Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q03146

- DDR1_MOUSE

UniProt

Q03146 - DDR1_MOUSE

Protein

Epithelial discoidin domain-containing receptor 1

Gene

Ddr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 147 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing, but also tumor cell invasion. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Phosphorylates PTPN11 By similarity. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing.By similarity1 Publication

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi213 – 2131Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi232 – 2321Calcium 1By similarity
    Metal bindingi232 – 2321Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi235 – 2351Calcium 2By similarity
    Metal bindingi237 – 2371Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi255 – 2551Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi257 – 2571Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi362 – 3621Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi363 – 3631Calcium 2By similarity
    Binding sitei653 – 6531ATPPROSITE-ProRule annotation
    Active sitei764 – 7641Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi614 – 6229ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. collagen binding Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW
    4. protein tyrosine kinase collagen receptor activity Source: UniProtKB

    GO - Biological processi

    1. branching involved in mammary gland duct morphogenesis Source: MGI
    2. collagen-activated tyrosine kinase receptor signaling pathway Source: UniProtKB
    3. ear development Source: MGI
    4. embryo implantation Source: MGI
    5. lactation Source: UniProtKB-KW
    6. mammary gland alveolus development Source: MGI
    7. negative regulation of cell proliferation Source: MGI
    8. peptidyl-tyrosine autophosphorylation Source: UniProtKB
    9. peptidyl-tyrosine phosphorylation Source: MGI
    10. regulation of cell growth Source: MGI
    11. regulation of cell-matrix adhesion Source: MGI
    12. regulation of extracellular matrix disassembly Source: UniProtKB
    13. smooth muscle cell-matrix adhesion Source: UniProtKB
    14. smooth muscle cell migration Source: UniProtKB
    15. wound healing, spreading of cells Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Receptor, Transferase, Tyrosine-protein kinase

    Keywords - Biological processi

    Lactation, Pregnancy

    Keywords - Ligandi

    ATP-binding, Calcium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.1. 3474.
    ReactomeiREACT_196607. Non-integrin membrane-ECM interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Epithelial discoidin domain-containing receptor 1 (EC:2.7.10.1)
    Short name:
    Epithelial discoidin domain receptor 1
    Alternative name(s):
    CD167 antigen-like family member A
    Cell adhesion kinase
    Discoidin receptor tyrosine kinase
    Protein-tyrosine kinase MPK-6
    Tyrosine kinase DDR
    Tyrosine-protein kinase CAK
    CD_antigen: CD167a
    Gene namesi
    Name:Ddr1
    Synonyms:Cak, Eddr1, Mpk6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:99216. Ddr1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: MGI
    3. receptor complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Mice are born at the expected Mendelian rate, but female mice are dwarfs and most of them are unable to bear offspring, due to defects in blastocyte implantation in the uterus. About one fifth can bear offspring, but for these the mammary gland fails to undergo proper differentiation during pregnancy, with hyperproliferation and abnormal branching of the mammary ducts, leading to a lactation defect. In addition, mice exhibit hearing loss, due to alterations of the inner ear. Mice display poor calcification of the fibula. They also exhibit defects in the structure of the slit diaphragm in kidney glomeruli, leading to proteinuria, but do not show overt signs of kidney dysfunction.3 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 911892Epithelial discoidin domain-containing receptor 1PRO_0000016743Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi32 ↔ 186PROSITE-ProRule annotation
    Disulfide bondi75 ↔ 178PROSITE-ProRule annotation
    Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi262 – 2621N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi305 ↔ 350PROSITE-ProRule annotation
    Glycosylationi372 – 3721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi392 – 3921N-linked (GlcNAc...)Sequence Analysis
    Modified residuei482 – 4821Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei511 – 5111Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei518 – 5181Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei738 – 7381Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei790 – 7901Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei794 – 7941Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei795 – 7951Phosphotyrosine; by autocatalysisBy similarity

    Post-translational modificationi

    Autophosphorylated in response to fibrillar collagen binding.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ03146.
    PRIDEiQ03146.

    PTM databases

    PhosphoSiteiQ03146.

    Expressioni

    Tissue specificityi

    Detected in the cochlea and the organ of Corti in the inner ear. Isoform 1 is predominant and is expressed in developing embryo and adult brain. Isoform 2 is expressed in various epithelial cells.1 Publication

    Gene expression databases

    ArrayExpressiQ03146.
    BgeeiQ03146.
    CleanExiMM_DDR1.
    GenevestigatoriQ03146.

    Interactioni

    Subunit structurei

    Homodimer. Interacts (via PPxY motif) with WWC1 (via WW domains) in a collagen-regulated manner. Forms a tripartite complex with WWC1 and PRKCZ, but predominantly in the absence of collagen. Interacts (tyrosine phosphorylated) with SHC1. Interacts with SRC. Interacts with MYH9. Interacts with CDH1. Interacts with PTPN11. Interacts with NCK2 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ03146. 1 interaction.
    MINTiMINT-5170014.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03146.
    SMRiQ03146. Positions 31-369, 599-911.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 415394ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini437 – 911475CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei416 – 43621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 186155F5/8 type CPROSITE-ProRule annotationAdd
    BLAST
    Domaini608 – 903296Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni193 – 369177DS-like domainBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi479 – 4824PPxY motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi379 – 41335Gly/Pro-richAdd
    BLAST
    Compositional biasi474 – 599126Gly/Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation
    Contains 1 F5/8 type C domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00750000117362.
    HOGENOMiHOG000043102.
    HOVERGENiHBG005461.
    InParanoidiQ03146.
    KOiK05124.
    OMAiCRFLFAG.
    OrthoDBiEOG77Q4W2.
    PhylomeDBiQ03146.
    TreeFamiTF317840.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    InterProiIPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR029566. DDR1.
    IPR008979. Galactose-bd-like.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR002011. Tyr_kinase_rcpt_2_CS.
    [Graphical view]
    PANTHERiPTHR24416:SF65. PTHR24416:SF65. 1 hit.
    PfamiPF00754. F5_F8_type_C. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00231. FA58C. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS01285. FA58C_1. 1 hit.
    PS01286. FA58C_2. 1 hit.
    PS50022. FA58C_3. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q03146-1) [UniParc]FASTAAdd to Basket

    Also known as: CAK I

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGTGTLSSLL LLLLLVTIGD ADMKGHFDPA KCRYALGMQD RTIPDSDISV    50
    SSSWSDSTAA RHSRLESSDG DGAWCPAGPV FPKEEEYLQV DLRRLHLVAL 100
    VGTQGRHAGG LGKEFSRSYR LRYSRDGRRW MDWKDRWGQE VISGNEDPGG 150
    VVLKDLGPPM VARLVRFYPR ADRVMSVCLR VELYGCLWRD GLLSYTAPVG 200
    QTMQLSEVMV HLNDSTYDGY TAGGLQYGGL GQLADGVVGL DDFRQSQELR 250
    VWPGYDYVGW SNQSFPTGYV EMEFEFDRLR TFQTMQVHCN NMHTLGARLP 300
    GGVECRFKRG PAMAWEGEPV RHALGGSLGD PRARAISVPL GGHVGRFLQC 350
    RFLFAGPWLL FSEISFISDV VNDSSDTFPP APWWPPGPPP TNFSSLELEP 400
    RGQQPVAKAE GSPTAILIGC LVAIILLLLL IIALMLWRLH WRRLLSKAER 450
    RVLEEELTVH LSVPGDTILI NNRPGPREPP PYQEPRPRGT PPHSAPCVPN 500
    GSALLLSNPA YRLLLATYAR PPRGPGPPTP AWAKPTNTQA CSGDYMEPEK 550
    PGAPLLPPPP QNSVPHYAEA DIVTLQGVTG GNTYAVPALP PGAVGDGPPR 600
    VDFPRSRLRF KEKLGEGQFG EVHLCEVEDP QDLVSSDFPI SVHKGHPLLV 650
    AVKILRPDAT KNARNDFLKE VKIMSRLKDP NIIRLLGVCV QDDPLCMITD 700
    YMENGDLNQF LSARQLENKA TQGLSGDTES DQGPTISYPM LLHVGAQIAS 750
    GMRYLATLNF VHRDLATRNC LVGENFTIKI ADFGMSRNLY AGDYYRVQGR 800
    AVLPIRWMAW ECILMGKFTT ASDVWAFGVT LWEVLMLCRS QPFGQLTDEQ 850
    VIENAGEFFR DQGRQVYLSR PPACPQTLYE LMLRCWSREP EQRPPFAQLH 900
    RFLADDALNT V 911
    Length:911
    Mass (Da):101,161
    Last modified:November 1, 1997 - v2
    Checksum:iDBB7FE03DDD79510
    GO
    Isoform 2 (identifier: Q03146-2) [UniParc]FASTAAdd to Basket

