Q03144 (SNO1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable glutamine amidotransferase SNO1
EC=2.6.-.-

Gene names

Name:	SNO1
Ordered Locus Names:	YMR095C
ORF Names:	YM6543.02C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be required for the production of pyridoxine (vitamin B6). Ref.4
Sequence similarities	Belongs to the glutamine amidotransferase pdxT/SNO family.

Ontologies

Keywords
Biological process	Pyridoxine biosynthesis
Domain	Glutamine amidotransferase
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	anti-apoptosis Inferred from mutant phenotype. Source: SGD glutamine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW pyridoxine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from direct assay. Source: SGD
Molecular function	protein binding Inferred from physical interaction. Source: IntAct transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SNZ1	Q03148	4	EBI-28190,EBI-17618
SNZ2	P53824	3	EBI-28190,EBI-17623

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 224	224	Probable glutamine amidotransferase SNO1		PRO_0000135619
Sites
	Active site	100	1	Nucleophile By similarity
	Active site	203	1	By similarity
	Active site	205	1	By similarity
	Binding site	129	1	Glutamine Potential

Sequences

	Sequence		Length	Mass (Da)
	Q03144 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: C0EC1B2382581D40	FASTA	224	24,907
	10 20 30 40 50 60 MHKTHSTMSG KSMKVIGVLA LQGAFLEHTN HLKRCLAEND YGIKIEIKTV KTPEDLAQCD 70 80 90 100 110 120 ALIIPGGEST SMSLIAQRTG LYPCLYEFVH NPEKVVWGTC AGLIFLSAQL ENESALVKTL 130 140 150 160 170 180 GVLKVDVRRN AFGRQAQSFT QKCDFSNFIP GCDNFPATFI RAPVIERILD PIAVKSLYEL 190 200 210 220 PVNGKDVVVA ATQNHNILVT SFHPELADSD TRFHDWFIRQ FVSN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. , Skelton J., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:90-93(1997) [PubMed: 9169872] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6." Rodriguez-Navarro S., Llorente B., Rodriguez-Manzaneque M.T., Ramne A., Uber G., Marchesan D., Dujon B., Herrero E., Sunnerhagen P., Perez-Ortin J.E. Yeast 19:1261-1276(2002) [PubMed: 12271461] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z49807 Genomic DNA. Translation: CAA89896.1. AY692745 Genomic DNA. Translation: AAT92764.1. BK006946 Genomic DNA. Translation: DAA09992.1.
PIR	S55081.
RefSeq	NP_013813.1. NM_001182595.1.
3D structure databases
ProteinModelPortal	Q03144.
SMR	Q03144. Positions 15-222.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1642N.
IntAct	Q03144. 12 interactions.
MINT	MINT-386947.
STRING	Q03144.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YMR095C; YMR095C; YMR095C.
GeneID	855120.
KEGG	sce:YMR095C.
NMPDR	fig|4932.3.peg.4860.
Organism-specific databases
CYGD	YMR095c.
SGD	S000004701. SNO1.
Phylogenomic databases
eggNOG	fuNOG09923.
GeneTree	EFGT00050000003446.
HOGENOM	HBG292341.
OMA	ARDGHER.
OrthoDB	EOG4R2742.
Gene expression databases
ArrayExpress	Q03144.
Genevestigator	Q03144.
GermOnline	YMR095C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR002161. Glutamine_amidoTferase_suPdxT. IPR021196. PdxT/SNO_CS. [Graphical view]
KO	K08681.
Pfam	PF01174. SNO. 1 hit. [Graphical view]
PIRSF	PIRSF005639. Glut_amidoT_SNO. 1 hit.
TIGRFAMs	TIGR03800. PLP_synth_Pdx2. 1 hit.
PROSITE	PS01236. PDXT_SNO_1. 1 hit. PS51130. PDXT_SNO_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	978473.

Entry information

Entry name

SNO1_YEAST

Accession

Primary (citable) accession number: Q03144
Secondary accession number(s): D6VZR8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	December 14, 2011
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program