Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q03060

- CREM_HUMAN

UniProt

Q03060 - CREM_HUMAN

Protein

cAMP-responsive element modulator

Gene

CREM

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 151 (01 Oct 2014)
      Sequence version 5 (22 Sep 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550).1 Publication
    Isoform 6: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.By similarity

    GO - Molecular functioni

    1. cAMP response element binding protein binding Source: UniProtKB
    2. DNA binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. sequence-specific DNA binding Source: InterPro
    5. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. glycosphingolipid metabolic process Source: Ensembl
    3. multicellular organismal development Source: UniProtKB-KW
    4. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    5. regulation of transcription, DNA-templated Source: UniProtKB
    6. signal transduction Source: ProtInc
    7. spermatogenesis Source: UniProtKB-KW
    8. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein, Repressor

    Keywords - Biological processi

    Biological rhythms, Differentiation, Spermatogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiQ03060.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    cAMP-responsive element modulator
    Alternative name(s):
    Inducible cAMP early repressor
    Short name:
    ICER
    Gene namesi
    Name:CREM
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:2352. CREM.

    Subcellular locationi

    Isoform 6 : Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB
    2. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26871.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361cAMP-responsive element modulatorPRO_0000076607Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei287 – 2871Phosphoserine2 PublicationsPROSITE-ProRule annotation
    Modified residuei290 – 2901Phosphoserine1 PublicationPROSITE-ProRule annotation
    Modified residuei293 – 2931Phosphoserine2 PublicationsPROSITE-ProRule annotation

    Post-translational modificationi

    Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome.1 Publication
    Stimulated by phosphorylation.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ03060.
    PaxDbiQ03060.
    PRIDEiQ03060.

    PTM databases

    PhosphoSiteiQ03060.

    Expressioni

    Tissue specificityi

    Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.3 Publications

    Gene expression databases

    ArrayExpressiQ03060.
    BgeeiQ03060.
    GenevestigatoriQ03060.

    Organism-specific databases

    HPAiCAB018352.
    HPA001818.

    Interactioni

    Subunit structurei

    Binds DNA as a dimer. Interacts with FHL5 By similarity. Interacts with CDC34.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi107780. 19 interactions.
    IntActiQ03060. 6 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03060.
    SMRiQ03060. Positions 123-149, 304-358.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini104 – 16360KIDPROSITE-ProRule annotationAdd
    BLAST
    Domaini302 – 36160bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni303 – 32826Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni330 – 35122Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation
    Contains 1 KID (kinase-inducible) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG300199.
    HOGENOMiHOG000007365.
    HOVERGENiHBG011077.
    InParanoidiQ03060.
    KOiK09052.
    OMAiESESAHM.
    PhylomeDBiQ03060.
    TreeFamiTF106464.

    Family and domain databases

    InterProiIPR004827. bZIP.
    IPR003102. Coactivator_CBP_pKID.
    IPR001630. Leuzip_CREB.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    PF02173. pKID. 1 hit.
    [Graphical view]
    PRINTSiPR00041. LEUZIPPRCREB.
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    PS50953. KID. 1 hit.
    [Graphical view]

    Sequences (29)i

    Sequence statusi: Complete.

    This entry describes 29 isoformsi produced by alternative promoter usage and alternative splicing. Align

    Isoform 1 (identifier: Q03060-5) [UniParc]FASTAAdd to Basket

    Also known as: CREM-BCEFGgammaHIbeta

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSKCARKKYI KTNPRQMTME TVESQHDGSI TASLTESKSA HVQTQTGQNS    50
    IPALAQVSVA GSGTRRGSPA VTLVQLPSGQ TIHVQGVIQT PQPWVIQSSE 100
    IHTVQVAAIA ETDESAESEG VIDSHKRREI LSRRPSYRKI LNELSSDVPG 150
    VPKIEEERSE EEGTPPSIAT MAVPTSIYQT STGQYIAIAQ GGTIQISNPG 200
    SDGVQGLQAL TMTNSGAPPP GATIVQYAAQ SADGTQQFFV PGSQVVVQDE 250
    ETELAPSHMA AATGDMPTYQ IRAPTAALPQ GVVMAASPGS LHSPQQLAEE 300
    ATRKRELRLM KNREAAKECR RRKKEYVKCL ESRVAVLEVQ NKKLIEELET 350
    LKDICSPKTD Y 361

    Note: Produced by alternative promoter usage.

    Length:361
    Mass (Da):38,940
    Last modified:September 22, 2009 - v5
    Checksum:iC1AF0DF57DFB0DAD
    GO
    Isoform 2 (identifier: Q03060-1) [UniParc]FASTAAdd to Basket

    Also known as: Beta, CREM-BCEFGHIbeta

    The sequence of this isoform differs from the canonical sequence as follows:
         249-260: Missing.

    Note: Produced by alternative splicing of isoform 1. Activator.

    Show »
    Length:349
    Mass (Da):37,628
    Checksum:iF6B8D2BF073C00C0
    GO
    Isoform 3 (identifier: Q03060-6) [UniParc]FASTAAdd to Basket

    Also known as: CREM-BCEFGIalpha, Tau

    The sequence of this isoform differs from the canonical sequence as follows:
         249-260: Missing.
         317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE

    Note: Produced by alternative splicing of isoform 1. Activator.

    Show »
    Length:348
    Mass (Da):37,577
    Checksum:i859AA3D3C2EB7D59
    GO
    Isoform 4 (identifier: Q03060-2) [UniParc]FASTAAdd to Basket

    Also known as: Alpha, CREM-BEFHIb, CREM-gamma

    The sequence of this isoform differs from the canonical sequence as follows:
         58-106: Missing.
         186-248: Missing.
         249-260: Missing.
         261-261: A → T

    Note: Produced by alternative splicing of isoform 1.

    Show »
    Length:237
    Mass (Da):26,320
    Checksum:i89C1F372F6E60AF0
    GO
    Isoform 5 (identifier: Q03060-7) [UniParc]FASTAAdd to Basket

    Also known as: CREM-theta2tau-gamma, CREM-theta2EFGHIb

    The sequence of this isoform differs from the canonical sequence as follows:
         1-104: Missing.
         105-105: Q → M
         249-260: Missing.

    Note: Produced by alternative promoter usage. Activator.

    Show »
    Length:245
    Mass (Da):26,513
    Checksum:i244821D6A4AD32CD
    GO
    Isoform 6 (identifier: Q03060-8) [UniParc]FASTAAdd to Basket

    Also known as: CREM2alpha-a, IcergammaHIalpha, ICER1, ICERI

    The sequence of this isoform differs from the canonical sequence as follows:
         1-240: Missing.
         241-248: PGSQVVVQ → MAVTGDDT
         317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE

    Note: Produced by alternative promoter usage. Repressor.Curated

    Show »
    Length:120
    Mass (Da):13,435
    Checksum:i723844391B15C4A8
    GO
    Isoform 7 (identifier: Q03060-9) [UniParc]FASTAAdd to Basket

    Also known as: CREM2alpha-b, IcerHIalpha, ICERIgamma

    The sequence of this isoform differs from the canonical sequence as follows:
         1-240: Missing.
         241-248: PGSQVVVQ → MAVTGDDT
         249-260: Missing.
         317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE

    Note: Produced by alternative splicing of isoform 6. Repressor.

    Show »
    Length:108
    Mass (Da):12,124
    Checksum:iBF84129AA7183E40
    GO
    Isoform 8 (identifier: Q03060-10) [UniParc]FASTAAdd to Basket

    Also known as: CREM 2beta-a, IcergammaHIbeta, ICERII

    The sequence of this isoform differs from the canonical sequence as follows:
         1-240: Missing.
         241-248: PGSQVVVQ → MAVTGDDT

    Note: Produced by alternative splicing of isoform 6. Repressor.Curated

    Show »
    Length:121
    Mass (Da):13,486
    Checksum:i6EFF7058EDE5FE79
    GO
    Isoform 9 (identifier: Q03060-11) [UniParc]FASTAAdd to Basket

    Also known as: CREM 2beta-b, IcerHIbeta, ICERIIgamma

    The sequence of this isoform differs from the canonical sequence as follows:
         1-240: Missing.
         241-248: PGSQVVVQ → MAVTGDDT
         249-260: Missing.

    Note: Produced by alternative splicing of isoform 6. Repressor.

    Show »
    Length:109
    Mass (Da):12,175
    Checksum:iE1B2CC0E4E59F383
    GO
    Isoform 10 (identifier: Q03060-12) [UniParc]FASTAAdd to Basket

    Also known as: CREMtheta1tau2beta, CREM-theta1EFGHIbeta

    The sequence of this isoform differs from the canonical sequence as follows:
         1-104: Missing.
         105-105: Q → MWWHQHNLCFRRPIEEDYSSGDVEEK
         249-260: Missing.

    Note: Produced by alternative promoter usage. Activator.

    Show »
    Length:270
    Mass (Da):29,656
    Checksum:i10A26E01D01D8FDC
    GO
    Isoform 11 (identifier: Q03060-13) [UniParc]FASTAAdd to Basket

    Also known as: CREM-theta1beta, CREM-theta1EFHIbeta

    The sequence of this isoform differs from the canonical sequence as follows:
         1-104: Missing.
         105-105: Q → MWWHQHNLCFRRPIEEDYSSGDVEEK
         186-248: Missing.
         261-261: A → T

    Note: Produced by alternative splicing of isoform 10. Repressor.

    Show »
    Length:219
    Mass (Da):24,774
    Checksum:iB7AB068F482F3C29
    GO
    Isoform 12 (identifier: Q03060-14) [UniParc]FASTAAdd to Basket

    Also known as: CREM-theta2beta, CREM-theta2EFHIb, CREM-theta2-gamma

    The sequence of this isoform differs from the canonical sequence as follows:
         1-104: Missing.
         105-105: Q → M
         186-248: Missing.
         261-261: A → T

    Note: Produced by alternative splicing of isoform 5. Repressor.

    Show »
    Length:194
    Mass (Da):21,630
    Checksum:iFA038D9739438F76
    GO
    Isoform 13 (identifier: Q03060-15) [UniParc]FASTAAdd to Basket

    Also known as: CREM-BEFGgammaHIbeta

    The sequence of this isoform differs from the canonical sequence as follows:
         58-106: Missing.

    Note: Produced by alternative splicing of isoform 1. Activator.

