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Protein

Formate dehydrogenase

Gene

aciA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the NAD+-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.UniRule annotation

Catalytic activityi

Formate + NAD+ = CO2 + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei94Substrate; via amide nitrogenUniRule annotation1
Binding sitei120SubstrateUniRule annotation1
Binding sitei196NADUniRule annotation1
Binding sitei257NAD; via carbonyl oxygenUniRule annotation1
Sitei259Important for catalytic activityUniRule annotation1
Binding sitei283NADUniRule annotation1
Sitei312Important for catalytic activityUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi175 – 176NADUniRule annotation2
Nucleotide bindingi231 – 235NADUniRule annotation5
Nucleotide bindingi312 – 315NADUniRule annotation4

GO - Molecular functioni

GO - Biological processi

  • acetate metabolic process Source: AspGD
  • formate catabolic process Source: EnsemblFungi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Formate dehydrogenaseUniRule annotation (EC:1.17.1.9UniRule annotation)
Short name:
FDHUniRule annotation
Alternative name(s):
Acetate inducible protein A1 Publication
NAD-dependent formate dehydrogenaseUniRule annotation
Gene namesi
Name:aciA1 Publication
ORF Names:AN6525
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome I
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000760241 – 365Formate dehydrogenaseAdd BLAST365

Proteomic databases

PRIDEiQ03134

Expressioni

Inductioni

Acetate induction mediated by the amdA regulatory gene.1 Publication

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi162425.CADANIAP00007297

Structurei

3D structure databases

ProteinModelPortaliQ03134
SMRiQ03134
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni3 – 120CatalyticUniRule annotationAdd BLAST118
Regioni121 – 313Coenzyme-bindingUniRule annotationAdd BLAST193
Regioni314 – 359CatalyticUniRule annotationAdd BLAST46

Sequence similaritiesi

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000136703
InParanoidiQ03134
KOiK00122
OMAiEVTYCNS
OrthoDBiEOG092C30ZL

Family and domain databases

CDDicd05302 FDH, 1 hit
HAMAPiMF_03210 Formate_dehydrogenase, 1 hit
InterProiView protein in InterPro
IPR006139 D-isomer_2_OHA_DH_cat_dom
IPR029753 D-isomer_DH_CS
IPR029752 D-isomer_DH_CS1
IPR006140 D-isomer_DH_NAD-bd
IPR033689 FDH_NAD-dep
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00389 2-Hacid_dh, 1 hit
PF02826 2-Hacid_dh_C, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00065 D_2_HYDROXYACID_DH_1, 1 hit
PS00670 D_2_HYDROXYACID_DH_2, 1 hit
PS00671 D_2_HYDROXYACID_DH_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q03134-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKVLMVLYD GGSHAKDQPG LLGTTENELG IRKWIEEQGH TLVTTSDKDG
60 70 80 90 100
ENSTFDKELV DAEVIITTPF HPGYLTAERL AKAKNLKLAV TAGIGSDHVD
110 120 130 140 150
LDAANKTNGG ITVAEVTGSN VVSVAEHVVM TILLLVRNFV PAHDQIRNGD
160 170 180 190 200
WNVAAVAKNE FDLENKVVGT VGVGRIGERV LRRLKPFDCK ELLYYDYQPL
210 220 230 240 250
RPEVEKEIGA RRVDSLEEMV SQCDVVTINC PLHEKTRGLF NKELISKMKP
260 270 280 290 300
GSWLVNTARG AIVVKEDVAE ALKSGHLRGY GGDVWFPQPA PKEHPLRYAE
310 320 330 340 350
HPWGGGNATV PHMSGTSIDA QIRYANGTKA ILDSYFSGRF DYQPQDLIVH
360
GGDYATKAYG QREKK
Length:365
Mass (Da):40,131
Last modified:November 16, 2011 - v3
Checksum:iC9AB2B4EFBFC540D
GO

Sequence cautioni

The sequence CAA77687 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAA57865 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11612 Genomic DNA Translation: CAA77687.1 Sequence problems.
AACD01000109 Genomic DNA Translation: EAA57865.1 Sequence problems.
BN001301 Genomic DNA Translation: CBF70916.1
PIRiS30088
RefSeqiXP_664129.1, XM_659037.1

Genome annotation databases

EnsemblFungiiCADANIAT00007297; CADANIAP00007297; CADANIAG00007297
EAA57865; EAA57865; AN6525.2
GeneIDi2870218
KEGGiani:AN6525.2

Similar proteinsi

Entry informationi

Entry nameiFDH_EMENI
AccessioniPrimary (citable) accession number: Q03134
Secondary accession number(s): C8V0K7, Q5AYV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: November 16, 2011
Last modified: May 23, 2018
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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