Reviewed, UniProtKB/Swiss-Prot Q03102 (YMN1_YEAST)

Names and origin

Protein names

Recommended name:
    Uncharacterized membrane protein YML131W

Gene names

Ordered Locus Names:	YML131W
ORF Names:	YM4987.04

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from direct assay. Source: SGD integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
RPL7A	P05737	1	EBI-27999,EBI-15422

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 365	365	Uncharacterized membrane protein YML131W		PRO_0000203238
Regions
	Topological domain	1 – 133	133	Cytoplasmic Potential
	Transmembrane	134 – 154	21	Potential
	Topological domain	155 – 169	15	Extracellular Potential
	Transmembrane	170 – 190	21	Potential
	Topological domain	191 – 365	175	Cytoplasmic Potential
Experimental info
	Sequence conflict	239	1	V → A in AAS56318. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q03102-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 11A71E0DA834F308	FASTA	365	39,976
	10 20 30 40 50 60 MVLAKQWVLK NLPTPGEPFN FHFHDPACTF ELIEKELSSE QLKDGELLLE TTYLSNDPAQ 70 80 90 100 110 120 KFWISSMDKN YAKGVQPGEI IPARGIGKVL ASRNKAFSPG DYVSAVTGWT THAIISQENV 130 140 150 160 170 180 QGLRKLDKNK VGKLWWYLSV LGGTSLTAYF IFFTYAQLQE REEDYGKVYL ISGAAGAVGT 190 200 210 220 230 240 VCIQLALNVF KASKVIAIAG GPEKVAFVES FGDNVVGVDY KDPSFKQKLI EAAGGENTVD 250 260 270 280 290 300 YFIDNVGSNV LEAGVLLLKQ RAMLIACGAI SAYNDPSKFV FKGYSFILTK RLVVKGVLVT 310 320 330 340 350 360 DNIDDFPKAL DKLGSLVKHG KIDLLKSATL EDGTGDKFKN VPLIWKGLFS GVNKGKLITK VNNEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. , Skelton J., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:90-93(1997) [PubMed: 9169872] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z50178 Genomic DNA. Translation: CAA90552.1. AY557992 Genomic DNA. Translation: AAS56318.1.
PIR	S58197.
RefSeq	NP_013575.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5615N.
IntAct	Q03102. 5 interactions.
STRING	Q03102.
Proteomic databases
PeptideAtlas	Q03102.
Genome annotation databases
Ensembl	YML131W; YML131W; YML131W; Saccharomyces cerevisiae. [Genome view]
GeneID	854908.
KEGG	sce:YML131W.
NMPDR	fig|4932.3.peg.4611.
Organism-specific databases
CYGD	YML131w.
SGD	S000004600. YML131W.
Phylogenomic databases
HOGENOM	HBG753318.
OMA	LTAYFIF.
OrthoDB	EOG99GN06.
Gene expression databases
ArrayExpress	Q03102.
Genevestigator	Q03102.
GermOnline	YML131W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR002085. ADH_SF_Zn. IPR013149. ADH_Zn-bd. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF00107. ADH_zinc_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	977899.

Entry information

Entry name

YMN1_YEAST

Accession

Primary (citable) accession number: Q03102
Secondary accession number(s): Q6Q5K5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	December 15, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)