Q03060 (CREM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
cAMP-responsive element modulator

Alternative name(s):
Inducible cAMP early repressor
Short name=ICER

Gene names

Name:

CREM

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation By similarity. Ref.13
Subunit structure	Binds DNA as a dimer. Interacts with FHL5 By similarity. Interacts with CDC34. Ref.13
Subcellular location	Nucleus.
Tissue specificity	Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes. Ref.12 Ref.14 Ref.15
Post-translational modification	Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome. Stimulated by phosphorylation By similarity.
Sequence similarities	Belongs to the bZIP family. Contains 1 bZIP (basic-leucine zipper) domain. Contains 1 KID (kinase-inducible) domain.
Sequence caution	The sequence AAB03751.1 differs from that shown. Reason: Erroneous termination at position 361. Translated as Tyr. The sequence AAF68266.2 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAH72496.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAH72497.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI12138.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI12139.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI12143.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Differentiation Spermatogenesis Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative promoter usage Alternative splicing Polymorphism
Ligand	DNA-binding
Molecular function	Activator Developmental protein Repressor
PTM	Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW glycosphingolipid metabolic process Inferred from electronic annotation. Source: Compara multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara regulation of transcription, DNA-dependent Inferred from direct assay Ref.1. Source: UniProtKB signal transduction Traceable author statement Ref.10. Source: ProtInc spermatogenesis Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Non-traceable author statement Ref.1. Source: UniProtKB transcription factor complex Inferred from electronic annotation. Source: Compara
Molecular_function	DNA binding Non-traceable author statement Ref.10. Source: UniProtKB cAMP response element binding protein binding Non-traceable author statement Ref.1. Source: UniProtKB sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 23 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q03060-5)

Also known as: CREM-BCEFGgammaHIbeta;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Produced by alternative promoter usage.

Isoform 2 (identifier: Q03060-1)

Also known as: Beta; CREM-BCEFGHIbeta;

The sequence of this isoform differs from the canonical sequence as follows:
     249-260: Missing.

Note: Produced by alternative splicing of isoform 1. Activator.

Isoform 3 (identifier: Q03060-6)

Also known as: CREM-BCEFGIalpha; Tau;

The sequence of this isoform differs from the canonical sequence as follows:
     249-260: Missing.
     317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE

Note: Produced by alternative splicing of isoform 1. Activator.

Isoform 4 (identifier: Q03060-2)

Also known as: Alpha; CREM-BEFHIb; CREM-gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     58-106: Missing.
     186-248: Missing.
     249-260: Missing.
     261-261: A → T

Note: Produced by alternative splicing of isoform 1.

Isoform 5 (identifier: Q03060-7)

Also known as: CREM-theta2tau-gamma; CREM-theta2EFGHIb;

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     105-105: Q → M
     249-260: Missing.

Note: Produced by alternative promoter usage. Activator.

Isoform 6 (identifier: Q03060-8)

Also known as: CREM2alpha-a; IcergammaHIalpha; ICER1; ICERI;

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     241-248: PGSQVVVQ → MAVTGDDT
     317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE

Note: Produced by alternative promoter usage. Repressor.

Isoform 7 (identifier: Q03060-9)

Also known as: CREM2alpha-b; IcerHIalpha; ICERIgamma;

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     241-248: PGSQVVVQ → MAVTGDDT
     249-260: Missing.
     317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE

Note: Produced by alternative splicing of isoform 6. Repressor.

Isoform 8 (identifier: Q03060-10)

Also known as: CREM 2beta-a; IcergammaHIbeta; ICERII;

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     241-248: PGSQVVVQ → MAVTGDDT

Note: Produced by alternative splicing of isoform 6. Repressor.

Isoform 9 (identifier: Q03060-11)

Also known as: CREM 2beta-b; IcerHIbeta; ICERIIgamma;

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     241-248: PGSQVVVQ → MAVTGDDT
     249-260: Missing.

Note: Produced by alternative splicing of isoform 6. Repressor.

Isoform 10 (identifier: Q03060-12)

Also known as: CREMtheta1tau2beta; CREM-theta1EFGHIbeta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     105-105: Q → MWWHQHNLCFRRPIEEDYSSGDVEEK
     249-260: Missing.

Note: Produced by alternative promoter usage. Activator.

Isoform 11 (identifier: Q03060-13)

Also known as: CREM-theta1beta; CREM-theta1EFHIbeta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     105-105: Q → MWWHQHNLCFRRPIEEDYSSGDVEEK
     186-248: Missing.
     261-261: A → T

Note: Produced by alternative splicing of isoform 10. Repressor.

Isoform 12 (identifier: Q03060-14)

Also known as: CREM-theta2beta; CREM-theta2EFHIb; CREM-theta2-gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     105-105: Q → M
     186-248: Missing.
     261-261: A → T

Note: Produced by alternative splicing of isoform 5. Repressor.

Isoform 13 (identifier: Q03060-15)

Also known as: CREM-BEFGgammaHIbeta;

The sequence of this isoform differs from the canonical sequence as follows:
     58-106: Missing.

