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Q03135

- CAV1_HUMAN

UniProt

Q03135 - CAV1_HUMAN

Protein

Caveolin-1

Gene

CAV1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity By similarity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.By similarity2 Publications

    GO - Molecular functioni

    1. cholesterol binding Source: HGNC
    2. enzyme binding Source: UniProtKB
    3. nitric-oxide synthase binding Source: BHF-UCL
    4. patched binding Source: BHF-UCL
    5. peptidase activator activity Source: BHF-UCL
    6. protein binding Source: BHF-UCL
    7. protein complex scaffold Source: BHF-UCL
    8. receptor binding Source: BHF-UCL
    9. structural molecule activity Source: UniProtKB

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. apoptotic signaling pathway Source: UniProtKB
    3. blood coagulation Source: Reactome
    4. calcium ion homeostasis Source: BHF-UCL
    5. calcium ion transport Source: BHF-UCL
    6. caveola assembly Source: BHF-UCL
    7. caveolin-mediated endocytosis Source: UniProtKB
    8. cellular calcium ion homeostasis Source: BHF-UCL
    9. cellular response to hyperoxia Source: UniProtKB
    10. cellular response to starvation Source: BHF-UCL
    11. cholesterol homeostasis Source: BHF-UCL
    12. cholesterol transport Source: HGNC
    13. cytosolic calcium ion homeostasis Source: BHF-UCL
    14. inactivation of MAPK activity Source: BHF-UCL
    15. lactation Source: Ensembl
    16. leukocyte migration Source: Reactome
    17. lipid storage Source: BHF-UCL
    18. maintenance of protein location in cell Source: BHF-UCL
    19. mammary gland development Source: BHF-UCL
    20. mammary gland involution Source: BHF-UCL
    21. MAPK cascade Source: Ensembl
    22. membrane depolarization Source: BHF-UCL
    23. negative regulation of anoikis Source: UniProtKB
    24. negative regulation of BMP signaling pathway Source: BHF-UCL
    25. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
    26. negative regulation of cytokine-mediated signaling pathway Source: Ensembl
    27. negative regulation of endothelial cell proliferation Source: BHF-UCL
    28. negative regulation of epithelial cell differentiation Source: BHF-UCL
    29. negative regulation of JAK-STAT cascade Source: BHF-UCL
    30. negative regulation of MAPK cascade Source: BHF-UCL
    31. negative regulation of nitric oxide biosynthetic process Source: BHF-UCL
    32. negative regulation of nitric-oxide synthase activity Source: Ensembl
    33. negative regulation of peptidyl-serine phosphorylation Source: BHF-UCL
    34. negative regulation of pinocytosis Source: UniProt
    35. negative regulation of protein binding Source: BHF-UCL
    36. negative regulation of protein ubiquitination Source: UniProtKB
    37. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    38. negative regulation of tyrosine phosphorylation of Stat5 protein Source: Ensembl
    39. nitric oxide homeostasis Source: BHF-UCL
    40. nitric oxide metabolic process Source: Reactome
    41. positive regulation of calcium ion transport into cytosol Source: BHF-UCL
    42. positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
    43. positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
    44. positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
    45. positive regulation of metalloenzyme activity Source: BHF-UCL
    46. positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
    47. positive regulation of vasoconstriction Source: BHF-UCL
    48. protein homooligomerization Source: BHF-UCL
    49. protein localization Source: BHF-UCL
    50. receptor internalization involved in canonical Wnt signaling pathway Source: BHF-UCL
    51. regulation of blood coagulation Source: BHF-UCL
    52. regulation of fatty acid metabolic process Source: BHF-UCL
    53. regulation of nitric-oxide synthase activity Source: Reactome
    54. regulation of peptidase activity Source: BHF-UCL
    55. regulation of smooth muscle contraction Source: BHF-UCL
    56. regulation of the force of heart contraction by chemical signal Source: Ensembl
    57. response to calcium ion Source: BHF-UCL
    58. response to estrogen Source: MGI
    59. response to hypoxia Source: BHF-UCL
    60. response to ischemia Source: Ensembl
    61. response to progesterone Source: MGI
    62. skeletal muscle tissue development Source: BHF-UCL
    63. small molecule metabolic process Source: Reactome
    64. T cell costimulation Source: UniProtKB
    65. triglyceride metabolic process Source: BHF-UCL
    66. vasculogenesis Source: BHF-UCL
    67. vasoconstriction Source: Ensembl
    68. vesicle organization Source: BHF-UCL
    69. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction

    Enzyme and pathway databases

    ReactomeiREACT_12477. eNOS activation.
    REACT_12541. NOSTRIN mediated eNOS trafficking.
    REACT_12560. Basigin interactions.
    REACT_494. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.
    SignaLinkiQ03135.

    Protein family/group databases

    TCDBi8.A.26.1.1. the caveolin (caveolin) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Caveolin-1
    Gene namesi
    Name:CAV1
    Synonyms:CAV
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:1527. CAV1.

    Subcellular locationi

    Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membranecaveola; Peripheral membrane protein. Membrane raft
    Note: Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.

    GO - Cellular componenti

    1. acrosomal membrane Source: Ensembl
    2. apical plasma membrane Source: BHF-UCL
    3. basolateral plasma membrane Source: BHF-UCL
    4. caveola Source: UniProtKB
    5. cell cortex Source: Ensembl
    6. cilium Source: Ensembl
    7. cytoplasmic vesicle Source: UniProtKB
    8. endocytic vesicle membrane Source: Reactome
    9. endoplasmic reticulum Source: HGNC
    10. endosome Source: UniProtKB
    11. Golgi membrane Source: HGNC
    12. integral component of plasma membrane Source: Ensembl
    13. intracellular Source: BHF-UCL
    14. lipid particle Source: Reactome
    15. membrane raft Source: UniProtKB
    16. perinuclear region of cytoplasm Source: UniProtKB
    17. plasma membrane Source: UniProtKB
    18. protein complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Golgi apparatus, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Congenital generalized lipodystrophy 3 (CGL3) [MIM:612526]: An autosomal recessive disorder characterized by a near complete absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Pulmonary hypertension, primary, 3 (PPH3) [MIM:615343]: A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Congenital generalized lipodystrophy, Disease mutation

    Organism-specific databases

    MIMi612526. phenotype.
    615343. phenotype.
    Orphaneti528. Berardinelli-Seip congenital lipodystrophy.
    220393. Diffuse cutaneous systemic sclerosis.
    275777. Heritable pulmonary arterial hypertension.
    220402. Limited cutaneous systemic sclerosis.
    PharmGKBiPA26107.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 178177Caveolin-1PRO_0000004764Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine3 Publications
    Modified residuei5 – 51N6-acetyllysine1 Publication
    Modified residuei6 – 61Phosphotyrosine1 Publication
    Modified residuei14 – 141Phosphotyrosine; by ABL12 Publications
    Modified residuei25 – 251Phosphotyrosine1 Publication
    Modified residuei37 – 371Phosphoserine5 Publications
    Modified residuei42 – 421Phosphotyrosine
    Lipidationi133 – 1331S-palmitoyl cysteineBy similarity
    Lipidationi143 – 1431S-palmitoyl cysteineBy similarity
    Lipidationi156 – 1561S-palmitoyl cysteineBy similarity

    Post-translational modificationi

    The initiator methionine for isoform 2 is removed during or just after translation. The new N-terminal amino acid is then N-acetylated.3 Publications
    Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.7 Publications

    Keywords - PTMi

    Acetylation, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    MaxQBiQ03135.
    PaxDbiQ03135.
    PeptideAtlasiQ03135.
    PRIDEiQ03135.

    PTM databases

    PhosphoSiteiQ03135.

    Expressioni

    Tissue specificityi

    Expressed in muscle and lung, less so in liver, brain and kidney.

    Gene expression databases

    ArrayExpressiQ03135.
    BgeeiQ03135.
    CleanExiHS_CAV1.
    GenevestigatoriQ03135.

    Organism-specific databases

    HPAiCAB003791.

    Interactioni

    Subunit structurei

    Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and STX1A. Interacts with rotavirus A NSP4. Interacts (via the N-terminus) with DPP4; the interaction is direct. Interacts with CTNNB1, CDH1 and JUP. Interacts with PACSIN2. Interacts with SLC7A9 By similarity. Interacts with BMX and BTK.By similarity5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Axin1O702395EBI-603614,EBI-6857773From a different organism.
    BIDP559573EBI-603614,EBI-519672
    F2RP251163EBI-603614,EBI-2803960
    FASP254453EBI-603614,EBI-494743
    Grb7Q031603EBI-603614,EBI-7100053From a different organism.
    ID1P411346EBI-603614,EBI-1215527
    LRP6O755813EBI-603614,EBI-910915
    MCL1Q078203EBI-603614,EBI-1003422
    PTPN1P180315EBI-603614,EBI-968788
    SCP2P223073EBI-603614,EBI-1050999
    TXNRD1Q168814EBI-603614,EBI-716617

    Protein-protein interaction databases

    BioGridi107305. 115 interactions.
    DIPiDIP-5960N.
    IntActiQ03135. 37 interactions.
    MINTiMINT-152933.
    STRINGi9606.ENSP00000339191.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03135.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 104103CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini126 – 17853CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei105 – 12521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the caveolin family.Curated

    Phylogenomic databases

    eggNOGiNOG86001.
    HOVERGENiHBG003422.
    InParanoidiQ03135.
    KOiK06278.
    OMAiRINMQKE.
    OrthoDBiEOG7V1FSD.
    PhylomeDBiQ03135.
    TreeFamiTF315736.

    Family and domain databases

    InterProiIPR001612. Caveolin.
    IPR015504. Caveolin_1.
    IPR018361. Caveolin_CS.
    [Graphical view]
    PANTHERiPTHR10844. PTHR10844. 1 hit.
    PTHR10844:SF5. PTHR10844:SF5. 1 hit.
    PfamiPF01146. Caveolin. 1 hit.
    [Graphical view]
    PROSITEiPS01210. CAVEOLIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative initiation. Align

    Isoform 1 (identifier: Q03135-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADELSEKQ VYDAHTKEID    50
    LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY 100
    RLLSALFGIP MALIWGIYFA ILSFLHIWAV VPCIKSFLIE IQCISRVYSI 150
    YVHTVCDPLF EAVGKIFSNV RINLQKEI 178
    Length:178
    Mass (Da):20,472
    Last modified:January 23, 2007 - v4
    Checksum:i2424DE9B5E6521D5
    GO
    Isoform 2 (identifier: Q03135-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-31: Missing.

    Note: Initiator Met-1 is removed. Contains a N-acetylalanine at position 2. Contains a phosphoserine at position 6.

    Show »
    Length:147
    Mass (Da):17,023
    Checksum:i1A7D806312F72A47
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti82 – 821D → H in CAA79476. (PubMed:1360410)Curated
    Sequence conflicti144 – 1441I → T in CAA79476. (PubMed:1360410)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti132 – 1321P → L in breast cancer; seems to form misfolded oligomers that are retained within the Golgi complex and are not targeted to caveolae or the plasma membrane. 1 Publication
    VAR_015103

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3131Missing in isoform 2. CuratedVSP_018692Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z18951 mRNA. Translation: CAA79476.1.
    AF095593, AF095591, AF095592 Genomic DNA. Translation: AAD23745.1.
    AJ133269 Genomic DNA. Translation: CAB63654.1.
    AF125348 Genomic DNA. Translation: AAD34722.1.
    BT007143 mRNA. Translation: AAP35807.1.
    BC009685 mRNA. Translation: AAH09685.1.
    BC082246 mRNA. Translation: AAH82246.1.
    CCDSiCCDS55156.1. [Q03135-2]
    CCDS5767.1. [Q03135-1]
    PIRiS26884.
    RefSeqiNP_001744.2. NM_001753.4. [Q03135-1]
    UniGeneiHs.74034.

    Genome annotation databases

    EnsembliENST00000341049; ENSP00000339191; ENSG00000105974. [Q03135-1]
    ENST00000393467; ENSP00000377110; ENSG00000105974. [Q03135-2]
    ENST00000393468; ENSP00000377111; ENSG00000105974. [Q03135-2]
    ENST00000405348; ENSP00000384348; ENSG00000105974. [Q03135-2]
    GeneIDi857.
    KEGGihsa:857.
    UCSCiuc003vif.2. human. [Q03135-1]

    Polymorphism databases

    DMDMi13637934.

    Keywords - Coding sequence diversityi

    Alternative initiation

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia

    Caveolin entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z18951 mRNA. Translation: CAA79476.1 .
    AF095593 , AF095591 , AF095592 Genomic DNA. Translation: AAD23745.1 .
    AJ133269 Genomic DNA. Translation: CAB63654.1 .
    AF125348 Genomic DNA. Translation: AAD34722.1 .
    BT007143 mRNA. Translation: AAP35807.1 .
    BC009685 mRNA. Translation: AAH09685.1 .
    BC082246 mRNA. Translation: AAH82246.1 .
    CCDSi CCDS55156.1. [Q03135-2 ]
    CCDS5767.1. [Q03135-1 ]
    PIRi S26884.
    RefSeqi NP_001744.2. NM_001753.4. [Q03135-1 ]
    UniGenei Hs.74034.

    3D structure databases

    ProteinModelPortali Q03135.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107305. 115 interactions.
    DIPi DIP-5960N.
    IntActi Q03135. 37 interactions.
    MINTi MINT-152933.
    STRINGi 9606.ENSP00000339191.

    Protein family/group databases

    TCDBi 8.A.26.1.1. the caveolin (caveolin) family.

    PTM databases

    PhosphoSitei Q03135.

    Polymorphism databases

    DMDMi 13637934.

    Proteomic databases

    MaxQBi Q03135.
    PaxDbi Q03135.
    PeptideAtlasi Q03135.
    PRIDEi Q03135.

    Protocols and materials databases

    DNASUi 857.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000341049 ; ENSP00000339191 ; ENSG00000105974 . [Q03135-1 ]
    ENST00000393467 ; ENSP00000377110 ; ENSG00000105974 . [Q03135-2 ]
    ENST00000393468 ; ENSP00000377111 ; ENSG00000105974 . [Q03135-2 ]
    ENST00000405348 ; ENSP00000384348 ; ENSG00000105974 . [Q03135-2 ]
    GeneIDi 857.
    KEGGi hsa:857.
    UCSCi uc003vif.2. human. [Q03135-1 ]

    Organism-specific databases

    CTDi 857.
    GeneCardsi GC07P116164.
    HGNCi HGNC:1527. CAV1.
    HPAi CAB003791.
    MIMi 601047. gene.
    612526. phenotype.
    615343. phenotype.
    neXtProti NX_Q03135.
    Orphaneti 528. Berardinelli-Seip congenital lipodystrophy.
    220393. Diffuse cutaneous systemic sclerosis.
    275777. Heritable pulmonary arterial hypertension.
    220402. Limited cutaneous systemic sclerosis.
    PharmGKBi PA26107.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG86001.
    HOVERGENi HBG003422.
    InParanoidi Q03135.
    KOi K06278.
    OMAi RINMQKE.
    OrthoDBi EOG7V1FSD.
    PhylomeDBi Q03135.
    TreeFami TF315736.

    Enzyme and pathway databases

    Reactomei REACT_12477. eNOS activation.
    REACT_12541. NOSTRIN mediated eNOS trafficking.
    REACT_12560. Basigin interactions.
    REACT_494. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.
    SignaLinki Q03135.

    Miscellaneous databases

    ChiTaRSi CAV1. human.
    GeneWikii Caveolin_1.
    GenomeRNAii 857.
    NextBioi 3556.
    PROi Q03135.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q03135.
    Bgeei Q03135.
    CleanExi HS_CAV1.
    Genevestigatori Q03135.

    Family and domain databases

    InterProi IPR001612. Caveolin.
    IPR015504. Caveolin_1.
    IPR018361. Caveolin_CS.
    [Graphical view ]
    PANTHERi PTHR10844. PTHR10844. 1 hit.
    PTHR10844:SF5. PTHR10844:SF5. 1 hit.
    Pfami PF01146. Caveolin. 1 hit.
    [Graphical view ]
    PROSITEi PS01210. CAVEOLIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles."
      Glenney J.R. Jr.
      FEBS Lett. 314:45-48(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    2. "Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines."
      Hurlstone A.F., Reid G., Reeves J.R., Fraser J., Strathdee G., Rahilly M., Parkinson E.K., Black D.M.
      Oncogene 18:1881-1890(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5' promoter region of the caveolin-1 gene in human breast cancer cell lines."
      Engelman J.A., Zhang X.L., Lisanti M.P.
      FEBS Lett. 448:221-230(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Lung.
    6. "N-terminal processing and modifications of caveolin-1 in caveolae from human adipocytes."
      Vainonen J.P., Aboulaich N., Turkina M.V., Stralfors P., Vener A.V.
      Biochem. Biophys. Res. Commun. 320:480-486(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-66, SUBCELLULAR LOCATION, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, PHOSPHORYLATION AT SER-37, CLEAVAGE OF INITIATOR METHIONINE (ISOFORM 2), ACETYLATION AT ALA-2 (ISOFORM 2), PHOSPHORYLATION AT SER-6 (ISOFORM 2).
      Tissue: Adipose tissue.
    7. "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."
      Aboulaich N., Vainonen J.P., Stralfors P., Vener A.V.
      Biochem. J. 383:237-248(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 58-65.
      Tissue: Adipocyte.
    8. "Phosphorylation of caveolin by src tyrosine kinases. The alpha-isoform of caveolin is selectively phosphorylated by v-Src in vivo."
      Li S., Seitz R., Lisanti M.P.
      J. Biol. Chem. 271:3863-3868(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT TYR-6; TYR-14 AND TYR-25.
    9. "Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx."
      Vargas L., Nore B.F., Berglof A., Heinonen J.E., Mattsson P.T., Smith C.I., Mohamed A.J.
      J. Biol. Chem. 277:9351-9357(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH BMX AND BTK.
    10. "Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex."
      Eberle H.B., Serrano R.L., Fuellekrug J., Schlosser A., Lehmann W.D., Lottspeich F., Kaloyanova D., Wieland F.T., Helms J.B.
      J. Cell Sci. 115:827-838(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GLIPR2.
      Tissue: Brain.
    11. "c-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14."
      Sanguinetti A.R., Mastick C.C.
      Cell. Signal. 15:289-298(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT TYR-14.
    12. "Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN."
      Schilling K., Opitz N., Wiesenthal A., Oess S., Tikkanen R., Mueller-Esterl W., Icking A.
      Mol. Biol. Cell 17:3870-3880(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NOSTRIN.
    13. "The rotavirus enterotoxin NSP4 directly interacts with the caveolar structural protein caveolin-1."
      Parr R.D., Storey S.M., Mitchell D.M., McIntosh A.L., Zhou M., Mir K.D., Ball J.M.
      J. Virol. 80:2842-2854(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ROTAVIRUS A NSP4.
    14. Cited for: FUNCTION, INTERACTION WITH DPP4, SUBCELLULAR LOCATION.
    15. Cited for: INVOLVEMENT IN CGL3.
    16. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2 AND LYS-5, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    20. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    21. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    22. "Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension."
      Austin E.D., Ma L., LeDuc C., Berman Rosenzweig E., Borczuk A., Phillips J.A. III, Palomero T., Sumazin P., Kim H.R., Talati M.H., West J., Loyd J.E., Chung W.K.
      Circ. Cardiovasc. Genet. 5:336-343(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN PPH3.
    23. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    24. "Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia."
      Lee H., Park D.S., Razani B., Russell R.G., Pestell R.G., Lisanti M.P.
      Am. J. Pathol. 161:1357-1369(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT LEU-132.

    Entry informationi

    Entry nameiCAV1_HUMAN
    AccessioniPrimary (citable) accession number: Q03135
    Secondary accession number(s): Q9UGP1, Q9UNG1, Q9UQH6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 168 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3