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Q030E7

- SYL_LACLS

UniProt

Q030E7 - SYL_LACLS

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Protein
Leucine--tRNA ligase
Gene
leuS, LACR_0875
Organism
Lactococcus lactis subsp. cremoris (strain SK11)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei612 – 6121ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLLAC272622:GJUG-875-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:LACR_0875
OrganismiLactococcus lactis subsp. cremoris (strain SK11)
Taxonomic identifieri272622 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000000240: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 829829Leucine--tRNA ligaseUniRule annotation
PRO_1000009360Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272622.LACR_0875.

Structurei

3D structure databases

ProteinModelPortaliQ030E7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotation
Add
BLAST
Motifi609 – 6135"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q030E7-1 [UniParc]FASTAAdd to Basket

« Hide

MEYNHQEIEA KWQKFWADNQ TFRTGTDKTK PKFYALDMFP YPSGAGLHVG    50
HPEGYTATDI LSRYKRAQGF NVLHPMGWDA FGLPAEQYAM DTGNDPAEFT 100
AENIANFKRQ INSLGFSYDW EREVNTTDPN FYKWTQWIFT KLYEKGLAYE 150
AEVAVNWVEE LGTAIANEEV LPDGTSERGG YPVVRKPMRQ WMLKITAYAE 200
RLLEDLEEVD WPESIKEMQR NWIGKSVGAD VTFKVEGTDK SFEVFTTRPD 250
TLFGATYAVL APEHDLVDAI TTPEQVQAVA DYRRQASLKS DLARTDLAKE 300
KTGAFTGAYA INPINGRKMP IWVADYVLAS YGHGAVMAVP AHDERDWEFA 350
KVYGLEILPV VEGGNVEEAV YTEDGPHINS EFLNGLDKAQ AIEKAIEFLE 400
EKKIGKKKIT YRLRDWLFSR QRYWGEPIPI IHWEDGTSTA LPENELPLVL 450
PVTSDIKPSG TGESPLANLT DWLEVTREDG VKGRRETNTM PQWAGSSWYY 500
LRYIDPHNTE ALADPELLKE WLPVDIYVGG AEHAVLHLLY ARFWHKVLYD 550
LGVVPTKEPF QKLFNQGMIL GTSYRDHRGA LVATDKVEKR DGGFYHMETG 600
EELEQAPAKM SKSLKNVVNP DDVVEHYGAD TLRVYEMFMG PLDASIPWSE 650
EGLEGARKFL DRVVRMIDNS EISDKNNGEL DKVYNETVKN VSERLDLMYF 700
NTAISQLMIF VNATNKAKIL PLEYANGFVQ LLAPFAPHIA EELWVKLGNE 750
AGISYVAWPT FDESKLVESE VEIVVQINGK LKAKIKIAKD LGRDELEKIG 800
REAVAEALEG KNVVKVIAVP NKLVNIVVK 829
Length:829
Mass (Da):93,895
Last modified:November 14, 2006 - v1
Checksum:i1C1600BBA51267E4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000425 Genomic DNA. Translation: ABJ72425.1.
RefSeqiYP_808847.1. NC_008527.1.

Genome annotation databases

EnsemblBacteriaiABJ72425; ABJ72425; LACR_0875.
GeneIDi4433308.
KEGGillc:LACR_0875.
PATRICi22288559. VBILacLac38071_1030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000425 Genomic DNA. Translation: ABJ72425.1 .
RefSeqi YP_808847.1. NC_008527.1.

3D structure databases

ProteinModelPortali Q030E7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272622.LACR_0875.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ72425 ; ABJ72425 ; LACR_0875 .
GeneIDi 4433308.
KEGGi llc:LACR_0875.
PATRICi 22288559. VBILacLac38071_1030.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci LLAC272622:GJUG-875-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SK11.

Entry informationi

Entry nameiSYL_LACLS
AccessioniPrimary (citable) accession number: Q030E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi