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Q03060 (CREM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 146. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
cAMP-responsive element modulator
Alternative name(s):
Inducible cAMP early repressor
Short name=ICER
Gene names
Name:CREM
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation By similarity. Ref.13

Subunit structure

Binds DNA as a dimer. Interacts with FHL5 By similarity. Interacts with CDC34. Ref.13

Subcellular location

Nucleus.

Tissue specificity

Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes. Ref.12 Ref.14 Ref.15

Post-translational modification

Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome.

Stimulated by phosphorylation By similarity.

Sequence similarities

Belongs to the bZIP family.

Contains 1 bZIP (basic-leucine zipper) domain.

Contains 1 KID (kinase-inducible) domain.

Sequence caution

The sequence AAB03751.1 differs from that shown. Reason: Erroneous termination at position 361. Translated as Tyr.

The sequence AAF68266.2 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processDifferentiation
Spermatogenesis
Transcription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative promoter usage
Alternative splicing
Polymorphism
   LigandDNA-binding
   Molecular functionActivator
Developmental protein
Repressor
   PTMPhosphoprotein
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

glycosphingolipid metabolic process

Inferred from electronic annotation. Source: Ensembl

multicellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

regulation of transcription, DNA-templated

Inferred from direct assay Ref.1. Source: UniProtKB

signal transduction

Traceable author statement Ref.10. Source: ProtInc

spermatogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Non-traceable author statement Ref.1. Source: UniProtKB

transcription factor complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionDNA binding

Non-traceable author statement Ref.10. Source: UniProtKB

cAMP response element binding protein binding

Non-traceable author statement Ref.1. Source: UniProtKB

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 29 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q03060-5)

Also known as: CREM-BCEFGgammaHIbeta;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Produced by alternative promoter usage.
Isoform 2 (identifier: Q03060-1)

Also known as: Beta; CREM-BCEFGHIbeta;

The sequence of this isoform differs from the canonical sequence as follows:
     249-260: Missing.
Note: Produced by alternative splicing of isoform 1. Activator.
Isoform 3 (identifier: Q03060-6)

Also known as: CREM-BCEFGIalpha; Tau;

The sequence of this isoform differs from the canonical sequence as follows:
     249-260: Missing.
     317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE
Note: Produced by alternative splicing of isoform 1. Activator.
Isoform 4 (identifier: Q03060-2)

Also known as: Alpha; CREM-BEFHIb; CREM-gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     58-106: Missing.
     186-248: Missing.
     249-260: Missing.
     261-261: A → T
Note: Produced by alternative splicing of isoform 1.
Isoform 5 (identifier: Q03060-7)

Also known as: CREM-theta2tau-gamma; CREM-theta2EFGHIb;

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     105-105: Q → M
     249-260: Missing.
Note: Produced by alternative promoter usage. Activator.
Isoform 6 (identifier: Q03060-8)

Also known as: CREM2alpha-a; IcergammaHIalpha; ICER1; ICERI;

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     241-248: PGSQVVVQ → MAVTGDDT
     317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE
Note: Produced by alternative promoter usage. Repressor.
Isoform 7 (identifier: Q03060-9)

Also known as: CREM2alpha-b; IcerHIalpha; ICERIgamma;

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     241-248: PGSQVVVQ → MAVTGDDT
     249-260: Missing.
     317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE
Note: Produced by alternative splicing of isoform 6. Repressor.
Isoform 8 (identifier: Q03060-10)

Also known as: CREM 2beta-a; IcergammaHIbeta; ICERII;

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     241-248: PGSQVVVQ → MAVTGDDT
Note: Produced by alternative splicing of isoform 6. Repressor.
Isoform 9 (identifier: Q03060-11)

Also known as: CREM 2beta-b; IcerHIbeta; ICERIIgamma;

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     241-248: PGSQVVVQ → MAVTGDDT
     249-260: Missing.
Note: Produced by alternative splicing of isoform 6. Repressor.
Isoform 10 (identifier: Q03060-12)

Also known as: CREMtheta1tau2beta; CREM-theta1EFGHIbeta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     105-105: Q → MWWHQHNLCFRRPIEEDYSSGDVEEK
     249-260: Missing.
Note: Produced by alternative promoter usage. Activator.
Isoform 11 (identifier: Q03060-13)

Also known as: CREM-theta1beta; CREM-theta1EFHIbeta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     105-105: Q → MWWHQHNLCFRRPIEEDYSSGDVEEK
     186-248: Missing.
     261-261: A → T
Note: Produced by alternative splicing of isoform 10. Repressor.
Isoform 12 (identifier: Q03060-14)

Also known as: CREM-theta2beta; CREM-theta2EFHIb; CREM-theta2-gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     105-105: Q → M
     186-248: Missing.
     261-261: A → T
Note: Produced by alternative splicing of isoform 5. Repressor.
Isoform 13 (identifier: Q03060-15)

Also known as: CREM-BEFGgammaHIbeta;

The sequence of this isoform differs from the canonical sequence as follows:
     58-106: Missing.
Note: Produced by alternative splicing of isoform 1. Activator.
Isoform 14 (identifier: Q03060-16)

Also known as: CREM-tau2-gamma; CREM-BEFGHIbeta;

The sequence of this isoform differs from the canonical sequence as follows:
     58-106: Missing.
     249-260: Missing.
Note: Produced by alternative splicing of isoform 1. Activator.
Isoform 15 (identifier: Q03060-17)

Also known as: CREM-BGHIbeta;

The sequence of this isoform differs from the canonical sequence as follows:
     58-106: Missing.
     107-185: Missing.
     249-260: Missing.
Note: Produced by alternative splicing of isoform 1. Repressor.
Isoform 16 (identifier: Q03060-19)

Also known as: CREM-deltaC-G; CREM-BgammaHIbeta;

The sequence of this isoform differs from the canonical sequence as follows:
     58-106: Missing.
     107-185: Missing.
     186-248: Missing.
Note: Produced by alternative splicing of isoform 1. Repressor.
Isoform 17 (identifier: Q03060-20)

Also known as: CREM-BHIbeta;

The sequence of this isoform differs from the canonical sequence as follows:
     186-248: Missing.
     249-260: Missing.
Note: Produced by alternative splicing of isoform 1. Repressor.
Isoform 18 (identifier: Q03060-21)

Also known as: CREM-BHIalpha;

The sequence of this isoform differs from the canonical sequence as follows:
     186-248: Missing.
     249-260: Missing.
     317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE
Note: Produced by alternative splicing of isoform 1. Repressor.
Isoform 19 (identifier: Q03060-22)

Also known as: CREM-theta1tau2gamma; CREM-theta1EFGgammaHIbeta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     105-105: Q → MWWHQHNLCFRRPIEEDYSSGDVEEK
Note: Produced by alternative splicing of isoform 10. Activator.
Isoform 20 (identifier: Q03060-23)

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     105-258: Missing.
     317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE
Note: No experimental confirmation available.
Isoform 21 (identifier: Q03060-24)

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MSKCARKKYIKT → MNRTQELSGQLS
     13-260: Missing.
     317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE
Note: No experimental confirmation available.
Isoform 22 (identifier: Q03060-25)

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.
     58-106: Missing.
     186-202: IAIAQGGTIQISNPGSD → SMYAAIRYDTVLALSLL
     203-361: Missing.
Note: No experimental confirmation available.
Isoform 23 (identifier: Q03060-26)

The sequence of this isoform differs from the canonical sequence as follows:
     58-106: Missing.
     186-248: Missing.
     249-249: D → N
     317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE
Isoform 24 (identifier: Q03060-27)

The sequence of this isoform differs from the canonical sequence as follows:
     1-248: Missing.
     249-260: DEETELAPSHMA → MNRTQELSGQLS
Note: Produced by alternative splicing.
Isoform 25 (identifier: Q03060-28)

The sequence of this isoform differs from the canonical sequence as follows:
     1-211: Missing.
     249-260: Missing.
Note: Produced by alternative splicing.
Isoform 26 (identifier: Q03060-29)

The sequence of this isoform differs from the canonical sequence as follows:
     1-236: Missing.
     237-248: QFFVPGSQVVVQ → MNRTQELSGQLS
Note: Produced by alternative splicing.
Isoform 27 (identifier: Q03060-30)

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.
     58-106: Missing.
     186-260: Missing.
     261-261: A → T
Note: Produced by alternative splicing.
Isoform 28 (identifier: Q03060-31)

