyperproliferation and abnormal branching of the mammary ducts, leading to a lactation defect. In addition, mice exhibit hearing loss, due to alterations of the inner ear. Mice display poor calcification of the fibula. They also exhibit defects in the structure of the slit diaphragm in kidney glomeruli, leading to proteinuria, but do not show overt signs of kidney dysfunction.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 911892Epithelial discoidin domain-containing receptor 1PRO_0000016743Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 186PROSITE-ProRule annotation
Disulfide bondi75 ↔ 178PROSITE-ProRule annotation
Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi262 – 2621N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi305 ↔ 350PROSITE-ProRule annotation
Glycosylationi372 – 3721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi392 – 3921N-linked (GlcNAc...)Sequence Analysis
Modified residuei482 – 4821Phosphotyrosine; by autocatalysisBy similarity
Modified residuei511 – 5111Phosphotyrosine; by autocatalysisBy similarity
Modified residuei518 – 5181Phosphotyrosine; by autocatalysisBy similarity
Modified residuei738 – 7381Phosphotyrosine; by autocatalysisBy similarity
Modified residuei790 – 7901Phosphotyrosine; by autocatalysisBy similarity
Modified residuei794 – 7941Phosphotyrosine; by autocatalysisBy similarity
Modified residuei795 – 7951Phosphotyrosine; by autocatalysisBy similarity

Post-translational modificationi

Autophosphorylated in response to fibrillar collagen binding.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ03146.
PaxDbiQ03146.
PRIDEiQ03146.

PTM databases

PhosphoSiteiQ03146.

Expressioni

Tissue specificityi

Detected in the cochlea and the organ of Corti in the inner ear. Isoform 1 is predominant and is expressed in developing embryo and adult brain. Isoform 2 is expressed in various epithelial cells.1 Publication

Gene expression databases

BgeeiQ03146.
CleanExiMM_DDR1.
ExpressionAtlasiQ03146. baseline and differential.
GenevisibleiQ03146. MM.

Interactioni

Subunit structurei

Homodimer. Interacts (via PPxY motif) with WWC1 (via WW domains) in a collagen-regulated manner. Forms a tripartite complex with WWC1 and PRKCZ, but predominantly in the absence of collagen. Interacts (tyrosine phosphorylated) with SHC1. Interacts with SRC. Interacts with MYH9. Interacts with CDH1. Interacts with PTPN11. Interacts with NCK2 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ03146. 1 interaction.
MINTiMINT-5170014.
STRINGi10090.ENSMUSP00000003628.

Structurei

3D structure databases

ProteinModelPortaliQ03146.
SMRiQ03146. Positions 31-369, 599-911.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 186155F5/8 type CPROSITE-ProRule annotationAdd
BLAST
Domaini608 – 903296Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni193 – 369177DS-like domainBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi479 – 4824PPxY motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi379 – 41335Gly/Pro-richAdd
BLAST
Compositional biasi474 – 599126Gly/Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation
Contains 1 F5/8 type C domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118818.
HOGENOMiHOG000043102.
HOVERGENiHBG005461.
InParanoidiQ03146.
KOiK05124.
OMAiCRFLFAG.
OrthoDBiEOG77Q4W2.
PhylomeDBiQ03146.
TreeFamiTF317840.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR000421. Coagulation_fac_5/8-C_type_dom.
IPR029566. DDR1.
IPR008979. Galactose-bd-like.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PANTHERiPTHR24416:SF65. PTHR24416:SF65. 1 hit.
PfamiPF00754. F5_F8_type_C. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00231. FA58C. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q03146-1) [UniParc]FASTAAdd to basket

