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Protein

Protein ENL

Gene

MLLT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.2 Publications

GO - Molecular functioni

  • DNA binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130382-MONOMER.
ReactomeiR-HSA-112382. Formation of RNA Pol II elongation complex.
R-HSA-112387. Elongation arrest and recovery.
R-HSA-674695. RNA Polymerase II Pre-transcription Events.
R-HSA-75955. RNA Polymerase II Transcription Elongation.
SIGNORiQ03111.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ENL
Alternative name(s):
YEATS domain-containing protein 1
Gene namesi
Name:MLLT1
Synonyms:ENL, LTG19, YEATS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:7134. MLLT1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • nucleolus Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: ProtInc
  • transcription elongation factor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving MLLT1 is associated with acute leukemias. Translocation t(11;19)(q23;p13.3) with KMT2A/MLL1. The result is a rogue activator protein.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi4298.
OpenTargetsiENSG00000130382.
PharmGKBiPA30848.

Polymorphism and mutation databases

BioMutaiMLLT1.
DMDMi116241350.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002159381 – 559Protein ENLAdd BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei155PhosphoserineCombined sources1
Modified residuei292PhosphoserineCombined sources1
Modified residuei296PhosphoserineCombined sources1
Modified residuei359PhosphoserineCombined sources1
Modified residuei361PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ03111.
MaxQBiQ03111.
PaxDbiQ03111.
PeptideAtlasiQ03111.
PRIDEiQ03111.

PTM databases

iPTMnetiQ03111.
PhosphoSitePlusiQ03111.

Expressioni

Gene expression databases

BgeeiENSG00000130382.
CleanExiHS_MLLT1.
GenevisibleiQ03111. HS.

Organism-specific databases

HPAiHPA031166.

Interactioni

Subunit structurei

Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Interacts with ALKBH4.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AFF4Q9UHB78EBI-1384215,EBI-395282
DOT1LQ8TEK36EBI-1384215,EBI-2619253

Protein-protein interaction databases

BioGridi110444. 47 interactors.
IntActiQ03111. 16 interactors.
STRINGi9606.ENSP00000252674.

Structurei

3D structure databases

ProteinModelPortaliQ03111.
SMRiQ03111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 112YEATSPROSITE-ProRule annotationAdd BLAST105

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi272 – 280Poly-Pro9
Compositional biasi319 – 325Poly-Ser7
Compositional biasi374 – 389Poly-SerAdd BLAST16
Compositional biasi457 – 460Poly-Pro4
Compositional biasi463 – 466Poly-Pro4

Sequence similaritiesi

Contains 1 YEATS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3149. Eukaryota.
COG5033. LUCA.
GeneTreeiENSGT00440000039936.
HOGENOMiHOG000033834.
HOVERGENiHBG004191.
InParanoidiQ03111.
KOiK15187.
OMAiCFTYDLF.
OrthoDBiEOG091G06LN.
PhylomeDBiQ03111.
TreeFamiTF314586.

Family and domain databases

InterProiIPR005033. YEATS.
[Graphical view]
PANTHERiPTHR23195. PTHR23195. 1 hit.
PfamiPF03366. YEATS. 1 hit.
[Graphical view]
PROSITEiPS51037. YEATS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNQCTVQVR LELGHRAQLR KKPTTEGFTH DWMVFVRGPE QCDIQHFVEK
60 70 80 90 100
VVFWLHDSFP KPRRVCKEPP YKVEESGYAG FIMPIEVHFK NKEEPRKVCF
110 120 130 140 150
TYDLFLNLEG NPPVNHLRCE KLTFNNPTTE FRYKLLRAGG VMVMPEGADT
160 170 180 190 200
VSRPSPDYPM LPTIPLSAFS DPKKTKPSHG SKDANKESSK TSKPHKVTKE
210 220 230 240 250
HRERPRKDSE SKSSSKELER EQAKSSKDTS RKLGEGRLPK EEKAPPPKAA
260 270 280 290 300
FKEPKMALKE TKLESTSPKG GPPPPPPPPP RASSKRPATA DSPKPSAKKQ
310 320 330 340 350
KKSSSKGSRS APGTSPRTSS SSSFSDKKPA KDKSSTRGEK VKAESEPREA
360 370 380 390 400
KKALEVEESN SEDEASFKSE SAQSSPSNSS SSSDSSSDSD FEPSQNHSQG
410 420 430 440 450
PLRSMVEDLQ SEESDEDDSS SGEEAAGKTN PGRDSRLSFS DSESDNSADS
460 470 480 490 500
SLPSREPPPP QKPPPPNSKV SGRRSPESCS KPEKILKKGT YDKAYTDELV
510 520 530 540 550
ELHRRLMALR ERNVLQQIVN LIEETGHFNV TNTTFDFDLF SLDETTVRKL