The sequence of this isoform differs from the canonical sequence as follows:
     58-106: Missing.
     249-260: Missing.
     317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE
Note: Produced by alternative splicing. No experimental confirmation available.
Isoform 29 (identifier: Q03060-32)

The sequence of this isoform differs from the canonical sequence as follows:
     58-106: Missing.
     186-260: Missing.
     261-261: A → T
     317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE
Note: Produced by alternative splicing. No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361cAMP-responsive element modulator
PRO_0000076607

Regions

Domain104 – 16360KID
Domain302 – 36160bZIP
Region303 – 32826Basic motif By similarity
Region330 – 35122Leucine-zipper By similarity

Amino acid modifications

Modified residue2871Phosphoserine Ref.16 Ref.17
Modified residue2901Phosphoserine Ref.16
Modified residue2931Phosphoserine Ref.16 Ref.17

Natural variations

Alternative sequence1 – 248248Missing in isoform 24.
VSP_046870
Alternative sequence1 – 240240Missing in isoform 6, isoform 7, isoform 8 and isoform 9.
VSP_026075
Alternative sequence1 – 236236Missing in isoform 26.
VSP_046871
Alternative sequence1 – 211211Missing in isoform 25.
VSP_046872
Alternative sequence1 – 104104Missing in isoform 5, isoform 10, isoform 11, isoform 12, isoform 19 and isoform 20.
VSP_025035
Alternative sequence1 – 1616Missing in isoform 22 and isoform 27.
VSP_043782
Alternative sequence1 – 1212MSKCA…KYIKT → MNRTQELSGQLS in isoform 21.
VSP_043713
Alternative sequence13 – 260248Missing in isoform 21.
VSP_043714
Alternative sequence58 – 10649Missing in isoform 4, isoform 13, isoform 14, isoform 15, isoform 16, isoform 22, isoform 23, isoform 27, isoform 28 and isoform 29.
VSP_000599
Alternative sequence105 – 258154Missing in isoform 20.
VSP_043580
Alternative sequence1051Q → MWWHQHNLCFRRPIEEDYSS GDVEEK in isoform 10, isoform 11 and isoform 19.
VSP_026076
Alternative sequence1051Q → M in isoform 5 and isoform 12.
VSP_025036
Alternative sequence107 – 18579Missing in isoform 15 and isoform 16.
VSP_026077
Alternative sequence186 – 26075Missing in isoform 27 and isoform 29.
VSP_046873
Alternative sequence186 – 24863Missing in isoform 4, isoform 11, isoform 12, isoform 16, isoform 17, isoform 18 and isoform 23.
VSP_000600
Alternative sequence186 – 20217IAIAQ…NPGSD → SMYAAIRYDTVLALSLL in isoform 22.
VSP_043783
Alternative sequence203 – 361159Missing in isoform 22.
VSP_043784
Alternative sequence237 – 24812QFFVP…QVVVQ → MNRTQELSGQLS in isoform 26.
VSP_046874
Alternative sequence241 – 2488PGSQVVVQ → MAVTGDDT in isoform 6, isoform 7, isoform 8 and isoform 9.
VSP_026078
Alternative sequence249 – 26012Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 7, isoform 9, isoform 10, isoform 14, isoform 15, isoform 17, isoform 18, isoform 25 and isoform 28.
VSP_025037
Alternative sequence249 – 26012DEETE…PSHMA → MNRTQELSGQLS in isoform 24.
VSP_046875
Alternative sequence2491D → N in isoform 23.
VSP_045234
Alternative sequence2611A → T in isoform 4, isoform 11, isoform 12, isoform 27 and isoform 29.
VSP_000601
Alternative sequence317 – 36145KECRR…PKTDY → RECRRKKKEYVKCLENRVAV LENQNKTLIEELKALKDLYC HKVE in isoform 3, isoform 6, isoform 7, isoform 18, isoform 20, isoform 21, isoform 23, isoform 28 and isoform 29.
VSP_025038
Natural variant2701Q → R. Ref.2
Corresponds to variant rs1804604 [ dbSNP | Ensembl ].
VAR_055561

Experimental info

Sequence conflict491N → I in AAC60616. Ref.11
Sequence conflict491N → I in AAC60617. Ref.11
Sequence conflict551A → R in CAA78858. Ref.10
Sequence conflict57 – 615VSVAG → CSELR in AAC60616. Ref.11
Sequence conflict57 – 615VSVAG → CSELR in AAC60617. Ref.11
Sequence conflict2921H → R in BAA03562. Ref.1
Sequence conflict2921H → R in BAA03564. Ref.3
Sequence conflict2921H → R in BAA03565. Ref.3
Sequence conflict2921H → R in BAA03566. Ref.3
Sequence conflict2921H → R in BAA03567. Ref.3
Isoform 6:
Sequence conflict71D → E in AAC19383. Ref.3
Sequence conflict1121K → R in AAC19383. Ref.3
Isoform 8:
Sequence conflict71D → E in AAB03751. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (CREM-BCEFGgammaHIbeta) [UniParc].

Last modified September 22, 2009. Version 5.
Checksum: C1AF0DF57DFB0DAD

FASTA36138,940
        10         20         30         40         50         60 
MSKCARKKYI KTNPRQMTME TVESQHDGSI TASLTESKSA HVQTQTGQNS IPALAQVSVA 

        70         80         90        100        110        120 
GSGTRRGSPA VTLVQLPSGQ TIHVQGVIQT PQPWVIQSSE IHTVQVAAIA ETDESAESEG 

       130        140        150        160        170        180 
VIDSHKRREI LSRRPSYRKI LNELSSDVPG VPKIEEERSE EEGTPPSIAT MAVPTSIYQT 

       190        200        210        220        230        240 
STGQYIAIAQ GGTIQISNPG SDGVQGLQAL TMTNSGAPPP GATIVQYAAQ SADGTQQFFV 

       250        260        270        280        290        300 
PGSQVVVQDE ETELAPSHMA AATGDMPTYQ IRAPTAALPQ GVVMAASPGS LHSPQQLAEE 

       310        320        330        340        350        360 
ATRKRELRLM KNREAAKECR RRKKEYVKCL ESRVAVLEVQ NKKLIEELET LKDICSPKTD 


Y 

« Hide

Isoform 2 (Beta) (CREM-BCEFGHIbeta) [UniParc].

Checksum: F6B8D2BF073C00C0
Show »

FASTA34937,628
Isoform 3 (CREM-BCEFGIalpha) (Tau) [UniParc].

Checksum: 859AA3D3C2EB7D59
Show »

FASTA34837,577
Isoform 4 (Alpha) (CREM-BEFHIb) (CREM-gamma) [UniParc].

Checksum: 89C1F372F6E60AF0
Show »

FASTA23726,320
Isoform 5 (CREM-theta2tau-gamma) (CREM-theta2EFGHIb) [UniParc].

Checksum: 244821D6A4AD32CD
Show »

FASTA24526,513
Isoform 6 (CREM2alpha-a) (IcergammaHIalpha) (ICER1) (ICERI) [UniParc].

Checksum: 723844391B15C4A8
Show »

FASTA12013,435
Isoform 7 (CREM2alpha-b) (IcerHIalpha) (ICERIgamma) [UniParc].

Checksum: BF84129AA7183E40
Show »

FASTA10812,124
Isoform 8 (CREM 2beta-a) (IcergammaHIbeta) (ICERII) [UniParc].

Checksum: 6EFF7058EDE5FE79
Show »

FASTA12113,486
Isoform 9 (CREM 2beta-b) (IcerHIbeta) (ICERIIgamma) [UniParc].

Checksum: E1B2CC0E4E59F383
Show »

FASTA10912,175
Isoform 10 (CREMtheta1tau2beta) (CREM-theta1EFGHIbeta) [UniParc].

Checksum: 10A26E01D01D8FDC
Show »

FASTA27029,656
Isoform 11 (CREM-theta1beta) (CREM-theta1EFHIbeta) [UniParc].

Checksum: B7AB068F482F3C29
Show »

FASTA21924,774
Isoform 12 (CREM-theta2beta) (CREM-theta2EFHIb) (CREM-theta2-gamma) [UniParc].

Checksum: FA038D9739438F76
Show »

FASTA19421,630
Isoform 13 (CREM-BEFGgammaHIbeta) [UniParc].

Checksum: 1C129B0200C8A1F7
Show »

FASTA31233,825
Isoform 14 (CREM-tau2-gamma) (CREM-BEFGHIbeta) [UniParc].

