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Q03134

- FDH_EMENI

UniProt

Q03134 - FDH_EMENI

Protein

Probable formate dehydrogenase

Gene

aciA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 3 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Formate + NAD+ = CO2 + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei259 – 2591By similarity
    Binding sitei283 – 2831NADBy similarity
    Active sitei312 – 3121Proton donorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi175 – 1762NADBy similarity
    Nucleotide bindingi257 – 2593NADBy similarity
    Nucleotide bindingi312 – 3154NADBy similarity

    GO - Molecular functioni

    1. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
    2. NAD binding Source: InterPro
    3. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro

    GO - Biological processi

    1. acetate metabolic process Source: ASPGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable formate dehydrogenase (EC:1.2.1.2)
    Alternative name(s):
    NAD-dependent formate dehydrogenase
    Short name:
    FDH
    Gene namesi
    Name:aciA
    ORF Names:AN6525
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome I

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: ASPGD
    2. intracellular Source: ASPGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 365365Probable formate dehydrogenasePRO_0000076024Add
    BLAST

    Proteomic databases

    PRIDEiQ03134.

    Expressioni

    Inductioni

    Acetate induction mediated by amda regulatory gene.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi162425.CADANIAP00007297.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03134.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1052.
    HOGENOMiHOG000136703.
    KOiK00122.
    OMAiGCRRVEN.
    OrthoDBiEOG769ZV3.

    Family and domain databases

    Gene3Di3.40.50.720. 2 hits.
    InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
    IPR006140. D-isomer_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00389. 2-Hacid_dh. 1 hit.
    PF02826. 2-Hacid_dh_C. 1 hit.
    [Graphical view]
    PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
    PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
    PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q03134-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKVLMVLYD GGSHAKDQPG LLGTTENELG IRKWIEEQGH TLVTTSDKDG    50
    ENSTFDKELV DAEVIITTPF HPGYLTAERL AKAKNLKLAV TAGIGSDHVD 100
    LDAANKTNGG ITVAEVTGSN VVSVAEHVVM TILLLVRNFV PAHDQIRNGD 150
    WNVAAVAKNE FDLENKVVGT VGVGRIGERV LRRLKPFDCK ELLYYDYQPL 200
    RPEVEKEIGA RRVDSLEEMV SQCDVVTINC PLHEKTRGLF NKELISKMKP 250
    GSWLVNTARG AIVVKEDVAE ALKSGHLRGY GGDVWFPQPA PKEHPLRYAE 300
    HPWGGGNATV PHMSGTSIDA QIRYANGTKA ILDSYFSGRF DYQPQDLIVH 350
    GGDYATKAYG QREKK 365
    Length:365
    Mass (Da):40,131
    Last modified:November 16, 2011 - v3
    Checksum:iC9AB2B4EFBFC540D
    GO

    Sequence cautioni

    The sequence CAA77687.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence EAA57865.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z11612 Genomic DNA. Translation: CAA77687.1. Sequence problems.
    AACD01000109 Genomic DNA. Translation: EAA57865.1. Sequence problems.
    BN001301 Genomic DNA. Translation: CBF70916.1.
    PIRiS30088.
    RefSeqiXP_664129.1. XM_659037.1.

    Genome annotation databases

    EnsemblFungiiCADANIAT00007297; CADANIAP00007297; CADANIAG00007297.
    GeneIDi2870218.
    KEGGiani:AN6525.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z11612 Genomic DNA. Translation: CAA77687.1 . Sequence problems.
    AACD01000109 Genomic DNA. Translation: EAA57865.1 . Sequence problems.
    BN001301 Genomic DNA. Translation: CBF70916.1 .
    PIRi S30088.
    RefSeqi XP_664129.1. XM_659037.1.

    3D structure databases

    ProteinModelPortali Q03134.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 162425.CADANIAP00007297.

    Proteomic databases

    PRIDEi Q03134.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANIAT00007297 ; CADANIAP00007297 ; CADANIAG00007297 .
    GeneIDi 2870218.
    KEGGi ani:AN6525.2.

    Phylogenomic databases

    eggNOGi COG1052.
    HOGENOMi HOG000136703.
    KOi K00122.
    OMAi GCRRVEN.
    OrthoDBi EOG769ZV3.

    Family and domain databases

    Gene3Di 3.40.50.720. 2 hits.
    InterProi IPR006139. D-isomer_2_OHA_DH_cat_dom.
    IPR006140. D-isomer_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00389. 2-Hacid_dh. 1 hit.
    PF02826. 2-Hacid_dh_C. 1 hit.
    [Graphical view ]
    PROSITEi PS00065. D_2_HYDROXYACID_DH_1. 1 hit.
    PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
    PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the amdA-regulated aciA gene of Aspergillus nidulans."
      Saleeba J.A., Cobbett C.S., Hynes M.J.
      Mol. Gen. Genet. 235:349-358(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

    Entry informationi

    Entry nameiFDH_EMENI
    AccessioniPrimary (citable) accession number: Q03134
    Secondary accession number(s): C8V0K7, Q5AYV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 96 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3