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Protein

Caveolin-1

Gene

CAV1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.By similarity2 Publications

GO - Molecular functioni

  • ATPase binding Source: ParkinsonsUK-UCL
  • cholesterol binding Source: HGNC
  • enzyme binding Source: UniProtKB
  • identical protein binding Source: BHF-UCL
  • inward rectifier potassium channel inhibitor activity Source: BHF-UCL
  • ion channel binding Source: BHF-UCL
  • nitric-oxide synthase binding Source: BHF-UCL
  • patched binding Source: BHF-UCL
  • peptidase activator activity Source: BHF-UCL
  • protein complex scaffold Source: BHF-UCL
  • protein kinase binding Source: BHF-UCL
  • receptor binding Source: BHF-UCL
  • structural molecule activity Source: UniProtKB

GO - Biological processi

  • angiogenesis Source: Ensembl
  • angiotensin-activated signaling pathway involved in heart process Source: BHF-UCL
  • apoptotic signaling pathway Source: UniProtKB
  • blood coagulation Source: Reactome
  • calcium ion homeostasis Source: BHF-UCL
  • calcium ion transport Source: BHF-UCL
  • caveola assembly Source: BHF-UCL
  • caveolin-mediated endocytosis Source: UniProtKB
  • cellular calcium ion homeostasis Source: BHF-UCL
  • cellular response to exogenous dsRNA Source: UniProtKB
  • cellular response to hyperoxia Source: UniProtKB
  • cellular response to peptide hormone stimulus Source: BHF-UCL
  • cellular response to starvation Source: BHF-UCL
  • cholesterol homeostasis Source: BHF-UCL
  • cholesterol transport Source: HGNC
  • cytosolic calcium ion homeostasis Source: BHF-UCL
  • inactivation of MAPK activity Source: BHF-UCL
  • lactation Source: Ensembl
  • leukocyte migration Source: Reactome
  • lipid storage Source: BHF-UCL
  • maintenance of protein location in cell Source: BHF-UCL
  • mammary gland development Source: BHF-UCL
  • mammary gland involution Source: BHF-UCL
  • MAPK cascade Source: Ensembl
  • membrane depolarization Source: BHF-UCL
  • negative regulation of anoikis Source: UniProtKB
  • negative regulation of BMP signaling pathway Source: BHF-UCL
  • negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  • negative regulation of cytokine-mediated signaling pathway Source: Ensembl
  • negative regulation of endothelial cell proliferation Source: BHF-UCL
  • negative regulation of epithelial cell differentiation Source: BHF-UCL
  • negative regulation of JAK-STAT cascade Source: BHF-UCL
  • negative regulation of MAPK cascade Source: BHF-UCL
  • negative regulation of nitric oxide biosynthetic process Source: BHF-UCL
  • negative regulation of nitric-oxide synthase activity Source: Ensembl
  • negative regulation of peptidyl-serine phosphorylation Source: BHF-UCL
  • negative regulation of peptidyl-tyrosine autophosphorylation Source: BHF-UCL
  • negative regulation of pinocytosis Source: UniProtKB
  • negative regulation of potassium ion transmembrane transport Source: BHF-UCL
  • negative regulation of protein binding Source: BHF-UCL
  • negative regulation of protein tyrosine kinase activity Source: BHF-UCL
  • negative regulation of protein ubiquitination Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • negative regulation of tyrosine phosphorylation of Stat5 protein Source: Ensembl
  • nitric oxide homeostasis Source: BHF-UCL
  • nitric oxide metabolic process Source: Reactome
  • positive regulation of calcium ion transport into cytosol Source: BHF-UCL
  • positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
  • positive regulation of cell adhesion molecule production Source: UniProtKB
  • positive regulation of ER-associated ubiquitin-dependent protein catabolic process Source: ParkinsonsUK-UCL
  • positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
  • positive regulation of gap junction assembly Source: BHF-UCL
  • positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
  • positive regulation of metalloenzyme activity Source: BHF-UCL
  • positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
  • positive regulation of protein binding Source: ParkinsonsUK-UCL
  • positive regulation of protein ubiquitination Source: ParkinsonsUK-UCL
  • positive regulation of toll-like receptor 3 signaling pathway Source: UniProtKB
  • positive regulation of vasoconstriction Source: BHF-UCL
  • protein homooligomerization Source: BHF-UCL
  • protein localization Source: BHF-UCL
  • protein localization to basolateral plasma membrane Source: BHF-UCL
  • protein localization to plasma membrane raft Source: BHF-UCL
  • receptor internalization involved in canonical Wnt signaling pathway Source: BHF-UCL
  • receptor-mediated endocytosis of virus by host cell Source: CACAO
  • regulation of blood coagulation Source: BHF-UCL
  • regulation of cardiac muscle cell action potential involved in regulation of contraction Source: BHF-UCL
  • regulation of cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
  • regulation of fatty acid metabolic process Source: BHF-UCL
  • regulation of heart rate by cardiac conduction Source: BHF-UCL
  • regulation of inward rectifier potassium channel activity Source: BHF-UCL
  • regulation of membrane repolarization during action potential Source: BHF-UCL
  • regulation of nitric-oxide synthase activity Source: Reactome
  • regulation of peptidase activity Source: BHF-UCL
  • regulation of smooth muscle contraction Source: BHF-UCL
  • regulation of the force of heart contraction by chemical signal Source: Ensembl
  • regulation of ventricular cardiac muscle cell action potential Source: BHF-UCL
  • response to calcium ion Source: BHF-UCL
  • response to estrogen Source: MGI
  • response to hypoxia Source: BHF-UCL
  • response to ischemia Source: Ensembl
  • response to progesterone Source: MGI
  • skeletal muscle tissue development Source: BHF-UCL
  • small molecule metabolic process Source: Reactome
  • T cell costimulation Source: UniProtKB
  • triglyceride metabolic process Source: BHF-UCL
  • vascular endothelial growth factor receptor signaling pathway Source: Reactome
  • vasculogenesis Source: BHF-UCL
  • vasoconstriction Source: Ensembl
  • vesicle organization Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

ReactomeiREACT_12477. eNOS activation.
REACT_12541. NOSTRIN mediated eNOS trafficking.
REACT_12560. Basigin interactions.
REACT_263991. VEGFR2 mediated vascular permeability.
REACT_264034. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_494. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.
SignaLinkiQ03135.

Protein family/group databases

TCDBi8.A.26.1.1. the caveolin (caveolin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolin-1
Gene namesi
Name:CAV1
Synonyms:CAV
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:1527. CAV1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 104103CytoplasmicSequence AnalysisAdd
BLAST
Intramembranei105 – 12521HelicalSequence AnalysisAdd
BLAST
Topological domaini126 – 17853CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • acrosomal membrane Source: Ensembl
  • apical plasma membrane Source: BHF-UCL
  • basolateral plasma membrane Source: BHF-UCL
  • caveola Source: UniProtKB
  • cell cortex Source: Ensembl
  • cilium Source: Ensembl
  • cytoplasmic vesicle Source: UniProtKB
  • cytosol Source: GOC
  • early endosome membrane Source: Reactome
  • endocytic vesicle membrane Source: Reactome
  • endoplasmic reticulum Source: HGNC
  • endoplasmic reticulum membrane Source: ParkinsonsUK-UCL
  • endosome Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • Golgi membrane Source: HGNC
  • integral component of plasma membrane Source: Ensembl
  • intracellular Source: BHF-UCL
  • lipid particle Source: Reactome
  • membrane raft Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Congenital generalized lipodystrophy 3 (CGL3)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive disorder characterized by a near complete absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes.

See also OMIM:612526
Pulmonary hypertension, primary, 3 (PPH3)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.

See also OMIM:615343
Partial lipodystrophy, congenital cataracts, and neurodegeneration syndrome (LCCNS)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of familial partial lipodystrophy associated with congenital cataracts and neurodegeneration leading to cerebellar and spinal cord dysfunction.

See also OMIM:606721

Keywords - Diseasei

Congenital generalized lipodystrophy, Disease mutation

Organism-specific databases

MIMi606721. phenotype.
612526. phenotype.
615343. phenotype.
Orphaneti528. Berardinelli-Seip congenital lipodystrophy.
220393. Diffuse cutaneous systemic sclerosis.
275777. Heritable pulmonary arterial hypertension.
220402. Limited cutaneous systemic sclerosis.
PharmGKBiPA26107.

Polymorphism and mutation databases

BioMutaiCAV1.
DMDMi13637934.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 178177Caveolin-1PRO_0000004764Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine3 Publications
Modified residuei5 – 51N6-acetyllysine1 Publication
Modified residuei6 – 61Phosphotyrosine1 Publication
Modified residuei14 – 141Phosphotyrosine; by ABL12 Publications
Modified residuei25 – 251Phosphotyrosine1 Publication
Modified residuei37 – 371Phosphoserine4 Publications
Lipidationi133 – 1331S-palmitoyl cysteineBy similarity
Lipidationi143 – 1431S-palmitoyl cysteineBy similarity
Lipidationi156 – 1561S-palmitoyl cysteineBy similarity

Post-translational modificationi

The initiator methionine for isoform 2 is removed during or just after translation. The new N-terminal amino acid is then N-acetylated.1 Publication
Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.3 Publications

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ03135.
PaxDbiQ03135.
PeptideAtlasiQ03135.
PRIDEiQ03135.