Checksum: C759C78AB56E0FC5
Show »

FASTA30032,514
Isoform 15 (CREM-BGHIbeta) [UniParc].

Checksum: 70AD0E7C1AD98BC2
Show »

FASTA22123,839
Isoform 16 (CREM-deltaC-G) (CREM-BgammaHIbeta) [UniParc].

Checksum: 112F9B233752BF64
Show »

FASTA17018,927
Isoform 17 (CREM-BHIbeta) [UniParc].

Checksum: 7E0BD230608E9563
Show »

FASTA28631,405
Isoform 18 (CREM-BHIalpha) [UniParc].

Checksum: C69A2CB4707EDEB4
Show »

FASTA28531,354
Isoform 19 (CREM-theta1tau2gamma) (CREM-theta1EFGgammaHIbeta) [UniParc].

Checksum: 16CD469D964E1310
Show »

FASTA28230,968
Isoform 20 [UniParc].

Checksum: 09B250970C67483E
Show »

FASTA10211,535
Isoform 21 [UniParc].

Checksum: 37EE6DBB1C791D37
Show »

FASTA11212,679
Isoform 22 [UniParc].

Checksum: 0AC3C47664350D9F
Show »

FASTA13714,871
Isoform 23 [UniParc].

Checksum: 1419AC7C6E2D6FD9
Show »

FASTA24827,549
Isoform 24 [UniParc].

Checksum: A42AA6716FE292A0
Show »

FASTA11312,730
Isoform 25 [UniParc].

Checksum: AC08D42670DFA05C
Show »

FASTA13815,116
Isoform 26 [UniParc].

Checksum: 848D9FD6E95B2AD1
Show »

FASTA12514,041
Isoform 27 [UniParc].

Checksum: 59881FC7317C817C
Show »

FASTA22124,385
Isoform 28 [UniParc].

Checksum: 148F966190E4787C
Show »

FASTA29932,463
Isoform 29 [UniParc].

Checksum: DCBB6E2218E14D07
Show »

FASTA23626,269

References

« Hide 'large scale' references
[1]"Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA."
Fujimoto T., Fujisawa J., Yoshida M.
J. Biochem. 115:298-303(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 6; 7; 8; 9 AND 23).
[2]"cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes."
Bodor J., Spetz A.L., Strominger J.L., Habener J.F.
Proc. Natl. Acad. Sci. U.S.A. 93:3536-3541(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8), ALTERNATIVE SPLICING (ISOFORMS 6; 7 AND 9), VARIANT ARG-270.
[3]"Human ICER1, a predicted alternative splice form of CREM, is evident in JEG-3 cells."
Brodie C.R., Boland L.M., Orr H.T.
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
[4]"The function of an isoform of hCREM gene in testis development."
Lu L., Huang X.Y., Xu M., Xu Z.Y., Li J.M., Zhou Z.M., Sha J.H.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
Tissue: Testis.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5; 7; 20 AND 21).
Tissue: Adrenal gland, Heart, Placenta and Testis.
[6]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 22).
Tissue: Brain, Testis and Uterus.
[8]"Searching for mutations in the human cAMP responsive element modulator (CREM) gene."
Vouk K., Lalli E., Scherer S.W., Sassone-Corsi P., Debeljak N., Komel R., Rozman D.
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-248.
[9]"Novel leader exons of the cyclic adenosine 3',5'-monophosphate response element modulator (CREM) gene, transcribed from promoters P3 and P4, are highly testis-specific in primates."
Gellersen B., Kempf R., Sandhowe R., Weinbauer G.F., Behr R.
Mol. Hum. Reprod. 8:965-976(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-26 (ISOFORM 10), ALTERNATIVE SPLICING (ISOFORMS 5; 10; 11 AND 12).
[10]"Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript."
Masquilier D., Foulkes N.S., Mattei M.-G., Sassone-Corsi P.
Cell Growth Differ. 4:931-937(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-361 (ISOFORMS 2 AND 3).
[11]"Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes."
Meyer T.E., Habener J.F.
Nucleic Acids Res. 20:6106-6106(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-360 (ISOFORM 4).
Tissue: Placenta.
[12]"Combinations of genetic changes in the human cAMP-responsive element modulator gene: a clue towards understanding some forms of male infertility?"
Vouk K., Hudler P., Strmsnik L., Fink M., Majdic G., Zorn B., Lalli E., Sassone-Corsi P., Debeljak N., Komel R., Rozman D.
Mol. Hum. Reprod. 11:567-574(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 262-361, TISSUE SPECIFICITY.
[13]"Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis."
Pati D., Meistrich M.L., Plon S.E.
Mol. Cell. Biol. 19:5001-5013(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CDC34, UBIQUITINATION.
[14]"CREM activator and repressor isoforms in human testis: sequence variations and inaccurate splicing during impaired spermatogenesis."
Behr R., Weinbauer G.F.
Mol. Hum. Reprod. 6:967-972(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING (ISOFORMS 2; 4; 13; 15; 17 AND 18), TISSUE SPECIFICITY.
[15]"Different CREM-isoform gene expression between equine and human normal and impaired spermatogenesis."
Bloecher S., Behr R., Weinbauer G.F., Bergmann M., Steger K.
Theriogenology 60:1357-1369(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING (ISOFORMS 5; 12; 14; 16 AND 19), TISSUE SPECIFICITY.
[16]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-287; SER-290 AND SER-293, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[17]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-287 AND SER-293, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[18]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D14825 mRNA. Translation: BAA03562.1.
D14826 mRNA. Translation: BAA03564.1.
D14826 mRNA. Translation: BAA03565.1.
D14826 mRNA. Translation: BAA03566.1.
D14826 mRNA. Translation: BAA03567.1.
U44836 mRNA. Translation: AAB03751.1. Sequence problems.
AF069065 mRNA. Translation: AAC19383.1.
AY292864 mRNA. Translation: AAP44115.1.
AK289379 mRNA. Translation: BAF82068.1.
AK290612 mRNA. Translation: BAF83301.1.
AK291566 mRNA. Translation: BAF84255.1.
AK301906 mRNA. Translation: BAG63333.1.
AL117336 Genomic DNA. No translation available.
AL157783 Genomic DNA. No translation available.
CH471072 Genomic DNA. Translation: EAW85917.1.
CH471072 Genomic DNA. Translation: EAW85918.1.
BC017117 mRNA. Translation: AAH17117.1.
BC066342 mRNA. Translation: AAH66342.1.
BC090051 mRNA. Translation: AAH90051.1.
AF213899 expand/collapse EMBL AC list , AF212158, AF213897, AF213898 Genomic DNA. Translation: AAF68266.2. Sequence problems.
AF417234 mRNA. Translation: AAN32656.1.
S68271 mRNA. Translation: AAC60616.2.
S68134 mRNA. Translation: AAC60617.2.
Z15159 mRNA. Translation: CAA78858.1.
AF217318, AF214665 Genomic DNA. Translation: AAF66158.2.
AF217318, AF214665 Genomic DNA. Translation: AAF68682.1.
PIRJC2087.
JC6135.
JX0307.
S26685.
RefSeqNP_001254491.1. NM_001267562.1.
NP_001254493.1. NM_001267564.1.
NP_001254496.1. NM_001267567.1.
NP_001254499.1. NM_001267570.1.
NP_001872.3. NM_001881.3.
NP_853549.1. NM_181571.2.
NP_874386.1. NM_182717.1.
NP_874387.1. NM_182718.1.
NP_874388.1. NM_182719.1.
NP_874389.1. NM_182720.1.
NP_874390.1. NM_182721.1.
NP_874392.1. NM_182723.1.
NP_874393.1. NM_182724.1.
NP_877570.1. NM_182769.2.
NP_877571.1. NM_182770.2.
NP_877572.1. NM_182771.1.
NP_877573.1. NM_182772.1.
NP_898829.1. NM_183011.1.
NP_898830.1. NM_183012.1.
NP_898831.1. NM_183013.2.
NP_898883.1. NM_183060.2.
UniGeneHs.200250.

3D structure databases

ProteinModelPortalQ03060.
SMRQ03060. Positions 123-149, 304-358.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107780. 19 interactions.
IntActQ03060. 6 interactions.

PTM databases

PhosphoSiteQ03060.

Polymorphism databases

DMDM259016392.

Proteomic databases

PaxDbQ03060.
PRIDEQ03060.

