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Reviewed, UniProtKB/Swiss-Prot Q03099 (YMN3_YEAST)

Last modified November 24, 2009. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Y' element ATP-dependent helicase YML133C
    EC=3.6.1.-
Gene names
Ordered Locus Names: YML133C
ORF Names: YM4987.01C, YM4987.02C
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length1374 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance. Ref.2

Induction

Induced in absence of telomerase TLC1. Ref.2

Sequence similarities

Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.

Contains 1 helicase ATP-binding domain.

Contains 1 helicase C-terminal domain.

Sequence caution

The sequence CAA90549.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAA90550.1 differs from that shown. Reason: Erroneous gene model prediction.

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Ontologies

Keywords
   DomainRepeat
   LigandATP-binding
Nucleotide-binding
   Molecular functionHelicase
Hydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentmitochondrion

Inferred from direct assay. Source: SGD

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP-dependent helicase activity

Inferred from electronic annotation. Source: InterPro

nucleic acid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13741374Y' element ATP-dependent helicase YML133C
PRO_0000102209

Regions

Domain375 – 552178Helicase ATP-binding
Domain609 – 758150Helicase C-terminal
Nucleotide binding388 – 3958ATP Potential

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Sequences

Sequence LengthMass (Da)Tools
Q03099-1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 9867CAC68D2C497E

FASTA1,374155,553
        10         20         30         40         50         60 
MKVSDRRKFE KANFDEFESA LNNKNDLVHC PSITLFESIP TEVRSFYEDE KSGLIKVVKF 

        70         80         90        100        110        120 
RTGAMDRKRS FEKIVVSVMV GKNVQKFLTF VEDEPDFQGG PIPSKYLIPK KINLMVYTLF 

       130        140        150        160        170        180 
QVHTLKFNRK DYDTLSLFYL NRGYYNELSF RVLERCHEIA SARPNDSSTM RTFTDFVSGA 

       190        200        210        220        230        240 
PIVRSLQKST IRRYGYNLAP HMFLLLHVDE LSIFSAYQAS LPGEKKVDTE RLKRDLCPRK 

       250        260        270        280        290        300 
PIEIKYFSQI CNDMMNKKDR LGDVLATAQR IRRRYNKNSS SEPRLKTLDG LTSERWIQWL 

       310        320        330        340        350        360 
GLESDYHCSF SSTRNAEDVV AGEAASSDHH QKISRVTRKR PREPKSTNDI LVAGQKLFGS 

       370        380        390        400        410        420 
SFEFRDLHQL RLCHEIYMAD TPSVAVQAPP GYGKTELFHL PLIALASKGD VKYVSFLFVP 

       430        440        450        460        470        480 
YTVLLANCMI RLSRCGCLNV APVRNFIEEG CDGVTDLYVG IYDDLASTNF TDRIAAWENI 

       490        500        510        520        530        540 
VECTFRTNNV KLGYLIVDEF HNFETEVYRQ SQFGGITNLD FDAFEKAIFL SGTAPEAVAD 

       550        560        570        580        590        600 
AALQRIGLTG LAKKSMDINE LKRSEDLSRG LSSYPTRMFN LIKEKSEVPL GHVHKIWKKV 

       610        620        630        640        650        660 
ESQPEEALKL LLALFEIEPE SKAIVVASTT NEVEELACSW RKYFRVVWIH GKLGAAEKVS 

       670        680        690        700        710        720 
RTKEFVTDGS MRVLIGTKLV TEGIDIKQLM MVIMLDNRLN IIELIQGVGR LRDGGLCYLL 

       730        740        750        760        770        780 
SRKNSWAARN RKGELPPIKE GCITEQVREF YGLESKKGKK GQHVGCCGSR TDLSADTVEL 

       790        800        810        820        830        840 
IERMDRLAEK QATASMSIVA LPSSFQESNS SDRCRKYCSS DEDSDTCIHG SANASTNATT 

       850        860        870        880        890        900 
NSSTNATTTA STNVRTSATT TASINVRTSA TTTESTNSST NATTTASTNV RTSATTTASI 

       910        920        930        940        950        960 
NVRTSATTTE STNSNTSATT TESTDSNTSA TTTESTDSNT SATTTASTNS STNATTTAST 

       970        980        990       1000       1010       1020 
NSSTNATTTE STNASAKEDA NKDGNAEDNR FHPVTDINKE SYKRKGSQMV LLERKKLKAQ 

      1030       1040       1050       1060       1070       1080 
FPNTSENMNV LQFLGFRSDE IKHLFLYGID IYFCPEGVFT QYGLCKGCQK MFELCVCWAG 

      1090       1100       1110       1120       1130       1140 
QKVSYRRMAW EALAVERMLR NDEEYKEYLE DIEPYHGDPV GYLKFFSVKR GEIYSQIQRN 

      1150       1160       1170       1180       1190       1200 
YAWYLAITRR RETISVLDST RGKQGSQVFR MSGRQIKELY YKVWSNLRES KTEVLQYFLN 

      1210       1220       1230       1240       1250       1260 
WDEKKCREEW EAKDDTVFVE ALEKVGVFQR LRSMTSAGLQ GPQYVKLQFS RHHRQLRSRY 

      1270       1280       1290       1300       1310       1320 
ELSLGMHLRD QLALGVTPSK VPHWTAFLSM LIGLFYNKTF RQKLEYLLEQ ISEVWLLPHW 

      1330       1340       1350       1360       1370 
VDLANVEVLA ADNTRVPLYM LMVAVHKELD SDDVPDGRFD IILLCRDSSR EVGE

« Hide

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References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed: 9169872] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is induced in survivors defective for telomerase."
Yamada M., Hayatsu N., Matsuura A., Ishikawa F.
J. Biol. Chem. 273:33360-33366(1998) [PubMed: 9837911] [Abstract]
Cited for: FUNCTION, INDUCTION.
+Additional computationally mapped references.

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Cross-references

Sequence databases

Z50178 Genomic DNA. Translation: CAA90549.1. Sequence problems.
Z50178 Genomic DNA. Translation: CAA90550.1. Sequence problems.
PIRS69875.
RefSeqNP_013573.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ03099. 2 interactions.
STRINGQ03099.

Genome annotation databases

EnsemblYML133C; YML133C; YML133C; Saccharomyces cerevisiae. [Genome view]
GeneID854906.
KEGGsce:YML133C.

Organism-specific databases

CYGDYML133c.
SGDS000004602. YML133C.

Phylogenomic databases

HOGENOMQ03099.
OrthoDBEOG97WQ52

Gene expression databases

GenevestigatorQ03099.
GermOnlineYML133C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR014001. DEAD-like_N.
IPR001650. DNA/RNA_helicase_C.
IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
[Graphical view]
PfamPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
PROSITEPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio977893.

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Entry information

Entry nameYMN3_YEAST
AccessionPrimary (citable) accession number: Q03099
Secondary accession number(s): Q12054
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 24, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents