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Q03135

- CAV1_HUMAN

UniProt

Q03135 - CAV1_HUMAN

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Protein

Caveolin-1

Gene
CAV1, CAV
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity By similarity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.2 Publications

GO - Molecular functioni

  1. cholesterol binding Source: HGNC
  2. enzyme binding Source: UniProtKB
  3. nitric-oxide synthase binding Source: BHF-UCL
  4. patched binding Source: BHF-UCL
  5. peptidase activator activity Source: BHF-UCL
  6. protein binding Source: BHF-UCL
  7. protein complex scaffold Source: BHF-UCL
  8. receptor binding Source: BHF-UCL
  9. structural molecule activity Source: UniProtKB

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. apoptotic signaling pathway Source: UniProtKB
  3. blood coagulation Source: Reactome
  4. calcium ion homeostasis Source: BHF-UCL
  5. calcium ion transport Source: BHF-UCL
  6. caveola assembly Source: BHF-UCL
  7. caveolin-mediated endocytosis Source: UniProtKB
  8. cellular calcium ion homeostasis Source: BHF-UCL
  9. cellular response to hyperoxia Source: UniProtKB
  10. cellular response to starvation Source: BHF-UCL
  11. cholesterol homeostasis Source: BHF-UCL
  12. cholesterol transport Source: HGNC
  13. cytosolic calcium ion homeostasis Source: BHF-UCL
  14. inactivation of MAPK activity Source: BHF-UCL
  15. lactation Source: Ensembl
  16. leukocyte migration Source: Reactome
  17. lipid storage Source: BHF-UCL
  18. maintenance of protein location in cell Source: BHF-UCL
  19. mammary gland development Source: BHF-UCL
  20. mammary gland involution Source: BHF-UCL
  21. MAPK cascade Source: Ensembl
  22. membrane depolarization Source: BHF-UCL
  23. negative regulation of anoikis Source: UniProtKB
  24. negative regulation of BMP signaling pathway Source: BHF-UCL
  25. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  26. negative regulation of cytokine-mediated signaling pathway Source: Ensembl
  27. negative regulation of endothelial cell proliferation Source: BHF-UCL
  28. negative regulation of epithelial cell differentiation Source: BHF-UCL
  29. negative regulation of JAK-STAT cascade Source: BHF-UCL
  30. negative regulation of MAPK cascade Source: BHF-UCL
  31. negative regulation of nitric oxide biosynthetic process Source: BHF-UCL
  32. negative regulation of nitric-oxide synthase activity Source: Ensembl
  33. negative regulation of peptidyl-serine phosphorylation Source: BHF-UCL
  34. negative regulation of pinocytosis Source: UniProt
  35. negative regulation of protein binding Source: BHF-UCL
  36. negative regulation of protein ubiquitination Source: UniProtKB
  37. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  38. negative regulation of tyrosine phosphorylation of Stat5 protein Source: Ensembl
  39. nitric oxide homeostasis Source: BHF-UCL
  40. nitric oxide metabolic process Source: Reactome
  41. positive regulation of calcium ion transport into cytosol Source: BHF-UCL
  42. positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
  43. positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
  44. positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
  45. positive regulation of metalloenzyme activity Source: BHF-UCL
  46. positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
  47. positive regulation of vasoconstriction Source: BHF-UCL
  48. protein homooligomerization Source: BHF-UCL
  49. protein localization Source: BHF-UCL
  50. receptor internalization involved in canonical Wnt signaling pathway Source: BHF-UCL
  51. regulation of blood coagulation Source: BHF-UCL
  52. regulation of fatty acid metabolic process Source: BHF-UCL
  53. regulation of nitric-oxide synthase activity Source: Reactome
  54. regulation of peptidase activity Source: BHF-UCL
  55. regulation of smooth muscle contraction Source: BHF-UCL
  56. regulation of the force of heart contraction by chemical signal Source: Ensembl
  57. response to calcium ion Source: BHF-UCL
  58. response to estrogen Source: MGI
  59. response to hypoxia Source: BHF-UCL
  60. response to ischemia Source: Ensembl
  61. response to progesterone Source: MGI
  62. skeletal muscle tissue development Source: BHF-UCL
  63. small molecule metabolic process Source: Reactome
  64. T cell costimulation Source: UniProtKB
  65. triglyceride metabolic process Source: BHF-UCL
  66. vasculogenesis Source: BHF-UCL
  67. vasoconstriction Source: Ensembl
  68. vesicle organization Source: BHF-UCL
  69. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

