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Q03114

- CDK5_RAT

UniProt

Q03114 - CDK5_RAT

Protein

Cyclin-dependent-like kinase 5

Gene

Cdk5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Inhibited by 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine), 1-isopropyl-4-aminobenzyl-6-ether-linked benzimidazoles, resveratrol, AT-7519 and olomoucine. Activated by CDK5R1 (p35) and CDK5R2 (p39) during the development of the nervous system; degradation of CDK5R1 (p35) and CDK5R2 (p39) by proteasome result in down regulation of kinase activity, during this process, CDK5 phosphorylates p35 and induces its ubiquitination and subsequent degradation. Kinase activity is mainly determined by the amount of p35 available and subcellular location; reversible association to plasma membrane inhibits activity. Long-term inactivation as well as CDK5R1 (p25)-mediated hyperactivation of CDK5 triggers cell death. The pro-death activity of hyperactivated CDK5 is suppressed by membrane association of CDK5, via myristoylation of p35. Brain-derived neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor (NGF), retinoic acid, laminin and neuregulin promote activity. Neurotoxicity enhances nuclear activity, thus leading to MEF2 phosphorylation and inhibition prior to apoptosis of cortical neurons. Repression by GSTP1 via p25/p35 translocation prevents neurodegeneration By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATPPROSITE-ProRule annotation
    Active sitei126 – 1261Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. acetylcholine receptor activator activity Source: UniProtKB
    2. ATP binding Source: UniProtKB-KW
    3. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
    4. cytoskeletal protein binding Source: BHF-UCL
    5. ephrin receptor binding Source: UniProtKB
    6. ErbB-2 class receptor binding Source: UniProtKB
    7. ErbB-3 class receptor binding Source: UniProtKB
    8. kinase activity Source: UniProtKB
    9. protein binding Source: UniProtKB
    10. protein kinase activity Source: MGI
    11. protein serine/threonine kinase activity Source: UniProtKB
    12. tau-protein kinase activity Source: UniProtKB

    GO - Biological processi

    1. axon extension Source: UniProtKB
    2. behavioral response to cocaine Source: Ensembl
    3. calcium ion import Source: Ensembl
    4. cell cycle Source: UniProtKB-KW
    5. cell division Source: UniProtKB-KW
    6. cell-matrix adhesion Source: Ensembl
    7. central nervous system development Source: RGD
    8. central nervous system neuron development Source: Ensembl
    9. cerebellar cortex formation Source: Ensembl
    10. corpus callosum development Source: Ensembl
    11. cortical actin cytoskeleton organization Source: RGD
    12. dendrite morphogenesis Source: Ensembl
    13. embryo development Source: UniProtKB
    14. exocytosis Source: RGD
    15. hippocampus development Source: Ensembl
    16. intracellular protein transport Source: Ensembl
    17. layer formation in cerebral cortex Source: Ensembl
    18. motor neuron axon guidance Source: Ensembl
    19. negative regulation of axon extension Source: Ensembl
    20. negative regulation of cell cycle Source: Ensembl
    21. negative regulation of protein export from nucleus Source: Ensembl
    22. negative regulation of protein ubiquitination Source: Ensembl
    23. negative regulation of synaptic plasticity Source: Ensembl
    24. negative regulation of transcription, DNA-templated Source: Ensembl
    25. neuron apoptotic process Source: RGD
    26. neuron differentiation Source: UniProtKB
    27. neuron migration Source: Ensembl
    28. neuron projection development Source: UniProtKB
    29. neuron projection morphogenesis Source: RGD
    30. nucleocytoplasmic transport Source: RGD
    31. oligodendrocyte differentiation Source: Ensembl
    32. peptidyl-serine phosphorylation Source: RGD
    33. peptidyl-threonine phosphorylation Source: Ensembl
    34. positive regulation of calcium ion-dependent exocytosis Source: Ensembl
    35. positive regulation of neuron apoptotic process Source: UniProtKB
    36. positive regulation of protein binding Source: Ensembl
    37. positive regulation of protein kinase activity Source: Ensembl
    38. positive regulation of protein targeting to membrane Source: Ensembl
    39. positive regulation of receptor activity Source: GOC
    40. protein autophosphorylation Source: RGD
    41. protein localization to synapse Source: Ensembl
    42. protein phosphorylation Source: MGI
    43. receptor catabolic process Source: Ensembl
    44. receptor clustering Source: Ensembl
    45. regulated secretory pathway Source: RGD
    46. regulation of cell migration Source: Ensembl
    47. regulation of dendritic spine morphogenesis Source: UniProtKB
    48. regulation of excitatory postsynaptic membrane potential Source: Ensembl
    49. regulation of synaptic plasticity Source: UniProtKB
    50. response to wounding Source: RGD
    51. rhythmic process Source: UniProtKB-KW
    52. Schwann cell development Source: Ensembl
    53. sensory perception of pain Source: Ensembl
    54. serine phosphorylation of STAT3 protein Source: Ensembl
    55. skeletal muscle tissue development Source: UniProtKB
    56. synapse assembly Source: Ensembl
    57. synaptic transmission, dopaminergic Source: Ensembl
    58. synaptic transmission, glutamatergic Source: Ensembl
    59. synaptic vesicle endocytosis Source: RGD
    60. visual learning Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Apoptosis, Biological rhythms, Cell cycle, Cell division, Neurogenesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.22. 5301.
    ReactomeiREACT_196232. Factors involved in megakaryocyte development and platelet production.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent-like kinase 5 (EC:2.7.11.1)
    Alternative name(s):
    Cell division protein kinase 5
    Serine/threonine-protein kinase PSSALRE
    Tau protein kinase II catalytic subunit
    Short name:
    TPKII catalytic subunit
    Gene namesi
    Name:Cdk5
    Synonyms:Cdkn5
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi70514. Cdk5.

    Subcellular locationi

    Cytoplasm By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity. Perikaryon By similarity. Cell projectionlamellipodium By similarity. Cell projectiongrowth cone By similarity. Nucleus By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity
    Note: In axonal growth cone with extension to the peripheral lamellipodia By similarity. Under neurotoxic stress and neuronal injury conditions, CDK5R1 (p35) is cleaved by calpain to generate CDK5R1 (p25) in response to increased intracellular calcium. The elevated level of p25, when in complex with CDK5, leads to its subcellular misallocation as well as its hyperactivation. Colocalizes with CTNND2 in the cell body of neuronal cells, and with CTNNB1 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Reversibly attached to the plasma membrane in an inactive form when complexed to dephosphorylated p35 or CDK5R2 (p39), p35 phosphorylation releases this attachment and activates CDK5 By similarity.By similarity

    GO - Cellular componenti

    1. axon Source: UniProtKB
    2. cell junction Source: RGD
    3. cyclin-dependent protein kinase 5 holoenzyme complex Source: RGD
    4. cytoplasm Source: UniProtKB
    5. cytoskeleton Source: RGD
    6. cytosol Source: Ensembl
    7. dendrite Source: UniProtKB
    8. filopodium Source: Ensembl
    9. growth cone Source: UniProtKB
    10. lamellipodium Source: UniProtKB-SubCell
    11. membrane Source: UniProtKB
    12. neuromuscular junction Source: UniProtKB
    13. neuronal cell body Source: UniProtKB
    14. nucleus Source: UniProtKB
    15. perikaryon Source: UniProtKB-SubCell
    16. postsynaptic density Source: UniProtKB
    17. postsynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Keywords - Diseasei

    Neurodegeneration

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292Cyclin-dependent-like kinase 5PRO_0000085786Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei15 – 151Phosphotyrosine; by ABL1, EPHA4 and FYNBy similarity
    Modified residuei56 – 561N6-acetyllysineBy similarity
    Modified residuei72 – 721PhosphoserineBy similarity
    Modified residuei159 – 1591PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylation on Tyr-15 by ABL1 and FYN, and on Ser-159 by casein kinase 1 promotes kinase activity. By contrast, phosphorylation at Thr-14 inhibits activity By similarity.By similarity
    Phosphorylation at Ser-159 is essential for maximal catalytic activity.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiQ03114.

    PTM databases

    PhosphoSiteiQ03114.

    Expressioni

    Tissue specificityi

    Expressed predominantly in post-mitotic neurons of the central and peripheral nervous system.

    Gene expression databases

    GenevestigatoriQ03114.