PTM databases

PhosphoSiteiQ03135.

Expressioni

Tissue specificityi

Expressed in muscle and lung, less so in liver, brain and kidney.

Gene expression databases

BgeeiQ03135.
CleanExiHS_CAV1.
ExpressionAtlasiQ03135. baseline and differential.
GenevisibleiQ03135. HS.

Organism-specific databases

HPAiCAB003791.
HPA049326.

Interactioni

Subunit structurei

Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and STX1A. Interacts with rotavirus A NSP4. Interacts (via the N-terminus) with DPP4; the interaction is direct. Interacts with CTNNB1, CDH1 and JUP. Interacts with PACSIN2. Interacts with SLC7A9 (By similarity). Interacts with BMX and BTK.By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Axin1O702395EBI-603614,EBI-6857773From a different organism.
BIDP559573EBI-603614,EBI-519672
EGFRP005335EBI-603614,EBI-297353
F2RP251163EBI-603614,EBI-2803960
FASP254453EBI-603614,EBI-494743
Grb7Q031603EBI-603614,EBI-7100053From a different organism.
ID1P411346EBI-603614,EBI-1215527
KCNH2Q128095EBI-603614,EBI-720643
LRP6O755813EBI-603614,EBI-910915
MCL1Q078203EBI-603614,EBI-1003422
NR3C1P041502EBI-603614,EBI-493507
PTPN1P180315EBI-603614,EBI-968788
RAC1P630003EBI-603614,EBI-413628
SCP2P223073EBI-603614,EBI-1050999
TXNRD1Q168814EBI-603614,EBI-716617

Protein-protein interaction databases

BioGridi107305. 133 interactions.
DIPiDIP-5960N.
IntActiQ03135. 43 interactions.
MINTiMINT-152933.
STRINGi9606.ENSP00000339191.

Structurei

3D structure databases

ProteinModelPortaliQ03135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the caveolin family.Curated

Phylogenomic databases

eggNOGiNOG86001.
GeneTreeiENSGT00390000014924.
HOVERGENiHBG003422.
InParanoidiQ03135.
KOiK06278.
OMAiVHTFCDP.
OrthoDBiEOG7V1FSD.
PhylomeDBiQ03135.
TreeFamiTF315736.

Family and domain databases

InterProiIPR001612. Caveolin.
IPR015504. Caveolin_1.
IPR018361. Caveolin_CS.
[Graphical view]
PANTHERiPTHR10844. PTHR10844. 1 hit.
PTHR10844:SF5. PTHR10844:SF5. 1 hit.
PfamiPF01146. Caveolin. 1 hit.
[Graphical view]
PROSITEiPS01210. CAVEOLIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform 1 (identifier: Q03135-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADELSEKQ VYDAHTKEID
60 70 80 90 100
LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY
110 120 130 140 150
RLLSALFGIP MALIWGIYFA ILSFLHIWAV VPCIKSFLIE IQCISRVYSI
160 170
YVHTVCDPLF EAVGKIFSNV RINLQKEI
Length:178
Mass (Da):20,472
Last modified:January 23, 2007 - v4
Checksum:i2424DE9B5E6521D5
GO
Isoform 2 (identifier: Q03135-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Note: Initiator Met-1 is removed. Contains a N-acetylalanine at position 2. Contains a phosphoserine at position 6.3 Publications
Show »
Length:147
Mass (Da):17,023
Checksum:i1A7D806312F72A47
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821D → H in CAA79476 (PubMed:1360410).Curated
Sequence conflicti144 – 1441I → T in CAA79476 (PubMed:1360410).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti132 – 1321P → L in breast cancer; seems to form misfolded oligomers that are retained within the Golgi complex and are not targeted to caveolae or the plasma membrane. 1 Publication
VAR_015103

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3131Missing in isoform 2. CuratedVSP_018692Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18951 mRNA. Translation: CAA79476.1.
AF095593, AF095591, AF095592 Genomic DNA. Translation: AAD23745.1.
AJ133269 Genomic DNA. Translation: CAB63654.1.
AF125348 Genomic DNA. Translation: AAD34722.1.
BT007143 mRNA. Translation: AAP35807.1.
BC009685 mRNA. Translation: AAH09685.1.
BC082246 mRNA. Translation: AAH82246.1.
CCDSiCCDS55156.1. [Q03135-2]
CCDS5767.1. [Q03135-1]
PIRiS26884.
RefSeqiNP_001744.2. NM_001753.4. [Q03135-1]
UniGeneiHs.74034.

Genome annotation databases

EnsembliENST00000341049; ENSP00000339191; ENSG00000105974. [Q03135-1]
ENST00000393467; ENSP00000377110; ENSG00000105974. [Q03135-2]
ENST00000393468; ENSP00000377111; ENSG00000105974. [Q03135-2]
ENST00000405348; ENSP00000384348; ENSG00000105974. [Q03135-2]
ENST00000614113; ENSP00000479447; ENSG00000105974. [Q03135-2]
GeneIDi857.
KEGGihsa:857.
UCSCiuc003vif.2. human. [Q03135-1]

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Wikipedia

Caveolin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18951 mRNA. Translation: CAA79476.1.
AF095593, AF095591, AF095592 Genomic DNA. Translation: AAD23745.1.
AJ133269 Genomic DNA. Translation: CAB63654.1.
AF125348 Genomic DNA. Translation: AAD34722.1.
BT007143 mRNA. Translation: AAP35807.1.
BC009685 mRNA. Translation: AAH09685.1.
BC082246 mRNA. Translation: AAH82246.1.
CCDSiCCDS55156.1. [Q03135-2]
CCDS5767.1. [Q03135-1]
PIRiS26884.
RefSeqiNP_001744.2. NM_001753.4. [Q03135-1]
UniGeneiHs.74034.

3D structure databases

ProteinModelPortaliQ03135.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107305. 133 interactions.
DIPiDIP-5960N.
IntActiQ03135. 43 interactions.
MINTiMINT-152933.
STRINGi9606.ENSP00000339191.

Protein family/group databases

TCDBi8.A.26.1.1. the caveolin (caveolin) family.

PTM databases

PhosphoSiteiQ03135.

Polymorphism and mutation databases

BioMutaiCAV1.
DMDMi13637934.

Proteomic databases

MaxQBiQ03135.
PaxDbiQ03135.
PeptideAtlasiQ03135.
PRIDEiQ03135.

Protocols and materials databases

DNASUi857.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341049; ENSP00000339191; ENSG00000105974. [Q03135-1]
ENST00000393467; ENSP00000377110; ENSG00000105974. [Q03135-2]
ENST00000393468; ENSP00000377111; ENSG00000105974. [Q03135-2]
ENST00000405348; ENSP00000384348; ENSG00000105974. [Q03135-2]
ENST00000614113; ENSP00000479447; ENSG00000105974. [Q03135-2]
GeneIDi857.
KEGGihsa:857.
UCSCiuc003vif.2. human. [Q03135-1]

Organism-specific databases

CTDi857.
GeneCardsiGC07P116164.
HGNCiHGNC:1527. CAV1.
HPAiCAB003791.
HPA049326.
MIMi601047. gene.
606721. phenotype.
612526. phenotype.
615343. phenotype.
neXtProtiNX_Q03135.
Orphaneti528. Berardinelli-Seip congenital lipodystrophy.
220393. Diffuse cutaneous systemic sclerosis.
275777. Heritable pulmonary arterial hypertension.
220402. Limited cutaneous systemic sclerosis.
PharmGKBiPA26107.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG86001.
GeneTreeiENSGT00390000014924.
HOVERGENiHBG003422.
InParanoidiQ03135.
KOiK06278.
OMAiVHTFCDP.
OrthoDBiEOG7V1FSD.
PhylomeDBiQ03135.
TreeFamiTF315736.

Enzyme and pathway databases

ReactomeiREACT_12477. eNOS activation.
REACT_12541. NOSTRIN mediated eNOS trafficking.
REACT_12560. Basigin interactions.
REACT_263991. VEGFR2 mediated vascular permeability.
REACT_264034. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_494. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.
SignaLinkiQ03135.

Miscellaneous databases

ChiTaRSiCAV1. human.
GeneWikiiCaveolin_1.
GenomeRNAii857.
NextBioi3556.
PROiQ03135.
SOURCEiSearch...

Gene expression databases

BgeeiQ03135.
CleanExiHS_CAV1.
ExpressionAtlasiQ03135. baseline and differential.
GenevisibleiQ03135. HS.

