Caveolin-1 - Homo sapiens (Human)

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

Alternative products

Sequence annotation (Features)

Sequences

References

Web resources

Cross-references

Entry information

Relevant documents

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

Alternative products

Sequence annotation (Features)

Sequences

References

Web resources

Cross-references

Entry information

Relevant documents

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Preferred order of sections

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Entry

#Exp.

IntAct

Notes

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

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Q03135 (CAV1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 153. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

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Names·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents Customize order

Protein names

Recommended name:
Caveolin-1

Gene names

Name:	CAV1
Synonyms:	CAV

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Sequence length	178 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

Function	May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity By similarity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Ref.8 Ref.13
Subunit structure	Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and STX1A. Interacts with rotavirus A NSP4. Interacts (via the N-terminus) with DPP4; the interaction is direct. Interacts with CTNNB1, CDH1 and JUP. Interacts with PACSIN2 By similarity. Interacts with BMX and BTK. Ref.8 Ref.9 Ref.11 Ref.12 Ref.13
Subcellular location	Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane › caveola; Peripheral membrane protein. Membrane raft. Note: Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Ref.6 Ref.8 Ref.13
Tissue specificity	Expressed in muscle and lung, less so in liver, brain and kidney.
Post-translational modification	The initiator methionine for isoform Beta is removed during or just after translation. The new N-terminal amino acid is then N-acetylated. Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress. Ref.6 Ref.10
Involvement in disease	Congenital generalized lipodystrophy 3 (CGL3) [MIM:612526]: An autosomal recessive disorder characterized by a near complete absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.21
Sequence similarities	Belongs to the caveolin family.

