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Q03073

- FIXN_BRADU

UniProt

Q03073 - FIXN_BRADU

Protein

Cytochrome c oxidase subunit 1 homolog, bacteroid

Gene

fixN

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c or a quinol are transferred to the bimetallic center formed by a high-spin heme and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi131 – 1311Iron (heme B axial ligand)Curated
    Metal bindingi280 – 2801Copper BCurated
    Metal bindingi330 – 3301Copper BCurated
    Metal bindingi331 – 3311Copper BCurated
    Metal bindingi418 – 4181Iron (high-spin heme B axial ligand)Curated
    Metal bindingi420 – 4201Iron (heme B axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciBJAP224911:GJEJ-2787-MONOMER.
    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 homolog, bacteroid (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome CBB3 subunit 1
    Cytochrome c oxidase polypeptide I homolog
    Heme B/copper cytochrome c oxidase subunit
    Gene namesi
    Name:fixN
    Ordered Locus Names:blr2763
    OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
    Taxonomic identifieri224911 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
    ProteomesiUP000002526: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane respiratory chain complex IV Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 549549Cytochrome c oxidase subunit 1 homolog, bacteroidPRO_0000183469Add
    BLAST

    Expressioni

    Developmental stagei

    Bacteroid (nitrogen-fixing endosymbiont).

    Inductioni

    By low oxygen levels.

    Interactioni

    Protein-protein interaction databases

    STRINGi224911.blr2763.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei39 – 5921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei132 – 15221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei201 – 22121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei228 – 24821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei279 – 29921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei312 – 33221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei344 – 36421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei382 – 40221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei423 – 44321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei458 – 47821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei512 – 53221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG3278.
    HOGENOMiHOG000277908.
    KOiK00404.
    OrthoDBiEOG6G7QZX.
    PhylomeDBiQ03073.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR004677. Cyt_c_oxidase_cbb3_su1.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    SUPFAMiSSF81442. SSF81442. 1 hit.
    TIGRFAMsiTIGR00780. ccoN. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q03073-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQPSISKSM TIGESGLAVV FAATAFLCVI AAAKALDAPF AFHAALSAAA    50
    SVAAVFCIVN RYFERPAALP PAEINGRPNY NMGPIKFSSF MAMFWGIAGF 100
    LVGLIIASQL AWPALNFDLP WISFGRLRPL HTSAVIFAFG GNVLIATSFY 150
    VVQKSCRVRL AGDLAPWFVV VGYNFFILVA GTGYLLGVTQ SKEYAEPEWY 200
    ADLWLTIVWV VYLLVFLATI IKRKEPHIFV ANWFYLAFIV TIAVLHLGNN 250
    PALPVSAFGS KSYVAWGGIQ DAMFQWWYGH NAVGFFLTAG FLAIMYYFIP 300
    KRAERPIYSY RLSIIHFWAL IFLYIWAGPH HLHYTALPDW TQTLGMTFSI 350
    MLWMPSWGGM INGLMTLSGA WDKLRTDPVL RMLVVSVAFY GMSTFEGPMM 400
    SIKVVNSLSH YTDWTIGHVH SGALGWVGFV SFGALYCLVP WAWNRKGLYS 450
    LKLVNWHFWV ATLGIVLYIS AMWVSGILQG LMWRAYTSLG FLEYSFIETV 500
    EAMHPFYIIR AAGGGLFLIG ALIMAYNLWM TVRVGEAEVQ MPVALQPAE 549
    Length:549
    Mass (Da):61,273
    Last modified:February 1, 1996 - v1
    Checksum:iEEFBB48F18C364E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07487 Genomic DNA. Translation: AAA26203.1.
    AJ005001 Genomic DNA. Translation: CAA06279.1.
    BA000040 Genomic DNA. Translation: BAC48028.1.
    PIRiA47468.
    RefSeqiNP_769403.1. NC_004463.1.

    Genome annotation databases

    EnsemblBacteriaiBAC48028; BAC48028; BAC48028.
    GeneIDi1054103.
    KEGGibja:blr2763.
    PATRICi21188974. VBIBraJap65052_2745.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07487 Genomic DNA. Translation: AAA26203.1 .
    AJ005001 Genomic DNA. Translation: CAA06279.1 .
    BA000040 Genomic DNA. Translation: BAC48028.1 .
    PIRi A47468.
    RefSeqi NP_769403.1. NC_004463.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224911.blr2763.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC48028 ; BAC48028 ; BAC48028 .
    GeneIDi 1054103.
    KEGGi bja:blr2763.
    PATRICi 21188974. VBIBraJap65052_2745.

    Phylogenomic databases

    eggNOGi COG3278.
    HOGENOMi HOG000277908.
    KOi K00404.
    OrthoDBi EOG6G7QZX.
    PhylomeDBi Q03073.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .
    BioCyci BJAP224911:GJEJ-2787-MONOMER.

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR004677. Cyt_c_oxidase_cbb3_su1.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81442. SSF81442. 1 hit.
    TIGRFAMsi TIGR00780. ccoN. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genes for a microaerobically induced oxidase complex in Bradyrhizobium japonicum are essential for a nitrogen-fixing endosymbiosis."
      Preisig O., Anthamatten D., Hennecke H.
      Proc. Natl. Acad. Sci. U.S.A. 90:3309-3313(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: USDA 110spc4.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

    Entry informationi

    Entry nameiFIXN_BRADU
    AccessioniPrimary (citable) accession number: Q03073
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This cytochrome oxidase is probably a cbb3-type.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3