    Show »
    Length:312
    Mass (Da):33,825
    Checksum:i1C129B0200C8A1F7
    GO
    Isoform 14 (identifier: Q03060-16) [UniParc]FASTAAdd to Basket

    Also known as: CREM-tau2-gamma, CREM-BEFGHIbeta

    The sequence of this isoform differs from the canonical sequence as follows:
         58-106: Missing.
         249-260: Missing.

    Note: Produced by alternative splicing of isoform 1. Activator.

    Show »
    Length:300
    Mass (Da):32,514
    Checksum:iC759C78AB56E0FC5
    GO
    Isoform 15 (identifier: Q03060-17) [UniParc]FASTAAdd to Basket

    Also known as: CREM-BGHIbeta

    The sequence of this isoform differs from the canonical sequence as follows:
         58-106: Missing.
         107-185: Missing.
         249-260: Missing.

    Note: Produced by alternative splicing of isoform 1. Repressor.

    Show »
    Length:221
    Mass (Da):23,839
    Checksum:i70AD0E7C1AD98BC2
    GO
    Isoform 16 (identifier: Q03060-19) [UniParc]FASTAAdd to Basket

    Also known as: CREM-deltaC-G, CREM-BgammaHIbeta

    The sequence of this isoform differs from the canonical sequence as follows:
         58-106: Missing.
         107-185: Missing.
         186-248: Missing.

    Note: Produced by alternative splicing of isoform 1. Repressor.

    Show »
    Length:170
    Mass (Da):18,927
    Checksum:i112F9B233752BF64
    GO
    Isoform 17 (identifier: Q03060-20) [UniParc]FASTAAdd to Basket

    Also known as: CREM-BHIbeta

    The sequence of this isoform differs from the canonical sequence as follows:
         186-248: Missing.
         249-260: Missing.

    Note: Produced by alternative splicing of isoform 1. Repressor.

    Show »
    Length:286
    Mass (Da):31,405
    Checksum:i7E0BD230608E9563
    GO
    Isoform 18 (identifier: Q03060-21) [UniParc]FASTAAdd to Basket

    Also known as: CREM-BHIalpha

    The sequence of this isoform differs from the canonical sequence as follows:
         186-248: Missing.
         249-260: Missing.
         317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE

    Note: Produced by alternative splicing of isoform 1. Repressor.

    Show »
    Length:285
    Mass (Da):31,354
    Checksum:iC69A2CB4707EDEB4
    GO
    Isoform 19 (identifier: Q03060-22) [UniParc]FASTAAdd to Basket

    Also known as: CREM-theta1tau2gamma, CREM-theta1EFGgammaHIbeta

    The sequence of this isoform differs from the canonical sequence as follows:
         1-104: Missing.
         105-105: Q → MWWHQHNLCFRRPIEEDYSSGDVEEK

    Note: Produced by alternative splicing of isoform 10. Activator.

    Show »
    Length:282
    Mass (Da):30,968
    Checksum:i16CD469D964E1310
    GO
    Isoform 20 (identifier: Q03060-23) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-104: Missing.
         105-258: Missing.
         317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE

    Note: No experimental confirmation available.

    Show »
    Length:102
    Mass (Da):11,535
    Checksum:i09B250970C67483E
    GO
    Isoform 21 (identifier: Q03060-24) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-12: MSKCARKKYIKT → MNRTQELSGQLS
         13-260: Missing.
         317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE

    Note: No experimental confirmation available.

    Show »
    Length:112
    Mass (Da):12,679
    Checksum:i37EE6DBB1C791D37
    GO
    Isoform 22 (identifier: Q03060-25) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-16: Missing.
         58-106: Missing.
         186-202: IAIAQGGTIQISNPGSD → SMYAAIRYDTVLALSLL
         203-361: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:137
    Mass (Da):14,871
    Checksum:i0AC3C47664350D9F
    GO
    Isoform 23 (identifier: Q03060-26) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         58-106: Missing.
         186-248: Missing.
         249-249: D → N
         317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE

    Show »
    Length:248
    Mass (Da):27,549
    Checksum:i1419AC7C6E2D6FD9
    GO
    Isoform 24 (identifier: Q03060-27) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-248: Missing.
         249-260: DEETELAPSHMA → MNRTQELSGQLS

    Note: Produced by alternative splicing.

    Show »
    Length:113
    Mass (Da):12,730
    Checksum:iA42AA6716FE292A0
    GO
    Isoform 25 (identifier: Q03060-28) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-211: Missing.
         249-260: Missing.

    Note: Produced by alternative splicing.

    Show »
    Length:138
    Mass (Da):15,116
    Checksum:iAC08D42670DFA05C
    GO
    Isoform 26 (identifier: Q03060-29) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-236: Missing.
         237-248: QFFVPGSQVVVQ → MNRTQELSGQLS

    Note: Produced by alternative splicing.

    Show »
    Length:125
    Mass (Da):14,041
    Checksum:i848D9FD6E95B2AD1
    GO
    Isoform 27 (identifier: Q03060-30) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-16: Missing.
         58-106: Missing.
         186-260: Missing.
         261-261: A → T

    Note: Produced by alternative splicing.

    Show »
    Length:221
    Mass (Da):24,385
    Checksum:i59881FC7317C817C
    GO
    Isoform 28 (identifier: Q03060-31) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         58-106: Missing.
         249-260: Missing.
         317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE

    Note: Produced by alternative splicing. No experimental confirmation available.

    Show »
    Length:299
    Mass (Da):32,463
    Checksum:i148F966190E4787C
    GO
    Isoform 29 (identifier: Q03060-32) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         58-106: Missing.
         186-260: Missing.
         261-261: A → T
         317-361: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE

    Note: Produced by alternative splicing. No experimental confirmation available.

    Show »
    Length:236
    Mass (Da):26,269
    Checksum:iDCBB6E2218E14D07
    GO

    Sequence cautioni

    The sequence AAB03751.1 differs from that shown. Reason: Erroneous termination at position 361. Translated as Tyr.
    The sequence AAF68266.2 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti49 – 491N → I in AAC60616. (PubMed:1461747)Curated
    Sequence conflicti49 – 491N → I in AAC60617. (PubMed:1461747)Curated
    Sequence conflicti55 – 551A → R in CAA78858. (PubMed:7916662)Curated
    Sequence conflicti57 – 615VSVAG → CSELR in AAC60616. (PubMed:1461747)Curated
    Sequence conflicti57 – 615VSVAG → CSELR in AAC60617. (PubMed:1461747)Curated
    Sequence conflicti292 – 2921H → R in BAA03562. (PubMed:8206879)Curated
    Sequence conflicti292 – 2921H → R in BAA03564. 1 PublicationCurated
    Sequence conflicti292 – 2921H → R in BAA03565. 1 PublicationCurated
    Sequence conflicti292 – 2921H → R in BAA03566. 1 PublicationCurated
    Sequence conflicti292 – 2921H → R in BAA03567. 1 PublicationCurated
    Isoform 6 (identifier: Q03060-8)
    Sequence conflicti7 – 71D → E in AAC19383. 1 PublicationCurated
    Sequence conflicti112 – 1121K → R in AAC19383. 1 PublicationCurated
    Isoform 8 (identifier: Q03060-10)
    Sequence conflicti7 – 71D → E in AAB03751. (PubMed:8622971)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti270 – 2701Q → R.1 Publication
    Corresponds to variant rs1804604 [ dbSNP | Ensembl ].
    VAR_055561

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 248248Missing in isoform 24. CuratedVSP_046870Add
    BLAST
    Alternative sequencei1 – 240240Missing in isoform 6, isoform 7, isoform 8 and isoform 9. 4 PublicationsVSP_026075Add
    BLAST
    Alternative sequencei1 – 236236Missing in isoform 26. CuratedVSP_046871Add
    BLAST
    Alternative sequencei1 – 211211Missing in isoform 25. CuratedVSP_046872Add
    BLAST
    Alternative sequencei1 – 104104Missing in isoform 5, isoform 10, isoform 11, isoform 12, isoform 19 and isoform 20. 4 PublicationsVSP_025035Add
    BLAST
    Alternative sequencei1 – 1616Missing in isoform 22 and isoform 27. 1 PublicationVSP_043782Add
    BLAST
    Alternative sequencei1 – 1212MSKCA…KYIKT → MNRTQELSGQLS in isoform 21. 1 PublicationVSP_043713Add
    BLAST
    Alternative sequencei13 – 260248Missing in isoform 21. 1 PublicationVSP_043714Add
    BLAST
    Alternative sequencei58 – 10649Missing in isoform 4, isoform 13, isoform 14, isoform 15, isoform 16, isoform 22, isoform 23, isoform 27, isoform 28 and isoform 29. 3 PublicationsVSP_000599Add
    BLAST
    Alternative sequencei105 – 258154Missing in isoform 20. 1 PublicationVSP_043580Add
    BLAST
    Alternative sequencei105 – 1051Q → MWWHQHNLCFRRPIEEDYSS GDVEEK in isoform 10, isoform 11 and isoform 19. 1 PublicationVSP_026076
    Alternative sequencei105 – 1051Q → M in isoform 5 and isoform 12. 3 PublicationsVSP_025036
    Alternative sequencei107 – 18579Missing in isoform 15 and isoform 16. CuratedVSP_026077Add
    BLAST
    Alternative sequencei186 – 26075Missing in isoform 27 and isoform 29. CuratedVSP_046873Add
    BLAST
    Alternative sequencei186 – 24863Missing in isoform 4, isoform 11, isoform 12, isoform 16, isoform 17, isoform 18 and isoform 23. 2 PublicationsVSP_000600Add
    BLAST
    Alternative sequencei186 – 20217IAIAQ…NPGSD → SMYAAIRYDTVLALSLL in isoform 22. 1 PublicationVSP_043783Add
    BLAST
    Alternative sequencei203 – 361159Missing in isoform 22. 1 PublicationVSP_043784Add
    BLAST
    Alternative sequencei237 – 24812QFFVP…QVVVQ → MNRTQELSGQLS in isoform 26. CuratedVSP_046874Add
    BLAST
    Alternative sequencei241 – 2488PGSQVVVQ → MAVTGDDT in isoform 6, isoform 7, isoform 8 and isoform 9. 4 PublicationsVSP_026078
    Alternative sequencei249 – 26012Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 7, isoform 9, isoform 10, isoform 14, isoform 15, isoform 17, isoform 18, isoform 25 and isoform 28. 7 PublicationsVSP_025037Add
    BLAST
    Alternative sequencei249 – 26012DEETE…PSHMA → MNRTQELSGQLS in isoform 24. CuratedVSP_046875Add
    BLAST
    Alternative sequencei249 – 2491D → N in isoform 23. 1 PublicationVSP_045234
    Alternative sequencei261 – 2611A → T in isoform 4, isoform 11, isoform 12, isoform 27 and isoform 29. 1 PublicationVSP_000601
    Alternative sequencei317 – 36145KECRR…PKTDY → RECRRKKKEYVKCLENRVAV LENQNKTLIEELKALKDLYC HKVE in isoform 3, isoform 6, isoform 7, isoform 18, isoform 20, isoform 21, isoform 23, isoform 28 and isoform 29. 4 PublicationsVSP_025038Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14825 mRNA. Translation: BAA03562.1.
    D14826 mRNA. Translation: BAA03564.1.
    D14826 mRNA. Translation: BAA03565.1.
    D14826 mRNA. Translation: BAA03566.1.
    D14826 mRNA. Translation: BAA03567.1.
    U44836 mRNA. Translation: AAB03751.1. Sequence problems.
    AF069065 mRNA. Translation: AAC19383.1.
    AY292864 mRNA. Translation: AAP44115.1.
    AK289379 mRNA. Translation: BAF82068.1.
    AK290612 mRNA. Translation: BAF83301.1.
    AK291566 mRNA. Translation: BAF84255.1.
    AK301906 mRNA. Translation: BAG63333.1.
    AL117336 Genomic DNA. No translation available.
    AL157783 Genomic DNA. No translation available.
    CH471072 Genomic DNA. Translation: EAW85917.1.
    CH471072 Genomic DNA. Translation: EAW85918.1.
    BC017117 mRNA. Translation: AAH17117.1.
    BC066342 mRNA. Translation: AAH66342.1.
    BC090051 mRNA. Translation: AAH90051.1.
    AF213899
    , AF212158, AF213897, AF213898 Genomic DNA. Translation: AAF68266.2. Sequence problems.
    AF417234 mRNA. Translation: AAN32656.1.
    S68271 mRNA. Translation: AAC60616.2.
    S68134 mRNA. Translation: AAC60617.2.
    Z15159 mRNA. Translation: CAA78858.1.
    AF217318, AF214665 Genomic DNA. Translation: AAF66158.2.
    AF217318, AF214665 Genomic DNA. Translation: AAF68682.1.
    CCDSiCCDS31181.1. [Q03060-32]
    CCDS53517.1. [Q03060-10]
    CCDS53518.1. [Q03060-9]
    CCDS53519.1. [Q03060-11]
    CCDS53520.1. [Q03060-27]
    CCDS53521.1. [Q03060-23]
    CCDS58074.1. [Q03060-22]
    CCDS58075.1. [Q03060-28]
    CCDS58076.1. [Q03060-29]
    CCDS7180.1. [Q03060-16]
    CCDS7181.1. [Q03060-31]
    CCDS7182.1. [Q03060-26]
    CCDS7183.1. [Q03060-30]
    CCDS7184.1. [Q03060-25]
    CCDS7185.1. [Q03060-12]
    CCDS7186.1. [Q03060-7]
    CCDS7187.1. [Q03060-8]
    CCDS7188.1. [Q03060-24]
    PIRiJC2087.
    JC6135.
    JX0307.
    S26685.
    RefSeqiNP_001254491.1. NM_001267562.1.
    NP_001254493.1. NM_001267564.1. [Q03060-22]
    NP_001254496.1. NM_001267567.1. [Q03060-28]
    NP_001254499.1. NM_001267570.1. [Q03060-29]
    NP_001872.3. NM_001881.3. [Q03060-25]
    NP_853549.1. NM_181571.2. [Q03060-16]
    NP_874386.1. NM_182717.1. [Q03060-8]
    NP_874387.1. NM_182718.1. [Q03060-11]
    NP_874388.1. NM_182719.1. [Q03060-10]
    NP_874389.1. NM_182720.1. [Q03060-9]
    NP_874390.1. NM_182721.1. [Q03060-24]
    NP_874392.1. NM_182723.1. [Q03060-23]
    NP_874393.1. NM_182724.1. [Q03060-27]
    NP_877570.1. NM_182769.2. [Q03060-7]
    NP_877571.1. NM_182770.2.
    NP_877572.1. NM_182771.1. [Q03060-12]
    NP_877573.1. NM_182772.1.
    NP_898829.1. NM_183011.1. [Q03060-31]
    NP_898830.1. NM_183012.1. [Q03060-32]
    NP_898831.1. NM_183013.2. [Q03060-26]
    NP_898883.1. NM_183060.2. [Q03060-30]
    XP_006717441.1. XM_006717378.1. [Q03060-16]
    XP_006717442.1. XM_006717379.1. [Q03060-31]
    XP_006717445.1. XM_006717382.1. [Q03060-2]
    XP_006717446.1. XM_006717383.1. [Q03060-32]
    XP_006717448.1. XM_006717385.1. [Q03060-28]
    UniGeneiHs.200250.

    Genome annotation databases

    EnsembliENST00000337656; ENSP00000337138; ENSG00000095794. [Q03060-31]
    ENST00000342105; ENSP00000341875; ENSG00000095794. [Q03060-7]
    ENST00000345491; ENSP00000265372; ENSG00000095794. [Q03060-16]
    ENST00000348787; ENSP00000345384; ENSG00000095794. [Q03060-30]
    ENST00000354759; ENSP00000346804; ENSG00000095794. [Q03060-26]
    ENST00000356917; ENSP00000349387; ENSG00000095794. [Q03060-9]
    ENST00000361599; ENSP00000354593; ENSG00000095794. [Q03060-12]
    ENST00000374726; ENSP00000363858; ENSG00000095794. [Q03060-25]
    ENST00000374728; ENSP00000363860; ENSG00000095794. [Q03060-30]
    ENST00000374734; ENSP00000363866; ENSG00000095794. [Q03060-32]
    ENST00000395887; ENSP00000379225; ENSG00000095794. [Q03060-22]
    ENST00000463314; ENSP00000418336; ENSG00000095794. [Q03060-28]
    ENST00000468236; ENSP00000419810; ENSG00000095794. [Q03060-29]
    ENST00000473940; ENSP00000420681; ENSG00000095794. [Q03060-8]
    ENST00000474931; ENSP00000417562; ENSG00000095794. [Q03060-24]
    ENST00000479070; ENSP00000420511; ENSG00000095794. [Q03060-15]
    ENST00000487763; ENSP00000417807; ENSG00000095794. [Q03060-10]
    ENST00000488328; ENSP00000417460; ENSG00000095794. [Q03060-11]
    ENST00000488741; ENSP00000419075; ENSG00000095794. [Q03060-23]
    ENST00000489321; ENSP00000419924; ENSG00000095794. [Q03060-25]
    ENST00000490511; ENSP00000417327; ENSG00000095794. [Q03060-27]
    GeneIDi1390.
    KEGGihsa:1390.
    UCSCiuc001ixx.3. human. [Q03060-25]
    uc001iya.3. human.
    uc001iyb.3. human. [Q03060-16]
    uc001iyc.3. human.
    uc001iyf.3. human. [Q03060-12]
    uc001iyh.3. human. [Q03060-7]
    uc001iyl.3. human. [Q03060-10]
    uc001iym.3. human. [Q03060-8]
    uc001iyn.3. human. [Q03060-11]
    uc001iyo.3. human. [Q03060-9]
    uc001iyp.3. human. [Q03060-23]
    uc001iyr.3. human. [Q03060-24]
    uc031pty.1. human. [Q03060-22]

    Polymorphism databases

    DMDMi259016392.

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14825 mRNA. Translation: BAA03562.1 .
    D14826 mRNA. Translation: BAA03564.1 .
    D14826 mRNA. Translation: BAA03565.1 .
    D14826 mRNA. Translation: BAA03566.1 .
    D14826 mRNA. Translation: BAA03567.1 .
    U44836 mRNA. Translation: AAB03751.1 . Sequence problems.
    AF069065 mRNA. Translation: AAC19383.1 .
    AY292864 mRNA. Translation: AAP44115.1 .
    AK289379 mRNA. Translation: BAF82068.1 .
    AK290612 mRNA. Translation: BAF83301.1 .
    AK291566 mRNA. Translation: BAF84255.1 .
    AK301906 mRNA. Translation: BAG63333.1 .
    AL117336 Genomic DNA. No translation available.
    AL157783 Genomic DNA. No translation available.
    CH471072 Genomic DNA. Translation: EAW85917.1 .
    CH471072 Genomic DNA. Translation: EAW85918.1 .
    BC017117 mRNA. Translation: AAH17117.1 .
    BC066342 mRNA. Translation: AAH66342.1 .
    BC090051 mRNA. Translation: AAH90051.1 .
    AF213899
    , AF212158 , AF213897 , AF213898 Genomic DNA. Translation: AAF68266.2 . Sequence problems.
    AF417234 mRNA. Translation: AAN32656.1 .
    S68271 mRNA. Translation: AAC60616.2 .
    S68134 mRNA. Translation: AAC60617.2 .
    Z15159 mRNA. Translation: CAA78858.1 .
    AF217318 , AF214665 Genomic DNA. Translation: AAF66158.2 .
    AF217318 , AF214665 Genomic DNA. Translation: AAF68682.1 .
    CCDSi CCDS31181.1. [Q03060-32 ]
    CCDS53517.1. [Q03060-10 ]
    CCDS53518.1. [Q03060-9 ]
    CCDS53519.1. [Q03060-11 ]
    CCDS53520.1. [Q03060-27 ]
    CCDS53521.1. [Q03060-23 ]
    CCDS58074.1. [Q03060-22 ]
    CCDS58075.1. [Q03060-28 ]
    CCDS58076.1. [Q03060-29 ]
    CCDS7180.1. [Q03060-16 ]
    CCDS7181.1. [Q03060-31 ]
    CCDS7182.1. [Q03060-26 ]
    CCDS7183.1. [Q03060-30 ]
    CCDS7184.1. [Q03060-25 ]
    CCDS7185.1. [Q03060-12 ]
    CCDS7186.1. [Q03060-7 ]
    CCDS7187.1. [Q03060-8 ]
    CCDS7188.1. [Q03060-24 ]
    PIRi JC2087.
    JC6135.
    JX0307.
    S26685.
    RefSeqi NP_001254491.1. NM_001267562.1.
    NP_001254493.1. NM_001267564.1. [Q03060-22 ]
    NP_001254496.1. NM_001267567.1. [Q03060-28 ]
    NP_001254499.1. NM_001267570.1. [Q03060-29 ]
    NP_001872.3. NM_001881.3. [Q03060-25 ]
    NP_853549.1. NM_181571.2. [Q03060-16 ]
    NP_874386.1. NM_182717.1. [Q03060-8 ]
    NP_874387.1. NM_182718.1. [Q03060-11 ]
    NP_874388.1. NM_182719.1. [Q03060-10 ]
    NP_874389.1. NM_182720.1. [Q03060-9 ]
    NP_874390.1. NM_182721.1. [Q03060-24 ]
    NP_874392.1. NM_182723.1. [Q03060-23 ]
    NP_874393.1. NM_182724.1. [Q03060-27 ]
    NP_877570.1. NM_182769.2. [Q03060-7 ]
    NP_877571.1. NM_182770.2.
    NP_877572.1. NM_182771.1. [Q03060-12 ]
    NP_877573.1. NM_182772.1.
    NP_898829.1. NM_183011.1. [Q03060-31 ]
    NP_898830.1. NM_183012.1. [Q03060-32 ]
    NP_898831.1. NM_183013.2. [Q03060-26 ]
    NP_898883.1. NM_183060.2. [Q03060-30 ]
    XP_006717441.1. XM_006717378.1. [Q03060-16 ]
    XP_006717442.1. XM_006717379.1. [Q03060-31 ]
    XP_006717445.1. XM_006717382.1. [Q03060-2 ]
    XP_006717446.1. XM_006717383.1. [Q03060-32 ]
    XP_006717448.1. XM_006717385.1. [Q03060-28 ]
    UniGenei Hs.200250.

    3D structure databases

    ProteinModelPortali Q03060.
    SMRi Q03060. Positions 123-149, 304-358.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107780. 19 interactions.
    IntActi Q03060. 6 interactions.

    PTM databases

    PhosphoSitei Q03060.

    Polymorphism databases

    DMDMi 259016392.

    Proteomic databases

    MaxQBi Q03060.
    PaxDbi Q03060.
    PRIDEi Q03060.

    Protocols and materials databases

    DNASUi 1390.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000337656 ; ENSP00000337138 ; ENSG00000095794 . [Q03060-31 ]
    ENST00000342105 ; ENSP00000341875 ; ENSG00000095794 . [Q03060-7 ]
    ENST00000345491 ; ENSP00000265372 ; ENSG00000095794 . [Q03060-16 ]
    ENST00000348787 ; ENSP00000345384 ; ENSG00000095794 . [Q03060-30 ]
    ENST00000354759 ; ENSP00000346804 ; ENSG00000095794 . [Q03060-26 ]
    ENST00000356917 ; ENSP00000349387 ; ENSG00000095794 . [Q03060-9 ]
    ENST00000361599 ; ENSP00000354593 ; ENSG00000095794 . [Q03060-12 ]
    ENST00000374726 ; ENSP00000363858 ; ENSG00000095794 . [Q03060-25 ]
    ENST00000374728 ; ENSP00000363860 ; ENSG00000095794 . [Q03060-30 ]
    ENST00000374734 ; ENSP00000363866 ; ENSG00000095794 . [Q03060-32 ]
    ENST00000395887 ; ENSP00000379225 ; ENSG00000095794 . [Q03060-22 ]
    ENST00000463314 ; ENSP00000418336 ; ENSG00000095794 . [Q03060-28 ]
    ENST00000468236 ; ENSP00000419810 ; ENSG00000095794 . [Q03060-29 ]
    ENST00000473940 ; ENSP00000420681 ; ENSG00000095794 . [Q03060-8 ]
    ENST00000474931 ; ENSP00000417562 ; ENSG00000095794 . [Q03060-24 ]
    ENST00000479070 ; ENSP00000420511 ; ENSG00000095794 . [Q03060-15 ]
    ENST00000487763 ; ENSP00000417807 ; ENSG00000095794 . [Q03060-10 ]
    ENST00000488328 ; ENSP00000417460 ; ENSG00000095794 . [Q03060-11 ]
    ENST00000488741 ; ENSP00000419075 ; ENSG00000095794 . [Q03060-23 ]
    ENST00000489321 ; ENSP00000419924 ; ENSG00000095794 . [Q03060-25 ]
    ENST00000490511 ; ENSP00000417327 ; ENSG00000095794 . [Q03060-27 ]
    GeneIDi 1390.
    KEGGi hsa:1390.
    UCSCi uc001ixx.3. human. [Q03060-25 ]
    uc001iya.3. human.
    uc001iyb.3. human. [Q03060-16 ]
    uc001iyc.3. human.
    uc001iyf.3. human. [Q03060-12 ]
    uc001iyh.3. human. [Q03060-7 ]
    uc001iyl.3. human. [Q03060-10 ]
    uc001iym.3. human. [Q03060-8 ]
    uc001iyn.3. human. [Q03060-11 ]
    uc001iyo.3. human. [Q03060-9 ]
    uc001iyp.3. human. [Q03060-23 ]
    uc001iyr.3. human. [Q03060-24 ]
    uc031pty.1. human. [Q03060-22 ]

    Organism-specific databases

    CTDi 1390.
    GeneCardsi GC10P035415.
    HGNCi HGNC:2352. CREM.
    HPAi CAB018352.
    HPA001818.
    MIMi 123812. gene.
    neXtProti NX_Q03060.
    PharmGKBi PA26871.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG300199.
    HOGENOMi HOG000007365.
    HOVERGENi HBG011077.
    InParanoidi Q03060.
    KOi K09052.
    OMAi ESESAHM.
    PhylomeDBi Q03060.
    TreeFami TF106464.

    Enzyme and pathway databases

    SignaLinki Q03060.

    Miscellaneous databases

    ChiTaRSi CREM. human.
    GeneWikii CAMP_responsive_element_modulator.
    GenomeRNAii 1390.
    NextBioi 5649.
    PROi Q03060.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q03060.
    Bgeei Q03060.
    Genevestigatori Q03060.

    Family and domain databases

    InterProi IPR004827. bZIP.
    IPR003102. Coactivator_CBP_pKID.
    IPR001630. Leuzip_CREB.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    PF02173. pKID. 1 hit.
    [Graphical view ]
    PRINTSi PR00041. LEUZIPPRCREB.
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    PS50953. KID. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA."
      Fujimoto T., Fujisawa J., Yoshida M.
      J. Biochem. 115:298-303(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 6; 7; 8; 9 AND 23).
    2. "cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes."
      Bodor J., Spetz A.L., Strominger J.L., Habener J.F.
      Proc. Natl. Acad. Sci. U.S.A. 93:3536-3541(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8), ALTERNATIVE SPLICING (ISOFORMS 6; 7 AND 9), VARIANT ARG-270.
    3. "Human ICER1, a predicted alternative splice form of CREM, is evident in JEG-3 cells."
      Brodie C.R., Boland L.M., Orr H.T.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
    4. "The function of an isoform of hCREM gene in testis development."
      Lu L., Huang X.Y., Xu M., Xu Z.Y., Li J.M., Zhou Z.M., Sha J.H.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
      Tissue: Testis.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5; 7; 20 AND 21).
      Tissue: Adrenal gland, Heart, Placenta and Testis.
    6. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 22).
      Tissue: Brain, Testis and Uterus.
    8. "Searching for mutations in the human cAMP responsive element modulator (CREM) gene."
      Vouk K., Lalli E., Scherer S.W., Sassone-Corsi P., Debeljak N., Komel R., Rozman D.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-248.
    9. "Novel leader exons of the cyclic adenosine 3',5'-monophosphate response element modulator (CREM) gene, transcribed from promoters P3 and P4, are highly testis-specific in primates."
      Gellersen B., Kempf R., Sandhowe R., Weinbauer G.F., Behr R.
      Mol. Hum. Reprod. 8:965-976(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-26 (ISOFORM 10), ALTERNATIVE SPLICING (ISOFORMS 5; 10; 11 AND 12).
    10. "Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript."
      Masquilier D., Foulkes N.S., Mattei M.-G., Sassone-Corsi P.
      Cell Growth Differ. 4:931-937(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-361 (ISOFORMS 2 AND 3).
    11. "Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes."
      Meyer T.E., Habener J.F.
      Nucleic Acids Res. 20:6106-6106(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-360 (ISOFORM 4).
      Tissue: Placenta.
    12. "Combinations of genetic changes in the human cAMP-responsive element modulator gene: a clue towards understanding some forms of male infertility?"
      Vouk K., Hudler P., Strmsnik L., Fink M., Majdic G., Zorn B., Lalli E., Sassone-Corsi P., Debeljak N., Komel R., Rozman D.
      Mol. Hum. Reprod. 11:567-574(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 262-361, TISSUE SPECIFICITY.
    13. "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis."
      Pati D., Meistrich M.L., Plon S.E.
      Mol. Cell. Biol. 19:5001-5013(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CDC34, UBIQUITINATION.
    14. "CREM activator and repressor isoforms in human testis: sequence variations and inaccurate splicing during impaired spermatogenesis."
      Behr R., Weinbauer G.F.
      Mol. Hum. Reprod. 6:967-972(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORMS 2; 4; 13; 15; 17 AND 18), TISSUE SPECIFICITY.
    15. "Different CREM-isoform gene expression between equine and human normal and impaired spermatogenesis."
      Bloecher S., Behr R., Weinbauer G.F., Bergmann M., Steger K.
      Theriogenology 60:1357-1369(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORMS 5; 12; 14; 16 AND 19), TISSUE SPECIFICITY.
    16. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-287; SER-290 AND SER-293, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-287 AND SER-293, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiCREM_HUMAN
    AccessioniPrimary (citable) accession number: Q03060
    Secondary accession number(s): A8K014
    , A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0, Q5W1B2, Q7Z2Q6, Q8IVD4, Q96AG7, Q9NZ98, Q9NZ99, Q9NZB9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 151 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3