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Q03111

- ENL_HUMAN

UniProt

Q03111 - ENL_HUMAN

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Protein

Protein ENL

Gene
MLLT1, ENL, LTG19, YEATS1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.2 Publications

GO - Molecular functioni

  1. DNA binding Source: ProtInc
  2. protein binding Source: IntAct

GO - Biological processi

  1. negative regulation of protein kinase activity Source: Ensembl
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ENL
Alternative name(s):
YEATS domain-containing protein 1
Gene namesi
Name:MLLT1
Synonyms:ENL, LTG19, YEATS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:7134. MLLT1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleolus Source: HPA
  3. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving MLLT1 is associated with acute leukemias. Translocation t(11;19)(q23;p13.3) with KMT2A/MLL1. The result is a rogue activator protein.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA30848.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Protein ENLPRO_0000215938Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine2 Publications
Modified residuei155 – 1551Phosphoserine1 Publication
Modified residuei292 – 2921Phosphoserine3 Publications
Modified residuei296 – 2961Phosphoserine2 Publications
Modified residuei359 – 3591Phosphoserine1 Publication
Modified residuei361 – 3611Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ03111.
PaxDbiQ03111.
PeptideAtlasiQ03111.
PRIDEiQ03111.

PTM databases

PhosphoSiteiQ03111.

Expressioni

Gene expression databases

BgeeiQ03111.
CleanExiHS_MLLT1.
GenevestigatoriQ03111.

Organism-specific databases

HPAiHPA031166.

Interactioni

Subunit structurei

Component of the super elongation complex (SEC), at least composed of AFF4, the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Interacts with ALKBH4.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AFF4Q9UHB78EBI-1384215,EBI-395282
DOT1LQ8TEK36EBI-1384215,EBI-2619253

Protein-protein interaction databases

BioGridi110444. 28 interactions.
IntActiQ03111. 15 interactions.
STRINGi9606.ENSP00000252674.

Structurei

3D structure databases

ProteinModelPortaliQ03111.
SMRiQ03111. Positions 29-136, 453-559.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 112105YEATSAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi272 – 2809Poly-Pro
Compositional biasi319 – 3257Poly-Ser
Compositional biasi374 – 38916Poly-SerAdd
BLAST
Compositional biasi457 – 4604Poly-Pro
Compositional biasi463 – 4664Poly-Pro

Sequence similaritiesi

Contains 1 YEATS domain.

Phylogenomic databases

eggNOGiCOG5033.
HOGENOMiHOG000033834.
HOVERGENiHBG004191.
InParanoidiQ03111.
KOiK15187.
OMAiSCSKPEK.
OrthoDBiEOG71G9V5.
PhylomeDBiQ03111.
TreeFamiTF314586.

Family and domain databases

InterProiIPR005033. YEATS.
[Graphical view]
PANTHERiPTHR23195. PTHR23195. 1 hit.
PfamiPF03366. YEATS. 1 hit.
[Graphical view]
PROSITEiPS51037. YEATS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03111-1 [UniParc]FASTAAdd to Basket

« Hide

MDNQCTVQVR LELGHRAQLR KKPTTEGFTH DWMVFVRGPE QCDIQHFVEK    50
VVFWLHDSFP KPRRVCKEPP YKVEESGYAG FIMPIEVHFK NKEEPRKVCF 100
TYDLFLNLEG NPPVNHLRCE KLTFNNPTTE FRYKLLRAGG VMVMPEGADT 150
VSRPSPDYPM LPTIPLSAFS DPKKTKPSHG SKDANKESSK TSKPHKVTKE 200
HRERPRKDSE SKSSSKELER EQAKSSKDTS RKLGEGRLPK EEKAPPPKAA 250
FKEPKMALKE TKLESTSPKG GPPPPPPPPP RASSKRPATA DSPKPSAKKQ 300
KKSSSKGSRS APGTSPRTSS SSSFSDKKPA KDKSSTRGEK VKAESEPREA 350
KKALEVEESN SEDEASFKSE SAQSSPSNSS SSSDSSSDSD FEPSQNHSQG 400
PLRSMVEDLQ SEESDEDDSS SGEEAAGKTN PGRDSRLSFS DSESDNSADS 450
SLPSREPPPP QKPPPPNSKV SGRRSPESCS KPEKILKKGT YDKAYTDELV 500
ELHRRLMALR ERNVLQQIVN LIEETGHFNV TNTTFDFDLF SLDETTVRKL 550
QSCLEAVAT 559
Length:559
Mass (Da):62,056
Last modified:October 17, 2006 - v2
Checksum:iA8480BA0F8742173
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti269 – 2702KG → NP in AAA58457. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04285 mRNA. Translation: AAA58457.1.
D14539 mRNA. Translation: BAA03406.1.
CCDSiCCDS12160.1.
PIRiB44265.
RefSeqiNP_005925.2. NM_005934.3.
UniGeneiHs.10095.

