Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q03113

- GNA12_HUMAN

UniProt

Q03113 - GNA12_HUMAN

Protein

Guanine nucleotide-binding protein subunit alpha-12

Gene

GNA12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. May play a role in the control of cell migration through the TOR signaling cascade.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi71 – 711MagnesiumBy similarity
    Metal bindingi208 – 2081MagnesiumBy similarity
    Binding sitei353 – 3531GTP; via amide nitrogenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi64 – 718GTPBy similarity
    Nucleotide bindingi202 – 2087GTPBy similarity
    Nucleotide bindingi227 – 2315GTPBy similarity
    Nucleotide bindingi296 – 2994GTPBy similarity

    GO - Molecular functioni

    1. D5 dopamine receptor binding Source: RefGenome
    2. G-protein beta/gamma-subunit complex binding Source: RefGenome
    3. GTPase activity Source: RefGenome
    4. GTP binding Source: UniProtKB-KW
    5. metal ion binding Source: UniProtKB-KW
    6. protein binding Source: UniProtKB
    7. signal transducer activity Source: RefGenome

    GO - Biological processi

    1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RefGenome
    2. blood coagulation Source: Reactome
    3. cell differentiation Source: Ensembl
    4. embryonic digit morphogenesis Source: Ensembl
    5. G-protein coupled receptor signaling pathway Source: ProtInc
    6. in utero embryonic development Source: Ensembl
    7. platelet activation Source: Reactome
    8. regulation of cell shape Source: Ensembl
    9. regulation of fibroblast migration Source: UniProtKB
    10. regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
    11. regulation of TOR signaling Source: UniProtKB
    12. response to drug Source: Ensembl
    13. Rho protein signal transduction Source: RefGenome

    Keywords - Molecular functioni

    Transducer

    Keywords - Ligandi

    GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_18407. G alpha (12/13) signalling events.
    REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
    SignaLinkiQ03113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide-binding protein subunit alpha-12
    Short name:
    G alpha-12
    Short name:
    G-protein subunit alpha-12
    Gene namesi
    Name:GNA12
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:4380. GNA12.

    Subcellular locationi

    GO - Cellular componenti

    1. brush border membrane Source: RefGenome
    2. heterotrimeric G-protein complex Source: RefGenome
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28765.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 381381Guanine nucleotide-binding protein subunit alpha-12PRO_0000203770Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi11 – 111S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiQ03113.
    PaxDbiQ03113.
    PRIDEiQ03113.

    PTM databases

    PhosphoSiteiQ03113.

    Expressioni

    Gene expression databases

    ArrayExpressiQ03113.
    BgeeiQ03113.
    CleanExiHS_GNA12.
    GenevestigatoriQ03113.

    Organism-specific databases

    HPAiCAB010046.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with UBXD5. Interacts (when active) with PPP5C (via TPR repeats); activates PPP5C phosphatase activity and translocates PPP5C to the cell membrane. Interacts with RGS22.2 Publications

    Protein-protein interaction databases

    BioGridi109030. 26 interactions.
    IntActiQ03113. 4 interactions.
    MINTiMINT-85969.
    STRINGi9606.ENSP00000275364.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03113.
    SMRiQ03113. Positions 56-373.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-alpha family. G(12) subfamily.Curated

    Phylogenomic databases

    eggNOGiNOG279688.
    HOGENOMiHOG000038729.
    HOVERGENiHBG063184.
    InParanoidiQ03113.
    KOiK04346.
    OMAiWQHSENE.
    OrthoDBiEOG7HF1JF.
    PhylomeDBiQ03113.
    TreeFamiTF300673.

    Family and domain databases

    Gene3Di1.10.400.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR000469. Gprotein_alpha_12.
    IPR001019. Gprotein_alpha_su.
    IPR011025. GproteinA_insert.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR10218. PTHR10218. 1 hit.
    PfamiPF00503. G-alpha. 1 hit.
    [Graphical view]
    PRINTSiPR00318. GPROTEINA.
    PR00440. GPROTEINA12.
    SMARTiSM00275. G_alpha. 1 hit.
    [Graphical view]
    SUPFAMiSSF47895. SSF47895. 1 hit.
    SSF52540. SSF52540. 2 hits.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative initiation. Align

