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Q03060

- CREM_HUMAN

UniProt

Q03060 - CREM_HUMAN

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Protein
cAMP-responsive element modulator
Gene
CREM
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation By similarity.1 Publication

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. cAMP response element binding protein binding Source: UniProtKB
  3. protein binding Source: UniProtKB
  4. sequence-specific DNA binding Source: InterPro
  5. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. glycosphingolipid metabolic process Source: Ensembl
  3. multicellular organismal development Source: UniProtKB-KW
  4. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  5. regulation of transcription, DNA-templated Source: UniProtKB
  6. signal transduction Source: ProtInc
  7. spermatogenesis Source: UniProtKB-KW
  8. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Spermatogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiQ03060.

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-responsive element modulator
Alternative name(s):
Inducible cAMP early repressor
Short name:
ICER
Gene namesi
Name:CREM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:2352. CREM.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB
  2. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26871.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361cAMP-responsive element modulator
PRO_0000076607Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei287 – 2871Phosphoserine2 Publications
Modified residuei290 – 2901Phosphoserine1 Publication
Modified residuei293 – 2931Phosphoserine2 Publications

Post-translational modificationi

Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome.
Stimulated by phosphorylation By similarity.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ03060.
PaxDbiQ03060.
PRIDEiQ03060.

PTM databases

PhosphoSiteiQ03060.

Expressioni

Tissue specificityi

Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.3 Publications

Gene expression databases

ArrayExpressiQ03060.
BgeeiQ03060.
GenevestigatoriQ03060.

Organism-specific databases

HPAiCAB018352.
HPA001818.

Interactioni

Subunit structurei

Binds DNA as a dimer. Interacts with FHL5 By similarity. Interacts with CDC34.1 Publication

Protein-protein interaction databases

BioGridi107780. 19 interactions.
IntActiQ03060. 6 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ03060.
SMRiQ03060. Positions 123-149, 304-358.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini104 – 16360KID
Add
BLAST
Domaini302 – 36160bZIP
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni303 – 32826Basic motif By similarity
Add
BLAST
Regioni330 – 35122Leucine-zipper By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the bZIP family.

Phylogenomic databases

eggNOGiNOG300199.
HOGENOMiHOG000007365.
HOVERGENiHBG011077.
InParanoidiQ03060.
KOiK09052.
OMAiESESAHM.
PhylomeDBiQ03060.
TreeFamiTF106464.

Family and domain databases

InterProiIPR004827. bZIP.
IPR003102. Coactivator_CBP_pKID.
IPR001630. Leuzip_CREB.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
PF02173. pKID. 1 hit.
[Graphical view]
PRINTSiPR00041. LEUZIPPRCREB.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
PS50953. KID. 1 hit.
[Graphical view]

Sequences (29)i

Sequence statusi: Complete.

This entry describes 29 isoformsi produced by alternative promoter usage and alternative splicing. Align

Isoform 1 (identifier: Q03060-5) [UniParc]FASTAAdd to Basket

Also known as: CREM-BCEFGgammaHIbeta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSKCARKKYI KTNPRQMTME TVESQHDGSI TASLTESKSA HVQTQTGQNS    50
IPALAQVSVA GSGTRRGSPA VTLVQLPSGQ TIHVQGVIQT PQPWVIQSSE 100
IHTVQVAAIA ETDESAESEG VIDSHKRREI LSRRPSYRKI LNELSSDVPG 150
VPKIEEERSE EEGTPPSIAT MAVPTSIYQT STGQYIAIAQ GGTIQISNPG 200
SDGVQGLQAL TMTNSGAPPP GATIVQYAAQ SADGTQQFFV PGSQVVVQDE 250
ETELAPSHMA AATGDMPTYQ IRAPTAALPQ GVVMAASPGS LHSPQQLAEE 300
ATRKRELRLM KNREAAKECR RRKKEYVKCL ESRVAVLEVQ NKKLIEELET 350
LKDICSPKTD Y 361

Note: Produced by alternative promoter usage.

Length:361
Mass (Da):38,940
Last modified:September 22, 2009 - v5
Checksum:iC1AF0DF57DFB0DAD
GO
Isoform 2 (identifier: Q03060-1) [UniParc]FASTAAdd to Basket

Also known as: Beta, CREM-BCEFGHIbeta

The sequence of this isoform differs from the canonical sequence as follows:
     249-260: Missing.

Note: Produced by alternative splicing of isoform 1. Activator.

Show »
Length:349
Mass (Da):37,628
Checksum:iF6B8D2BF073C00C0
GO
Isoform 3 (identifier: Q03060-6) [UniParc]FASTAAdd to Basket

Also known as: CREM-BCEFGIalpha, Tau

The sequence of this isoform differs from the canonical sequence as follows:
     249-260: Missing.
     317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE

Note: Produced by alternative splicing of isoform 1. Activator.