Genome annotation databases

EnsembliENST00000252674; ENSP00000252674; ENSG00000130382.
GeneIDi4298.
KEGGihsa:4298.
UCSCiuc002mek.3. human.

Polymorphism databases

DMDMi116241350.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04285 mRNA. Translation: AAA58457.1 .
D14539 mRNA. Translation: BAA03406.1 .
CCDSi CCDS12160.1.
PIRi B44265.
RefSeqi NP_005925.2. NM_005934.3.
UniGenei Hs.10095.

3D structure databases

ProteinModelPortali Q03111.
SMRi Q03111. Positions 29-136, 453-559.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110444. 28 interactions.
IntActi Q03111. 15 interactions.
STRINGi 9606.ENSP00000252674.

PTM databases

PhosphoSitei Q03111.

Polymorphism databases

DMDMi 116241350.

Proteomic databases

MaxQBi Q03111.
PaxDbi Q03111.
PeptideAtlasi Q03111.
PRIDEi Q03111.

Protocols and materials databases

DNASUi 4298.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000252674 ; ENSP00000252674 ; ENSG00000130382 .
GeneIDi 4298.
KEGGi hsa:4298.
UCSCi uc002mek.3. human.

Organism-specific databases

CTDi 4298.
GeneCardsi GC19M006210.
HGNCi HGNC:7134. MLLT1.
HPAi HPA031166.
MIMi 159556. gene.
neXtProti NX_Q03111.
PharmGKBi PA30848.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5033.
HOGENOMi HOG000033834.
HOVERGENi HBG004191.
InParanoidi Q03111.
KOi K15187.
OMAi SCSKPEK.
OrthoDBi EOG71G9V5.
PhylomeDBi Q03111.
TreeFami TF314586.

Miscellaneous databases

ChiTaRSi MLLT1. human.
GeneWikii MLLT1.
GenomeRNAii 4298.
NextBioi 16919.
PROi Q03111.
SOURCEi Search...

Gene expression databases

Bgeei Q03111.
CleanExi HS_MLLT1.
Genevestigatori Q03111.

Family and domain databases

InterProi IPR005033. YEATS.
[Graphical view ]
PANTHERi PTHR23195. PTHR23195. 1 hit.
Pfami PF03366. YEATS. 1 hit.
[Graphical view ]
PROSITEi PS51037. YEATS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias."
    Tkachuk D.C., Kohler S., Cleary M.L.
    Cell 71:691-700(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia."
    Yamamoto K., Seto M., Komatsu H., Iida S., Akao Y., Kojima S., Kodera Y., Nakazawa S., Ariyoshi Y., Takahashi T., Ueda R.
    Oncogene 8:2617-2625(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells."
    Rubnitz J.E., Morrissey J., Savage P.A., Cleary M.L.
    Blood 84:1747-1752(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-292 AND SER-296, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-155, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-292, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription."
    He N., Liu M., Hsu J., Xue Y., Chou S., Burlingame A., Krogan N.J., Alber T., Zhou Q.
    Mol. Cell 38:428-438(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE SEC COMPLEX.
  10. "AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia."
    Lin C., Smith E.R., Takahashi H., Lai K.C., Martin-Brown S., Florens L., Washburn M.P., Conaway J.W., Conaway R.C., Shilatifard A.
    Mol. Cell 37:429-437(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE SEC COMPLEX.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-292; SER-296; SER-359 AND SER-361, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Human ALKBH4 interacts with proteins associated with transcription."
    Bjornstad L.G., Meza T.J., Otterlei M., Olafsrud S.M., Meza-Zepeda L.A., Falnes P.O.
    PLoS ONE 7:E49045-E49045(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ALKBH4.
  13. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiENL_HUMAN
AccessioniPrimary (citable) accession number: Q03111
Secondary accession number(s): Q14768
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 17, 2006
Last modified: September 3, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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