Q03104 (MSC1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Meiotic sister chromatid recombination protein 1

Gene names

Name:	MSC1
Ordered Locus Names:	YML128C
ORF Names:	YM4987.07C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	513 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Miscellaneous

Originally MSC1 was identified in a screen for mutants that show an increase in meiotic unequal sister-chromatid recombination (SCR). Present with 1070 molecules/cell in log phase SD medium. Ref.7

Ontologies

Keywords
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	reciprocal meiotic recombination Inferred from mutant phenotype Ref.5. Source: SGD
Cellular component	endoplasmic reticulum Inferred from direct assay. Source: SGD mitochondrion Inferred from direct assay Ref.4. Source: SGD plasma membrane enriched fraction Inferred from direct assay. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 513	513	Meiotic sister chromatid recombination protein 1		PRO_0000096591
Amino acid modifications
	Modified residue	237	1	Phosphothreonine Ref.8
	Modified residue	243	1	Phosphoserine Ref.8
Experimental info
	Sequence conflict	52	1	T → I AA sequence Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q03104 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: FFD0BD1CB35205A4	FASTA	513	59,589
	10 20 30 40 50 60 MKQFKLVNAV SASFVLIGLV LANSDSVFDK WTQEDLADYL RDNKKSLEKY ATDSIEDLKT 70 80 90 100 110 120 EASQVWDKHA QPKPWWQVWS SDSSSVSNSN PGWFGYTGSS DHPVSDWLFD TWSTDSLRNF 130 140 150 160 170 180 LKKNGVDVDD AKASKDSLVK TAKENFNKIS KSLKSSGYYP SSSYFDSWST KDLQNWLNDN 190 200 210 220 230 240 GIDYDKAVQS KDELVQKVKE NIYRTSEKAE QQRLGLLESL DLAHQQILDT SGQIKDTVFD 250 260 270 280 290 300 KWSSDQLTNW LESHKVNIDK NMAKKHDYLV RMAKENSANL KDDIYWYLDY MKRESSPFLT 310 320 330 340 350 360 KTPEYVGSVW DSSKNFLTNL YSKFRGKTDN VINDTFLVGL DSWPKDKLKM FLDARGIKYS 370 380 390 400 410 420 MLSTEHQLRE LVKKSRNEKL KILPKDYQKY FDNSNWSLDD IKGWFADKKD DFQDSQTYST 430 440 450 460 470 480 IMQDFDKVSK NTNDAKDQIA KTWSNTFQSW SQEDLLQYLK SFGVPVKQTS TKDDLINLAK 490 500 510 QNTQWLFGTV KEPAYKRYLH NVKNWSKSIL GFN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. , Skelton J., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:90-93(1997) [PubMed: 9169872] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Yeast mitochondrial dehydrogenases are associated in a supramolecular complex." Grandier-Vazeille X., Bathany K., Chaignepain S., Camougrand N., Manon S., Schmitter J.-M. Biochemistry 40:9758-9769(2001) [PubMed: 11502169] [Abstract] Cited for: PROTEIN SEQUENCE OF 49-53; 171-180 AND 241-250. Strain: ATCC 201238 / W303-1B.
[5]	"Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination." Thompson D.A., Stahl F.W. Genetics 153:621-641(1999) [PubMed: 10511544] [Abstract] Cited for: MUTANT ANALYSIS.
[6]	Erratum Thompson D.A., Stahl F.W. Genetics 164:1241-1241(2003)
[7]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]	"Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase." Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B., van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C. Mol. Cell. Proteomics 6:1896-1906(2007) [PubMed: 17761666] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-237 AND SER-243, MASS SPECTROMETRY. Strain: ATCC 76625 / YPH499.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z50178 Genomic DNA. Translation: CAA90555.1. AY693046 Genomic DNA. Translation: AAT93065.1. BK006946 Genomic DNA. Translation: DAA09771.1.
PIR	S58200.
RefSeq	NP_013578.1. NM_001182491.1.
3D structure databases
ProteinModelPortal	Q03104.
ModBase	Search...
Protein-protein interaction databases
STRING	Q03104.
2D gel databases
UCD-2DPAGE	Q03104.
Proteomic databases
PeptideAtlas	Q03104.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YML128C; YML128C; YML128C.
GeneID	854911.
KEGG	sce:YML128C.
NMPDR	fig|4932.3.peg.4614.
Organism-specific databases
CYGD	YML128c.
SGD	S000004597. MSC1.
Phylogenomic databases
eggNOG	fuNOG08222.
GeneTree	EFGT00050000006584.
HOGENOM	HBG203539.
OMA	AYLDSYG.
OrthoDB	EOG4S4SQG.
Gene expression databases
ArrayExpress	Q03104.
Genevestigator	Q03104.
GermOnline	YML128C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR018803. Stress_response_Ish1. [Graphical view]
Pfam	PF10281. Ish1. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	977908.

Entry information

Entry name

MSC1_YEAST

Accession

Primary (citable) accession number: Q03104
Secondary accession number(s): D6W0F7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	December 14, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program