Show »
Length:348
Mass (Da):37,577
Checksum:i859AA3D3C2EB7D59
GO
Isoform 4 (identifier: Q03060-2) [UniParc]FASTAAdd to Basket

Also known as: Alpha, CREM-BEFHIb, CREM-gamma

The sequence of this isoform differs from the canonical sequence as follows:
     58-106: Missing.
     186-248: Missing.
     249-260: Missing.
     261-261: A → T

Note: Produced by alternative splicing of isoform 1.

Show »
Length:237
Mass (Da):26,320
Checksum:i89C1F372F6E60AF0
GO
Isoform 5 (identifier: Q03060-7) [UniParc]FASTAAdd to Basket

Also known as: CREM-theta2tau-gamma, CREM-theta2EFGHIb

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     105-105: Q → M
     249-260: Missing.

Note: Produced by alternative promoter usage. Activator.

Show »
Length:245
Mass (Da):26,513
Checksum:i244821D6A4AD32CD
GO
Isoform 6 (identifier: Q03060-8) [UniParc]FASTAAdd to Basket

Also known as: CREM2alpha-a, IcergammaHIalpha, ICER1, ICERI

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     241-248: PGSQVVVQ → MAVTGDDT
     317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE

Note: Produced by alternative promoter usage. Repressor.

Show »
Length:120
Mass (Da):13,435
Checksum:i723844391B15C4A8
GO
Isoform 7 (identifier: Q03060-9) [UniParc]FASTAAdd to Basket

Also known as: CREM2alpha-b, IcerHIalpha, ICERIgamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     241-248: PGSQVVVQ → MAVTGDDT
     249-260: Missing.
     317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE

Note: Produced by alternative splicing of isoform 6. Repressor.

Show »
Length:108
Mass (Da):12,124
Checksum:iBF84129AA7183E40
GO
Isoform 8 (identifier: Q03060-10) [UniParc]FASTAAdd to Basket

Also known as: CREM 2beta-a, IcergammaHIbeta, ICERII

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     241-248: PGSQVVVQ → MAVTGDDT

Note: Produced by alternative splicing of isoform 6. Repressor.

Show »
Length:121
Mass (Da):13,486
Checksum:i6EFF7058EDE5FE79
GO
Isoform 9 (identifier: Q03060-11) [UniParc]FASTAAdd to Basket

Also known as: CREM 2beta-b, IcerHIbeta, ICERIIgamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     241-248: PGSQVVVQ → MAVTGDDT
     249-260: Missing.

Note: Produced by alternative splicing of isoform 6. Repressor.

Show »
Length:109
Mass (Da):12,175
Checksum:iE1B2CC0E4E59F383
GO
Isoform 10 (identifier: Q03060-12) [UniParc]FASTAAdd to Basket

Also known as: CREMtheta1tau2beta, CREM-theta1EFGHIbeta

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     105-105: Q → MWWHQHNLCFRRPIEEDYSSGDVEEK
     249-260: Missing.

Note: Produced by alternative promoter usage. Activator.

Show »
Length:270
Mass (Da):29,656
Checksum:i10A26E01D01D8FDC
GO
Isoform 11 (identifier: Q03060-13) [UniParc]FASTAAdd to Basket

Also known as: CREM-theta1beta, CREM-theta1EFHIbeta

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     105-105: Q → MWWHQHNLCFRRPIEEDYSSGDVEEK
     186-248: Missing.
     261-261: A → T

Note: Produced by alternative splicing of isoform 10. Repressor.

Show »
Length:219
Mass (Da):24,774
Checksum:iB7AB068F482F3C29
GO
Isoform 12 (identifier: Q03060-14) [UniParc]FASTAAdd to Basket

Also known as: CREM-theta2beta, CREM-theta2EFHIb, CREM-theta2-gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     105-105: Q → M
     186-248: Missing.
     261-261: A → T

Note: Produced by alternative splicing of isoform 5. Repressor.

Show »
Length:194
Mass (Da):21,630
Checksum:iFA038D9739438F76
GO
Isoform 13 (identifier: Q03060-15) [UniParc]FASTAAdd to Basket

Also known as: CREM-BEFGgammaHIbeta

The sequence of this isoform differs from the canonical sequence as follows:
     58-106: Missing.

Note: Produced by alternative splicing of isoform 1. Activator.

Show »
Length:312
Mass (Da):33,825
Checksum:i1C129B0200C8A1F7
GO
Isoform 14 (identifier: Q03060-16) [UniParc]FASTAAdd to Basket

Also known as: CREM-tau2-gamma, CREM-BEFGHIbeta

The sequence of this isoform differs from the canonical sequence as follows:
     58-106: Missing.
     249-260: Missing.

Note: Produced by alternative splicing of isoform 1. Activator.

Show »
Length:300
Mass (Da):32,514
Checksum:iC759C78AB56E0FC5
GO
Isoform 15 (identifier: Q03060-17) [UniParc]FASTAAdd to Basket

Also known as: CREM-BGHIbeta

The sequence of this isoform differs from the canonical sequence as follows:
     58-106: Missing.
     107-185: Missing.
     249-260: Missing.

Note: Produced by alternative splicing of isoform 1. Repressor.

Show »
Length:221
Mass (Da):23,839
Checksum:i70AD0E7C1AD98BC2
GO
Isoform 16 (identifier: Q03060-19) [UniParc]FASTAAdd to Basket

Also known as: CREM-deltaC-G, CREM-BgammaHIbeta

The sequence of this isoform differs from the canonical sequence as follows:
     58-106: Missing.
     107-185: Missing.
     186-248: Missing.

Note: Produced by alternative splicing of isoform 1. Repressor.

Show »
Length:170
Mass (Da):18,927
Checksum:i112F9B233752BF64
GO
Isoform 17 (identifier: Q03060-20) [UniParc]FASTAAdd to Basket

Also known as: CREM-BHIbeta

The sequence of this isoform differs from the canonical sequence as follows:
     186-248: Missing.
     249-260: Missing.

Note: Produced by alternative splicing of isoform 1. Repressor.

Show »
Length:286
Mass (Da):31,405
Checksum:i7E0BD230608E9563
GO
Isoform 18 (identifier: Q03060-21) [UniParc]FASTAAdd to Basket

Also known as: CREM-BHIalpha

The sequence of this isoform differs from the canonical sequence as follows:
     186-248: Missing.
     249-260: Missing.
     317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE

Note: Produced by alternative splicing of isoform 1. Repressor.

Show »
Length:285
Mass (Da):31,354
Checksum:iC69A2CB4707EDEB4
GO
Isoform 19 (identifier: Q03060-22) [UniParc]FASTAAdd to Basket

Also known as: CREM-theta1tau2gamma, CREM-theta1EFGgammaHIbeta

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     105-105: Q → MWWHQHNLCFRRPIEEDYSSGDVEEK

Note: Produced by alternative splicing of isoform 10. Activator.

Show »
Length:282
Mass (Da):30,968
Checksum:i16CD469D964E1310
GO
Isoform 20 (identifier: Q03060-23) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     105-258: Missing.
     317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE

Note: No experimental confirmation available.

Show »
Length:102
Mass (Da):11,535
Checksum:i09B250970C67483E
GO
Isoform 21 (identifier: Q03060-24) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MSKCARKKYIKT → MNRTQELSGQLS
     13-260: Missing.
     317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE

Note: No experimental confirmation available.

Show »
Length:112
Mass (Da):12,679
Checksum:i37EE6DBB1C791D37
GO
Isoform 22 (identifier: Q03060-25) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.
     58-106: Missing.
     186-202: IAIAQGGTIQISNPGSD → SMYAAIRYDTVLALSLL
     203-361: Missing.

Note: No experimental confirmation available.

Show »
Length:137
Mass (Da):14,871
Checksum:i0AC3C47664350D9F
GO
Isoform 23 (identifier: Q03060-26) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-106: Missing.
     186-248: Missing.
     249-249: D → N
     317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE

Show »
Length:248
Mass (Da):27,549
Checksum:i1419AC7C6E2D6FD9
GO
Isoform 24 (identifier: Q03060-27) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-248: Missing.
     249-260: DEETELAPSHMA → MNRTQELSGQLS

Note: Produced by alternative splicing.

Show »
Length:113
Mass (Da):12,730
Checksum:iA42AA6716FE292A0
GO
Isoform 25 (identifier: Q03060-28) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-211: Missing.
     249-260: Missing.

Note: Produced by alternative splicing.

Show »
Length:138
Mass (Da):15,116
Checksum:iAC08D42670DFA05C
GO
Isoform 26 (identifier: Q03060-29) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-236: Missing.
     237-248: QFFVPGSQVVVQ → MNRTQELSGQLS

Note: Produced by alternative splicing.

Show »
Length:125
Mass (Da):14,041
Checksum:i848D9FD6E95B2AD1
GO
Isoform 27 (identifier: Q03060-30) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.
     58-106: Missing.
     186-260: Missing.
     261-261: A → T

Note: Produced by alternative splicing.

Show »
Length:221
Mass (Da):24,385
Checksum:i59881FC7317C817C
GO
Isoform 28 (identifier: Q03060-31) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-106: Missing.
     249-260: Missing.
     317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE

Note: Produced by alternative splicing. No experimental confirmation available.

Show »
Length:299
Mass (Da):32,463
Checksum:i148F966190E4787C
GO
Isoform 29 (identifier: Q03060-32) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-106: Missing.
     186-260: Missing.
     261-261: A → T
     317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE

Note: Produced by alternative splicing. No experimental confirmation available.

Show »
Length:236
Mass (Da):26,269
Checksum:iDCBB6E2218E14D07
GO

Sequence cautioni

The sequence AAB03751.1 differs from that shown. Reason: Erroneous termination at position 361. Translated as Tyr.
The sequence AAF68266.2 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti270 – 2701Q → R.1 Publication
Corresponds to variant rs1804604 [ dbSNP | Ensembl ].
VAR_055561

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 248248Missing in isoform 24.
VSP_046870Add
BLAST
Alternative sequencei1 – 240240Missing in isoform 6, isoform 7, isoform 8 and isoform 9.
VSP_026075Add
BLAST
Alternative sequencei1 – 236236Missing in isoform 26.
VSP_046871Add
BLAST
Alternative sequencei1 – 211211Missing in isoform 25.
VSP_046872Add
BLAST
Alternative sequencei1 – 104104Missing in isoform 5, isoform 10, isoform 11, isoform 12, isoform 19 and isoform 20.
VSP_025035Add
BLAST
Alternative sequencei1 – 1616Missing in isoform 22 and isoform 27.
VSP_043782Add
BLAST
Alternative sequencei1 – 1212MSKCA…KYIKT → MNRTQELSGQLS in isoform 21.
VSP_043713Add
BLAST
Alternative sequencei13 – 260248Missing in isoform 21.
VSP_043714Add
BLAST
Alternative sequencei58 – 10649Missing in isoform 4, isoform 13, isoform 14, isoform 15, isoform 16, isoform 22, isoform 23, isoform 27, isoform 28 and isoform 29.
VSP_000599Add
BLAST
Alternative sequencei105 – 258154Missing in isoform 20.
VSP_043580Add
BLAST
Alternative sequencei105 – 1051Q → MWWHQHNLCFRRPIEEDYSS GDVEEK in isoform 10, isoform 11 and isoform 19.
VSP_026076
Alternative sequencei105 – 1051Q → M in isoform 5 and isoform 12.
VSP_025036
Alternative sequencei107 – 18579Missing in isoform 15 and isoform 16.
VSP_026077Add
BLAST
Alternative sequencei186 – 26075Missing in isoform 27 and isoform 29.
VSP_046873Add
BLAST
Alternative sequencei186 – 24863Missing in isoform 4, isoform 11, isoform 12, isoform 16, isoform 17, isoform 18 and isoform 23.
VSP_000600Add
BLAST
Alternative sequencei186 – 20217IAIAQ…NPGSD → SMYAAIRYDTVLALSLL in isoform 22.
VSP_043783Add
BLAST
Alternative sequencei203 – 361159Missing in isoform 22.
VSP_043784Add
BLAST
Alternative sequencei237 – 24812QFFVP…QVVVQ → MNRTQELSGQLS in isoform 26.
VSP_046874Add
BLAST
Alternative sequencei241 – 2488PGSQVVVQ → MAVTGDDT in isoform 6, isoform 7, isoform 8 and isoform 9.
VSP_026078
Alternative sequencei249 – 26012Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 7, isoform 9, isoform 10, isoform 14, isoform 15, isoform 17, isoform 18, isoform 25 and isoform 28.
VSP_025037Add
BLAST
Alternative sequencei249 – 26012DEETE…PSHMA → MNRTQELSGQLS in isoform 24.
VSP_046875Add
BLAST
Alternative sequencei249 – 2491D → N in isoform 23.
VSP_045234
Alternative sequencei261 – 2611A → T in isoform 4, isoform 11, isoform 12, isoform 27 and isoform 29.
VSP_000601
Alternative sequencei317 – 36145KECRR…PKTDY → RECRRKKKEYVKCLENRVAV LENQNKTLIEELKALKDLYC HKVE in isoform 3, isoform 6, isoform 7, isoform 18, isoform 20, isoform 21, isoform 23, isoform 28 and isoform 29.
VSP_025038Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491N → I in AAC60616. 1 Publication
Sequence conflicti49 – 491N → I in AAC60617. 1 Publication
Sequence conflicti55 – 551A → R in CAA78858. 1 Publication
Sequence conflicti57 – 615VSVAG → CSELR in AAC60616. 1 Publication
Sequence conflicti57 – 615VSVAG → CSELR in AAC60617. 1 Publication
Sequence conflicti292 – 2921H → R in BAA03562. 1 Publication
Sequence conflicti292 – 2921H → R in BAA03564. 1 Publication
Sequence conflicti292 – 2921H → R in BAA03565. 1 Publication
Sequence conflicti292 – 2921H → R in BAA03566. 1 Publication
Sequence conflicti292 – 2921H → R in BAA03567. 1 Publication
Isoform 6 (identifier: Q03060-8)
Sequence conflicti7 – 71D → E in AAC19383. 1 Publication
Sequence conflicti112 – 1121K → R in AAC19383. 1 Publication
Isoform 8 (identifier: Q03060-10)
Sequence conflicti7 – 71D → E in AAB03751. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D14825 mRNA. Translation: BAA03562.1.
D14826 mRNA. Translation: BAA03564.1.
D14826 mRNA. Translation: BAA03565.1.
D14826 mRNA. Translation: BAA03566.1.
D14826 mRNA. Translation: BAA03567.1.
U44836 mRNA. Translation: AAB03751.1. Sequence problems.
AF069065 mRNA. Translation: AAC19383.1.
AY292864 mRNA. Translation: AAP44115.1.
AK289379 mRNA. Translation: BAF82068.1.
AK290612 mRNA. Translation: BAF83301.1.
AK291566 mRNA. Translation: BAF84255.1.
AK301906 mRNA. Translation: BAG63333.1.
AL117336 Genomic DNA. No translation available.
AL157783 Genomic DNA. No translation available.
CH471072 Genomic DNA. Translation: EAW85917.1.
CH471072 Genomic DNA. Translation: EAW85918.1.
BC017117 mRNA. Translation: AAH17117.1.
BC066342 mRNA. Translation: AAH66342.1.
BC090051 mRNA. Translation: AAH90051.1.
AF213899
, AF212158, AF213897, AF213898 Genomic DNA. Translation: AAF68266.2. Sequence problems.
AF417234 mRNA. Translation: AAN32656.1.
S68271 mRNA. Translation: AAC60616.2.
S68134 mRNA. Translation: AAC60617.2.
Z15159 mRNA. Translation: CAA78858.1.
AF217318, AF214665 Genomic DNA. Translation: AAF66158.2.
AF217318, AF214665 Genomic DNA. Translation: AAF68682.1.
CCDSiCCDS31181.1. [Q03060-32]
CCDS53517.1. [Q03060-10]
CCDS53518.1. [Q03060-9]
CCDS53519.1. [Q03060-11]
CCDS53520.1. [Q03060-27]
CCDS53521.1. [Q03060-23]
CCDS58074.1. [Q03060-22]
CCDS58075.1. [Q03060-28]
CCDS58076.1. [Q03060-29]
CCDS7180.1. [Q03060-16]
CCDS7181.1. [Q03060-31]
CCDS7182.1. [Q03060-26]
CCDS7183.1. [Q03060-30]
CCDS7184.1. [Q03060-25]
CCDS7185.1. [Q03060-12]
CCDS7186.1. [Q03060-7]
CCDS7187.1. [Q03060-8]
CCDS7188.1. [Q03060-24]
PIRiJC2087.
JC6135.
JX0307.
S26685.
RefSeqiNP_001254491.1. NM_001267562.1.
NP_001254493.1. NM_001267564.1. [Q03060-22]
NP_001254496.1. NM_001267567.1. [Q03060-28]
NP_001254499.1. NM_001267570.1. [Q03060-29]
NP_001872.3. NM_001881.3. [Q03060-25]
NP_853549.1. NM_181571.2. [Q03060-16]
NP_874386.1. NM_182717.1. [Q03060-8]
NP_874387.1. NM_182718.1. [Q03060-11]
NP_874388.1. NM_182719.1. [Q03060-10]
NP_874389.1. NM_182720.1. [Q03060-9]
NP_874390.1. NM_182721.1. [Q03060-24]
NP_874392.1. NM_182723.1. [Q03060-23]
NP_874393.1. NM_182724.1. [Q03060-27]
NP_877570.1. NM_182769.2. [Q03060-7]
NP_877571.1. NM_182770.2.
NP_877572.1. NM_182771.1. [Q03060-12]
NP_877573.1. NM_182772.1.
NP_898829.1. NM_183011.1. [Q03060-31]
NP_898830.1. NM_183012.1. [Q03060-32]
NP_898831.1. NM_183013.2. [Q03060-26]
NP_898883.1. NM_183060.2. [Q03060-30]
XP_006717441.1. XM_006717378.1. [Q03060-16]
XP_006717442.1. XM_006717379.1. [Q03060-31]
XP_006717445.1. XM_006717382.1. [Q03060-2]
XP_006717446.1. XM_006717383.1. [Q03060-32]
XP_006717448.1. XM_006717385.1. [Q03060-28]
UniGeneiHs.200250.

Genome annotation databases

EnsembliENST00000333809; ENSP00000333055; ENSG00000095794. [Q03060-6]
ENST00000337656; ENSP00000337138; ENSG00000095794. [Q03060-31]
ENST00000342105; ENSP00000341875; ENSG00000095794. [Q03060-7]
ENST00000345491; ENSP00000265372; ENSG00000095794. [Q03060-16]
ENST00000348787; ENSP00000345384; ENSG00000095794. [Q03060-30]
ENST00000354759; ENSP00000346804; ENSG00000095794. [Q03060-26]
ENST00000356917; ENSP00000349387; ENSG00000095794. [Q03060-9]
ENST00000361599; ENSP00000354593; ENSG00000095794. [Q03060-12]
ENST00000374726; ENSP00000363858; ENSG00000095794. [Q03060-25]
ENST00000374728; ENSP00000363860; ENSG00000095794. [Q03060-30]
ENST00000374734; ENSP00000363866; ENSG00000095794. [Q03060-32]
ENST00000395887; ENSP00000379225; ENSG00000095794. [Q03060-22]
ENST00000395895; ENSP00000379232; ENSG00000095794. [Q03060-5]
ENST00000463314; ENSP00000418336; ENSG00000095794. [Q03060-28]
ENST00000468236; ENSP00000419810; ENSG00000095794. [Q03060-29]
ENST00000473940; ENSP00000420681; ENSG00000095794. [Q03060-8]
ENST00000474931; ENSP00000417562; ENSG00000095794. [Q03060-24]
ENST00000479070; ENSP00000420511; ENSG00000095794. [Q03060-15]
ENST00000487763; ENSP00000417807; ENSG00000095794. [Q03060-10]
ENST00000488328; ENSP00000417460; ENSG00000095794. [Q03060-11]
ENST00000488741; ENSP00000419075; ENSG00000095794. [Q03060-23]
ENST00000489321; ENSP00000419924; ENSG00000095794. [Q03060-25]
ENST00000490511; ENSP00000417327; ENSG00000095794. [Q03060-27]
GeneIDi1390.
KEGGihsa:1390.
UCSCiuc001ixx.3. human. [Q03060-25]
uc001iya.3. human.
uc001iyb.3. human. [Q03060-16]
uc001iyc.3. human.
uc001iyf.3. human. [Q03060-12]
uc001iyh.3. human. [Q03060-7]
uc001iyl.3. human. [Q03060-10]
uc001iym.3. human. [Q03060-8]
uc001iyn.3. human. [Q03060-11]
uc001iyo.3. human. [Q03060-9]
uc001iyp.3. human. [Q03060-23]
uc001iyr.3. human. [Q03060-24]
uc031pty.1. human. [Q03060-22]

Polymorphism databases

DMDMi259016392.

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D14825 mRNA. Translation: BAA03562.1 .
D14826 mRNA. Translation: BAA03564.1 .
D14826 mRNA. Translation: BAA03565.1 .
D14826 mRNA. Translation: BAA03566.1 .
D14826 mRNA. Translation: BAA03567.1 .
U44836 mRNA. Translation: AAB03751.1 . Sequence problems.
AF069065 mRNA. Translation: AAC19383.1 .
AY292864 mRNA. Translation: AAP44115.1 .
AK289379 mRNA. Translation: BAF82068.1 .
AK290612 mRNA. Translation: BAF83301.1 .
AK291566 mRNA. Translation: BAF84255.1 .
AK301906 mRNA. Translation: BAG63333.1 .
AL117336 Genomic DNA. No translation available.
AL157783 Genomic DNA. No translation available.
CH471072 Genomic DNA. Translation: EAW85917.1 .
CH471072 Genomic DNA. Translation: EAW85918.1 .
BC017117 mRNA. Translation: AAH17117.1 .
BC066342 mRNA. Translation: AAH66342.1 .
BC090051 mRNA. Translation: AAH90051.1 .
AF213899
, AF212158 , AF213897 , AF213898 Genomic DNA. Translation: AAF68266.2 . Sequence problems.
AF417234 mRNA. Translation: AAN32656.1 .
S68271 mRNA. Translation: AAC60616.2 .
S68134 mRNA. Translation: AAC60617.2 .
Z15159 mRNA. Translation: CAA78858.1 .
AF217318 , AF214665 Genomic DNA. Translation: AAF66158.2 .
AF217318 , AF214665 Genomic DNA. Translation: AAF68682.1 .
CCDSi CCDS31181.1. [Q03060-32 ]
CCDS53517.1. [Q03060-10 ]
CCDS53518.1. [Q03060-9 ]
CCDS53519.1. [Q03060-11 ]
CCDS53520.1. [Q03060-27 ]
CCDS53521.1. [Q03060-23 ]
CCDS58074.1. [Q03060-22 ]
CCDS58075.1. [Q03060-28 ]
CCDS58076.1. [Q03060-29 ]
CCDS7180.1. [Q03060-16 ]
CCDS7181.1. [Q03060-31 ]
CCDS7182.1. [Q03060-26 ]
CCDS7183.1. [Q03060-30 ]
CCDS7184.1. [Q03060-25 ]
CCDS7185.1. [Q03060-12 ]
CCDS7186.1. [Q03060-7 ]
CCDS7187.1. [Q03060-8 ]
CCDS7188.1. [Q03060-24 ]
PIRi JC2087.
JC6135.
JX0307.
S26685.
RefSeqi NP_001254491.1. NM_001267562.1.
NP_001254493.1. NM_001267564.1. [Q03060-22 ]
NP_001254496.1. NM_001267567.1. [Q03060-28 ]
NP_001254499.1. NM_001267570.1. [Q03060-29 ]
NP_001872.3. NM_001881.3. [Q03060-25 ]
NP_853549.1. NM_181571.2. [Q03060-16 ]
NP_874386.1. NM_182717.1. [Q03060-8 ]
NP_874387.1. NM_182718.1. [Q03060-11 ]
NP_874388.1. NM_182719.1. [Q03060-10 ]
NP_874389.1. NM_182720.1. [Q03060-9 ]
NP_874390.1. NM_182721.1. [Q03060-24 ]
NP_874392.1. NM_182723.1. [Q03060-23 ]
NP_874393.1. NM_182724.1. [Q03060-27 ]
NP_877570.1. NM_182769.2. [Q03060-7 ]
NP_877571.1. NM_182770.2.
NP_877572.1. NM_182771.1. [Q03060-12 ]
NP_877573.1. NM_182772.1.
NP_898829.1. NM_183011.1. [Q03060-31 ]
NP_898830.1. NM_183012.1. [Q03060-32 ]
NP_898831.1. NM_183013.2. [Q03060-26 ]
NP_898883.1. NM_183060.2. [Q03060-30 ]
XP_006717441.1. XM_006717378.1. [Q03060-16 ]
XP_006717442.1. XM_006717379.1. [Q03060-31 ]
XP_006717445.1. XM_006717382.1. [Q03060-2 ]
XP_006717446.1. XM_006717383.1. [Q03060-32 ]
XP_006717448.1. XM_006717385.1. [Q03060-28 ]
UniGenei Hs.200250.

3D structure databases

ProteinModelPortali Q03060.
SMRi Q03060. Positions 123-149, 304-358.
ModBasei Search...

Protein-protein interaction databases

BioGridi 107780. 19 interactions.
IntActi Q03060. 6 interactions.

PTM databases

PhosphoSitei Q03060.

Polymorphism databases

DMDMi 259016392.

Proteomic databases

MaxQBi Q03060.
PaxDbi Q03060.
PRIDEi Q03060.

Protocols and materials databases

DNASUi 1390.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000333809 ; ENSP00000333055 ; ENSG00000095794 . [Q03060-6 ]
ENST00000337656 ; ENSP00000337138 ; ENSG00000095794 . [Q03060-31 ]
ENST00000342105 ; ENSP00000341875 ; ENSG00000095794 . [Q03060-7 ]
ENST00000345491 ; ENSP00000265372 ; ENSG00000095794 . [Q03060-16 ]
ENST00000348787 ; ENSP00000345384 ; ENSG00000095794 . [Q03060-30 ]
ENST00000354759 ; ENSP00000346804 ; ENSG00000095794 . [Q03060-26 ]
ENST00000356917 ; ENSP00000349387 ; ENSG00000095794 . [Q03060-9 ]
ENST00000361599 ; ENSP00000354593 ; ENSG00000095794 . [Q03060-12 ]
ENST00000374726 ; ENSP00000363858 ; ENSG00000095794 . [Q03060-25 ]
ENST00000374728 ; ENSP00000363860 ; ENSG00000095794 . [Q03060-30 ]
ENST00000374734 ; ENSP00000363866 ; ENSG00000095794 . [Q03060-32 ]
ENST00000395887 ; ENSP00000379225 ; ENSG00000095794 . [Q03060-22 ]
ENST00000395895 ; ENSP00000379232 ; ENSG00000095794 . [Q03060-5 ]
ENST00000463314 ; ENSP00000418336 ; ENSG00000095794 . [Q03060-28 ]
ENST00000468236 ; ENSP00000419810 ; ENSG00000095794 . [Q03060-29 ]
ENST00000473940 ; ENSP00000420681 ; ENSG00000095794 . [Q03060-8 ]
ENST00000474931 ; ENSP00000417562 ; ENSG00000095794 . [Q03060-24 ]
ENST00000479070 ; ENSP00000420511 ; ENSG00000095794 . [Q03060-15 ]
ENST00000487763 ; ENSP00000417807 ; ENSG00000095794 . [Q03060-10 ]
ENST00000488328 ; ENSP00000417460 ; ENSG00000095794 . [Q03060-11 ]
ENST00000488741 ; ENSP00000419075 ; ENSG00000095794 . [Q03060-23 ]
ENST00000489321 ; ENSP00000419924 ; ENSG00000095794 . [Q03060-25 ]
ENST00000490511 ; ENSP00000417327 ; ENSG00000095794 . [Q03060-27 ]
GeneIDi 1390.
KEGGi hsa:1390.
UCSCi uc001ixx.3. human. [Q03060-25 ]
uc001iya.3. human.
uc001iyb.3. human. [Q03060-16 ]
uc001iyc.3. human.
uc001iyf.3. human. [Q03060-12 ]
uc001iyh.3. human. [Q03060-7 ]
uc001iyl.3. human. [Q03060-10 ]
uc001iym.3. human. [Q03060-8 ]
uc001iyn.3. human. [Q03060-11 ]
uc001iyo.3. human. [Q03060-9 ]
uc001iyp.3. human. [Q03060-23 ]
uc001iyr.3. human. [Q03060-24 ]
uc031pty.1. human. [Q03060-22 ]

Organism-specific databases

CTDi 1390.
GeneCardsi GC10P035415.
HGNCi HGNC:2352. CREM.
HPAi CAB018352.
HPA001818.
MIMi 123812. gene.
neXtProti NX_Q03060.
PharmGKBi PA26871.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG300199.
HOGENOMi HOG000007365.
HOVERGENi HBG011077.
InParanoidi Q03060.
KOi K09052.
OMAi ESESAHM.
PhylomeDBi Q03060.
TreeFami TF106464.

Enzyme and pathway databases

SignaLinki Q03060.

Miscellaneous databases

ChiTaRSi CREM. human.
GeneWikii CAMP_responsive_element_modulator.
GenomeRNAii 1390.
NextBioi 5649.
PROi Q03060.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q03060.
Bgeei Q03060.
Genevestigatori Q03060.

Family and domain databases

InterProi IPR004827. bZIP.
IPR003102. Coactivator_CBP_pKID.
IPR001630. Leuzip_CREB.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
PF02173. pKID. 1 hit.
[Graphical view ]
PRINTSi PR00041. LEUZIPPRCREB.
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
PS50953. KID. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA."
    Fujimoto T., Fujisawa J., Yoshida M.
    J. Biochem. 115:298-303(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 6; 7; 8; 9 AND 23).
  2. "cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes."
    Bodor J., Spetz A.L., Strominger J.L., Habener J.F.
    Proc. Natl. Acad. Sci. U.S.A. 93:3536-3541(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8), ALTERNATIVE SPLICING (ISOFORMS 6; 7 AND 9), VARIANT ARG-270.
  3. "Human ICER1, a predicted alternative splice form of CREM, is evident in JEG-3 cells."
    Brodie C.R., Boland L.M., Orr H.T.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
  4. "The function of an isoform of hCREM gene in testis development."
    Lu L., Huang X.Y., Xu M., Xu Z.Y., Li J.M., Zhou Z.M., Sha J.H.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
    Tissue: Testis.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5; 7; 20 AND 21).
    Tissue: Adrenal gland, Heart, Placenta and Testis.
  6. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 22).
    Tissue: Brain, Testis and Uterus.
  8. "Searching for mutations in the human cAMP responsive element modulator (CREM) gene."
    Vouk K., Lalli E., Scherer S.W., Sassone-Corsi P., Debeljak N., Komel R., Rozman D.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-248.
  9. "Novel leader exons of the cyclic adenosine 3',5'-monophosphate response element modulator (CREM) gene, transcribed from promoters P3 and P4, are highly testis-specific in primates."
    Gellersen B., Kempf R., Sandhowe R., Weinbauer G.F., Behr R.
    Mol. Hum. Reprod. 8:965-976(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-26 (ISOFORM 10), ALTERNATIVE SPLICING (ISOFORMS 5; 10; 11 AND 12).
  10. "Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript."
    Masquilier D., Foulkes N.S., Mattei M.-G., Sassone-Corsi P.
    Cell Growth Differ. 4:931-937(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-361 (ISOFORMS 2 AND 3).
  11. "Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes."
    Meyer T.E., Habener J.F.
    Nucleic Acids Res. 20:6106-6106(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-360 (ISOFORM 4).
    Tissue: Placenta.
  12. "Combinations of genetic changes in the human cAMP-responsive element modulator gene: a clue towards understanding some forms of male infertility?"
    Vouk K., Hudler P., Strmsnik L., Fink M., Majdic G., Zorn B., Lalli E., Sassone-Corsi P., Debeljak N., Komel R., Rozman D.
    Mol. Hum. Reprod. 11:567-574(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 262-361, TISSUE SPECIFICITY.
  13. "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis."
    Pati D., Meistrich M.L., Plon S.E.
    Mol. Cell. Biol. 19:5001-5013(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CDC34, UBIQUITINATION.
  14. "CREM activator and repressor isoforms in human testis: sequence variations and inaccurate splicing during impaired spermatogenesis."
    Behr R., Weinbauer G.F.
    Mol. Hum. Reprod. 6:967-972(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORMS 2; 4; 13; 15; 17 AND 18), TISSUE SPECIFICITY.
  15. "Different CREM-isoform gene expression between equine and human normal and impaired spermatogenesis."
    Bloecher S., Behr R., Weinbauer G.F., Bergmann M., Steger K.
    Theriogenology 60:1357-1369(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORMS 5; 12; 14; 16 AND 19), TISSUE SPECIFICITY.
  16. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-287; SER-290 AND SER-293, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-287 AND SER-293, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiCREM_HUMAN
AccessioniPrimary (citable) accession number: Q03060
Secondary accession number(s): A8K014
, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0, Q5W1B2, Q7Z2Q6, Q8IVD4, Q96AG7, Q9NZ98, Q9NZ99, Q9NZB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: September 22, 2009
Last modified: September 3, 2014
This is version 150 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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