Q03066 (RPSC_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RNA polymerase sigma-C factor

Gene names

Name:	sigC
Ordered Locus Names:	all1692

Organism

Nostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
Sequence similarities	Belongs to the sigma-70 factor family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Molecular function	Sigma factor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transcription initiation, DNA-dependent Inferred from electronic annotation. Source: InterPro
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro sigma factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 416	416	RNA polymerase sigma-C factor		PRO_0000093936
Regions
	DNA binding	374 – 393	20	H-T-H motif By similarity
	Motif	205 – 218	14	Polymerase core binding Potential
Experimental info
	Sequence conflict	52	1	A → R in AAA22047. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q03066 [UniParc]. Last modified January 23, 2002. Version 2. Checksum: 0467340EA278964F	FASTA	416	47,374
	10 20 30 40 50 60 MPATSFYADA AYNTQKSRQA LDPDIAIDDS DLSVDEIQEL EIAAADPATF GASANRRSTD 70 80 90 100 110 120 LVRLYLQEIG RVRLLGRDEE VSEAQKVQRY LKLRIVLANA VKQGDEVATP YLHLIEVQER 130 140 150 160 170 180 LASELGHRPS LERWAATAGI NLCDLKPILS EGKRRWAEIA KMTVEELEKM QSQGLQSKEH 190 200 210 220 230 240 MIKANLRLVV SVAKKYQNRG LELLDLVQEG TLGLERAVEK FDPTKGYRFS TYAYWWIRQG 250 260 270 280 290 300 ITRAIATSSR TIRLPVHITE KLNKIKKAQR KIAQEKGRTP TLEDLAIELD MTPTQVREVL 310 320 330 340 350 360 LRVPRSVSLE TKVGKDKDTE LGELLETDGV TPEEMLMRES LQRDLQHLLA DLTSRERDVI 370 380 390 400 410 LMRFGLADGH PYSLAEIGRA LDLSRERVRQ IESKALQKLR QPKRRNLIRD YLESLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of multiple RNA polymerase sigma factor homologs in the cyanobacterium Anabaena sp. strain PCC 7120: cloning, expression, and inactivation of the sigB and sigC genes." Brahamsha B., Haselkorn R. J. Bacteriol. 174:7273-7282(1992) [PubMed: 1385387] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7120 / UTEX 2576.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M95759 Genomic DNA. Translation: AAA22047.1. BA000019 Genomic DNA. Translation: BAB78058.1.
PIR	AF2017. C47017.
RefSeq	NP_485732.1. NC_003272.1.
3D structure databases
ProteinModelPortal	Q03066.
SMR	Q03066. Positions 171-246.
ModBase	Search...
Protein-protein interaction databases
STRING	Q03066.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1105284.
GenomeReviews	Gene locus all1692 in contig BA000019_GR.
KEGG	ana:all1692.
NMPDR	fig|103690.1.peg.1999.
PATRIC	22773430. VBINosSp37423_2194.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0568.
HOGENOM	HBG745096.
OMA	KVGKDKD.
PhylomeDB	Q03066.
ProtClustDB	PRK07598.
Enzyme and pathway databases
BioCyc	NSP103690:ALL1692-MONOMER.
Family and domain databases
InterPro	IPR014284. RNA_pol_sigma-70. IPR000943. RNA_pol_sigma70. IPR009042. RNA_pol_sigma70_r1_2. IPR007627. RNA_pol_sigma70_r2. IPR007624. RNA_pol_sigma70_r3. IPR007630. RNA_pol_sigma70_r4. IPR013325. RNA_pol_sigma_r2. IPR013324. RNA_pol_sigma_r3_r4. IPR017848. RNA_pol_sigma_RpoD_cyanobac. IPR011991. WHTH_trsnscrt_rep_DNA-bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 2 hits.
KO	K03087.
Pfam	PF00140. Sigma70_r1_2. 1 hit. PF04542. Sigma70_r2. 1 hit. PF04539. Sigma70_r3. 1 hit. PF04545. Sigma70_r4. 1 hit. [Graphical view]
PRINTS	PR00046. SIGMA70FCT.
SUPFAM	SSF88946. Sigma_r2. 1 hit. SSF88659. Sigma_r3_r4. 2 hits.
TIGRFAMs	TIGR02997. Sig70-cyanoRpoD. 1 hit. TIGR02937. Sigma70-ECF. 1 hit.
PROSITE	PS00715. SIGMA70_1. 1 hit. PS00716. SIGMA70_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RPSC_NOSS1

Accession

Primary (citable) accession number: Q03066

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	January 23, 2002
Last modified:	January 25, 2012
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program