    Also known as: CAK II

    The sequence of this isoform differs from the canonical sequence as follows:
         503-539: Missing.

    Show »
    Length:874
    Mass (Da):97,207
    Checksum:iA649B2FCE360BA5B
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei503 – 53937Missing in isoform 2. 1 PublicationVSP_002954Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L57509 mRNA. Translation: AAB05209.1.
    X57240 mRNA. Translation: CAA40516.1.
    CCDSiCCDS28703.1. [Q03146-1]
    CCDS37603.1. [Q03146-2]
    PIRiS30502.
    RefSeqiNP_001185760.1. NM_001198831.1. [Q03146-1]
    NP_001185762.1. NM_001198833.1. [Q03146-1]
    NP_031610.1. NM_007584.2. [Q03146-1]
    NP_766550.1. NM_172962.1. [Q03146-2]
    XP_006523596.1. XM_006523533.1. [Q03146-1]
    XP_006523597.1. XM_006523534.1. [Q03146-1]
    XP_006523598.1. XM_006523535.1. [Q03146-1]
    XP_006523599.1. XM_006523536.1. [Q03146-1]
    XP_006523600.1. XM_006523537.1. [Q03146-1]
    UniGeneiMm.5021.

    Genome annotation databases

    EnsembliENSMUST00000003628; ENSMUSP00000003628; ENSMUSG00000003534. [Q03146-1]
    ENSMUST00000097333; ENSMUSP00000094945; ENSMUSG00000003534. [Q03146-2]
    ENSMUST00000117301; ENSMUSP00000112570; ENSMUSG00000003534. [Q03146-1]
    ENSMUST00000119825; ENSMUSP00000113062; ENSMUSG00000003534. [Q03146-1]
    ENSMUST00000166980; ENSMUSP00000133047; ENSMUSG00000003534. [Q03146-1]
    GeneIDi12305.
    KEGGimmu:12305.
    UCSCiuc008cih.2. mouse. [Q03146-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L57509 mRNA. Translation: AAB05209.1 .
    X57240 mRNA. Translation: CAA40516.1 .
    CCDSi CCDS28703.1. [Q03146-1 ]
    CCDS37603.1. [Q03146-2 ]
    PIRi S30502.
    RefSeqi NP_001185760.1. NM_001198831.1. [Q03146-1 ]
    NP_001185762.1. NM_001198833.1. [Q03146-1 ]
    NP_031610.1. NM_007584.2. [Q03146-1 ]
    NP_766550.1. NM_172962.1. [Q03146-2 ]
    XP_006523596.1. XM_006523533.1. [Q03146-1 ]
    XP_006523597.1. XM_006523534.1. [Q03146-1 ]
    XP_006523598.1. XM_006523535.1. [Q03146-1 ]
    XP_006523599.1. XM_006523536.1. [Q03146-1 ]
    XP_006523600.1. XM_006523537.1. [Q03146-1 ]
    UniGenei Mm.5021.

