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Reviewed, UniProtKB/Swiss-Prot Q03111 (ENL_HUMAN)

Last modified November 4, 2008. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Protein ENL
Alternative name(s):
    YEATS domain-containing protein 1
Gene names
Name: MLLT1
Synonyms: ENL, LTG19, YEATS1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length559 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Capable of activating transcription from synthetic reporter genes in both lymphoid and myeloid cells.

Subcellular location

Nucleus.

Involvement in disease

A chromosomal aberration involving MLLT1 is associated with acute leukemias. Translocation t(11;19)(q23;p13.3) with MLL/HRX. The result is a rogue activator protein.

Sequence similarities

Contains 1 YEATS domain.

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Ontologies

Keywords

   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityChromosomal rearrangement
   DiseaseProto-oncogene
   Molecular functionActivator
   PTMPhosphoprotein

Gene Ontology (GO)

   Biological processtranscription from RNA polymerase II promoter Ref.3

Traceable author statement. Source: ProtInc

   Cellular componentnucleus Ref.3

Traceable author statement. Source: ProtInc

   Molecular functionDNA binding

Traceable author statement. Source: ProtInc

RNA polymerase II transcription factor activity Ref.3

Traceable author statement. Source: ProtInc

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 559559Protein ENL
PRO_0000215938

Regions

Domain8 – 112105YEATS
Compositional bias272 – 2809Poly-Pro
Compositional bias319 – 3257Poly-Ser
Compositional bias374 – 38916Poly-Ser
Compositional bias457 – 4604Poly-Pro
Compositional bias463 – 4664Poly-Pro

Amino acid modifications

Modified residue2091Phosphoserine
Modified residue2921Phosphoserine
Modified residue3591Phosphoserine
Modified residue3611Phosphoserine
Modified residue3661Phosphoserine
Modified residue4751Phosphoserine

Experimental info

Sequence conflict269 – 2702KG → NP in AAA58457. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Q03111-1 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: A8480BA0F8742173

FASTA55962,056
        10         20         30         40         50         60 
MDNQCTVQVR LELGHRAQLR KKPTTEGFTH DWMVFVRGPE QCDIQHFVEK VVFWLHDSFP 

        70         80         90        100        110        120 
KPRRVCKEPP YKVEESGYAG FIMPIEVHFK NKEEPRKVCF TYDLFLNLEG NPPVNHLRCE 

       130        140        150        160        170        180 
KLTFNNPTTE FRYKLLRAGG VMVMPEGADT VSRPSPDYPM LPTIPLSAFS DPKKTKPSHG 

       190        200        210        220        230        240 
SKDANKESSK TSKPHKVTKE HRERPRKDSE SKSSSKELER EQAKSSKDTS RKLGEGRLPK 

       250        260        270        280        290        300 
EEKAPPPKAA FKEPKMALKE TKLESTSPKG GPPPPPPPPP RASSKRPATA DSPKPSAKKQ 

       310        320        330        340        350        360 
KKSSSKGSRS APGTSPRTSS SSSFSDKKPA KDKSSTRGEK VKAESEPREA KKALEVEESN 

       370        380        390        400        410        420 
SEDEASFKSE SAQSSPSNSS SSSDSSSDSD FEPSQNHSQG PLRSMVEDLQ SEESDEDDSS 

       430        440        450        460        470        480 
SGEEAAGKTN PGRDSRLSFS DSESDNSADS SLPSREPPPP QKPPPPNSKV SGRRSPESCS 

       490        500        510        520        530        540 
KPEKILKKGT YDKAYTDELV ELHRRLMALR ERNVLQQIVN LIEETGHFNV TNTTFDFDLF 

       550 
SLDETTVRKL QSCLEAVAT

« Hide

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References

« Hide 'large scale' references
[1]"Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias."
Tkachuk D.C., Kohler S., Cleary M.L.
Cell 71:691-700(1992) [PubMed: 1423624] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia."
Yamamoto K., Seto M., Komatsu H., Iida S., Akao Y., Kojima S., Kodera Y., Nakazawa S., Ariyoshi Y., Takahashi T., Ueda R.
Oncogene 8:2617-2625(1993) [PubMed: 8378076] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells."
Rubnitz J.E., Morrissey J., Savage P.A., Cleary M.L.
Blood 84:1747-1752(1994) [PubMed: 8080983] [Abstract]
Cited for: CHARACTERIZATION.
[4]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed: 17081983] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209; SER-359; SER-361; SER-366 AND SER-475, MASS SPECTROMETRY.
Tissue: Epithelium.
[5]"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-292, MASS SPECTROMETRY.
Tissue: Epithelium.
+Additional computationally mapped references.

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Cross-references

Sequence databases

L04285 mRNA. Translation: AAA58457.1.
D14539 mRNA. Translation: BAA03406.1.
PIRB44265.
RefSeqNP_005925.2.
UniGeneHs.705366

3D structure databases

ModBaseSearch...

PTM databases

PhosphoSiteQ03111.

Proteomic databases

PeptideAtlasQ03111.

Genome annotation databases

EnsemblENSG00000130382. Homo sapiens. [Contig view]
GeneID4298.
KEGGhsa:4298.

Organism-specific databases

H-InvDBHIX0040042.
HGNCHGNC:7134. MLLT1.
MIM159556. gene.
PharmGKBPA30848.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ03111.
HOVERGENQ03111.

Gene expression databases

ArrayExpressQ03111.
CleanExHS_MLLT1.
GermOnlineENSG00000130382. Homo sapiens.

Family and domain databases

InterProIPR005033. YEATS.
[Graphical view]
PANTHERPTHR23195. YEATS. 1 hit.
PfamPF03366. YEATS. 1 hit.
[Graphical view]
PROSITEPS51037. YEATS. 1 hit.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

Other Resources

NextBio16919.
SOURCESearch...

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Entry information

Entry nameENL_HUMAN
AccessionPrimary (citable) accession number: Q03111
Secondary accession number(s): Q14768
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 17, 2006
Last modified: November 4, 2008
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents