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Q03135 (CAV1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 163. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Caveolin-1
Gene names
Name:CAV1
Synonyms:CAV
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity By similarity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Ref.8 Ref.13

Subunit structure

Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and STX1A. Interacts with rotavirus A NSP4. Interacts (via the N-terminus) with DPP4; the interaction is direct. Interacts with CTNNB1, CDH1 and JUP. Interacts with PACSIN2. Interacts with SLC7A9 By similarity. Interacts with BMX and BTK. Ref.8 Ref.9 Ref.11 Ref.12 Ref.13

Subcellular location

Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membranecaveola; Peripheral membrane protein. Membrane raft. Note: Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Ref.6 Ref.8 Ref.13

Tissue specificity

Expressed in muscle and lung, less so in liver, brain and kidney.

Post-translational modification

The initiator methionine for isoform Beta is removed during or just after translation. The new N-terminal amino acid is then N-acetylated. Ref.6

Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress. Ref.6 Ref.10

Involvement in disease

Congenital generalized lipodystrophy 3 (CGL3) [MIM:612526]: An autosomal recessive disorder characterized by a near complete absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.14

Pulmonary hypertension, primary, 3 (PPH3) [MIM:615343]: A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.21

Sequence similarities

Belongs to the caveolin family.

Ontologies

Keywords
   Biological processHost-virus interaction
   Cellular componentCell membrane
Golgi apparatus
Membrane
   Coding sequence diversityAlternative initiation
   DiseaseCongenital generalized lipodystrophy
Disease mutation
   PTMAcetylation
Lipoprotein
Palmitate
Phosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processMAPK cascade

Inferred from electronic annotation. Source: Ensembl

T cell costimulation

Inferred from direct assay Ref.13. Source: UniProtKB

angiogenesis

Inferred from electronic annotation. Source: Ensembl

apoptotic signaling pathway

Inferred from mutant phenotype PubMed 21382479. Source: UniProtKB

blood coagulation

Traceable author statement. Source: Reactome

calcium ion homeostasis

Inferred from sequence or structural similarity. Source: BHF-UCL

calcium ion transport

Inferred from sequence or structural similarity. Source: BHF-UCL

caveola assembly

Inferred from mutant phenotype PubMed 12633858. Source: BHF-UCL

caveolin-mediated endocytosis

Inferred from direct assay PubMed 19931615. Source: UniProtKB

cellular calcium ion homeostasis

Inferred from sequence or structural similarity. Source: BHF-UCL

cellular response to hyperoxia

Inferred from mutant phenotype PubMed 21382479. Source: UniProtKB

cellular response to starvation

Inferred from expression pattern PubMed 15657086. Source: BHF-UCL

cholesterol homeostasis

Inferred from sequence or structural similarity. Source: BHF-UCL

cholesterol transport

Traceable author statement PubMed 11294831. Source: HGNC

cytosolic calcium ion homeostasis

Inferred from direct assay PubMed 19052258. Source: BHF-UCL

inactivation of MAPK activity

Inferred from sequence or structural similarity. Source: BHF-UCL

lactation

Inferred from electronic annotation. Source: Ensembl

leukocyte migration

Traceable author statement. Source: Reactome

lipid storage

Inferred from sequence or structural similarity. Source: BHF-UCL

maintenance of protein location in cell

Inferred from sequence or structural similarity. Source: BHF-UCL

mammary gland development

Inferred from sequence or structural similarity. Source: BHF-UCL

mammary gland involution

Inferred from sequence or structural similarity. Source: BHF-UCL

membrane depolarization

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of BMP signaling pathway

Inferred from direct assay PubMed 15657086. Source: BHF-UCL

negative regulation of JAK-STAT cascade

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of MAPK cascade

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of anoikis

Inferred from mutant phenotype PubMed 22277751. Source: UniProtKB

negative regulation of canonical Wnt signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cytokine-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of endothelial cell proliferation

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of epithelial cell differentiation

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of nitric oxide biosynthetic process

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of nitric-oxide synthase activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of peptidyl-serine phosphorylation

Inferred from direct assay PubMed 18081315. Source: BHF-UCL

negative regulation of pinocytosis

Inferred from mutant phenotype PubMed 23583380. Source: UniProt

negative regulation of protein binding

Inferred from direct assay PubMed 16890161. Source: BHF-UCL

negative regulation of protein ubiquitination

Inferred from mutant phenotype PubMed 22277751. Source: UniProtKB

negative regulation of transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of tyrosine phosphorylation of Stat5 protein

