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Q03146 (DDR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Epithelial discoidin domain-containing receptor 1
Short name=Epithelial discoidin domain receptor 1
EC=2.7.10.1
Alternative name(s):
CD167 antigen-like family member A
Cell adhesion kinase
Discoidin receptor tyrosine kinase
Protein-tyrosine kinase MPK-6
Tyrosine kinase DDR
Tyrosine-protein kinase CAK
CD_antigen=CD167a
Gene names
Name:Ddr1
Synonyms:Cak, Eddr1, Mpk6
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length911 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in cell-cell interactions and recognition By similarity.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit structure

Interacts (via PPxY motif) with WWC1 (via WW domains) in a collagen-regulated manner. Forms a tripartite complex with WWC1 and PRKCZ, but predominantly in the absence of collagen By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Isoform 1 is predominant and is expressed in developing embryo and adult brain. Isoform 2 is expressed in various epithelial cells.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Contains 1 F5/8 type C domain.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainSignal
Transmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Receptor
Transferase
Tyrosine-protein kinase
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processbranching involved in mammary gland duct morphogenesis

Inferred from mutant phenotype. Source: MGI

cell adhesion

Inferred from electronic annotation. Source: InterPro

ear development

Inferred from mutant phenotype. Source: MGI

embryo implantation

Inferred from mutant phenotype. Source: MGI

mammary gland alveolus development

Inferred from mutant phenotype. Source: MGI

negative regulation of cell proliferation

Inferred from mutant phenotype. Source: MGI

peptidyl-tyrosine phosphorylation

Inferred from direct assay. Source: MGI

regulation of cell growth

Inferred from mutant phenotype. Source: MGI

regulation of cell-matrix adhesion

Inferred from mutant phenotype. Source: MGI

transmembrane receptor protein tyrosine kinase signaling pathway

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

transmembrane receptor protein tyrosine kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q03146-1)

Also known as: CAK I;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q03146-2)

Also known as: CAK II;

The sequence of this isoform differs from the canonical sequence as follows:
     503-539: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 911892Epithelial discoidin domain-containing receptor 1
PRO_0000016743

Regions

Topological domain20 – 414395Extracellular Potential
Transmembrane415 – 44127Helical; Potential
Topological domain442 – 911470Cytoplasmic Potential
Domain32 – 186155F5/8 type C
Domain608 – 903296Protein kinase
Nucleotide binding614 – 6229ATP By similarity
Motif479 – 4824PPxY motif
Compositional bias379 – 41335Gly/Pro-rich
Compositional bias474 – 599126Gly/Pro-rich

Sites

Active site7641Proton acceptor By similarity
Binding site6531ATP By similarity

Amino acid modifications

Modified residue5111Phosphotyrosine; by autocatalysis By similarity
Modified residue7901Phosphotyrosine; by autocatalysis By similarity
Modified residue7941Phosphotyrosine; by autocatalysis By similarity
Modified residue7951Phosphotyrosine; by autocatalysis By similarity
Glycosylation2131N-linked (GlcNAc...) Potential
Glycosylation2621N-linked (GlcNAc...) Potential
Glycosylation3721N-linked (GlcNAc...) Potential
Glycosylation3921N-linked (GlcNAc...) Potential
Disulfide bond32 ↔ 186 By similarity

Natural variations

Alternative sequence503 – 53937Missing in isoform 2.
VSP_002954

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (CAK I) [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: DBB7FE03DDD79510

FASTA911101,161
        10         20         30         40         50         60 
MGTGTLSSLL LLLLLVTIGD ADMKGHFDPA KCRYALGMQD RTIPDSDISV SSSWSDSTAA 

        70         80         90        100        110        120 
RHSRLESSDG DGAWCPAGPV FPKEEEYLQV DLRRLHLVAL VGTQGRHAGG LGKEFSRSYR 

       130        140        150        160        170        180 
LRYSRDGRRW MDWKDRWGQE VISGNEDPGG VVLKDLGPPM VARLVRFYPR ADRVMSVCLR 

       190        200        210        220        230        240 
VELYGCLWRD GLLSYTAPVG QTMQLSEVMV HLNDSTYDGY TAGGLQYGGL GQLADGVVGL 

       250        260        270        280        290        300 
DDFRQSQELR VWPGYDYVGW SNQSFPTGYV EMEFEFDRLR TFQTMQVHCN NMHTLGARLP 

       310        320        330        340        350        360 
GGVECRFKRG PAMAWEGEPV RHALGGSLGD PRARAISVPL GGHVGRFLQC RFLFAGPWLL 

