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Q03134 (FDH_EMENI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable formate dehydrogenase

EC=1.2.1.2
Alternative name(s):
NAD-dependent formate dehydrogenase
Short name=FDH
Gene names
Name:aciA
ORF Names:AN6525
OrganismEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) [Reference proteome]
Taxonomic identifier227321 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Formate + NAD+ = CO2 + NADH.

Subunit structure

Homodimer By similarity.

Induction

Acetate induction mediated by amda regulatory gene.

Sequence similarities

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.

Sequence caution

The sequence CAA77687.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence EAA57865.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 365365Probable formate dehydrogenase
PRO_0000076024

Regions

Nucleotide binding175 – 1762NAD By similarity
Nucleotide binding257 – 2593NAD By similarity
Nucleotide binding312 – 3154NAD By similarity

Sites

Active site2591 By similarity
Active site3121Proton donor By similarity
Binding site2831NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q03134 [UniParc].

Last modified November 16, 2011. Version 3.
Checksum: C9AB2B4EFBFC540D

FASTA36540,131
        10         20         30         40         50         60 
MGKVLMVLYD GGSHAKDQPG LLGTTENELG IRKWIEEQGH TLVTTSDKDG ENSTFDKELV 

        70         80         90        100        110        120 
DAEVIITTPF HPGYLTAERL AKAKNLKLAV TAGIGSDHVD LDAANKTNGG ITVAEVTGSN 

       130        140        150        160        170        180 
VVSVAEHVVM TILLLVRNFV PAHDQIRNGD WNVAAVAKNE FDLENKVVGT VGVGRIGERV 

       190        200        210        220        230        240 
LRRLKPFDCK ELLYYDYQPL RPEVEKEIGA RRVDSLEEMV SQCDVVTINC PLHEKTRGLF 

       250        260        270        280        290        300 
NKELISKMKP GSWLVNTARG AIVVKEDVAE ALKSGHLRGY GGDVWFPQPA PKEHPLRYAE 

       310        320        330        340        350        360 
HPWGGGNATV PHMSGTSIDA QIRYANGTKA ILDSYFSGRF DYQPQDLIVH GGDYATKAYG 


QREKK 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the amdA-regulated aciA gene of Aspergillus nidulans."
Saleeba J.A., Cobbett C.S., Hynes M.J.
Mol. Gen. Genet. 235:349-358(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae."
Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. expand/collapse author list , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.
Nature 438:1105-1115(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[3]"The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G. expand/collapse author list , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z11612 Genomic DNA. Translation: CAA77687.1. Sequence problems.
AACD01000109 Genomic DNA. Translation: EAA57865.1. Sequence problems.
BN001301 Genomic DNA. Translation: CBF70916.1.
PIRS30088.
RefSeqXP_664129.1. XM_659037.1.

3D structure databases

ProteinModelPortalQ03134.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING162425.CADANIAP00007297.

Proteomic databases

PRIDEQ03134.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADANIAT00007297; CADANIAP00007297; CADANIAG00007297.
GeneID2870218.
KEGGani:AN6525.2.

Phylogenomic databases

eggNOGCOG1052.
HOGENOMHOG000136703.
KOK00122.
OMAEVTYCNS.
OrthoDBEOG769ZV3.

Family and domain databases

Gene3D3.40.50.720. 2 hits.
InterProIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_2_OHA_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFDH_EMENI
AccessionPrimary (citable) accession number: Q03134
Secondary accession number(s): C8V0K7, Q5AYV5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: November 16, 2011
Last modified: April 16, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families