Protocols and materials databases

DNASU1390.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000333809; ENSP00000333055; ENSG00000095794. [Q03060-6]
ENST00000337656; ENSP00000337138; ENSG00000095794. [Q03060-31]
ENST00000342105; ENSP00000341875; ENSG00000095794. [Q03060-7]
ENST00000345491; ENSP00000265372; ENSG00000095794. [Q03060-16]
ENST00000348787; ENSP00000345384; ENSG00000095794. [Q03060-30]
ENST00000354759; ENSP00000346804; ENSG00000095794. [Q03060-26]
ENST00000356917; ENSP00000349387; ENSG00000095794. [Q03060-9]
ENST00000361599; ENSP00000354593; ENSG00000095794. [Q03060-12]
ENST00000374726; ENSP00000363858; ENSG00000095794. [Q03060-25]
ENST00000374728; ENSP00000363860; ENSG00000095794. [Q03060-30]
ENST00000374734; ENSP00000363866; ENSG00000095794. [Q03060-32]
ENST00000395887; ENSP00000379225; ENSG00000095794. [Q03060-22]
ENST00000395895; ENSP00000379232; ENSG00000095794. [Q03060-5]
ENST00000463314; ENSP00000418336; ENSG00000095794. [Q03060-28]
ENST00000468236; ENSP00000419810; ENSG00000095794. [Q03060-29]
ENST00000473940; ENSP00000420681; ENSG00000095794. [Q03060-8]
ENST00000474931; ENSP00000417562; ENSG00000095794. [Q03060-24]
ENST00000479070; ENSP00000420511; ENSG00000095794. [Q03060-15]
ENST00000487763; ENSP00000417807; ENSG00000095794. [Q03060-10]
ENST00000488328; ENSP00000417460; ENSG00000095794. [Q03060-11]
ENST00000488741; ENSP00000419075; ENSG00000095794. [Q03060-23]
ENST00000489321; ENSP00000419924; ENSG00000095794. [Q03060-25]
ENST00000490511; ENSP00000417327; ENSG00000095794. [Q03060-27]
GeneID1390.
KEGGhsa:1390.
UCSCuc001ixx.3. human. [Q03060-25]
uc001iya.3. human.
uc001iyb.3. human. [Q03060-16]
uc001iyf.3. human. [Q03060-12]
uc001iyh.3. human. [Q03060-7]
uc001iyl.3. human. [Q03060-10]
uc001iym.3. human. [Q03060-8]
uc001iyn.3. human. [Q03060-11]
uc001iyo.3. human. [Q03060-9]
uc001iyp.3. human. [Q03060-23]
uc001iyr.3. human. [Q03060-24]
uc031pty.1. human. [Q03060-22]

Organism-specific databases

CTD1390.
GeneCardsGC10P035415.
HGNCHGNC:2352. CREM.
HPACAB018352.
HPA001818.
MIM123812. gene.
neXtProtNX_Q03060.
PharmGKBPA26871.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG300199.
HOGENOMHOG000007365.
HOVERGENHBG011077.
InParanoidQ03060.
KOK09052.
OMAESESAHM.
PhylomeDBQ03060.
TreeFamTF106464.

Enzyme and pathway databases

SignaLinkQ03060.

Gene expression databases

ArrayExpressQ03060.
BgeeQ03060.
GenevestigatorQ03060.

Family and domain databases

InterProIPR004827. bZIP.
IPR003102. Coactivator_CBP_pKID.
IPR001630. Leuzip_CREB.
[Graphical view]
PfamPF00170. bZIP_1. 1 hit.
PF02173. pKID. 1 hit.
[Graphical view]
PRINTSPR00041. LEUZIPPRCREB.
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
PS50953. KID. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCREM. human.
GeneWikiCAMP_responsive_element_modulator.
GenomeRNAi1390.
NextBio5649.
PROQ03060.
SOURCESearch...

Entry information

Entry nameCREM_HUMAN
AccessionPrimary (citable) accession number: Q03060
Secondary accession number(s): A8K014 expand/collapse secondary AC list , A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0, Q5W1B2, Q7Z2Q6, Q8IVD4, Q96AG7, Q9NZ98, Q9NZ99, Q9NZB9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: September 22, 2009
Last modified: April 16, 2014
This is version 146 of the entry and version 5 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM