ID   PO3F1_HUMAN             Reviewed;         451 AA.
AC   Q03052; Q5TAG2;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 3.
DT   03-NOV-2009, entry version 93.
DE   RecName: Full=POU domain, class 3, transcription factor 1;
DE   AltName: Full=Octamer-binding transcription factor 6;
DE            Short=Oct-6;
DE   AltName: Full=POU domain transcription factor SCIP;
GN   Name=POU3F1; Synonyms=OCT6, OTF6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=94217723; PubMed=7909356;
RA   Faus I., Hsu H.J., Fuchs E.;
RT   "Oct-6: a regulator of keratinocyte gene expression in stratified
RT   squamous epithelia.";
RL   Mol. Cell. Biol. 14:3263-3275(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA   Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA   Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA   Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA   Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA   Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA   Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA   Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA   Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA   Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA   Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA   Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA   Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA   Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 53-451.
RX   MEDLINE=93197134; PubMed=8451175; DOI=10.1093/nar/21.4.1043;
RA   Tobler A., Schreiber E., Fontana A.;
RT   "The human Oct-6 POU transcription factor lacks the first 50 amino
RT   acids of its murine counterpart.";
RL   Nucleic Acids Res. 21:1043-1043(1993).
CC   -!- FUNCTION: Transcription factor that binds to the octamer motif
CC       (5'-ATTTGCAT-3'). Thought to be involved in early embryogenesis
CC       and neurogenesis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Expressed in embryonal stem cells and in the
CC       developing brain.
CC   -!- SIMILARITY: Belongs to the POU transcription factor family. Class-
CC       3 subfamily.
CC   -!- SIMILARITY: Contains 1 homeobox DNA-binding domain.
CC   -!- SIMILARITY: Contains 1 POU-specific domain.
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DR   EMBL; L26494; AAA59965.1; -; mRNA.
DR   EMBL; AL139158; CAI23136.1; -; Genomic_DNA.
DR   EMBL; CH471059; EAX07298.1; -; Genomic_DNA.
DR   EMBL; Z18284; CAA79158.1; -; mRNA.
DR   IPI; IPI00008840; -.
DR   PIR; A56018; A56018.
DR   RefSeq; NP_002690.3; -.
DR   UniGene; Hs.1837; -.
DR   HSSP; P14859; 1CQT.
DR   SMR; Q03052; 250-396.
DR   DIP; DIP:277N; -.
DR   STRING; Q03052; -.
DR   PRIDE; Q03052; -.
DR   Ensembl; ENST00000373012; ENSP00000362103; ENSG00000185668; Homo sapiens.
DR   GeneID; 5453; -.
DR   KEGG; hsa:5453; -.
DR   UCSC; uc001ccp.1; human.
DR   CTD; 5453; -.
DR   GeneCards; GC01M038282; -.
DR   H-InvDB; HIX0028895; -.
DR   HGNC; HGNC:9214; POU3F1.
DR   MIM; 602479; gene.
DR   PharmGKB; PA33538; -.
DR   HOVERGEN; Q03052; -.
DR   OMA; HPQWLPT; -.
DR   ArrayExpress; Q03052; -.
DR   Bgee; Q03052; -.
DR   CleanEx; HS_POU3F1; -.
DR   Genevestigator; Q03052; -.
DR   GermOnline; ENSG00000185668; Homo sapiens.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR   GO; GO:0003700; F:transcription factor activity; TAS:ProtInc.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001356; Homeobox.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR012287; Homeodomain-rel.
DR   InterPro; IPR013847; POU.
DR   InterPro; IPR000327; POU_specific.
DR   Gene3D; G3DSA:1.10.10.60; Homeodomain-rel; 1.
DR   Pfam; PF00046; Homeobox; 1.
DR   Pfam; PF00157; Pou; 1.
DR   PRINTS; PR00028; POUDOMAIN.
DR   ProDom; PD000010; Homeobox; 1.
DR   ProDom; PD000583; POU; 1.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00352; POU; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00035; POU_1; 1.
DR   PROSITE; PS00465; POU_2; 1.
DR   PROSITE; PS51179; POU_3; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Homeobox; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN         1    451       POU domain, class 3, transcription factor
FT                                1.
FT                                /FTId=PRO_0000100720.
FT   DOMAIN      247    321       POU-specific.
FT   DNA_BIND    339    398       Homeobox.
FT   COMPBIAS     27     45       Ala-rich.
FT   COMPBIAS     59    242       Gly-rich.
FT   COMPBIAS    225    228       Poly-Ala.
FT   COMPBIAS    418    423       Poly-Gly.
FT   COMPBIAS    430    435       Poly-Pro.
FT   COMPBIAS    439    444       Poly-His.
FT   CONFLICT     27     28       Missing (in Ref. 1; AAA59965).
FT   CONFLICT     87     88       GP -> A (in Ref. 1; AAA59965 and 4;
FT                                CAA79158).
SQ   SEQUENCE   451 AA;  45496 MW;  563217BD6A3D00CD CRC64;
     MATTAQYLPR GPGGGAGGTG PLMHPDAAAA AAAAAAAERL HAGAAYREVQ KLMHHEWLGA
     GAGHPVGLAH PQWLPTGGGG GGDWAGGPHL EHGKAGGGGT GRADDGGGGG GFHARLVHQG
     AAHAGAAWAQ GSTAHHLGPA MSPSPGASGG HQPQPLGLYA QAAYPGGGGG GLAGMLAAGG
     GGAGPGLHHA LHEDGHEAQL EPSPPPHLGA HGHAHGHAHA GGLHAAAAHL HPGAGGGGSS
     VGEHSDEDAP SSDDLEQFAK QFKQRRIKLG FTQADVGLAL GTLYGNVFSQ TTICRFEALQ
     LSFKNMCKLK PLLNKWLEET DSSSGSPTNL DKIAAQGRKR KKRTSIEVGV KGALESHFLK
     CPKPSAHEIT GLADSLQLEK EVVRVWFCNR RQKEKRMTPA AGAGHPPMDD VYAPGELGPG
     GGGASPPSAP PPPPPAALHH HHHHTLPGSV Q
//