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Protein

Y' element ATP-dependent helicase YML133C

Gene

YML133C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi388 – 395ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • helicase activity Source: SGD
  • nucleic acid binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32711-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Y' element ATP-dependent helicase YML133C (EC:3.6.4.12)
Gene namesi
Ordered Locus Names:YML133C
ORF Names:YM4987.01C, YM4987.02C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML133C.
SGDiS000004602. YML133C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001022091 – 1374Y' element ATP-dependent helicase YML133CAdd BLAST1374

Proteomic databases

PRIDEiQ03099.

Expressioni

Inductioni

Induced in absence of telomerase TLC1.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi35072. 3 interactors.
DIPiDIP-7582N.
MINTiMINT-545653.

Structurei

3D structure databases

ProteinModelPortaliQ03099.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini375 – 552Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST178
Domaini609 – 758Helicase C-terminalPROSITE-ProRule annotationAdd BLAST150

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00440000033744.
OrthoDBiEOG092C1JVR.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR021646. Sir1_ORC-binding.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF11603. Sir1. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03099-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSDRRKFE KANFDEFESA LNNKNDLVHC PSITLFESIP TEVRSFYEDE
60 70 80 90 100
KSGLIKVVKF RTGAMDRKRS FEKIVVSVMV GKNVQKFLTF VEDEPDFQGG
110 120 130 140 150
PIPSKYLIPK KINLMVYTLF QVHTLKFNRK DYDTLSLFYL NRGYYNELSF
160 170 180 190 200
RVLERCHEIA SARPNDSSTM RTFTDFVSGA PIVRSLQKST IRRYGYNLAP
210 220 230 240 250
HMFLLLHVDE LSIFSAYQAS LPGEKKVDTE RLKRDLCPRK PIEIKYFSQI
260 270 280 290 300
CNDMMNKKDR LGDVLATAQR IRRRYNKNSS SEPRLKTLDG LTSERWIQWL
310 320 330 340 350
GLESDYHCSF SSTRNAEDVV AGEAASSDHH QKISRVTRKR PREPKSTNDI
360 370 380 390 400
LVAGQKLFGS SFEFRDLHQL RLCHEIYMAD TPSVAVQAPP GYGKTELFHL
410 420 430 440 450
PLIALASKGD VKYVSFLFVP YTVLLANCMI RLSRCGCLNV APVRNFIEEG
460 470 480 490 500
CDGVTDLYVG IYDDLASTNF TDRIAAWENI VECTFRTNNV KLGYLIVDEF
510 520 530 540 550
HNFETEVYRQ SQFGGITNLD FDAFEKAIFL SGTAPEAVAD AALQRIGLTG
560 570 580 590 600
LAKKSMDINE LKRSEDLSRG LSSYPTRMFN LIKEKSEVPL GHVHKIWKKV
610 620 630 640 650
ESQPEEALKL LLALFEIEPE SKAIVVASTT NEVEELACSW RKYFRVVWIH
660 670 680 690 700
GKLGAAEKVS RTKEFVTDGS MRVLIGTKLV TEGIDIKQLM MVIMLDNRLN
710 720 730 740 750
IIELIQGVGR LRDGGLCYLL SRKNSWAARN RKGELPPIKE GCITEQVREF
760 770 780 790 800
YGLESKKGKK GQHVGCCGSR TDLSADTVEL IERMDRLAEK QATASMSIVA
810 820 830 840 850
LPSSFQESNS SDRCRKYCSS DEDSDTCIHG SANASTNATT NSSTNATTTA
860 870 880 890 900
STNVRTSATT TASINVRTSA TTTESTNSST NATTTASTNV RTSATTTASI
910 920 930 940 950
NVRTSATTTE STNSNTSATT TESTDSNTSA TTTESTDSNT SATTTASTNS
960 970 980 990 1000
STNATTTAST NSSTNATTTE STNASAKEDA NKDGNAEDNR FHPVTDINKE
1010 1020 1030 1040 1050
SYKRKGSQMV LLERKKLKAQ FPNTSENMNV LQFLGFRSDE IKHLFLYGID
1060 1070 1080 1090 1100
IYFCPEGVFT QYGLCKGCQK MFELCVCWAG QKVSYRRMAW EALAVERMLR
1110 1120 1130 1140 1150
NDEEYKEYLE DIEPYHGDPV GYLKFFSVKR GEIYSQIQRN YAWYLAITRR
1160 1170 1180 1190 1200
RETISVLDST RGKQGSQVFR MSGRQIKELY YKVWSNLRES KTEVLQYFLN
1210 1220 1230 1240 1250
WDEKKCREEW EAKDDTVFVE ALEKVGVFQR LRSMTSAGLQ GPQYVKLQFS
1260 1270 1280 1290 1300
RHHRQLRSRY ELSLGMHLRD QLALGVTPSK VPHWTAFLSM LIGLFYNKTF
1310 1320 1330 1340 1350
RQKLEYLLEQ ISEVWLLPHW VDLANVEVLA ADNTRVPLYM LMVAVHKELD
1360 1370
SDDVPDGRFD IILLCRDSSR EVGE
Length:1,374
Mass (Da):155,553
Last modified:November 1, 1997 - v1
Checksum:i9867CAC68D2C497E
GO

Sequence cautioni

The sequence CAA90549 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA90550 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50178 Genomic DNA. Translation: CAA90549.1. Sequence problems.
Z50178 Genomic DNA. Translation: CAA90550.1. Sequence problems.
BK006946 Genomic DNA. Translation: DAA09766.1.
PIRiS69875.
RefSeqiNP_013573.1. NM_001182496.1.

Genome annotation databases

EnsemblFungiiYML133C; YML133C; YML133C.
GeneIDi854906.
KEGGisce:YML133C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50178 Genomic DNA. Translation: CAA90549.1. Sequence problems.
Z50178 Genomic DNA. Translation: CAA90550.1. Sequence problems.
BK006946 Genomic DNA. Translation: DAA09766.1.
PIRiS69875.
RefSeqiNP_013573.1. NM_001182496.1.

3D structure databases

ProteinModelPortaliQ03099.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35072. 3 interactors.
DIPiDIP-7582N.
MINTiMINT-545653.

Proteomic databases

PRIDEiQ03099.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYML133C; YML133C; YML133C.
GeneIDi854906.
KEGGisce:YML133C.

Organism-specific databases

EuPathDBiFungiDB:YML133C.
SGDiS000004602. YML133C.

Phylogenomic databases

GeneTreeiENSGT00440000033744.
OrthoDBiEOG092C1JVR.

Enzyme and pathway databases

BioCyciYEAST:G3O-32711-MONOMER.

Miscellaneous databases

PROiQ03099.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR021646. Sir1_ORC-binding.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF11603. Sir1. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYMN3_YEAST
AccessioniPrimary (citable) accession number: Q03099
Secondary accession number(s): D6W0F2, Q12054
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.