ReactomeiREACT_12477. eNOS activation.
REACT_12541. NOSTRIN mediated eNOS trafficking.
REACT_12560. Basigin interactions.
REACT_494. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.
SignaLinkiQ03135.

Protein family/group databases

TCDBi8.A.26.1.1. the caveolin (caveolin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolin-1
Gene namesi
Name:CAV1
Synonyms:CAV
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:1527. CAV1.

Subcellular locationi

Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membranecaveola; Peripheral membrane protein. Membrane raft
Note: Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.3 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 104103Cytoplasmic Reviewed predictionAdd
BLAST
Intramembranei105 – 12521Helical; Reviewed predictionAdd
BLAST
Topological domaini126 – 17853Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. acrosomal membrane Source: Ensembl
  2. apical plasma membrane Source: BHF-UCL
  3. basolateral plasma membrane Source: BHF-UCL
  4. caveola Source: UniProtKB
  5. cell cortex Source: Ensembl
  6. cilium Source: Ensembl
  7. cytoplasmic vesicle Source: UniProtKB
  8. endocytic vesicle membrane Source: Reactome
  9. endoplasmic reticulum Source: HGNC
  10. endosome Source: UniProtKB
  11. Golgi membrane Source: HGNC
  12. integral component of plasma membrane Source: Ensembl
  13. intracellular Source: BHF-UCL
  14. lipid particle Source: Reactome
  15. membrane raft Source: UniProtKB
  16. perinuclear region of cytoplasm Source: UniProtKB
  17. plasma membrane Source: UniProtKB
  18. protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Congenital generalized lipodystrophy 3 (CGL3) [MIM:612526]: An autosomal recessive disorder characterized by a near complete absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Pulmonary hypertension, primary, 3 (PPH3) [MIM:615343]: A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Keywords - Diseasei

Congenital generalized lipodystrophy, Disease mutation

Organism-specific databases

MIMi612526. phenotype.
615343. phenotype.
Orphaneti528. Berardinelli-Seip congenital lipodystrophy.
220393. Diffuse cutaneous systemic sclerosis.
275777. Heritable pulmonary arterial hypertension.
220402. Limited cutaneous systemic sclerosis.
PharmGKBiPA26107.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 178177Caveolin-1PRO_0000004764Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine3 Publications
Modified residuei5 – 51N6-acetyllysine1 Publication
Modified residuei6 – 61Phosphotyrosine2 Publications
Modified residuei14 – 141Phosphotyrosine; by ABL12 Publications
Modified residuei25 – 251Phosphotyrosine1 Publication
Modified residuei37 – 371Phosphoserine5 Publications
Modified residuei42 – 421Phosphotyrosine
Lipidationi133 – 1331S-palmitoyl cysteine By similarity
Lipidationi143 – 1431S-palmitoyl cysteine By similarity
Lipidationi156 – 1561S-palmitoyl cysteine By similarity

Post-translational modificationi

The initiator methionine for isoform 2 is removed during or just after translation. The new N-terminal amino acid is then N-acetylated.1 Publication
Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.3 Publications

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ03135.
PaxDbiQ03135.
PeptideAtlasiQ03135.
PRIDEiQ03135.

PTM databases

PhosphoSiteiQ03135.

Expressioni

Tissue specificityi

Expressed in muscle and lung, less so in liver, brain and kidney.

Gene expression databases

ArrayExpressiQ03135.
BgeeiQ03135.
CleanExiHS_CAV1.
GenevestigatoriQ03135.

