Q03102 (YMN1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized membrane protein YML131W

Gene names

Ordered Locus Names:	YML131W
ORF Names:	YM4987.04

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from direct assay. Source: SGD integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 365	365	Uncharacterized membrane protein YML131W		PRO_0000203238
Regions
	Topological domain	1 – 133	133	Cytoplasmic Potential
	Transmembrane	134 – 154	21	Helical; Potential
	Topological domain	155 – 169	15	Extracellular Potential
	Transmembrane	170 – 190	21	Helical; Potential
	Topological domain	191 – 365	175	Cytoplasmic Potential
Experimental info
	Sequence conflict	239	1	V → A in AAS56318. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q03102 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 11A71E0DA834F308	FASTA	365	39,976
	10 20 30 40 50 60 MVLAKQWVLK NLPTPGEPFN FHFHDPACTF ELIEKELSSE QLKDGELLLE TTYLSNDPAQ 70 80 90 100 110 120 KFWISSMDKN YAKGVQPGEI IPARGIGKVL ASRNKAFSPG DYVSAVTGWT THAIISQENV 130 140 150 160 170 180 QGLRKLDKNK VGKLWWYLSV LGGTSLTAYF IFFTYAQLQE REEDYGKVYL ISGAAGAVGT 190 200 210 220 230 240 VCIQLALNVF KASKVIAIAG GPEKVAFVES FGDNVVGVDY KDPSFKQKLI EAAGGENTVD 250 260 270 280 290 300 YFIDNVGSNV LEAGVLLLKQ RAMLIACGAI SAYNDPSKFV FKGYSFILTK RLVVKGVLVT 310 320 330 340 350 360 DNIDDFPKAL DKLGSLVKHG KIDLLKSATL EDGTGDKFKN VPLIWKGLFS GVNKGKLITK VNNEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. , Skelton J., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:90-93(1997) [PubMed: 9169872] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. Strain: ATCC 208353 / W303-1A.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z50178 Genomic DNA. Translation: CAA90552.1. AY557992 Genomic DNA. Translation: AAS56318.1. BK006946 Genomic DNA. Translation: DAA09768.1.
PIR	S58197.
RefSeq	NP_013575.1. NM_001182494.1.
3D structure databases
ProteinModelPortal	Q03102.
SMR	Q03102. Positions 1-364.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5615N.
IntAct	Q03102. 2 interactions.
MINT	MINT-521030.
STRING	Q03102.
Proteomic databases
PeptideAtlas	Q03102.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YML131W; YML131W; YML131W.
GeneID	854908.
KEGG	sce:YML131W.
NMPDR	fig|4932.3.peg.4611.
Organism-specific databases
CYGD	YML131w.
SGD	S000004600. YML131W.
Phylogenomic databases
eggNOG	fuNOG09437.
GeneTree	EFGT00050000001799.
HOGENOM	HBG753318.
OMA	EKCKWVE.
OrthoDB	EOG47Q1FV.
Gene expression databases
ArrayExpress	Q03102.
Genevestigator	Q03102.
GermOnline	YML131W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR013149. ADH_C. IPR002085. ADH_SF_Zn-type. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K07119.
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF00107. ADH_zinc_N. 1 hit. [Graphical view]
SUPFAM	SSF50129. GroES_like. 1 hit.
ProtoNet	Search...
Other
NextBio	977899.

Entry information

Entry name

YMN1_YEAST

Accession

Primary (citable) accession number: Q03102
Secondary accession number(s): D6W0F4, Q6Q5K5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	December 14, 2011
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program