       370        380        390        400        410        420 
FSEISFISDV VNDSSDTFPP APWWPPGPPP TNFSSLELEP RGQQPVAKAE GSPTAILIGC 

       430        440        450        460        470        480 
LVAIILLLLL IIALMLWRLH WRRLLSKAER RVLEEELTVH LSVPGDTILI NNRPGPREPP 

       490        500        510        520        530        540 
PYQEPRPRGT PPHSAPCVPN GSALLLSNPA YRLLLATYAR PPRGPGPPTP AWAKPTNTQA 

       550        560        570        580        590        600 
CSGDYMEPEK PGAPLLPPPP QNSVPHYAEA DIVTLQGVTG GNTYAVPALP PGAVGDGPPR 

       610        620        630        640        650        660 
VDFPRSRLRF KEKLGEGQFG EVHLCEVEDP QDLVSSDFPI SVHKGHPLLV AVKILRPDAT 

       670        680        690        700        710        720 
KNARNDFLKE VKIMSRLKDP NIIRLLGVCV QDDPLCMITD YMENGDLNQF LSARQLENKA 

       730        740        750        760        770        780 
TQGLSGDTES DQGPTISYPM LLHVGAQIAS GMRYLATLNF VHRDLATRNC LVGENFTIKI 

       790        800        810        820        830        840 
ADFGMSRNLY AGDYYRVQGR AVLPIRWMAW ECILMGKFTT ASDVWAFGVT LWEVLMLCRS 

       850        860        870        880        890        900 
QPFGQLTDEQ VIENAGEFFR DQGRQVYLSR PPACPQTLYE LMLRCWSREP EQRPPFAQLH 

       910 
RFLADDALNT V

« Hide

Isoform 2 (CAK II) [UniParc].

Checksum: A649B2FCE360BA5B
Show »

FASTA87497,207

References

[1]"Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines."
Perez J.L., Jing S.Q., Wong T.W.
Oncogene 12:1469-1477(1996) [PubMed: 8622863] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6.
[2]"An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain."
Gilardi-Hebenstreit P., Nieto M.A., Frain M., Mattei M.-G., Chestier A., Wilkinson D.G., Charnay P.
Oncogene 7:2499-2506(1992) [PubMed: 1281307] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 766-822.
Strain: C57BL/6.
Tissue: Embryonic brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L57509 mRNA. Translation: AAB05209.1.
X57240 mRNA. Translation: CAA40516.1.
IPIIPI00129221.
IPI00226685.
PIRS30502.
RefSeqNP_001185760.1. NM_001198831.1.
NP_001185762.1. NM_001198833.1.
NP_031610.1. NM_007584.2.
NP_766550.1. NM_172962.1.
UniGeneMm.5021.

3D structure databases

ProteinModelPortalQ03146.
SMRQ03146. Positions 28-189, 600-905.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-5170014.
STRINGQ03146.

PTM databases

PhosphoSiteQ03146.

Proteomic databases

PRIDEQ03146.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000003628; ENSMUSP00000003628; ENSMUSG00000003534.
ENSMUST00000097333; ENSMUSP00000094945; ENSMUSG00000003534.
ENSMUST00000117301; ENSMUSP00000112570; ENSMUSG00000003534.
ENSMUST00000119825; ENSMUSP00000113062; ENSMUSG00000003534.
GeneID12305.
KEGGmmu:12305.

Organism-specific databases

CTD780.
MGIMGI:99216. Ddr1.

Phylogenomic databases

HOGENOMHBG387802.
HOVERGENHBG005461.
InParanoidQ03146.
OMALNVRKGH.
OrthoDBEOG4H19V5.
PhylomeDBQ03146.

Enzyme and pathway databases

BRENDA2.7.10.1. 3474.

Gene expression databases

ArrayExpressQ03146.
BgeeQ03146.
CleanExMM_DDR1.
GenevestigatorQ03146.
GermOnlineENSMUSG00000003534. Mus musculus.

Family and domain databases

InterProIPR000421. Coagulation_fac_5/8-C_type_dom.
IPR008979. Galactose-bd-like.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR001245. Ser-Thr/Tyr_kinase.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
KOK05124.
PfamPF00754. F5_F8_type_C. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSPR00109. TYRKINASE.
SMARTSM00231. FA58C. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF49785. Gal_bind_like. 1 hit.
SSF56112. Kinase_like. 1 hit.
PROSITEPS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. False negative.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio280834.
SOURCESearch...

Entry information

Entry nameDDR1_MOUSE
AccessionPrimary (citable) accession number: Q03146
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 1, 1997
Last modified: November 16, 2011
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents