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Protein

Transcriptional regulator NRG1

Gene

NRG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor involved in regulation of glucose repression. Binds to UAS-1 in the STA1 promoter.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri174 – 19623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri202 – 22625C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cellular hyperosmotic salinity response Source: SGD
  • negative regulation of cellular hyperosmotic salinity response by negative regulation of transcription from RNA polymerase II promoter Source: SGD
  • negative regulation of cellular response to alkaline pH by negative regulation of transcription from RNA polymerase II promoter Source: SGD
  • negative regulation of invasive growth in response to glucose limitation Source: SGD
  • negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter Source: SGD
  • negative regulation of transcription from RNA polymerase II promoter Source: SGD
  • negative regulation of transcription from RNA polymerase II promoter by glucose Source: SGD
  • pseudohyphal growth Source: SGD
  • single-species surface biofilm formation Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-29657-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator NRG1
Alternative name(s):
Zinc finger protein MSS1
Gene namesi
Name:NRG1
Synonyms:MSS1
Ordered Locus Names:YDR043C
ORF Names:YD5112.01C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR043C.
SGDiS000002450. NRG1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231Transcriptional regulator NRG1PRO_0000046812Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei163 – 1631PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ03125.

PTM databases

iPTMnetiQ03125.

Interactioni

GO - Molecular functioni

  • RNA polymerase II repressing transcription factor binding Source: SGD

Protein-protein interaction databases

BioGridi32098. 153 interactions.
DIPiDIP-2434N.
MINTiMINT-2732523.

Structurei

3D structure databases

ProteinModelPortaliQ03125.
SMRiQ03125. Positions 172-226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri174 – 19623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri202 – 22625C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00650000094227.
HOGENOMiHOG000065960.
InParanoidiQ03125.
OrthoDBiEOG092C5UG7.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03125-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFYPYNYSNL NVSTMPALPG ISAFDGMQDE ENVEISPERK YQTLLPVLTN
60 70 80 90 100
SHVVENELKH KLNKTAFDFR YQTKSENGSE KWEPKYLITP NLQTRSVSFD
110 120 130 140 150
NSSVQYNSDS SEKSSLSQLT CNSSIIQQPE NGIVSNDAYN KMANSRYSLK
160 170 180 190 200
TRKQRTDPRN TLSDEEDLEQ RRKYICKICA RGFTTSGHLA RHNRIHTGEK
210 220 230
NHCCPYKGCT QRFSRHDNCL QHYRTHLKKG Q
Length:231
Mass (Da):26,743
Last modified:November 1, 1996 - v1
Checksum:i50F7E7ED4690D109
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013167 Genomic DNA. Translation: AAD01510.1.
Z49812 Genomic DNA. Translation: CAA89965.1.
AY557653 Genomic DNA. Translation: AAS55979.1.
BK006938 Genomic DNA. Translation: DAA11891.1.
PIRiS55078.
RefSeqiNP_010328.3. NM_001180351.3.

Genome annotation databases

EnsemblFungiiYDR043C; YDR043C; YDR043C.
GeneIDi851613.
KEGGisce:YDR043C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013167 Genomic DNA. Translation: AAD01510.1.
Z49812 Genomic DNA. Translation: CAA89965.1.
AY557653 Genomic DNA. Translation: AAS55979.1.
BK006938 Genomic DNA. Translation: DAA11891.1.
PIRiS55078.
RefSeqiNP_010328.3. NM_001180351.3.

3D structure databases

ProteinModelPortaliQ03125.
SMRiQ03125. Positions 172-226.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32098. 153 interactions.
DIPiDIP-2434N.
MINTiMINT-2732523.

PTM databases

iPTMnetiQ03125.

Proteomic databases

PRIDEiQ03125.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR043C; YDR043C; YDR043C.
GeneIDi851613.
KEGGisce:YDR043C.

Organism-specific databases

EuPathDBiFungiDB:YDR043C.
SGDiS000002450. NRG1.

Phylogenomic databases

GeneTreeiENSGT00650000094227.
HOGENOMiHOG000065960.
InParanoidiQ03125.
OrthoDBiEOG092C5UG7.

Enzyme and pathway databases

BioCyciYEAST:G3O-29657-MONOMER.

Miscellaneous databases

PROiQ03125.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNRG1_YEAST
AccessioniPrimary (citable) accession number: Q03125
Secondary accession number(s): D6VS31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 556 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.