    Interactioni

    Subunit structurei

    Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity. Under neurotoxic stress and neuronal injury conditions, p35 is cleaved by calpain to generate p25 that hyperactivates CDK5, that becomes functionally disabled and often toxic. Found in a trimolecular complex with CABLES1 and ABL1. Interacts with CABLES1 and CABLES2 By similarity. Interacts with AATK and GSTP1. Binds to HDAC1 when in complex with p25. Interaction with myristoylation p35 promotes CDK5 association with membranes. Both isoforms 1 and 2 interacts with beta-catenin/CTNNB1. Interacts with delta-catenin/CTNND2 and APEX1. Interacts with P53/TP53 in neurons. Interacts with PTK2/FAK1 By similarity. Interacts with EPHA4; may mediate the activation of NGEF by EPHA4. The complex p35/CDK5 interacts with CLOCK By similarity.By similarity

    Protein-protein interaction databases

    BioGridi250852. 6 interactions.
    DIPiDIP-29351N.
    IntActiQ03114. 3 interactions.
    MINTiMINT-246942.
    STRINGi10116.ENSRNOP00000011052.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03114.
    SMRiQ03114. Positions 1-292.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 286283Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00600000083998.
    HOGENOMiHOG000233024.
    HOVERGENiHBG014652.
    InParanoidiQ03114.
    KOiK02090.
    OMAiTMTKLPD.
    OrthoDBiEOG7966H8.
    PhylomeDBiQ03114.
    TreeFamiTF101023.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q03114-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR    50
    EICLLKELKH KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP 100
    EIVKSLLFQL LKGLGFCHSR NVLHRDLKPQ NLLINRNGEL KLADFGLARA 150
    FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS TSIDMWSAGC IFAELANAGR 200
    PLFPGNDVDD QLKRIFRLLG TPTEEQWPAM TKLPDYKPYP MYPATTSLVN 250
    VVPKLNATGR DLLQNLLKCN PVQRISAEEA LQHPYFSDFC PP 292
    Length:292
    Mass (Da):33,254
    Last modified:October 1, 1993 - v1
    Checksum:i4CBFF80794F931DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L02121 mRNA. Translation: AAA40902.1.
    PIRiA46365.
    RefSeqiNP_543161.1. NM_080885.1.
    UniGeneiRn.10749.

    Genome annotation databases

    EnsembliENSRNOT00000011052; ENSRNOP00000011052; ENSRNOG00000008017.
    GeneIDi140908.
    KEGGirno:140908.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L02121 mRNA. Translation: AAA40902.1 .
    PIRi A46365.
    RefSeqi NP_543161.1. NM_080885.1.
    UniGenei Rn.10749.

    3D structure databases

    ProteinModelPortali Q03114.
    SMRi Q03114. Positions 1-292.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 250852. 6 interactions.
    DIPi DIP-29351N.
    IntActi Q03114. 3 interactions.
    MINTi MINT-246942.
    STRINGi 10116.ENSRNOP00000011052.

    Chemistry

    BindingDBi Q03114.
    ChEMBLi CHEMBL5901.

    PTM databases

    PhosphoSitei Q03114.

    Proteomic databases

    PRIDEi Q03114.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000011052 ; ENSRNOP00000011052 ; ENSRNOG00000008017 .
    GeneIDi 140908.
    KEGGi rno:140908.

    Organism-specific databases

    CTDi 1020.
    RGDi 70514. Cdk5.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00600000083998.
    HOGENOMi HOG000233024.
    HOVERGENi HBG014652.
    InParanoidi Q03114.
    KOi K02090.
    OMAi TMTKLPD.
    OrthoDBi EOG7966H8.
    PhylomeDBi Q03114.
    TreeFami TF101023.

    Enzyme and pathway databases

    BRENDAi 2.7.11.22. 5301.
    Reactomei REACT_196232. Factors involved in megakaryocyte development and platelet production.

    Miscellaneous databases

    NextBioi 620745.
    PROi Q03114.

    Gene expression databases

    Genevestigatori Q03114.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA."
      Xiong Y., Zhang H., Beach D.H.
      Cell 71:505-514(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression."
      Hellmich M.R., Pant H.C., Wada E., Battey J.F.
      Proc. Natl. Acad. Sci. U.S.A. 89:10867-10871(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. Cited for: INTERACTION WITH AATK.
    4. "Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism."
      Fu W.Y., Chen Y., Sahin M., Zhao X.S., Shi L., Bikoff J.B., Lai K.O., Yung W.H., Fu A.K., Greenberg M.E., Ip N.Y.
      Nat. Neurosci. 10:67-76(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH EPHA4, SUBCELLULAR LOCATION.
    5. "Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity."
      Seeburg D.P., Feliu-Mojer M., Gaiottino J., Pak D.T., Sheng M.
      Neuron 58:571-583(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PHOSPHORYLATION OF SIPA1L1.

    Entry informationi

    Entry nameiCDK5_RAT
    AccessioniPrimary (citable) accession number: Q03114
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 134 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3