Organism-specific databases

HPAiCAB003791.

Interactioni

Subunit structurei

Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and STX1A. Interacts with rotavirus A NSP4. Interacts (via the N-terminus) with DPP4; the interaction is direct. Interacts with CTNNB1, CDH1 and JUP. Interacts with PACSIN2. Interacts with SLC7A9 By similarity. Interacts with BMX and BTK.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Axin1O702395EBI-603614,EBI-6857773From a different organism.
BIDP559573EBI-603614,EBI-519672
F2RP251163EBI-603614,EBI-2803960
FASP254453EBI-603614,EBI-494743
Grb7Q031603EBI-603614,EBI-7100053From a different organism.
ID1P411346EBI-603614,EBI-1215527
LRP6O755813EBI-603614,EBI-910915
MCL1Q078203EBI-603614,EBI-1003422
PTPN1P180315EBI-603614,EBI-968788
SCP2P223073EBI-603614,EBI-1050999
TXNRD1Q168814EBI-603614,EBI-716617

Protein-protein interaction databases

BioGridi107305. 115 interactions.
DIPiDIP-5960N.
IntActiQ03135. 37 interactions.
MINTiMINT-152933.
STRINGi9606.ENSP00000339191.

Structurei

3D structure databases

ProteinModelPortaliQ03135.

Family & Domainsi

Sequence similaritiesi

Belongs to the caveolin family.

Phylogenomic databases

eggNOGiNOG86001.
HOVERGENiHBG003422.
InParanoidiQ03135.
KOiK06278.
OMAiRINMQKE.
OrthoDBiEOG7V1FSD.
PhylomeDBiQ03135.
TreeFamiTF315736.

Family and domain databases

InterProiIPR001612. Caveolin.
IPR015504. Caveolin_1.
IPR018361. Caveolin_CS.
[Graphical view]
PANTHERiPTHR10844. PTHR10844. 1 hit.
PTHR10844:SF5. PTHR10844:SF5. 1 hit.
PfamiPF01146. Caveolin. 1 hit.
[Graphical view]
PROSITEiPS01210. CAVEOLIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform 1 (identifier: Q03135-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADELSEKQ VYDAHTKEID    50
LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY 100
RLLSALFGIP MALIWGIYFA ILSFLHIWAV VPCIKSFLIE IQCISRVYSI 150
YVHTVCDPLF EAVGKIFSNV RINLQKEI 178
Length:178
Mass (Da):20,472
Last modified:January 23, 2007 - v4
Checksum:i2424DE9B5E6521D5
GO
Isoform 2 (identifier: Q03135-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Note: Initiator Met-1 is removed. Contains a N-acetylalanine at position 2. Contains a phosphoserine at position 6.

Show »
Length:147
Mass (Da):17,023
Checksum:i1A7D806312F72A47
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti132 – 1321P → L in breast cancer; seems to form misfolded oligomers that are retained within the Golgi complex and are not targeted to caveolae or the plasma membrane. 1 Publication
VAR_015103

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3131Missing in isoform 2. VSP_018692Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821D → H in CAA79476. 1 Publication
Sequence conflicti144 – 1441I → T in CAA79476. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z18951 mRNA. Translation: CAA79476.1.
AF095593, AF095591, AF095592 Genomic DNA. Translation: AAD23745.1.
AJ133269 Genomic DNA. Translation: CAB63654.1.
AF125348 Genomic DNA. Translation: AAD34722.1.
BT007143 mRNA. Translation: AAP35807.1.
BC009685 mRNA. Translation: AAH09685.1.
BC082246 mRNA. Translation: AAH82246.1.
CCDSiCCDS55156.1. [Q03135-2]
CCDS5767.1. [Q03135-1]
PIRiS26884.
RefSeqiNP_001744.2. NM_001753.4. [Q03135-1]
UniGeneiHs.74034.