Keywords
Biological process	Host-virus interaction
Cellular component	Cell membrane Golgi apparatus Membrane
Coding sequence diversity	Alternative initiation
Disease	Congenital generalized lipodystrophy Disease mutation
PTM	Acetylation Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	MAPK cascade Inferred from electronic annotation. Source: Compara T cell costimulation Inferred from direct assay Ref.13. Source: UniProtKB angiogenesis Inferred from electronic annotation. Source: Compara apoptotic signaling pathway Inferred from mutant phenotype PubMed 21382479. Source: UniProtKB blood coagulation Traceable author statement. Source: Reactome calcium ion transport Inferred from sequence or structural similarity. Source: BHF-UCL caveola assembly Inferred from mutant phenotype PubMed 12633858. Source: BHF-UCL caveolin-mediated endocytosis Inferred from direct assay PubMed 19931615. Source: UniProtKB cellular response to hyperoxia Inferred from mutant phenotype PubMed 21382479. Source: UniProtKB cellular response to starvation Inferred from expression pattern PubMed 15657086. Source: BHF-UCL cholesterol homeostasis Inferred from sequence or structural similarity. Source: BHF-UCL cholesterol transport Traceable author statement PubMed 11294831. Source: HGNC cytosolic calcium ion homeostasis Inferred from direct assay PubMed 19052258. Source: BHF-UCL inactivation of MAPK activity Inferred from sequence or structural similarity. Source: BHF-UCL lactation Inferred from electronic annotation. Source: Compara leukocyte migration Traceable author statement. Source: Reactome lipid storage Inferred from sequence or structural similarity. Source: BHF-UCL maintenance of protein location in cell Inferred from sequence or structural similarity. Source: BHF-UCL mammary gland involution Inferred from sequence or structural similarity. Source: BHF-UCL membrane depolarization Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of BMP signaling pathway Inferred from direct assay PubMed 15657086. Source: BHF-UCL negative regulation of JAK-STAT cascade Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of anoikis Inferred from mutant phenotype PubMed 22277751. Source: UniProtKB negative regulation of canonical Wnt receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of cytokine-mediated signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of endothelial cell proliferation Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of epithelial cell differentiation Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of nitric oxide biosynthetic process Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of nitric-oxide synthase activity Inferred from electronic annotation. Source: Compara negative regulation of peptidyl-serine phosphorylation Inferred from direct assay PubMed 18081315. Source: BHF-UCL negative regulation of protein binding Inferred from direct assay PubMed 16890161. Source: BHF-UCL negative regulation of protein ubiquitination Inferred from mutant phenotype PubMed 22277751. Source: UniProtKB negative regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of tyrosine phosphorylation of Stat5 protein Inferred from electronic annotation. Source: Compara nitric oxide homeostasis Inferred from sequence or structural similarity. Source: BHF-UCL nitric oxide metabolic process Traceable author statement. Source: Reactome positive regulation of calcium ion transport into cytosol Inferred from sequence or structural similarity PubMed 19052258. Source: BHF-UCL positive regulation of canonical Wnt receptor signaling pathway Inferred from mutant phenotype PubMed 16890161. Source: BHF-UCL positive regulation of extrinsic apoptotic signaling pathway Inferred from mutant phenotype PubMed 21382479. Source: UniProtKB positive regulation of intrinsic apoptotic signaling pathway Inferred from mutant phenotype PubMed 21382479. Source: UniProtKB positive regulation of metalloenzyme activity Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of peptidyl-serine phosphorylation Inferred from direct assay PubMed 18081315. Source: BHF-UCL positive regulation of vasoconstriction Inferred from sequence or structural similarity. Source: BHF-UCL protein homooligomerization Inferred from sequence or structural similarity. Source: BHF-UCL receptor internalization involved in canonical Wnt receptor signaling pathway Inferred from mutant phenotype PubMed 16890161. Source: BHF-UCL regulation of blood coagulation Inferred from mutant phenotype PubMed 17848177. Source: BHF-UCL regulation of fatty acid metabolic process Inferred from sequence or structural similarity. Source: BHF-UCL regulation of nitric-oxide synthase activity Traceable author statement. Source: Reactome regulation of smooth muscle contraction Inferred from sequence or structural similarity. Source: BHF-UCL regulation of the force of heart contraction by chemical signal Inferred from electronic annotation. Source: Compara response to calcium ion Inferred from sequence or structural similarity PubMed 19052258. Source: BHF-UCL response to estrogen stimulus Inferred from direct assay PubMed 12388746. Source: MGI response to hypoxia Inferred from sequence or structural similarity. Source: BHF-UCL response to ischemia Inferred from electronic annotation. Source: Compara response to progesterone stimulus Inferred from direct assay PubMed 12388746. Source: MGI skeletal muscle tissue development Inferred from sequence or structural similarity. Source: BHF-UCL small molecule metabolic process Traceable author statement. Source: Reactome triglyceride metabolic process Inferred from sequence or structural similarity. Source: BHF-UCL vasculogenesis Inferred from sequence or structural similarity. Source: BHF-UCL vasoconstriction Inferred from electronic annotation. Source: Compara vesicle organization Inferred from direct assay PubMed 12743374. Source: BHF-UCL virus-host interaction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Golgi membrane Inferred from direct assay PubMed 11294831. Source: HGNC acrosomal membrane Inferred from electronic annotation. Source: Compara apical plasma membrane Inferred from direct assay PubMed 16904002. Source: BHF-UCL basolateral plasma membrane Inferred from direct assay PubMed 16904002. Source: BHF-UCL caveola Inferred from direct assay Ref.6. Source: UniProtKB cell cortex Inferred from electronic annotation. Source: Compara endocytic vesicle membrane Traceable author statement. Source: Reactome endoplasmic reticulum part Inferred from direct assay PubMed 22792322. Source: MGI endosome Inferred from direct assay PubMed 20682791. Source: UniProtKB integral to plasma membrane Inferred from electronic annotation. Source: Compara lipid particle Traceable author statement. Source: Reactome perinuclear region of cytoplasm Inferred from direct assay PubMed 19931615. Source: UniProtKB protein complex Inferred from electronic annotation. Source: Compara
Molecular_function	cholesterol binding Traceable author statement PubMed 11294831. Source: HGNC peptidase activator activity Inferred from sequence or structural similarity. Source: BHF-UCL protein complex scaffold Traceable author statement PubMed 19052258. Source: BHF-UCL
Complete GO annotation...

With	Entry	#Exp.	IntAct
BID	P55957	3	EBI-603614,EBI-519672
F2R	P25116	3	EBI-603614,EBI-2803960
FAS	P25445	3	EBI-603614,EBI-494743
ID1	P41134	6	EBI-603614,EBI-1215527
MCL1	Q07820	3	EBI-603614,EBI-1003422
SCP2	P22307	3	EBI-603614,EBI-1050999

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Initiator methionine

Removed Ref.6

Chain

2 – 178

177

Caveolin-1

PRO_0000004764

Topological domain

2 – 104

103

Cytoplasmic Potential

Intramembrane

105 – 125

Helical; Potential

Topological domain

126 – 178

Cytoplasmic Potential

Modified residue

N-acetylserine Ref.6 Ref.16

Modified residue

N6-acetyllysine Ref.16

Modified residue

Phosphotyrosine

Modified residue

Phosphotyrosine; by ABL1 Ref.10

Modified residue

Phosphotyrosine

Modified residue

Phosphoserine Ref.14 Ref.15 Ref.17 Ref.19

Modified residue

Phosphotyrosine

Lipidation

133

S-palmitoyl cysteine By similarity

Lipidation

143

S-palmitoyl cysteine By similarity

Lipidation

156

S-palmitoyl cysteine By similarity

Alternative sequence

1 – 31

Missing in isoform Beta.