Also known as: CAK I

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTGTLSSLL LLLLLVTIGD ADMKGHFDPA KCRYALGMQD RTIPDSDISV
60 70 80 90 100
SSSWSDSTAA RHSRLESSDG DGAWCPAGPV FPKEEEYLQV DLRRLHLVAL
110 120 130 140 150
VGTQGRHAGG LGKEFSRSYR LRYSRDGRRW MDWKDRWGQE VISGNEDPGG
160 170 180 190 200
VVLKDLGPPM VARLVRFYPR ADRVMSVCLR VELYGCLWRD GLLSYTAPVG
210 220 230 240 250
QTMQLSEVMV HLNDSTYDGY TAGGLQYGGL GQLADGVVGL DDFRQSQELR
260 270 280 290 300
VWPGYDYVGW SNQSFPTGYV EMEFEFDRLR TFQTMQVHCN NMHTLGARLP
310 320 330 340 350
GGVECRFKRG PAMAWEGEPV RHALGGSLGD PRARAISVPL GGHVGRFLQC
360 370 380 390 400
RFLFAGPWLL FSEISFISDV VNDSSDTFPP APWWPPGPPP TNFSSLELEP
410 420 430 440 450
RGQQPVAKAE GSPTAILIGC LVAIILLLLL IIALMLWRLH WRRLLSKAER
460 470 480 490 500
RVLEEELTVH LSVPGDTILI NNRPGPREPP PYQEPRPRGT PPHSAPCVPN
510 520 530 540 550
GSALLLSNPA YRLLLATYAR PPRGPGPPTP AWAKPTNTQA CSGDYMEPEK
560 570 580 590 600
PGAPLLPPPP QNSVPHYAEA DIVTLQGVTG GNTYAVPALP PGAVGDGPPR
610 620 630 640 650
VDFPRSRLRF KEKLGEGQFG EVHLCEVEDP QDLVSSDFPI SVHKGHPLLV
660 670 680 690 700
AVKILRPDAT KNARNDFLKE VKIMSRLKDP NIIRLLGVCV QDDPLCMITD
710 720 730 740 750
YMENGDLNQF LSARQLENKA TQGLSGDTES DQGPTISYPM LLHVGAQIAS
760 770 780 790 800
GMRYLATLNF VHRDLATRNC LVGENFTIKI ADFGMSRNLY AGDYYRVQGR
810 820 830 840 850
AVLPIRWMAW ECILMGKFTT ASDVWAFGVT LWEVLMLCRS QPFGQLTDEQ
860 870 880 890 900
VIENAGEFFR DQGRQVYLSR PPACPQTLYE LMLRCWSREP EQRPPFAQLH
910
RFLADDALNT V
Length:911
Mass (Da):101,161
Last modified:November 1, 1997 - v2
Checksum:iDBB7FE03DDD79510
GO
Isoform 2 (identifier: Q03146-2) [UniParc]FASTAAdd to basket

Also known as: CAK II

The sequence of this isoform differs from the canonical sequence as follows:
     503-539: Missing.

Show »
Length:874
Mass (Da):97,207
Checksum:iA649B2FCE360BA5B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei503 – 53937Missing in isoform 2. 1 PublicationVSP_002954Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L57509 mRNA. Translation: AAB05209.1.
X57240 mRNA. Translation: CAA40516.1.
CCDSiCCDS28703.1. [Q03146-1]
CCDS37603.1. [Q03146-2]
PIRiS30502.
RefSeqiNP_001185760.1. NM_001198831.1. [Q03146-1]
NP_001185762.1. NM_001198833.1. [Q03146-1]
NP_031610.1. NM_007584.2. [Q03146-1]
NP_766550.1. NM_172962.1. [Q03146-2]
XP_006523596.1. XM_006523533.1. [Q03146-1]
XP_006523597.1. XM_006523534.1. [Q03146-1]
XP_006523598.1. XM_006523535.2. [Q03146-1]
XP_006523599.1. XM_006523536.2. [Q03146-1]
XP_006523600.1. XM_006523537.1. [Q03146-1]
UniGeneiMm.5021.

Genome annotation databases

EnsembliENSMUST00000003628; ENSMUSP00000003628; ENSMUSG00000003534. [Q03146-1]
ENSMUST00000097333; ENSMUSP00000094945; ENSMUSG00000003534. [Q03146-2]
ENSMUST00000117301; ENSMUSP00000112570; ENSMUSG00000003534. [Q03146-1]
ENSMUST00000119825; ENSMUSP00000113062; ENSMUSG00000003534. [Q03146-1]
ENSMUST00000166980; ENSMUSP00000133047; ENSMUSG00000003534. [Q03146-1]
GeneIDi12305.
KEGGimmu:12305.
UCSCiuc008cih.2. mouse. [Q03146-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L57509 mRNA. Translation: AAB05209.1.
X57240 mRNA. Translation: CAA40516.1.
CCDSiCCDS28703.1. [Q03146-1]
CCDS37603.1. [Q03146-2]
PIRiS30502.
RefSeqiNP_001185760.1. NM_001198831.1. [Q03146-1]
NP_001185762.1. NM_001198833.1. [Q03146-1]
NP_031610.1. NM_007584.2. [Q03146-1]
NP_766550.1. NM_172962.1. [Q03146-2]
XP_006523596.1. XM_006523533.1. [Q03146-1]
XP_006523597.1. XM_006523534.1. [Q03146-1]
XP_006523598.1. XM_006523535.2. [Q03146-1]
XP_006523599.1. XM_006523536.2. [Q03146-1]
XP_006523600.1. XM_006523537.1. [Q03146-1]
UniGeneiMm.5021.

3D structure databases

ProteinModelPortaliQ03146.
SMRiQ03146. Positions 31-369, 599-911.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ03146. 1 interaction.
MINTiMINT-5170014.
STRINGi10090.ENSMUSP00000003628.

PTM databases

PhosphoSiteiQ03146.

Proteomic databases

MaxQBiQ03146.
PaxDbiQ03146.
PRIDEiQ03146.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003628; ENSMUSP00000003628; ENSMUSG00000003534. [Q03146-1]
ENSMUST00000097333; ENSMUSP00000094945; ENSMUSG00000003534. [Q03146-2]
ENSMUST00000117301; ENSMUSP00000112570; ENSMUSG00000003534. [Q03146-1]
ENSMUST00000119825; ENSMUSP00000113062; ENSMUSG00000003534. [Q03146-1]
ENSMUST00000166980; ENSMUSP00000133047; ENSMUSG00000003534. [Q03146-1]
GeneIDi12305.
KEGGimmu:12305.
UCSCiuc008cih.2. mouse. [Q03146-1]

Organism-specific databases

CTDi780.
MGIiMGI:99216. Ddr1.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118818.
HOGENOMiHOG000043102.
HOVERGENiHBG005461.
InParanoidiQ03146.
KOiK05124.
OMAiCRFLFAG.
OrthoDBiEOG77Q4W2.
PhylomeDBiQ03146.
TreeFamiTF317840.

Enzyme and pathway databases

BRENDAi2.7.10.1. 3474.
ReactomeiREACT_320075. Non-integrin membrane-ECM interactions.

Miscellaneous databases

ChiTaRSiDdr1. mouse.
NextBioi280834.
PROiQ03146.
SOURCEiSearch...

Gene expression databases

BgeeiQ03146.
CleanExiMM_DDR1.
ExpressionAtlasiQ03146. baseline and differential.
GenevisibleiQ03146. MM.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR000421. Coagulation_fac_5/8-C_type_dom.
IPR029566. DDR1.
IPR008979. Galactose-bd-like.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PANTHERiPTHR24416:SF65. PTHR24416:SF65. 1 hit.
PfamiPF00754. F5_F8_type_C. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00231. FA58C. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines."
    Perez J.L., Jing S.Q., Wong T.W.
    Oncogene 12:1469-1477(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6.
  2. "An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain."
    Gilardi-Hebenstreit P., Nieto M.A., Frain M., Mattei M.-G., Chestier A., Wilkinson D.G., Charnay P.
    Oncogene 7:2499-2506(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 766-822.
    Strain: C57BL/6.
    Tissue: Embryonic brain.
  3. "Discoidin domain receptor 1 tyrosine kinase has an essential role in mammary gland development."
    Vogel W.F., Aszodi A., Alves F., Pawson T.
    Mol. Cell. Biol. 21:2906-2917(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  4. "Tyrosine kinase activity of discoidin domain receptor 1 is necessary for smooth muscle cell migration and matrix metalloproteinase expression."
    Hou G., Vogel W.F., Bendeck M.P.
    Circ. Res. 90:1147-1149(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "DDR1-deficient mice show localized subepithelial GBM thickening with focal loss of slit diaphragms and proteinuria."
    Gross O., Beirowski B., Harvey S.J., McFadden C., Chen D., Tam S., Thorner P.S., Smyth N., Addicks K., Bloch W., Ninomiya Y., Sado Y., Weber M., Vogel W.F.
    Kidney Int. 66:102-111(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  6. "Inner ear defects and hearing loss in mice lacking the collagen receptor DDR1."
    Meyer zum Gottesberge A.M., Gross O., Becker-Lendzian U., Massing T., Vogel W.F.
    Lab. Invest. 88:27-37(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiDDR1_MOUSE
AccessioniPrimary (citable) accession number: Q03146
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 1, 1997
Last modified: June 24, 2015
This is version 154 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.