Genome annotation databases

EnsembliENST00000341049; ENSP00000339191; ENSG00000105974. [Q03135-1]
ENST00000393467; ENSP00000377110; ENSG00000105974. [Q03135-2]
ENST00000393468; ENSP00000377111; ENSG00000105974. [Q03135-2]
ENST00000405348; ENSP00000384348; ENSG00000105974. [Q03135-2]
GeneIDi857.
KEGGihsa:857.
UCSCiuc003vif.2. human. [Q03135-1]

Polymorphism databases

DMDMi13637934.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Wikipedia

Caveolin entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z18951 mRNA. Translation: CAA79476.1 .
AF095593 , AF095591 , AF095592 Genomic DNA. Translation: AAD23745.1 .
AJ133269 Genomic DNA. Translation: CAB63654.1 .
AF125348 Genomic DNA. Translation: AAD34722.1 .
BT007143 mRNA. Translation: AAP35807.1 .
BC009685 mRNA. Translation: AAH09685.1 .
BC082246 mRNA. Translation: AAH82246.1 .
CCDSi CCDS55156.1. [Q03135-2 ]
CCDS5767.1. [Q03135-1 ]
PIRi S26884.
RefSeqi NP_001744.2. NM_001753.4. [Q03135-1 ]
UniGenei Hs.74034.

3D structure databases

ProteinModelPortali Q03135.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107305. 115 interactions.
DIPi DIP-5960N.
IntActi Q03135. 37 interactions.
MINTi MINT-152933.
STRINGi 9606.ENSP00000339191.

Protein family/group databases

TCDBi 8.A.26.1.1. the caveolin (caveolin) family.

PTM databases

PhosphoSitei Q03135.

Polymorphism databases

DMDMi 13637934.

Proteomic databases

MaxQBi Q03135.
PaxDbi Q03135.
PeptideAtlasi Q03135.
PRIDEi Q03135.

Protocols and materials databases

DNASUi 857.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000341049 ; ENSP00000339191 ; ENSG00000105974 . [Q03135-1 ]
ENST00000393467 ; ENSP00000377110 ; ENSG00000105974 . [Q03135-2 ]
ENST00000393468 ; ENSP00000377111 ; ENSG00000105974 . [Q03135-2 ]
ENST00000405348 ; ENSP00000384348 ; ENSG00000105974 . [Q03135-2 ]
GeneIDi 857.
KEGGi hsa:857.
UCSCi uc003vif.2. human. [Q03135-1 ]

Organism-specific databases

CTDi 857.
GeneCardsi GC07P116164.
HGNCi HGNC:1527. CAV1.
HPAi CAB003791.
MIMi 601047. gene.
612526. phenotype.
615343. phenotype.
neXtProti NX_Q03135.
Orphaneti 528. Berardinelli-Seip congenital lipodystrophy.
220393. Diffuse cutaneous systemic sclerosis.
275777. Heritable pulmonary arterial hypertension.
220402. Limited cutaneous systemic sclerosis.
PharmGKBi PA26107.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG86001.
HOVERGENi HBG003422.
InParanoidi Q03135.
KOi K06278.
OMAi RINMQKE.
OrthoDBi EOG7V1FSD.
PhylomeDBi Q03135.
TreeFami TF315736.

Enzyme and pathway databases

Reactomei REACT_12477. eNOS activation.
REACT_12541. NOSTRIN mediated eNOS trafficking.
REACT_12560. Basigin interactions.
REACT_494. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.
SignaLinki Q03135.

Miscellaneous databases

ChiTaRSi CAV1. human.
GeneWikii Caveolin_1.
GenomeRNAii 857.
NextBioi 3556.
PROi Q03135.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q03135.
Bgeei Q03135.
CleanExi HS_CAV1.
Genevestigatori Q03135.

Family and domain databases

InterProi IPR001612. Caveolin.
IPR015504. Caveolin_1.
IPR018361. Caveolin_CS.
[Graphical view ]
PANTHERi PTHR10844. PTHR10844. 1 hit.
PTHR10844:SF5. PTHR10844:SF5. 1 hit.
Pfami PF01146. Caveolin. 1 hit.
[Graphical view ]
PROSITEi PS01210. CAVEOLIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles."
    Glenney J.R. Jr.
    FEBS Lett. 314:45-48(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines."
    Hurlstone A.F., Reid G., Reeves J.R., Fraser J., Strathdee G., Rahilly M., Parkinson E.K., Black D.M.
    Oncogene 18:1881-1890(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5' promoter region of the caveolin-1 gene in human breast cancer cell lines."
    Engelman J.A., Zhang X.L., Lisanti M.P.
    FEBS Lett. 448:221-230(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Lung.
  6. "N-terminal processing and modifications of caveolin-1 in caveolae from human adipocytes."
    Vainonen J.P., Aboulaich N., Turkina M.V., Stralfors P., Vener A.V.
    Biochem. Biophys. Res. Commun. 320:480-486(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-66, SUBCELLULAR LOCATION, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, PHOSPHORYLATION AT SER-37, CLEAVAGE OF INITIATOR METHIONINE (ISOFORM 2), ACETYLATION AT ALA-2 (ISOFORM 2), PHOSPHORYLATION AT SER-6 (ISOFORM 2).
    Tissue: Adipose tissue.
  7. "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."
    Aboulaich N., Vainonen J.P., Stralfors P., Vener A.V.
    Biochem. J. 383:237-248(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 58-65.
    Tissue: Adipocyte.
  8. "Phosphorylation of caveolin by src tyrosine kinases. The alpha-isoform of caveolin is selectively phosphorylated by v-Src in vivo."
    Li S., Seitz R., Lisanti M.P.
    J. Biol. Chem. 271:3863-3868(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-6; TYR-14 AND TYR-25.
  9. "Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx."
    Vargas L., Nore B.F., Berglof A., Heinonen J.E., Mattsson P.T., Smith C.I., Mohamed A.J.
    J. Biol. Chem. 277:9351-9357(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH BMX AND BTK.
  10. "Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex."
    Eberle H.B., Serrano R.L., Fuellekrug J., Schlosser A., Lehmann W.D., Lottspeich F., Kaloyanova D., Wieland F.T., Helms J.B.
    J. Cell Sci. 115:827-838(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GLIPR2.
    Tissue: Brain.
  11. "c-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14."
    Sanguinetti A.R., Mastick C.C.
    Cell. Signal. 15:289-298(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-14.
  12. "Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN."
    Schilling K., Opitz N., Wiesenthal A., Oess S., Tikkanen R., Mueller-Esterl W., Icking A.
    Mol. Biol. Cell 17:3870-3880(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NOSTRIN.
  13. "The rotavirus enterotoxin NSP4 directly interacts with the caveolar structural protein caveolin-1."
    Parr R.D., Storey S.M., Mitchell D.M., McIntosh A.L., Zhou M., Mir K.D., Ball J.M.
    J. Virol. 80:2842-2854(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ROTAVIRUS A NSP4.
  14. Cited for: FUNCTION, INTERACTION WITH DPP4, SUBCELLULAR LOCATION.
  15. Cited for: INVOLVEMENT IN CGL3.
  16. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2 AND LYS-5, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  20. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  21. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  22. "Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension."
    Austin E.D., Ma L., LeDuc C., Berman Rosenzweig E., Borczuk A., Phillips J.A. III, Palomero T., Sumazin P., Kim H.R., Talati M.H., West J., Loyd J.E., Chung W.K.
    Circ. Cardiovasc. Genet. 5:336-343(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN PPH3.
  23. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  24. "Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia."
    Lee H., Park D.S., Razani B., Russell R.G., Pestell R.G., Lisanti M.P.
    Am. J. Pathol. 161:1357-1369(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT LEU-132.

Entry informationi

Entry nameiCAV1_HUMAN
AccessioniPrimary (citable) accession number: Q03135
Secondary accession number(s): Q9UGP1, Q9UNG1, Q9UQH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 167 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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