Note: Produced by alternative splicing of isoform 1. Activator.

Isoform 14 (identifier: Q03060-16)

Also known as: CREM-tau2-gamma; CREM-BEFGHIbeta;

The sequence of this isoform differs from the canonical sequence as follows:
     58-106: Missing.
     249-260: Missing.

Note: Produced by alternative splicing of isoform 1. Activator.

Isoform 15 (identifier: Q03060-17)

Also known as: CREM-BGHIbeta;

The sequence of this isoform differs from the canonical sequence as follows:
     58-106: Missing.
     107-185: Missing.
     249-260: Missing.

Note: Produced by alternative splicing of isoform 1. Repressor.

Isoform 16 (identifier: Q03060-19)

Also known as: CREM-deltaC-G; CREM-BgammaHIbeta;

The sequence of this isoform differs from the canonical sequence as follows:
     58-106: Missing.
     107-185: Missing.
     186-248: Missing.

Note: Produced by alternative splicing of isoform 1. Repressor.

Isoform 17 (identifier: Q03060-20)

Also known as: CREM-BHIbeta;

The sequence of this isoform differs from the canonical sequence as follows:
     186-248: Missing.
     249-260: Missing.

Note: Produced by alternative splicing of isoform 1. Repressor.

Isoform 18 (identifier: Q03060-21)

Also known as: CREM-BHIalpha;

The sequence of this isoform differs from the canonical sequence as follows:
     186-248: Missing.
     249-260: Missing.
     317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE

Note: Produced by alternative splicing of isoform 1. Repressor.

Isoform 19 (identifier: Q03060-22)

Also known as: CREM-theta1tau2gamma; CREM-theta1EFGgammaHIbeta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     105-105: Q → MWWHQHNLCFRRPIEEDYSSGDVEEK

Note: Produced by alternative splicing of isoform 10. Activator.

Isoform 20 (identifier: Q03060-23)

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     105-258: Missing.
     317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE

Note: No experimental confirmation available.

Isoform 21 (identifier: Q03060-24)

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MSKCARKKYIKT → MNRTQELSGQLS
     13-260: Missing.
     317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE

Note: No experimental confirmation available.

Isoform 22 (identifier: Q03060-25)

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.
     58-106: Missing.
     186-202: IAIAQGGTIQISNPGSD → SMYAAIRYDTVLALSLL
     203-361: Missing.

Note: No experimental confirmation available.

Isoform 23 (identifier: Q03060-26)

The sequence of this isoform differs from the canonical sequence as follows:
     58-106: Missing.
     186-248: Missing.
     249-249: D → N
     317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	cAMP-responsive element modulator		PRO_0000076607
Regions
	Domain	104 – 163	60	KID
	Domain	302 – 361	60	bZIP
	Region	303 – 328	26	Basic motif By similarity
	Region	330 – 351	22	Leucine-zipper By similarity
Amino acid modifications
	Modified residue	287	1	Phosphoserine Ref.16 Ref.17
	Modified residue	290	1	Phosphoserine Ref.16
	Modified residue	293	1	Phosphoserine Ref.16 Ref.17
Natural variations
	Alternative sequence	1 – 240	240	Missing in isoform 6, isoform 7, isoform 8 and isoform 9.		VSP_026075
	Alternative sequence	1 – 104	104	Missing in isoform 5, isoform 10, isoform 11, isoform 12, isoform 19 and isoform 20.		VSP_025035
	Alternative sequence	1 – 16	16	Missing in isoform 22.		VSP_043782
	Alternative sequence	1 – 12	12	MSKCA…KYIKT → MNRTQELSGQLS in isoform 21.		VSP_043713
	Alternative sequence	13 – 260	248	Missing in isoform 21.		VSP_043714
	Alternative sequence	58 – 106	49	Missing in isoform 4, isoform 13, isoform 14, isoform 15, isoform 16, isoform 22 and isoform 23.		VSP_000599
	Alternative sequence	105 – 258	154	Missing in isoform 20.		VSP_043580
	Alternative sequence	105	1	Q → MWWHQHNLCFRRPIEEDYSS GDVEEK in isoform 10, isoform 11 and isoform 19.		VSP_026076
	Alternative sequence	105	1	Q → M in isoform 5 and isoform 12.		VSP_025036
	Alternative sequence	107 – 185	79	Missing in isoform 15 and isoform 16.		VSP_026077
	Alternative sequence	186 – 248	63	Missing in isoform 4, isoform 11, isoform 12, isoform 16, isoform 17, isoform 18 and isoform 23.		VSP_000600
	Alternative sequence	186 – 202	17	IAIAQ…NPGSD → SMYAAIRYDTVLALSLL in isoform 22.		VSP_043783
	Alternative sequence	203 – 361	159	Missing in isoform 22.		VSP_043784
	Alternative sequence	241 – 248	8	PGSQVVVQ → MAVTGDDT in isoform 6, isoform 7, isoform 8 and isoform 9.		VSP_026078
	Alternative sequence	249 – 260	12	Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 7, isoform 9, isoform 10, isoform 14, isoform 15, isoform 17 and isoform 18.		VSP_025037
	Alternative sequence	249	1	D → N in isoform 23.		VSP_045234
	Alternative sequence	261	1	A → T in isoform 4, isoform 11 and isoform 12.		VSP_000601
	Alternative sequence	317 – 361	45	KECRR…PKTDY → RECRRKKKEYVKCLENRVAV LENQNKTLIEELKALKDLYC HKVE in isoform 3, isoform 6, isoform 7, isoform 18, isoform 20, isoform 21 and isoform 23.		VSP_025038
	Natural variant	270	1	Q → R. Ref.2 Corresponds to variant rs1804604 [ dbSNP | Ensembl ].		VAR_055561
Experimental info
	Sequence conflict	49	1	N → I in AAC60616. Ref.11
	Sequence conflict	49	1	N → I in AAC60617. Ref.11
	Sequence conflict	55	1	A → R in CAA78858. Ref.10
	Sequence conflict	57 – 61	5	VSVAG → CSELR in AAC60616. Ref.11
	Sequence conflict	57 – 61	5	VSVAG → CSELR in AAC60617. Ref.11
	Sequence conflict	292	1	H → R in BAA03562. Ref.1
	Sequence conflict	292	1	H → R in BAA03564. Ref.3
	Sequence conflict	292	1	H → R in BAA03565. Ref.3
	Sequence conflict	292	1	H → R in BAA03566. Ref.3
	Sequence conflict	292	1	H → R in BAA03567. Ref.3
Isoform 6:
	Sequence conflict	7	1	D → E in AAC19383. Ref.3
	Sequence conflict	112	1	K → R in AAC19383. Ref.3
Isoform 8:
	Sequence conflict	7	1	D → E in AAB03751. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (CREM-BCEFGgammaHIbeta) [UniParc]. Last modified September 22, 2009. Version 5. Checksum: C1AF0DF57DFB0DAD	FASTA	361	38,940
	10 20 30 40 50 60 MSKCARKKYI KTNPRQMTME TVESQHDGSI TASLTESKSA HVQTQTGQNS IPALAQVSVA 70 80 90 100 110 120 GSGTRRGSPA VTLVQLPSGQ TIHVQGVIQT PQPWVIQSSE IHTVQVAAIA ETDESAESEG 130 140 150 160 170 180 VIDSHKRREI LSRRPSYRKI LNELSSDVPG VPKIEEERSE EEGTPPSIAT MAVPTSIYQT 190 200 210 220 230 240 STGQYIAIAQ GGTIQISNPG SDGVQGLQAL TMTNSGAPPP GATIVQYAAQ SADGTQQFFV 250 260 270 280 290 300 PGSQVVVQDE ETELAPSHMA AATGDMPTYQ IRAPTAALPQ GVVMAASPGS LHSPQQLAEE 310 320 330 340 350 360 ATRKRELRLM KNREAAKECR RRKKEYVKCL ESRVAVLEVQ NKKLIEELET LKDICSPKTD Y
	Isoform 2 (Beta) (CREM-BCEFGHIbeta) [UniParc]. Checksum: F6B8D2BF073C00C0	FASTA	349	37,628
	10 20 30 40 50 60 MSKCARKKYI KTNPRQMTME TVESQHDGSI TASLTESKSA HVQTQTGQNS IPALAQVSVA 70 80 90 100 110 120 GSGTRRGSPA VTLVQLPSGQ TIHVQGVIQT PQPWVIQSSE IHTVQVAAIA ETDESAESEG 130 140 150 160 170 180 VIDSHKRREI LSRRPSYRKI LNELSSDVPG VPKIEEERSE EEGTPPSIAT MAVPTSIYQT 190 200 210 220 230 240 STGQYIAIAQ GGTIQISNPG SDGVQGLQAL TMTNSGAPPP GATIVQYAAQ SADGTQQFFV 250 260 270 280 290 300 PGSQVVVQAA TGDMPTYQIR APTAALPQGV VMAASPGSLH SPQQLAEEAT RKRELRLMKN 310 320 330 340 REAAKECRRR KKEYVKCLES RVAVLEVQNK KLIEELETLK DICSPKTDY
	Isoform 3 (CREM-BCEFGIalpha) (Tau) [UniParc]. Checksum: 859AA3D3C2EB7D59	FASTA	348	37,577
	10 20 30 40 50 60 MSKCARKKYI KTNPRQMTME TVESQHDGSI TASLTESKSA HVQTQTGQNS IPALAQVSVA 70 80 90 100 110 120 GSGTRRGSPA VTLVQLPSGQ TIHVQGVIQT PQPWVIQSSE IHTVQVAAIA ETDESAESEG 130 140 150 160 170 180 VIDSHKRREI LSRRPSYRKI LNELSSDVPG VPKIEEERSE EEGTPPSIAT MAVPTSIYQT 190 200 210 220 230 240 STGQYIAIAQ GGTIQISNPG SDGVQGLQAL TMTNSGAPPP GATIVQYAAQ SADGTQQFFV 250 260 270 280 290 300 PGSQVVVQAA TGDMPTYQIR APTAALPQGV VMAASPGSLH SPQQLAEEAT RKRELRLMKN 310 320 330 340 REAARECRRK KKEYVKCLEN RVAVLENQNK TLIEELKALK DLYCHKVE
	Isoform 4 (Alpha) (CREM-BEFHIb) (CREM-gamma) [UniParc]. Checksum: 89C1F372F6E60AF0	FASTA	237	26,320
	10 20 30 40 50 60 MSKCARKKYI KTNPRQMTME TVESQHDGSI TASLTESKSA HVQTQTGQNS IPALAQVAAI 70 80 90 100 110 120 AETDESAESE GVIDSHKRRE ILSRRPSYRK ILNELSSDVP GVPKIEEERS EEEGTPPSIA 130 140 150 160 170 180 TMAVPTSIYQ TSTGQYTATG DMPTYQIRAP TAALPQGVVM AASPGSLHSP QQLAEEATRK 190 200 210 220 230 RELRLMKNRE AAKECRRRKK EYVKCLESRV AVLEVQNKKL IEELETLKDI CSPKTDY
	Isoform 5 (CREM-theta2tau-gamma) (CREM-theta2EFGHIb) [UniParc]. Checksum: 244821D6A4AD32CD	FASTA	245	26,513
	10 20 30 40 50 60 MVAAIAETDE SAESEGVIDS HKRREILSRR PSYRKILNEL SSDVPGVPKI EEERSEEEGT 70 80 90 100 110 120 PPSIATMAVP TSIYQTSTGQ YIAIAQGGTI QISNPGSDGV QGLQALTMTN SGAPPPGATI 130 140 150 160 170 180 VQYAAQSADG TQQFFVPGSQ VVVQAATGDM PTYQIRAPTA ALPQGVVMAA SPGSLHSPQQ 190 200 210 220 230 240 LAEEATRKRE LRLMKNREAA KECRRRKKEY VKCLESRVAV LEVQNKKLIE ELETLKDICS PKTDY
	Isoform 6 (CREM2alpha-a) (IcergammaHIalpha) (ICER1) (ICERI) [UniParc]. Checksum: 723844391B15C4A8	FASTA	120	13,435
	10 20 30 40 50 60 MAVTGDDTDE ETELAPSHMA AATGDMPTYQ IRAPTAALPQ GVVMAASPGS LHSPQQLAEE 70 80 90 100 110 120 ATRKRELRLM KNREAARECR RKKKEYVKCL ENRVAVLENQ NKTLIEELKA LKDLYCHKVE
	Isoform 7 (CREM2alpha-b) (IcerHIalpha) (ICERIgamma) [UniParc]. Checksum: BF84129AA7183E40	FASTA	108	12,124
	10 20 30 40 50 60 MAVTGDDTAA TGDMPTYQIR APTAALPQGV VMAASPGSLH SPQQLAEEAT RKRELRLMKN 70 80 90 100 REAARECRRK KKEYVKCLEN RVAVLENQNK TLIEELKALK DLYCHKVE
	Isoform 8 (CREM 2beta-a) (IcergammaHIbeta) (ICERII) [UniParc]. Checksum: 6EFF7058EDE5FE79	FASTA	121	13,486
	10 20 30 40 50 60 MAVTGDDTDE ETELAPSHMA AATGDMPTYQ IRAPTAALPQ GVVMAASPGS LHSPQQLAEE 70 80 90 100 110 120 ATRKRELRLM KNREAAKECR RRKKEYVKCL ESRVAVLEVQ NKKLIEELET LKDICSPKTD Y
	Isoform 9 (CREM 2beta-b) (IcerHIbeta) (ICERIIgamma) [UniParc]. Checksum: E1B2CC0E4E59F383	FASTA	109	12,175
	10 20 30 40 50 60 MAVTGDDTAA TGDMPTYQIR APTAALPQGV VMAASPGSLH SPQQLAEEAT RKRELRLMKN 70 80 90 100 REAAKECRRR KKEYVKCLES RVAVLEVQNK KLIEELETLK DICSPKTDY
	Isoform 10 (CREMtheta1tau2beta) (CREM-theta1EFGHIbeta) [UniParc]. Checksum: 10A26E01D01D8FDC	FASTA	270	29,656
	10 20 30 40 50 60 MWWHQHNLCF RRPIEEDYSS GDVEEKVAAI AETDESAESE GVIDSHKRRE ILSRRPSYRK 70 80 90 100 110 120 ILNELSSDVP GVPKIEEERS EEEGTPPSIA TMAVPTSIYQ TSTGQYIAIA QGGTIQISNP 130 140 150 160 170 180 GSDGVQGLQA LTMTNSGAPP PGATIVQYAA QSADGTQQFF VPGSQVVVQA ATGDMPTYQI 190 200 210 220 230 240 RAPTAALPQG VVMAASPGSL HSPQQLAEEA TRKRELRLMK NREAAKECRR RKKEYVKCLE 250 260 270 SRVAVLEVQN KKLIEELETL KDICSPKTDY
	Isoform 11 (CREM-theta1beta) (CREM-theta1EFHIbeta) [UniParc]. Checksum: B7AB068F482F3C29	FASTA	219	24,774
	10 20 30 40 50 60 MWWHQHNLCF RRPIEEDYSS GDVEEKVAAI AETDESAESE GVIDSHKRRE ILSRRPSYRK 70 80 90 100 110 120 ILNELSSDVP GVPKIEEERS EEEGTPPSIA TMAVPTSIYQ TSTGQYDEET ELAPSHMATA 130 140 150 160 170 180 TGDMPTYQIR APTAALPQGV VMAASPGSLH SPQQLAEEAT RKRELRLMKN REAAKECRRR 190 200 210 KKEYVKCLES RVAVLEVQNK KLIEELETLK DICSPKTDY
	Isoform 12 (CREM-theta2beta) (CREM-theta2EFHIb) (CREM-theta2-gamma) [UniParc]. Checksum: FA038D9739438F76	FASTA	194	21,630
	10 20 30 40 50 60 MVAAIAETDE SAESEGVIDS HKRREILSRR PSYRKILNEL SSDVPGVPKI EEERSEEEGT 70 80 90 100 110 120 PPSIATMAVP TSIYQTSTGQ YDEETELAPS HMATATGDMP TYQIRAPTAA LPQGVVMAAS 130 140 150 160 170 180 PGSLHSPQQL AEEATRKREL RLMKNREAAK ECRRRKKEYV KCLESRVAVL EVQNKKLIEE 190 LETLKDICSP KTDY
	Isoform 13 (CREM-BEFGgammaHIbeta) [UniParc]. Checksum: 1C129B0200C8A1F7	FASTA	312	33,825
	10 20 30 40 50 60 MSKCARKKYI KTNPRQMTME TVESQHDGSI TASLTESKSA HVQTQTGQNS IPALAQVAAI 70 80 90 100 110 120 AETDESAESE GVIDSHKRRE ILSRRPSYRK ILNELSSDVP GVPKIEEERS EEEGTPPSIA 130 140 150 160 170 180 TMAVPTSIYQ TSTGQYIAIA QGGTIQISNP GSDGVQGLQA LTMTNSGAPP PGATIVQYAA 190 200 210 220 230 240 QSADGTQQFF VPGSQVVVQD EETELAPSHM AAATGDMPTY QIRAPTAALP QGVVMAASPG 250 260 270 280 290 300 SLHSPQQLAE EATRKRELRL MKNREAAKEC RRRKKEYVKC LESRVAVLEV QNKKLIEELE 310 TLKDICSPKT DY
	Isoform 14 (CREM-tau2-gamma) (CREM-BEFGHIbeta) [UniParc]. Checksum: C759C78AB56E0FC5	FASTA	300	32,514
	10 20 30 40 50 60 MSKCARKKYI KTNPRQMTME TVESQHDGSI TASLTESKSA HVQTQTGQNS IPALAQVAAI 70 80 90 100 110 120 AETDESAESE GVIDSHKRRE ILSRRPSYRK ILNELSSDVP GVPKIEEERS EEEGTPPSIA 130 140 150 160 170 180 TMAVPTSIYQ TSTGQYIAIA QGGTIQISNP GSDGVQGLQA LTMTNSGAPP PGATIVQYAA 190 200 210 220 230 240 QSADGTQQFF VPGSQVVVQA ATGDMPTYQI RAPTAALPQG VVMAASPGSL HSPQQLAEEA 250 260 270 280 290 300 TRKRELRLMK NREAAKECRR RKKEYVKCLE SRVAVLEVQN KKLIEELETL KDICSPKTDY
	Isoform 15 (CREM-BGHIbeta) [UniParc]. Checksum: 70AD0E7C1AD98BC2	FASTA	221	23,839
	10 20 30 40 50 60 MSKCARKKYI KTNPRQMTME TVESQHDGSI TASLTESKSA HVQTQTGQNS IPALAQVIAI 70 80 90 100 110 120 AQGGTIQISN PGSDGVQGLQ ALTMTNSGAP PPGATIVQYA AQSADGTQQF FVPGSQVVVQ 130 140 150 160 170 180 AATGDMPTYQ IRAPTAALPQ GVVMAASPGS LHSPQQLAEE ATRKRELRLM KNREAAKECR 190 200 210 220 RRKKEYVKCL ESRVAVLEVQ NKKLIEELET LKDICSPKTD Y
	Isoform 16 (CREM-deltaC-G) (CREM-BgammaHIbeta) [UniParc]. Checksum: 112F9B233752BF64	FASTA	170	18,927
	10 20 30 40 50 60 MSKCARKKYI KTNPRQMTME TVESQHDGSI TASLTESKSA HVQTQTGQNS IPALAQVDEE 70 80 90 100 110 120 TELAPSHMAA ATGDMPTYQI RAPTAALPQG VVMAASPGSL HSPQQLAEEA TRKRELRLMK 130 140 150 160 170 NREAAKECRR RKKEYVKCLE SRVAVLEVQN KKLIEELETL KDICSPKTDY
	Isoform 17 (CREM-BHIbeta) [UniParc]. Checksum: 7E0BD230608E9563	FASTA	286	31,405
	10 20 30 40 50 60 MSKCARKKYI KTNPRQMTME TVESQHDGSI TASLTESKSA HVQTQTGQNS IPALAQVSVA 70 80 90 100 110 120 GSGTRRGSPA VTLVQLPSGQ TIHVQGVIQT PQPWVIQSSE IHTVQVAAIA ETDESAESEG 130 140 150 160 170 180 VIDSHKRREI LSRRPSYRKI LNELSSDVPG VPKIEEERSE EEGTPPSIAT MAVPTSIYQT 190 200 210 220 230 240 STGQYAATGD MPTYQIRAPT AALPQGVVMA ASPGSLHSPQ QLAEEATRKR ELRLMKNREA 250 260 270 280 AKECRRRKKE YVKCLESRVA VLEVQNKKLI EELETLKDIC SPKTDY
	Isoform 18 (CREM-BHIalpha) [UniParc]. Checksum: C69A2CB4707EDEB4	FASTA	285	31,354
	10 20 30 40 50 60 MSKCARKKYI KTNPRQMTME TVESQHDGSI TASLTESKSA HVQTQTGQNS IPALAQVSVA 70 80 90 100 110 120 GSGTRRGSPA VTLVQLPSGQ TIHVQGVIQT PQPWVIQSSE IHTVQVAAIA ETDESAESEG 130 140 150 160 170 180 VIDSHKRREI LSRRPSYRKI LNELSSDVPG VPKIEEERSE EEGTPPSIAT MAVPTSIYQT 190 200 210 220 230 240 STGQYAATGD MPTYQIRAPT AALPQGVVMA ASPGSLHSPQ QLAEEATRKR ELRLMKNREA 250 260 270 280 ARECRRKKKE YVKCLENRVA VLENQNKTLI EELKALKDLY CHKVE
	Isoform 19 (CREM-theta1tau2gamma) (CREM-theta1EFGgammaHIbeta) [UniParc]. Checksum: 16CD469D964E1310	FASTA	282	30,968
	10 20 30 40 50 60 MWWHQHNLCF RRPIEEDYSS GDVEEKVAAI AETDESAESE GVIDSHKRRE ILSRRPSYRK 70 80 90 100 110 120 ILNELSSDVP GVPKIEEERS EEEGTPPSIA TMAVPTSIYQ TSTGQYIAIA QGGTIQISNP 130 140 150 160 170 180 GSDGVQGLQA LTMTNSGAPP PGATIVQYAA QSADGTQQFF VPGSQVVVQD EETELAPSHM 190 200 210 220 230 240 AAATGDMPTY QIRAPTAALP QGVVMAASPG SLHSPQQLAE EATRKRELRL MKNREAAKEC 250 260 270 280 RRRKKEYVKC LESRVAVLEV QNKKLIEELE TLKDICSPKT DY
	Isoform 20 [UniParc]. Checksum: 09B250970C67483E	FASTA	102	11,535
	10 20 30 40 50 60 MAAATGDMPT YQIRAPTAAL PQGVVMAASP GSLHSPQQLA EEATRKRELR LMKNREAARE 70 80 90 100 CRRKKKEYVK CLENRVAVLE NQNKTLIEEL KALKDLYCHK VE
	Isoform 21 [UniParc]. Checksum: 37EE6DBB1C791D37	FASTA	112	12,679
	10 20 30 40 50 60 MNRTQELSGQ LSAATGDMPT YQIRAPTAAL PQGVVMAASP GSLHSPQQLA EEATRKRELR 70 80 90 100 110 LMKNREAARE CRRKKKEYVK CLENRVAVLE NQNKTLIEEL KALKDLYCHK VE
	Isoform 22 [UniParc]. Checksum: 0AC3C47664350D9F	FASTA	137	14,871
	10 20 30 40 50 60 MTMETVESQH DGSITASLTE SKSAHVQTQT GQNSIPALAQ VAAIAETDES AESEGVIDSH 70 80 90 100 110 120 KRREILSRRP SYRKILNELS SDVPGVPKIE EERSEEEGTP PSIATMAVPT SIYQTSTGQY 130 SMYAAIRYDT VLALSLL
	Isoform 23 [UniParc]. Checksum: 1419AC7C6E2D6FD9	FASTA	248	27,549
	10 20 30 40 50 60 MSKCARKKYI KTNPRQMTME TVESQHDGSI TASLTESKSA HVQTQTGQNS IPALAQVAAI 70 80 90 100 110 120 AETDESAESE GVIDSHKRRE ILSRRPSYRK ILNELSSDVP GVPKIEEERS EEEGTPPSIA 130 140 150 160 170 180 TMAVPTSIYQ TSTGQYNEET ELAPSHMAAA TGDMPTYQIR APTAALPQGV VMAASPGSLH 190 200 210 220 230 240 SPQQLAEEAT RKRELRLMKN REAARECRRK KKEYVKCLEN RVAVLENQNK TLIEELKALK DLYCHKVE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA." Fujimoto T., Fujisawa J., Yoshida M. J. Biochem. 115:298-303(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 6; 7; 8; 9 AND 23).
[2]	"cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes." Bodor J., Spetz A.L., Strominger J.L., Habener J.F. Proc. Natl. Acad. Sci. U.S.A. 93:3536-3541(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8), ALTERNATIVE SPLICING (ISOFORMS 6; 7 AND 9), VARIANT ARG-270.
[3]	"Human ICER1, a predicted alternative splice form of CREM, is evident in JEG-3 cells." Brodie C.R., Boland L.M., Orr H.T. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
[4]	"The function of an isoform of hCREM gene in testis development." Lu L., Huang X.Y., Xu M., Xu Z.Y., Li J.M., Zhou Z.M., Sha J.H. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5). Tissue: Testis.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5; 7; 20 AND 21). Tissue: Adrenal gland, Heart, Placenta and Testis.
[6]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 22). Tissue: Brain, Testis and Uterus.
[8]	"Searching for mutations in the human cAMP responsive element modulator (CREM) gene." Vouk K., Lalli E., Scherer S.W., Sassone-Corsi P., Debeljak N., Komel R., Rozman D. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-248.
[9]	"Novel leader exons of the cyclic adenosine 3',5'-monophosphate response element modulator (CREM) gene, transcribed from promoters P3 and P4, are highly testis-specific in primates." Gellersen B., Kempf R., Sandhowe R., Weinbauer G.F., Behr R. Mol. Hum. Reprod. 8:965-976(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-26 (ISOFORM 10), ALTERNATIVE SPLICING (ISOFORMS 5; 10; 11 AND 12).
[10]	"Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript." Masquilier D., Foulkes N.S., Mattei M.-G., Sassone-Corsi P. Cell Growth Differ. 4:931-937(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-361 (ISOFORMS 2 AND 3).
[11]	"Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes." Meyer T.E., Habener J.F. Nucleic Acids Res. 20:6106-6106(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-360 (ISOFORM 4). Tissue: Placenta.
[12]	"Combinations of genetic changes in the human cAMP-responsive element modulator gene: a clue towards understanding some forms of male infertility?" Vouk K., Hudler P., Strmsnik L., Fink M., Majdic G., Zorn B., Lalli E., Sassone-Corsi P., Debeljak N., Komel R., Rozman D. Mol. Hum. Reprod. 11:567-574(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 262-361, TISSUE SPECIFICITY.
[13]	"Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis." Pati D., Meistrich M.L., Plon S.E. Mol. Cell. Biol. 19:5001-5013(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH CDC34, UBIQUITINATION.
[14]	"CREM activator and repressor isoforms in human testis: sequence variations and inaccurate splicing during impaired spermatogenesis." Behr R., Weinbauer G.F. Mol. Hum. Reprod. 6:967-972(2000) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORMS 2; 4; 13; 15; 17 AND 18), TISSUE SPECIFICITY.
[15]	"Different CREM-isoform gene expression between equine and human normal and impaired spermatogenesis." Bloecher S., Behr R., Weinbauer G.F., Bergmann M., Steger K. Theriogenology 60:1357-1369(2003) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORMS 5; 12; 14; 16 AND 19), TISSUE SPECIFICITY.
[16]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-287; SER-290 AND SER-293, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[17]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-287 AND SER-293, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[18]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D14825 mRNA. Translation: BAA03562.1. D14826 mRNA. Translation: BAA03564.1. D14826 mRNA. Translation: BAA03565.1. D14826 mRNA. Translation: BAA03566.1. D14826 mRNA. Translation: BAA03567.1. U44836 mRNA. Translation: AAB03751.1. Sequence problems. AF069065 mRNA. Translation: AAC19383.1. AY292864 mRNA. Translation: AAP44115.1. AK289379 mRNA. Translation: BAF82068.1. AK290612 mRNA. Translation: BAF83301.1. AK291566 mRNA. Translation: BAF84255.1. AK301906 mRNA. Translation: BAG63333.1. AL117336, AL157783 Genomic DNA. Translation: CAH72495.1. AL117336, AL157783 Genomic DNA. Translation: CAH72496.1. Sequence problems. AL117336, AL157783 Genomic DNA. Translation: CAH72497.1. Sequence problems. AL117336, AL157783 Genomic DNA. Translation: CAH72499.1. AL117336, AL157783 Genomic DNA. Translation: CAH72500.1. AL157783, AL117336 Genomic DNA. Translation: CAI12137.1. AL157783, AL117336 Genomic DNA. Translation: CAI12138.1. Sequence problems. AL157783, AL117336 Genomic DNA. Translation: CAI12139.1. Sequence problems. AL157783 Genomic DNA. Translation: CAI12141.1. AL157783 Genomic DNA. Translation: CAI12143.1. Sequence problems. AL157783, AL117336 Genomic DNA. Translation: CAI12145.1. AL157783, AL117336 Genomic DNA. Translation: CAI12147.1. CH471072 Genomic DNA. Translation: EAW85918.1. BC017117 mRNA. Translation: AAH17117.1. BC066342 mRNA. Translation: AAH66342.1. BC090051 mRNA. Translation: AAH90051.1. AF213899 , AF212158, AF213897, AF213898 Genomic DNA. Translation: AAF68266.2. Sequence problems. AF417234 mRNA. Translation: AAN32656.1. S68271 mRNA. Translation: AAC60616.2. S68134 mRNA. Translation: AAC60617.2. Z15159 mRNA. Translation: CAA78858.1. AF217318, AF214665 Genomic DNA. Translation: AAF66158.2. AF217318, AF214665 Genomic DNA. Translation: AAF68682.1.
IPI	IPI00014322. IPI00216396. IPI00337311. IPI00337364. IPI00337365. IPI00337613. IPI00375605. IPI00375650. IPI00376141. IPI00377146. IPI00641528. IPI00748922. IPI00847200. IPI00847295. IPI00847382. IPI00847411. IPI00847491. IPI00847704. IPI00847842. IPI00848007. IPI00848206. IPI00848332.
PIR	JC2087. JC6135. JX0307. S26685.
RefSeq	NP_001254491.1. NM_001267562.1. NP_001254493.1. NM_001267564.1. NP_001254499.1. NM_001267570.1. NP_001872.3. NM_001881.3. NP_853549.1. NM_181571.2. NP_874386.1. NM_182717.1. NP_874387.1. NM_182718.1. NP_874388.1. NM_182719.1. NP_874389.1. NM_182720.1. NP_874390.1. NM_182721.1. NP_874392.1. NM_182723.1. NP_874393.1. NM_182724.1. NP_877570.1. NM_182769.2. NP_877571.1. NM_182770.2. NP_877572.1. NM_182771.1. NP_877573.1. NM_182772.1. NP_898829.1. NM_183011.1. NP_898830.1. NM_183012.1. NP_898831.1. NM_183013.2.
UniGene	Hs.200250. Hs.686182.
3D structure databases
ProteinModelPortal	Q03060.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q03060. 6 interactions.
PTM databases
PhosphoSite	Q03060.
Polymorphism databases
DMDM	259016392.
Proteomic databases
PaxDb	Q03060.
PRIDE	Q03060.
Protocols and materials databases
DNASU	1390.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000333809; ENSP00000333055; ENSG00000095794. ENST00000342105; ENSP00000341875; ENSG00000095794. ENST00000345491; ENSP00000265372; ENSG00000095794. ENST00000354759; ENSP00000346804; ENSG00000095794. ENST00000356917; ENSP00000349387; ENSG00000095794. ENST00000361599; ENSP00000354593; ENSG00000095794. ENST00000374722; ENSP00000363854; ENSG00000095794. ENST00000374726; ENSP00000363858; ENSG00000095794. ENST00000395887; ENSP00000379225; ENSG00000095794. ENST00000395895; ENSP00000379232; ENSG00000095794. ENST00000473940; ENSP00000420681; ENSG00000095794. ENST00000474931; ENSP00000417562; ENSG00000095794. ENST00000479070; ENSP00000420511; ENSG00000095794. ENST00000487763; ENSP00000417807; ENSG00000095794. ENST00000488328; ENSP00000417460; ENSG00000095794. ENST00000488741; ENSP00000419075; ENSG00000095794. ENST00000489321; ENSP00000419924; ENSG00000095794.
GeneID	1390.
KEGG	hsa:1390.
UCSC	uc001iyb.3. human. uc001iyf.3. human. uc001iyh.3. human. uc001iyl.3. human. uc001iyn.3. human.
Organism-specific databases
CTD	1390.
GeneCards	GC10P035415.
HGNC	HGNC:2352. CREM.
HPA	CAB018352. HPA001818.
MIM	123812. gene.
neXtProt	NX_Q03060.
PharmGKB	PA26871.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG300199.
HOGENOM	HOG000007365.
HOVERGEN	HBG011077.
InParanoid	Q03060.
KO	K09052.
OMA	ESESAHM.
Gene expression databases
ArrayExpress	Q03060.
Bgee	Q03060.
Genevestigator	Q03060.
GermOnline	ENSG00000095794. Homo sapiens.
Family and domain databases
InterPro	IPR004827. bZIP. IPR003102. Coactivator_CBP_pKID. IPR001630. Leuzip_CREB. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. PF02173. pKID. 1 hit. [Graphical view]
PRINTS	PR00041. LEUZIPPRCREB.
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. PS50953. KID. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CREM. human.
GenomeRNAi	1390.
NextBio	5649.
SOURCE	Search...

Entry information

Entry name

CREM_HUMAN

Accession

Primary (citable) accession number: Q03060
Secondary accession number(s): A8K014 , A8K3J7, A8K6A1, B4DXC1, O75519, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A8, Q5W1A9, Q5W1B0, Q5W1B2, Q7Z2Q6, Q8IVD4, Q96AG7, Q9NZ98, Q9NZ99, Q9NZB9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	September 22, 2009
Last modified:	May 1, 2013
This is version 137 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.