Family and domain databases

InterProiIPR001612. Caveolin.
IPR015504. Caveolin_1.
IPR018361. Caveolin_CS.
[Graphical view]
PANTHERiPTHR10844. PTHR10844. 1 hit.
PTHR10844:SF5. PTHR10844:SF5. 1 hit.
PfamiPF01146. Caveolin. 1 hit.
[Graphical view]
PROSITEiPS01210. CAVEOLIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles."
    Glenney J.R. Jr.
    FEBS Lett. 314:45-48(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines."
    Hurlstone A.F., Reid G., Reeves J.R., Fraser J., Strathdee G., Rahilly M., Parkinson E.K., Black D.M.
    Oncogene 18:1881-1890(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5' promoter region of the caveolin-1 gene in human breast cancer cell lines."
    Engelman J.A., Zhang X.L., Lisanti M.P.
    FEBS Lett. 448:221-230(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Lung.
  6. "N-terminal processing and modifications of caveolin-1 in caveolae from human adipocytes."
    Vainonen J.P., Aboulaich N., Turkina M.V., Stralfors P., Vener A.V.
    Biochem. Biophys. Res. Commun. 320:480-486(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-66, SUBCELLULAR LOCATION, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, PHOSPHORYLATION AT SER-37, CLEAVAGE OF INITIATOR METHIONINE (ISOFORM 2), ACETYLATION AT ALA-2 (ISOFORM 2), PHOSPHORYLATION AT SER-6 (ISOFORM 2).
    Tissue: Adipose tissue.
  7. "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."
    Aboulaich N., Vainonen J.P., Stralfors P., Vener A.V.
    Biochem. J. 383:237-248(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 58-65.
    Tissue: Adipocyte.
  8. "Phosphorylation of caveolin by src tyrosine kinases. The alpha-isoform of caveolin is selectively phosphorylated by v-Src in vivo."
    Li S., Seitz R., Lisanti M.P.
    J. Biol. Chem. 271:3863-3868(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-6; TYR-14 AND TYR-25.
  9. "Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx."
    Vargas L., Nore B.F., Berglof A., Heinonen J.E., Mattsson P.T., Smith C.I., Mohamed A.J.
    J. Biol. Chem. 277:9351-9357(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH BMX AND BTK.
  10. "Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex."
    Eberle H.B., Serrano R.L., Fuellekrug J., Schlosser A., Lehmann W.D., Lottspeich F., Kaloyanova D., Wieland F.T., Helms J.B.
    J. Cell Sci. 115:827-838(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GLIPR2.
    Tissue: Brain.
  11. "c-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14."
    Sanguinetti A.R., Mastick C.C.
    Cell. Signal. 15:289-298(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-14.
  12. "Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN."
    Schilling K., Opitz N., Wiesenthal A., Oess S., Tikkanen R., Mueller-Esterl W., Icking A.
    Mol. Biol. Cell 17:3870-3880(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NOSTRIN.
  13. "The rotavirus enterotoxin NSP4 directly interacts with the caveolar structural protein caveolin-1."
    Parr R.D., Storey S.M., Mitchell D.M., McIntosh A.L., Zhou M., Mir K.D., Ball J.M.
    J. Virol. 80:2842-2854(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ROTAVIRUS A NSP4.
  14. Cited for: FUNCTION, INTERACTION WITH DPP4, SUBCELLULAR LOCATION.
  15. Cited for: INVOLVEMENT IN CGL3.
  16. "Heterozygous CAV1 frameshift mutations (MIM 601047) in patients with atypical partial lipodystrophy and hypertriglyceridemia."
    Cao H., Alston L., Ruschman J., Hegele R.A.
    Lipids Health Dis. 7:3-3(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN LCCNS.
  17. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  18. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 (ISOFORM 2), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS] (ISOFORM 2).
  19. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2 AND LYS-5, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 (ISOFORM 2), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS] (ISOFORM 2).
    Tissue: Cervix carcinoma.
  21. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  22. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  23. "Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension."
    Austin E.D., Ma L., LeDuc C., Berman Rosenzweig E., Borczuk A., Phillips J.A. III, Palomero T., Sumazin P., Kim H.R., Talati M.H., West J., Loyd J.E., Chung W.K.
    Circ. Cardiovasc. Genet. 5:336-343(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN PPH3.
  24. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  25. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  26. "Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia."
    Lee H., Park D.S., Razani B., Russell R.G., Pestell R.G., Lisanti M.P.
    Am. J. Pathol. 161:1357-1369(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT LEU-132.

Entry informationi

Entry nameiCAV1_HUMAN
AccessioniPrimary (citable) accession number: Q03135
Secondary accession number(s): Q9UGP1, Q9UNG1, Q9UQH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 177 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.