VSP_018692

Natural variant

132

P → L in breast cancer; seems to form misfolded oligomers that are retained within the Golgi complex and are not targeted to caveolae or the plasma membrane. Ref.20

VAR_015103

Sequence conflict

D → H in CAA79476. Ref.1

Sequence conflict

144

I → T in CAA79476. Ref.1

Sequence		Length	Mass (Da)
Isoform Alpha [UniParc]. Last modified January 23, 2007. Version 4. Checksum: 2424DE9B5E6521D5 Show »	FASTA	178	20,472
10 20 30 40 50 60 MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADELSEKQ VYDAHTKEID LVNRDPKHLN 70 80 90 100 110 120 DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY RLLSALFGIP MALIWGIYFA 130 140 150 160 170 ILSFLHIWAV VPCIKSFLIE IQCISRVYSI YVHTVCDPLF EAVGKIFSNV RINLQKEI « Hide
Isoform Beta [UniParc]. Checksum: 1A7D806312F72A47 Show »	FASTA	147	17,023
10 20 30 40 50 60 MADELSEKQV YDAHTKEIDL VNRDPKHLND DVVKIDFEDV IAEPEGTHSF DGIWKASFTT 70 80 90 100 110 120 FTVTKYWFYR LLSALFGIPM ALIWGIYFAI LSFLHIWAVV PCIKSFLIEI QCISRVYSIY 130 140 VHTVCDPLFE AVGKIFSNVR INLQKEI « Hide

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles." Glenney J.R. Jr. FEBS Lett. 314:45-48(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[2]	"Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines." Hurlstone A.F., Reid G., Reeves J.R., Fraser J., Strathdee G., Rahilly M., Parkinson E.K., Black D.M. Oncogene 18:1881-1890(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5' promoter region of the caveolin-1 gene in human breast cancer cell lines." Engelman J.A., Zhang X.L., Lisanti M.P. FEBS Lett. 448:221-230(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Lung.
[6]	"N-terminal processing and modifications of caveolin-1 in caveolae from human adipocytes." Vainonen J.P., Aboulaich N., Turkina M.V., Stralfors P., Vener A.V. Biochem. Biophys. Res. Commun. 320:480-486(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-66, SUBCELLULAR LOCATION, ACETYLATION AT SER-2, PHOSPHORYLATION. Tissue: Adipose tissue.
[7]	"Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes." Aboulaich N., Vainonen J.P., Stralfors P., Vener A.V. Biochem. J. 383:237-248(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 58-65. Tissue: Adipocyte.
[8]	"Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx." Vargas L., Nore B.F., Berglof A., Heinonen J.E., Mattsson P.T., Smith C.I., Mohamed A.J. J. Biol. Chem. 277:9351-9357(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH BMX AND BTK.
[9]	"Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex." Eberle H.B., Serrano R.L., Fuellekrug J., Schlosser A., Lehmann W.D., Lottspeich F., Kaloyanova D., Wieland F.T., Helms J.B. J. Cell Sci. 115:827-838(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH GLIPR2. Tissue: Brain.
[10]	"c-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14." Sanguinetti A.R., Mastick C.C. Cell. Signal. 15:289-298(2003) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT TYR-14.
[11]	"Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN." Schilling K., Opitz N., Wiesenthal A., Oess S., Tikkanen R., Mueller-Esterl W., Icking A. Mol. Biol. Cell 17:3870-3880(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH NOSTRIN.
[12]	"The rotavirus enterotoxin NSP4 directly interacts with the caveolar structural protein caveolin-1." Parr R.D., Storey S.M., Mitchell D.M., McIntosh A.L., Zhou M., Mir K.D., Ball J.M. J. Virol. 80:2842-2854(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ROTAVIRUS A NSP4.
[13]	"Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1." Ohnuma K., Uchiyama M., Yamochi T., Nishibashi K., Hosono O., Takahashi N., Kina S., Tanaka H., Lin X., Dang N.H., Morimoto C. J. Biol. Chem. 282:10117-10131(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH DPP4, SUBCELLULAR LOCATION.
[14]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, MASS SPECTROMETRY.
[16]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2 AND LYS-5, MASS SPECTROMETRY.
[17]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[18]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[19]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, MASS SPECTROMETRY.
[20]	"Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia." Lee H., Park D.S., Razani B., Russell R.G., Pestell R.G., Lisanti M.P. Am. J. Pathol. 161:1357-1369(2002) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT LEU-132.
[21]	"Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy." Kim C.A., Delepine M., Boutet E., El Mourabit H., Le Lay S., Meier M., Nemani M., Bridel E., Leite C.C., Bertola D.R., Semple R.K., O'Rahilly S., Dugail I., Capeau J., Lathrop M., Magre J. J. Clin. Endocrinol. Metab. 93:1129-1134(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN CGL3.
+	Additional computationally mapped references.

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Wikipedia

Caveolin entry

Sequence databases
EMBL GenBank DDBJ	Z18951 mRNA. Translation: CAA79476.1. AF095593, AF095591, AF095592 Genomic DNA. Translation: AAD23745.1. AJ133269 Genomic DNA. Translation: CAB63654.1. AF125348 Genomic DNA. Translation: AAD34722.1. BT007143 mRNA. Translation: AAP35807.1. BC009685 mRNA. Translation: AAH09685.1. BC082246 mRNA. Translation: AAH82246.1.
IPI	IPI00009236. IPI00759683.
PIR	S26884.
RefSeq	NP_001744.2. NM_001753.4.
UniGene	Hs.74034.
3D structure databases
ProteinModelPortal	Q03135.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5960N.
IntAct	Q03135. 17 interactions.
MINT	MINT-152933.
STRING	9606.ENSP00000339191.
PTM databases
PhosphoSite	Q03135.
Polymorphism databases
DMDM	13637934.
Proteomic databases
PaxDb	Q03135.
PeptideAtlas	Q03135.
PRIDE	Q03135.
Protocols and materials databases
DNASU	857.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341049; ENSP00000339191; ENSG00000105974. ENST00000393467; ENSP00000377110; ENSG00000105974. ENST00000393468; ENSP00000377111; ENSG00000105974. ENST00000405348; ENSP00000384348; ENSG00000105974.
GeneID	857.
KEGG	hsa:857.
UCSC	uc003vif.2. human.
Organism-specific databases
CTD	857.
GeneCards	GC07P116164.
HGNC	HGNC:1527. CAV1.
HPA	CAB003791.
MIM	601047. gene. 612526. phenotype.
neXtProt	NX_Q03135.
Orphanet	528. Berardinelli-Seip congenital lipodystrophy. 220393. Diffuse cutaneous systemic sclerosis. 275777. Heritable pulmonary arterial hypertension. 220402. Limited cutaneous systemic sclerosis.
PharmGKB	PA26107.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG86001.
HOVERGEN	HBG003422.
InParanoid	Q03135.
KO	K06278.
OMA	VHTFCDP.
OrthoDB	EOG4JQ3ZP.
PhylomeDB	Q03135.
Enzyme and pathway databases
Pathway_Interaction_DB	insulin_pathway. Insulin Pathway. pdgfrapathway. PDGFR-alpha signaling pathway. ptp1bpathway. Signaling events mediated by PTP1B. vegfr1_2_pathway. Signaling events mediated by VEGFR1 and VEGFR2. tgfbrpathway. TGF-beta receptor signaling. tnfpathway. TNF receptor signaling pathway. vegfr1_pathway. VEGFR1 specific signals.
Reactome	REACT_111217. Metabolism. REACT_604. Hemostasis.
SignaLink	Q03135.
Gene expression databases
ArrayExpress	Q03135.
Bgee	Q03135.
CleanEx	HS_CAV1.
Genevestigator	Q03135.
GermOnline	ENSG00000105974. Homo sapiens.
Family and domain databases
InterPro	IPR001612. Caveolin. IPR015504. Caveolin_1. IPR018361. Caveolin_CS. [Graphical view]
PANTHER	PTHR10844. PTHR10844. 1 hit. PTHR10844:SF5. PTHR10844:SF5. 1 hit.
Pfam	PF01146. Caveolin. 1 hit. [Graphical view]
PROSITE	PS01210. CAVEOLIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CAV1. human.
GenomeRNAi	857.
NextBio	3556.
SOURCE	Search...

Entry name

CAV1_HUMAN

Accession

Primary (citable) accession number: Q03135
Secondary accession number(s): Q9UGP1, Q9UNG1, Q9UQH6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	January 23, 2007
Last modified:	May 29, 2013
This is version 153 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]

Isoform Alpha (identifier: Q03135-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Beta (identifier: Q03135-2)

The sequence of this isoform differs from the canonical sequence as follows:
1-31: Missing.

Note: Initiator Met-1 is removed. Contains a N-acetylalanine at position 2.