    3D structure databases

    ProteinModelPortali Q03146.
    SMRi Q03146. Positions 31-369, 599-911.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q03146. 1 interaction.
    MINTi MINT-5170014.

    PTM databases

    PhosphoSitei Q03146.

    Proteomic databases

    PaxDbi Q03146.
    PRIDEi Q03146.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000003628 ; ENSMUSP00000003628 ; ENSMUSG00000003534 . [Q03146-1 ]
    ENSMUST00000097333 ; ENSMUSP00000094945 ; ENSMUSG00000003534 . [Q03146-2 ]
    ENSMUST00000117301 ; ENSMUSP00000112570 ; ENSMUSG00000003534 . [Q03146-1 ]
    ENSMUST00000119825 ; ENSMUSP00000113062 ; ENSMUSG00000003534 . [Q03146-1 ]
    ENSMUST00000166980 ; ENSMUSP00000133047 ; ENSMUSG00000003534 . [Q03146-1 ]
    GeneIDi 12305.
    KEGGi mmu:12305.
    UCSCi uc008cih.2. mouse. [Q03146-1 ]

    Organism-specific databases

    CTDi 780.
    MGIi MGI:99216. Ddr1.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00750000117362.
    HOGENOMi HOG000043102.
    HOVERGENi HBG005461.
    InParanoidi Q03146.
    KOi K05124.
    OMAi CRFLFAG.
    OrthoDBi EOG77Q4W2.
    PhylomeDBi Q03146.
    TreeFami TF317840.

    Enzyme and pathway databases

    BRENDAi 2.7.10.1. 3474.
    Reactomei REACT_196607. Non-integrin membrane-ECM interactions.

    Miscellaneous databases

    ChiTaRSi DDR1. mouse.
    NextBioi 280834.
    PROi Q03146.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q03146.
    Bgeei Q03146.
    CleanExi MM_DDR1.
    Genevestigatori Q03146.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    InterProi IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR029566. DDR1.
    IPR008979. Galactose-bd-like.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR002011. Tyr_kinase_rcpt_2_CS.
    [Graphical view ]
    PANTHERi PTHR24416:SF65. PTHR24416:SF65. 1 hit.
    Pfami PF00754. F5_F8_type_C. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00231. FA58C. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS01285. FA58C_1. 1 hit.
    PS01286. FA58C_2. 1 hit.
    PS50022. FA58C_3. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines."
      Perez J.L., Jing S.Q., Wong T.W.
      Oncogene 12:1469-1477(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6.
    2. "An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain."
      Gilardi-Hebenstreit P., Nieto M.A., Frain M., Mattei M.-G., Chestier A., Wilkinson D.G., Charnay P.
      Oncogene 7:2499-2506(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 766-822.
      Strain: C57BL/6.
      Tissue: Embryonic brain.
    3. "Discoidin domain receptor 1 tyrosine kinase has an essential role in mammary gland development."
      Vogel W.F., Aszodi A., Alves F., Pawson T.
      Mol. Cell. Biol. 21:2906-2917(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    4. "Tyrosine kinase activity of discoidin domain receptor 1 is necessary for smooth muscle cell migration and matrix metalloproteinase expression."
      Hou G., Vogel W.F., Bendeck M.P.
      Circ. Res. 90:1147-1149(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "DDR1-deficient mice show localized subepithelial GBM thickening with focal loss of slit diaphragms and proteinuria."
      Gross O., Beirowski B., Harvey S.J., McFadden C., Chen D., Tam S., Thorner P.S., Smyth N., Addicks K., Bloch W., Ninomiya Y., Sado Y., Weber M., Vogel W.F.
      Kidney Int. 66:102-111(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    6. "Inner ear defects and hearing loss in mice lacking the collagen receptor DDR1."
      Meyer zum Gottesberge A.M., Gross O., Becker-Lendzian U., Massing T., Vogel W.F.
      Lab. Invest. 88:27-37(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiDDR1_MOUSE
    AccessioniPrimary (citable) accession number: Q03146
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 147 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3