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Protein

Transcription factor HES-5

Gene

Hes5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor HES-5
Alternative name(s):
Hairy and enhancer of split 5
Gene namesi
Name:Hes5
Synonyms:Hes-5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi621340. Hes5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272131 – 166Transcription factor HES-5Add BLAST166

Proteomic databases

PaxDbiQ03062.
PRIDEiQ03062.

Expressioni

Tissue specificityi

Expressed predominantly in embryonic neural lineage cells.1 Publication

Gene expression databases

BgeeiENSRNOG00000013850.
GenevisibleiQ03062. RN.

Interactioni

Subunit structurei

Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.By similarity

Protein-protein interaction databases

IntActiQ03062. 2 interactors.
MINTiMINT-3376257.
STRINGi10116.ENSRNOP00000018769.

Structurei

3D structure databases

ProteinModelPortaliQ03062.
SMRiQ03062.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 72bHLHPROSITE-ProRule annotationAdd BLAST57
Domaini88 – 119OrangePROSITE-ProRule annotationAdd BLAST32

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi163 – 166WRPW motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 31Arg/Lys-rich (basic)Add BLAST18
Compositional biasi74 – 79Poly-Ala6
Compositional biasi122 – 141Pro-richAdd BLAST20

Domaini

Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
Contains 1 Orange domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IWTV. Eukaryota.
ENOG41120DD. LUCA.
GeneTreeiENSGT00700000104168.
HOGENOMiHOG000236346.
HOVERGENiHBG005960.
InParanoidiQ03062.
KOiK06055.
OMAiDGFTQCA.
OrthoDBiEOG091G0V3D.
PhylomeDBiQ03062.
TreeFamiTF351373.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR003650. Orange_dom.
[Graphical view]
PfamiPF07527. Hairy_orange. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00511. ORANGE. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS51054. ORANGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03062-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSTVAVEM LSPKEKNRLR KPVVEKMRRD RINSSIEQLK LLLEQEFARH
60 70 80 90 100
QPNSKLEKAD ILEMAVSYLK HSKAFAAAAG PKSLHQDYSE GYSWCLQEAV
110 120 130 140 150
QFLTLHAASD TQMKLLYHFQ RPPAPAAPVK ETPTPGAAPQ PARSSTKAAA
160
SVSTSRQSAC GLWRPW
Length:166
Mass (Da):18,452
Last modified:June 1, 1994 - v1
Checksum:iCAA5046F07B1B0C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12516 mRNA. Translation: BAA02081.1.
PIRiA45119.
RefSeqiNP_077359.1. NM_024383.1.
UniGeneiRn.22422.

Genome annotation databases

EnsembliENSRNOT00000018769; ENSRNOP00000018769; ENSRNOG00000013850.
GeneIDi79225.
KEGGirno:79225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12516 mRNA. Translation: BAA02081.1.
PIRiA45119.
RefSeqiNP_077359.1. NM_024383.1.
UniGeneiRn.22422.

3D structure databases

ProteinModelPortaliQ03062.
SMRiQ03062.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ03062. 2 interactors.
MINTiMINT-3376257.
STRINGi10116.ENSRNOP00000018769.

Proteomic databases

PaxDbiQ03062.
PRIDEiQ03062.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018769; ENSRNOP00000018769; ENSRNOG00000013850.
GeneIDi79225.
KEGGirno:79225.

Organism-specific databases

CTDi388585.
RGDi621340. Hes5.

Phylogenomic databases

eggNOGiENOG410IWTV. Eukaryota.
ENOG41120DD. LUCA.
GeneTreeiENSGT00700000104168.
HOGENOMiHOG000236346.
HOVERGENiHBG005960.
InParanoidiQ03062.
KOiK06055.
OMAiDGFTQCA.
OrthoDBiEOG091G0V3D.
PhylomeDBiQ03062.
TreeFamiTF351373.

Miscellaneous databases

PROiQ03062.

Gene expression databases

BgeeiENSRNOG00000013850.
GenevisibleiQ03062. RN.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR003650. Orange_dom.
[Graphical view]
PfamiPF07527. Hairy_orange. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00511. ORANGE. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS51054. ORANGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHES5_RAT
AccessioniPrimary (citable) accession number: Q03062
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.