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Q03134

- FDH_EMENI

UniProt

Q03134 - FDH_EMENI

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Protein
Probable formate dehydrogenase
Gene
aciA, AN6525
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei259 – 2591 By similarity
Binding sitei283 – 2831NAD By similarity
Active sitei312 – 3121Proton donor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi175 – 1762NAD By similarity
Nucleotide bindingi257 – 2593NAD By similarity
Nucleotide bindingi312 – 3154NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
  3. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. acetate metabolic process Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Probable formate dehydrogenase (EC:1.2.1.2)
Alternative name(s):
NAD-dependent formate dehydrogenase
Short name:
FDH
Gene namesi
Name:aciA
ORF Names:AN6525
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: ASPGD
  2. intracellular Source: ASPGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 365365Probable formate dehydrogenase
PRO_0000076024Add
BLAST

Proteomic databases

PRIDEiQ03134.

Expressioni

Inductioni

Acetate induction mediated by amda regulatory gene.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi162425.CADANIAP00007297.

Structurei

3D structure databases

ProteinModelPortaliQ03134.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1052.
HOGENOMiHOG000136703.
KOiK00122.
OMAiGCRRVEN.
OrthoDBiEOG769ZV3.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03134-1 [UniParc]FASTAAdd to Basket

« Hide

MGKVLMVLYD GGSHAKDQPG LLGTTENELG IRKWIEEQGH TLVTTSDKDG    50
ENSTFDKELV DAEVIITTPF HPGYLTAERL AKAKNLKLAV TAGIGSDHVD 100
LDAANKTNGG ITVAEVTGSN VVSVAEHVVM TILLLVRNFV PAHDQIRNGD 150
WNVAAVAKNE FDLENKVVGT VGVGRIGERV LRRLKPFDCK ELLYYDYQPL 200
RPEVEKEIGA RRVDSLEEMV SQCDVVTINC PLHEKTRGLF NKELISKMKP 250
GSWLVNTARG AIVVKEDVAE ALKSGHLRGY GGDVWFPQPA PKEHPLRYAE 300
HPWGGGNATV PHMSGTSIDA QIRYANGTKA ILDSYFSGRF DYQPQDLIVH 350
GGDYATKAYG QREKK 365
Length:365
Mass (Da):40,131
Last modified:November 16, 2011 - v3
Checksum:iC9AB2B4EFBFC540D
GO

Sequence cautioni

The sequence CAA77687.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence EAA57865.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z11612 Genomic DNA. Translation: CAA77687.1. Sequence problems.
AACD01000109 Genomic DNA. Translation: EAA57865.1. Sequence problems.
BN001301 Genomic DNA. Translation: CBF70916.1.
PIRiS30088.
RefSeqiXP_664129.1. XM_659037.1.

Genome annotation databases

EnsemblFungiiCADANIAT00007297; CADANIAP00007297; CADANIAG00007297.
GeneIDi2870218.
KEGGiani:AN6525.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z11612 Genomic DNA. Translation: CAA77687.1 . Sequence problems.
AACD01000109 Genomic DNA. Translation: EAA57865.1 . Sequence problems.
BN001301 Genomic DNA. Translation: CBF70916.1 .
PIRi S30088.
RefSeqi XP_664129.1. XM_659037.1.

3D structure databases

ProteinModelPortali Q03134.
ModBasei Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00007297.

Proteomic databases

PRIDEi Q03134.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00007297 ; CADANIAP00007297 ; CADANIAG00007297 .
GeneIDi 2870218.
KEGGi ani:AN6525.2.

Phylogenomic databases

eggNOGi COG1052.
HOGENOMi HOG000136703.
KOi K00122.
OMAi GCRRVEN.
OrthoDBi EOG769ZV3.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view ]
PROSITEi PS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the amdA-regulated aciA gene of Aspergillus nidulans."
    Saleeba J.A., Cobbett C.S., Hynes M.J.
    Mol. Gen. Genet. 235:349-358(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiFDH_EMENI
AccessioniPrimary (citable) accession number: Q03134
Secondary accession number(s): C8V0K7, Q5AYV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: November 16, 2011
Last modified: September 3, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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