Reviewed,
UniProtKB/Swiss-Prot Q03113 (GNA12_HUMAN)
Last modified
November 25, 2008.
Version 79.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Guanine nucleotide-binding protein subunit alpha-12 Short name=G-protein subunit alpha-12 Short name=G alpha-12 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 381 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. |
| Subunit structure | G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with UBXD5. |
| Subcellular location | |
| Sequence similarities | Belongs to the G-alpha family. G(12) subfamily. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Membrane |
| Ligand | GTP-binding Nucleotide-binding |
| Molecular function | Transducer |
| PTM | Lipoprotein Palmitate |
Gene Ontology (GO) | |
| Biological process | G-protein coupled receptor protein signaling pathway Traceable author statement. Source: ProtInc blood coagulationTraceable author statement. Source: ProtInc |
| Cellular component | plasma membrane Inferred from Experiment. Source: Reactome |
| Molecular function | GTP binding Inferred from electronic annotation. Source: InterPro GTPase activityTraceable author statement. Source: ProtInc protein bindingInferred from physical interaction. Source: UniProtKB signal transducer activityNon-traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 381 | 380 | Guanine nucleotide-binding protein subunit alpha-12 | PRO_0000203770 | |||||
Regions | |||||||||
| Nucleotide binding | 64 – 71 | 8 | GTP By similarity | ||||||
| Nucleotide binding | 227 – 231 | 5 | GTP By similarity | ||||||
| Nucleotide binding | 296 – 299 | 4 | GTP By similarity | ||||||
Amino acid modifications | |||||||||
| Lipidation | 11 | 1 | S-palmitoyl cysteine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 126 | 1 | K → E in AAM12615. Ref.2 | ||||||
| Sequence conflict | 323 | 1 | R → Q in AAA35867. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product." Chan A.M.-L., Fleming T.P., McGovern E.S., Chedid M., Miki T., Aaronson S.A. Mol. Cell. Biol. 13:762-768(1993) [PubMed: 8423800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [3] | "The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. Wilson R.K.Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [5] | "Socius, a novel binding partner of Galpha12/13, promotes the Galpha12-induced RhoA activation." Tateiwa K., Katoh H., Negishi M. Biochem. Biophys. Res. Commun. 337:615-620(2005) [PubMed: 16202387] [Abstract] Cited for: INTERACTION WITH UBXD5. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| L01694 mRNA. Translation: AAA35867.1. AF493901 mRNA. Translation: AAM12615.1. AC006028 Genomic DNA. Translation: AAP21870.1. AC004933 Genomic DNA. Translation: AAD05026.1. BC111464 mRNA. Translation: AAI11465.1. | |
| PIR | A48071. |
| RefSeq | NP_031379.2. |
| UniGene | Hs.487341 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1CUL based on UniProtKB P04896. |
| SMR | Q03113. Positions 56-373. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q03113. |
Genome annotation databases | |
| Ensembl | ENSG00000146535. Homo sapiens. [Contig view] |
| GeneID | 2768. |
| KEGG | hsa:2768. |
Organism-specific databases | |
| H-InvDB | HIX0006438. |
| HGNC | HGNC:4380. GNA12. |
| HPA | CAB010046. |
| MIM | 604394. gene. |
| PharmGKB | PA28765. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | Q03113. |
| HOVERGEN | Q03113. |
Enzyme and pathway databases | |
| Reactome | REACT_604. Hemostasis. |
Gene expression databases | |
| ArrayExpress | Q03113. |
| CleanEx | HS_GNA12. |
| GermOnline | ENSG00000146535. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001019. Gprotein_alph_bd. IPR000469. Gprotein_alpha12. [Graphical view] |
| PANTHER | PTHR10218. Gprotein_alph_bd. 1 hit. |
| Pfam | PF00503. G-alpha. 1 hit. [Graphical view] |
| PRINTS | PR00318. GPROTEINA. PR00440. GPROTEINA12. |
| ProDom | PD000281. Gprotein_alpha. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 10888. |
| SOURCE | Search... |
Entry information
| Entry name | GNA12_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q03113 Secondary accession number(s): Q2T9L1 Q9UDU9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 7 Human chromosome 7: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


