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Protein

Transcriptional regulator MET31

Gene

MET31

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Auxiliary transcriptional regulator of sulfur amino acid metabolism. Involved in the transcriptional activation of MET28.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri95 – 11723C2H2-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • regulation of sulfur amino acid metabolic process Source: SGD
  • regulation of transcription from RNA polymerase II promoter Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-33952-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator MET31
Alternative name(s):
Methionine-requiring protein 31
Gene namesi
Name:MET31
Ordered Locus Names:YPL038W
ORF Names:P7102.12
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL038W.
SGDiS000005959. MET31.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 177177Transcriptional regulator MET31PRO_0000046808Add
BLAST

Proteomic databases

MaxQBiQ03081.
PeptideAtlasiQ03081.

PTM databases

iPTMnetiQ03081.

Interactioni

Subunit structurei

Interacts with MET4 and MET28.1 Publication

Protein-protein interaction databases

BioGridi36141. 38 interactions.
DIPiDIP-1445N.
IntActiQ03081. 15 interactions.
MINTiMINT-396058.

Structurei

3D structure databases

ProteinModelPortaliQ03081.
SMRiQ03081. Positions 91-143.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri95 – 11723C2H2-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00730000113983.
HOGENOMiHOG000000993.
InParanoidiQ03081.
OrthoDBiEOG7TTQJG.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03081-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLAQDMNVD EIFLKQAAEA IAVISSSPTH TDPIIRELLH RIRQSSPLSA
60 70 80 90 100
VIPAPENVLK AGEPENMARG LIRIPETQTK RTGGNNHSKE GAQLYSCAKC
110 120 130 140 150
QLKFSRSSDL RRHEKVHSLV LPHICSNCGK GFARKDALKR HSNTLTCQRN
160 170
RKKLSEGSDV DVDELIKDAI KNGTGLL
Length:177
Mass (Da):19,557
Last modified:November 1, 1996 - v1
Checksum:iBAF5C76E24A25AEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44030 Genomic DNA. Translation: AAB68182.1.
BK006949 Genomic DNA. Translation: DAA11392.1.
PIRiS62037.
RefSeqiNP_015287.1. NM_001183852.1.

Genome annotation databases

EnsemblFungiiYPL038W; YPL038W; YPL038W.
GeneIDi856069.
KEGGisce:YPL038W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44030 Genomic DNA. Translation: AAB68182.1.
BK006949 Genomic DNA. Translation: DAA11392.1.
PIRiS62037.
RefSeqiNP_015287.1. NM_001183852.1.

3D structure databases

ProteinModelPortaliQ03081.
SMRiQ03081. Positions 91-143.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36141. 38 interactions.
DIPiDIP-1445N.
IntActiQ03081. 15 interactions.
MINTiMINT-396058.

PTM databases

iPTMnetiQ03081.

Proteomic databases

MaxQBiQ03081.
PeptideAtlasiQ03081.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL038W; YPL038W; YPL038W.
GeneIDi856069.
KEGGisce:YPL038W.

Organism-specific databases

EuPathDBiFungiDB:YPL038W.
SGDiS000005959. MET31.

Phylogenomic databases

GeneTreeiENSGT00730000113983.
HOGENOMiHOG000000993.
InParanoidiQ03081.
OrthoDBiEOG7TTQJG.

Enzyme and pathway databases

BioCyciYEAST:G3O-33952-MONOMER.

Miscellaneous databases

PROiQ03081.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Multiple transcriptional activation complexes tether the yeast activator Met4 to DNA."
    Blaiseau P.L., Thomas D.
    EMBO J. 17:6327-6336(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH MET4 AND MET28.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMET31_YEAST
AccessioniPrimary (citable) accession number: Q03081
Secondary accession number(s): D6W3X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 521 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.