QSCLEAVAT
Length:559
Mass (Da):62,056
Last modified:October 17, 2006 - v2
Checksum:iA8480BA0F8742173
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti269 – 270KG → NP in AAA58457 (PubMed:1423624).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04285 mRNA. Translation: AAA58457.1.
D14539 mRNA. Translation: BAA03406.1.
CCDSiCCDS12160.1.
PIRiB44265.
RefSeqiNP_005925.2. NM_005934.3.
UniGeneiHs.10095.

Genome annotation databases

EnsembliENST00000252674; ENSP00000252674; ENSG00000130382.
GeneIDi4298.
KEGGihsa:4298.
UCSCiuc002mek.4. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04285 mRNA. Translation: AAA58457.1.
D14539 mRNA. Translation: BAA03406.1.
CCDSiCCDS12160.1.
PIRiB44265.
RefSeqiNP_005925.2. NM_005934.3.
UniGeneiHs.10095.

3D structure databases

ProteinModelPortaliQ03111.
SMRiQ03111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110444. 47 interactors.
IntActiQ03111. 16 interactors.
STRINGi9606.ENSP00000252674.

PTM databases

iPTMnetiQ03111.
PhosphoSitePlusiQ03111.

Polymorphism and mutation databases

BioMutaiMLLT1.
DMDMi116241350.

Proteomic databases

EPDiQ03111.
MaxQBiQ03111.
PaxDbiQ03111.
PeptideAtlasiQ03111.
PRIDEiQ03111.

Protocols and materials databases

DNASUi4298.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252674; ENSP00000252674; ENSG00000130382.
GeneIDi4298.
KEGGihsa:4298.
UCSCiuc002mek.4. human.

Organism-specific databases

CTDi4298.
DisGeNETi4298.
GeneCardsiMLLT1.
HGNCiHGNC:7134. MLLT1.
HPAiHPA031166.
MIMi159556. gene.
neXtProtiNX_Q03111.
OpenTargetsiENSG00000130382.
PharmGKBiPA30848.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3149. Eukaryota.
COG5033. LUCA.
GeneTreeiENSGT00440000039936.
HOGENOMiHOG000033834.
HOVERGENiHBG004191.
InParanoidiQ03111.
KOiK15187.
OMAiCFTYDLF.
OrthoDBiEOG091G06LN.
PhylomeDBiQ03111.
TreeFamiTF314586.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130382-MONOMER.
ReactomeiR-HSA-112382. Formation of RNA Pol II elongation complex.
R-HSA-112387. Elongation arrest and recovery.
R-HSA-674695. RNA Polymerase II Pre-transcription Events.
R-HSA-75955. RNA Polymerase II Transcription Elongation.
SIGNORiQ03111.

Miscellaneous databases

ChiTaRSiMLLT1. human.
GeneWikiiMLLT1.
GenomeRNAii4298.
PROiQ03111.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130382.
CleanExiHS_MLLT1.
GenevisibleiQ03111. HS.

Family and domain databases

InterProiIPR005033. YEATS.
[Graphical view]
PANTHERiPTHR23195. PTHR23195. 1 hit.
PfamiPF03366. YEATS. 1 hit.
[Graphical view]
PROSITEiPS51037. YEATS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiENL_HUMAN
AccessioniPrimary (citable) accession number: Q03111
Secondary accession number(s): Q14768
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.