    Isoform 1 (identifier: Q03113-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGVVRTLSR CLLPAEAGGA RERRAGSGAR DAEREARRRS RDIDALLARE    50
    RRAVRRLVKI LLLGAGESGK STFLKQMRII HGREFDQKAL LEFRDTIFDN 100
    ILKGSRVLVD ARDKLGIPWQ YSENEKHGMF LMAFENKAGL PVEPATFQLY 150
    VPALSALWRD SGIREAFSRR SEFQLGESVK YFLDNLDRIG QLNYFPSKQD 200
    ILLARKATKG IVEHDFVIKK IPFKMVDVGG QRSQRQKWFQ CFDGITSILF 250
    MVSSSEYDQV LMEDRRTNRL VESMNIFETI VNNKLFFNVS IILFLNKMDL 300
    LVEKVKTVSI KKHFPDFRGD PHRLEDVQRY LVQCFDRKRR NRSKPLFHHF 350
    TTAIDTENVR FVFHAVKDTI LQENLKDIML Q 381
    Length:381
    Mass (Da):44,279
    Last modified:January 23, 2007 - v4
    Checksum:i04C3F12B29255F89
    GO
    Isoform 2 (identifier: Q03113-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-103: MSGVVRTLSR...RDTIFDNILK → MKRRMFPRPC...HLLIAHPGSR

    Show »
    Length:322
    Mass (Da):37,601
    Checksum:iAB035356C0AACD6F
    GO
    Isoform 3 (identifier: Q03113-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-76: Missing.
         174-190: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:288
    Mass (Da):34,002
    Checksum:i72CABE32D6FC5D6C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti126 – 1261K → E in AAM12615. 1 PublicationCurated
    Sequence conflicti323 – 3231R → Q in AAA35867. (PubMed:8423800)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti68 – 681S → G.1 Publication
    Corresponds to variant rs11552939 [ dbSNP | Ensembl ].
    VAR_071044
    Natural varianti242 – 2421F → L.
    Corresponds to variant rs45606633 [ dbSNP | Ensembl ].
    VAR_049359
    Natural varianti330 – 3301Y → H.
    Corresponds to variant rs45583847 [ dbSNP | Ensembl ].
    VAR_049360

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 103103MSGVV…DNILK → MKRRMFPRPCLARMPGSRGS GSTPDGNRKCCRFEHLLIAH PGSR in isoform 2. 1 PublicationVSP_055171Add
    BLAST
    Alternative sequencei1 – 7676Missing in isoform 3. 1 PublicationVSP_055230Add
    BLAST
    Alternative sequencei174 – 19017Missing in isoform 3. 1 PublicationVSP_055231Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L01694 mRNA. Translation: AAA35867.1.
    AF493901 mRNA. Translation: AAM12615.1.
    AK127842 mRNA. Translation: BAG54584.1.
    AK295830 mRNA. Translation: BAH12193.1.
    AC006028 Genomic DNA. Translation: AAP21870.1.
    AC004933 Genomic DNA. Translation: AAD05026.1.
    CH236953 Genomic DNA. Translation: EAL23961.1.
    BC087537 mRNA. Translation: AAH87537.1.
    BC111464 mRNA. Translation: AAI11465.1.
    CCDSiCCDS5335.1. [Q03113-1]
    CCDS64584.1. [Q03113-2]
    PIRiA48071.
    RefSeqiNP_001269370.1. NM_001282441.1.
    NP_031379.2. NM_007353.2.
    UniGeneiHs.487341.

    Genome annotation databases

    EnsembliENST00000275364; ENSP00000275364; ENSG00000146535. [Q03113-1]
    ENST00000407904; ENSP00000385935; ENSG00000146535. [Q03113-2]
    GeneIDi2768.
    KEGGihsa:2768.
    UCSCiuc003smu.3. human. [Q03113-1]

    Polymorphism databases

    DMDMi38258934.

    Keywords - Coding sequence diversityi

    Alternative initiation, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L01694 mRNA. Translation: AAA35867.1 .
    AF493901 mRNA. Translation: AAM12615.1 .
    AK127842 mRNA. Translation: BAG54584.1 .
    AK295830 mRNA. Translation: BAH12193.1 .
    AC006028 Genomic DNA. Translation: AAP21870.1 .
    AC004933 Genomic DNA. Translation: AAD05026.1 .
    CH236953 Genomic DNA. Translation: EAL23961.1 .
    BC087537 mRNA. Translation: AAH87537.1 .
    BC111464 mRNA. Translation: AAI11465.1 .
    CCDSi CCDS5335.1. [Q03113-1 ]
    CCDS64584.1. [Q03113-2 ]
    PIRi A48071.
    RefSeqi NP_001269370.1. NM_001282441.1.
    NP_031379.2. NM_007353.2.
    UniGenei Hs.487341.

    3D structure databases

    ProteinModelPortali Q03113.
    SMRi Q03113. Positions 56-373.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109030. 26 interactions.
    IntActi Q03113. 4 interactions.
    MINTi MINT-85969.
    STRINGi 9606.ENSP00000275364.

    PTM databases

    PhosphoSitei Q03113.

    Polymorphism databases

    DMDMi 38258934.

    Proteomic databases

    MaxQBi Q03113.
    PaxDbi Q03113.
    PRIDEi Q03113.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000275364 ; ENSP00000275364 ; ENSG00000146535 . [Q03113-1 ]
    ENST00000407904 ; ENSP00000385935 ; ENSG00000146535 . [Q03113-2 ]
    GeneIDi 2768.
    KEGGi hsa:2768.
    UCSCi uc003smu.3. human. [Q03113-1 ]

    Organism-specific databases

    CTDi 2768.
    GeneCardsi GC07M002767.
    HGNCi HGNC:4380. GNA12.
    HPAi CAB010046.
    MIMi 604394. gene.
    neXtProti NX_Q03113.
    PharmGKBi PA28765.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG279688.
    HOGENOMi HOG000038729.
    HOVERGENi HBG063184.
    InParanoidi Q03113.
    KOi K04346.
    OMAi WQHSENE.
    OrthoDBi EOG7HF1JF.
    PhylomeDBi Q03113.
    TreeFami TF300673.

    Enzyme and pathway databases

    Reactomei REACT_18407. G alpha (12/13) signalling events.
    REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
    SignaLinki Q03113.

    Miscellaneous databases

    ChiTaRSi GNA12. human.
    GeneWikii GNA12.
    GenomeRNAii 2768.
    NextBioi 10888.
    PROi Q03113.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q03113.
    Bgeei Q03113.
    CleanExi HS_GNA12.
    Genevestigatori Q03113.

    Family and domain databases

    Gene3Di 1.10.400.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR000469. Gprotein_alpha_12.
    IPR001019. Gprotein_alpha_su.
    IPR011025. GproteinA_insert.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR10218. PTHR10218. 1 hit.
    Pfami PF00503. G-alpha. 1 hit.
    [Graphical view ]
    PRINTSi PR00318. GPROTEINA.
    PR00440. GPROTEINA12.
    SMARTi SM00275. G_alpha. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47895. SSF47895. 1 hit.
    SSF52540. SSF52540. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product."
      Chan A.M.-L., Fleming T.P., McGovern E.S., Chedid M., Miki T., Aaronson S.A.
      Mol. Cell. Biol. 13:762-768(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Hippocampus and Placenta.
    4. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLY-68.
      Tissue: Brain and Pancreas.
    7. "Socius, a novel binding partner of Galpha12/13, promotes the Galpha12-induced RhoA activation."
      Tateiwa K., Katoh H., Negishi M.
      Biochem. Biophys. Res. Commun. 337:615-620(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UBXD5.
    8. "RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits."
      Hu Y., Xing J., Chen L., Guo X., Du Y., Zhao C., Zhu Y., Lin M., Zhou Z., Sha J.
      Biol. Reprod. 79:1021-1029(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RGS22.
      Tissue: Testis.
    9. "PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12."
      Gan X., Wang J., Wang C., Sommer E., Kozasa T., Srinivasula S., Alessi D., Offermanns S., Simon M.I., Wu D.
      Nat. Cell Biol. 14:686-696(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN TOR SIGNALING.

    Entry informationi

    Entry nameiGNA12_HUMAN
    AccessioniPrimary (citable) accession number: Q03113
    Secondary accession number(s): A4D204
    , B3KXS2, B7Z3F7, Q2T9L1, Q5PPR5, Q86UM8, Q8TD71, Q9UDU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 139 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3