Inferred from electronic annotation. Source: Ensembl

nitric oxide homeostasis

Inferred from sequence or structural similarity. Source: BHF-UCL

nitric oxide metabolic process

Traceable author statement. Source: Reactome

positive regulation of calcium ion transport into cytosol

Inferred from sequence or structural similarity PubMed 19052258. Source: BHF-UCL

positive regulation of canonical Wnt signaling pathway

Inferred from mutant phenotype PubMed 16890161. Source: BHF-UCL

positive regulation of extrinsic apoptotic signaling pathway

Inferred from mutant phenotype PubMed 21382479. Source: UniProtKB

positive regulation of intrinsic apoptotic signaling pathway

Inferred from mutant phenotype PubMed 21382479. Source: UniProtKB

positive regulation of metalloenzyme activity

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of peptidyl-serine phosphorylation

Inferred from direct assay PubMed 18081315. Source: BHF-UCL

positive regulation of vasoconstriction

Inferred from sequence or structural similarity. Source: BHF-UCL

protein homooligomerization

Inferred from sequence or structural similarity. Source: BHF-UCL

protein localization

Inferred from sequence or structural similarity. Source: BHF-UCL

receptor internalization involved in canonical Wnt signaling pathway

Inferred from mutant phenotype PubMed 16890161. Source: BHF-UCL

regulation of blood coagulation

Inferred from mutant phenotype PubMed 17848177. Source: BHF-UCL

regulation of fatty acid metabolic process

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of nitric-oxide synthase activity

Traceable author statement. Source: Reactome

regulation of peptidase activity

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of smooth muscle contraction

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of the force of heart contraction by chemical signal

Inferred from electronic annotation. Source: Ensembl

response to calcium ion

Inferred from sequence or structural similarity PubMed 19052258. Source: BHF-UCL

response to estrogen

Inferred from direct assay PubMed 12388746. Source: MGI

response to hypoxia

Inferred from sequence or structural similarity. Source: BHF-UCL

response to ischemia

Inferred from electronic annotation. Source: Ensembl

response to progesterone

Inferred from direct assay PubMed 12388746. Source: MGI

skeletal muscle tissue development

Inferred from sequence or structural similarity. Source: BHF-UCL

small molecule metabolic process

Traceable author statement. Source: Reactome

triglyceride metabolic process

Inferred from sequence or structural similarity. Source: BHF-UCL

vasculogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

vasoconstriction

Inferred from electronic annotation. Source: Ensembl

vesicle organization

Inferred from direct assay PubMed 12743374. Source: BHF-UCL

viral process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi membrane

Inferred from direct assay PubMed 11294831. Source: HGNC

acrosomal membrane

Inferred from electronic annotation. Source: Ensembl

apical plasma membrane

Inferred from direct assay PubMed 16904002. Source: BHF-UCL

basolateral plasma membrane

Inferred from direct assay PubMed 16904002. Source: BHF-UCL

caveola

Inferred from direct assay Ref.6. Source: UniProtKB

cell cortex

Inferred from electronic annotation. Source: Ensembl

cilium

Inferred from electronic annotation. Source: Ensembl

cytoplasmic vesicle

Inferred from direct assay PubMed 19931615. Source: UniProtKB

endocytic vesicle membrane

Traceable author statement. Source: Reactome

endoplasmic reticulum

Inferred from direct assay PubMed 11294831. Source: HGNC

endosome

Inferred from direct assay PubMed 20682791. Source: UniProtKB

integral component of plasma membrane

Inferred from electronic annotation. Source: Ensembl

intracellular

Inferred from direct assay PubMed 15703204. Source: BHF-UCL

lipid particle

Traceable author statement. Source: Reactome

membrane raft

Inferred from direct assay PubMed 21382479PubMed 23262137. Source: UniProtKB

perinuclear region of cytoplasm

Inferred from direct assay PubMed 19931615. Source: UniProtKB

plasma membrane

Inferred from direct assay PubMed 23262137. Source: UniProtKB

protein complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functioncholesterol binding

Traceable author statement PubMed 11294831. Source: HGNC

enzyme binding

Inferred from physical interaction PubMed 20122998. Source: UniProtKB

nitric-oxide synthase binding

Inferred from physical interaction PubMed 12852865. Source: BHF-UCL

patched binding

Non-traceable author statement PubMed 11278759. Source: BHF-UCL

peptidase activator activity

Inferred from sequence or structural similarity. Source: BHF-UCL

protein complex scaffold

Traceable author statement PubMed 19052258. Source: BHF-UCL

receptor binding

Inferred from physical interaction PubMed 16890161. Source: BHF-UCL

structural molecule activity

Inferred from direct assay Ref.9. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]
Isoform Alpha (identifier: Q03135-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Beta (identifier: Q03135-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.
Note: Initiator Met-1 is removed. Contains a N-acetylalanine at position 2.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.6
Chain2 – 178177Caveolin-1
PRO_0000004764

Regions

Topological domain2 – 104103Cytoplasmic Potential
Intramembrane105 – 12521Helical; Potential
Topological domain126 – 17853Cytoplasmic Potential

Amino acid modifications

Modified residue21N-acetylserine Ref.6 Ref.17 Ref.22
Modified residue51N6-acetyllysine Ref.17
Modified residue61Phosphotyrosine
Modified residue141Phosphotyrosine; by ABL1 Ref.10
Modified residue251Phosphotyrosine
Modified residue371Phosphoserine Ref.15 Ref.16 Ref.18 Ref.20
Modified residue421Phosphotyrosine
Lipidation1331S-palmitoyl cysteine By similarity
Lipidation1431S-palmitoyl cysteine By similarity
Lipidation1561S-palmitoyl cysteine By similarity

Natural variations

Alternative sequence1 – 3131Missing in isoform Beta.
VSP_018692
Natural variant1321P → L in breast cancer; seems to form misfolded oligomers that are retained within the Golgi complex and are not targeted to caveolae or the plasma membrane. Ref.23
VAR_015103

Experimental info

Sequence conflict821D → H in CAA79476. Ref.1
Sequence conflict1441I → T in CAA79476. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform Alpha [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: 2424DE9B5E6521D5

FASTA17820,472
        10         20         30         40         50         60 
MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADELSEKQ VYDAHTKEID LVNRDPKHLN 

        70         80         90        100        110        120 
DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY RLLSALFGIP MALIWGIYFA 

       130        140        150        160        170 
ILSFLHIWAV VPCIKSFLIE IQCISRVYSI YVHTVCDPLF EAVGKIFSNV RINLQKEI 

« Hide

Isoform Beta [UniParc].

Checksum: 1A7D806312F72A47
Show »

FASTA14717,023

References

« Hide 'large scale' references
[1]"The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles."
Glenney J.R. Jr.
FEBS Lett. 314:45-48(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[2]"Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines."
Hurlstone A.F., Reid G., Reeves J.R., Fraser J., Strathdee G., Rahilly M., Parkinson E.K., Black D.M.
Oncogene 18:1881-1890(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5' promoter region of the caveolin-1 gene in human breast cancer cell lines."
Engelman J.A., Zhang X.L., Lisanti M.P.
FEBS Lett. 448:221-230(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Lung.
[6]"N-terminal processing and modifications of caveolin-1 in caveolae from human adipocytes."
Vainonen J.P., Aboulaich N., Turkina M.V., Stralfors P., Vener A.V.
Biochem. Biophys. Res. Commun. 320:480-486(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-66, SUBCELLULAR LOCATION, ACETYLATION AT SER-2, PHOSPHORYLATION.
Tissue: Adipose tissue.
[7]"Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."
Aboulaich N., Vainonen J.P., Stralfors P., Vener A.V.
Biochem. J. 383:237-248(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 58-65.
Tissue: Adipocyte.
[8]"Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx."
Vargas L., Nore B.F., Berglof A., Heinonen J.E., Mattsson P.T., Smith C.I., Mohamed A.J.
J. Biol. Chem. 277:9351-9357(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH BMX AND BTK.
[9]"Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex."
Eberle H.B., Serrano R.L., Fuellekrug J., Schlosser A., Lehmann W.D., Lottspeich F., Kaloyanova D., Wieland F.T., Helms J.B.
J. Cell Sci. 115:827-838(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH GLIPR2.
Tissue: Brain.
[10]"c-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14."
Sanguinetti A.R., Mastick C.C.
Cell. Signal. 15:289-298(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT TYR-14.
[11]"Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN."
Schilling K., Opitz N., Wiesenthal A., Oess S., Tikkanen R., Mueller-Esterl W., Icking A.
Mol. Biol. Cell 17:3870-3880(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH NOSTRIN.
[12]"The rotavirus enterotoxin NSP4 directly interacts with the caveolar structural protein caveolin-1."
Parr R.D., Storey S.M., Mitchell D.M., McIntosh A.L., Zhou M., Mir K.D., Ball J.M.
J. Virol. 80:2842-2854(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ROTAVIRUS A NSP4.
[13]"Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1."
Ohnuma K., Uchiyama M., Yamochi T., Nishibashi K., Hosono O., Takahashi N., Kina S., Tanaka H., Lin X., Dang N.H., Morimoto C.
J. Biol. Chem. 282:10117-10131(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH DPP4, SUBCELLULAR LOCATION.
[14]"Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy."
Kim C.A., Delepine M., Boutet E., El Mourabit H., Le Lay S., Meier M., Nemani M., Bridel E., Leite C.C., Bertola D.R., Semple R.K., O'Rahilly S., Dugail I., Capeau J., Lathrop M., Magre J.
J. Clin. Endocrinol. Metab. 93:1129-1134(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN CGL3.
[15]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[16]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[17]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2 AND LYS-5, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[18]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[19]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[20]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[21]"Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension."
Austin E.D., Ma L., LeDuc C., Berman Rosenzweig E., Borczuk A., Phillips J.A. III, Palomero T., Sumazin P., Kim H.R., Talati M.H., West J., Loyd J.E., Chung W.K.
Circ. Cardiovasc. Genet. 5:336-343(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN PPH3.
[22]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[23]"Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia."
Lee H., Park D.S., Razani B., Russell R.G., Pestell R.G., Lisanti M.P.
Am. J. Pathol. 161:1357-1369(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT LEU-132.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z18951 mRNA. Translation: CAA79476.1.
AF095593, AF095591, AF095592 Genomic DNA. Translation: AAD23745.1.
AJ133269 Genomic DNA. Translation: CAB63654.1.
AF125348 Genomic DNA. Translation: AAD34722.1.
BT007143 mRNA. Translation: AAP35807.1.
BC009685 mRNA. Translation: AAH09685.1.
BC082246 mRNA. Translation: AAH82246.1.
PIRS26884.
RefSeqNP_001744.2. NM_001753.4.
UniGeneHs.74034.

3D structure databases

ProteinModelPortalQ03135.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107305. 110 interactions.
DIPDIP-5960N.
IntActQ03135. 37 interactions.
MINTMINT-152933.
STRING9606.ENSP00000339191.

Protein family/group databases

TCDB8.A.26.1.1. the caveolin (caveolin) family.

PTM databases

PhosphoSiteQ03135.

Polymorphism databases

DMDM13637934.

Proteomic databases

PaxDbQ03135.
PeptideAtlasQ03135.
PRIDEQ03135.

Protocols and materials databases

DNASU857.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000341049; ENSP00000339191; ENSG00000105974. [Q03135-1]
ENST00000393467; ENSP00000377110; ENSG00000105974. [Q03135-2]
ENST00000393468; ENSP00000377111; ENSG00000105974. [Q03135-2]
ENST00000405348; ENSP00000384348; ENSG00000105974. [Q03135-2]
GeneID857.
KEGGhsa:857.
UCSCuc003vif.2. human. [Q03135-1]

Organism-specific databases

CTD857.
GeneCardsGC07P116164.
HGNCHGNC:1527. CAV1.
HPACAB003791.
MIM601047. gene.
612526. phenotype.
615343. phenotype.
neXtProtNX_Q03135.
Orphanet528. Berardinelli-Seip congenital lipodystrophy.
220393. Diffuse cutaneous systemic sclerosis.
275777. Heritable pulmonary arterial hypertension.
220402. Limited cutaneous systemic sclerosis.
PharmGKBPA26107.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG86001.
HOVERGENHBG003422.
InParanoidQ03135.
KOK06278.
OMAVHTFCDP.
OrthoDBEOG7V1FSD.
PhylomeDBQ03135.
TreeFamTF315736.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_604. Hemostasis.
SignaLinkQ03135.

Gene expression databases

ArrayExpressQ03135.
BgeeQ03135.
CleanExHS_CAV1.
GenevestigatorQ03135.

Family and domain databases

InterProIPR001612. Caveolin.
IPR015504. Caveolin_1.
IPR018361. Caveolin_CS.
[Graphical view]
PANTHERPTHR10844. PTHR10844. 1 hit.
PTHR10844:SF5. PTHR10844:SF5. 1 hit.
PfamPF01146. Caveolin. 1 hit.
[Graphical view]
PROSITEPS01210. CAVEOLIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCAV1. human.
GeneWikiCaveolin_1.
GenomeRNAi857.
NextBio3556.
PROQ03135.
SOURCESearch...

Entry information

Entry nameCAV1_HUMAN
AccessionPrimary (citable) accession number: Q03135
Secondary accession number(s): Q9UGP1, Q9UNG1, Q9UQH6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 163 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM