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Q03052 (PO3F1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 138. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain, class 3, transcription factor 1
Alternative name(s):
Octamer-binding protein 6
Short name=Oct-6
Octamer-binding transcription factor 6
Short name=OTF-6
POU domain transcription factor SCIP
Gene names
Name:POU3F1
Synonyms:OCT6, OTF6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length451 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Thought to be involved in early embryogenesis and neurogenesis.

Subcellular location

Nucleus.

Tissue specificity

Expressed in embryonal stem cells and in the developing brain.

Sequence similarities

Belongs to the POU transcription factor family. Class-3 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 451451POU domain, class 3, transcription factor 1
PRO_0000100720

Regions

Domain247 – 32175POU-specific
DNA binding339 – 39860Homeobox
Compositional bias27 – 4519Ala-rich
Compositional bias59 – 242184Gly-rich
Compositional bias225 – 2284Poly-Ala
Compositional bias418 – 4236Poly-Gly
Compositional bias430 – 4356Poly-Pro
Compositional bias439 – 4446Poly-His

Experimental info

Sequence conflict27 – 282Missing in AAA59965. Ref.1
Sequence conflict87 – 882GP → A in AAA59965. Ref.1
Sequence conflict87 – 882GP → A in CAA79158. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q03052 [UniParc].

Last modified December 16, 2008. Version 3.
Checksum: 563217BD6A3D00CD

FASTA45145,496
        10         20         30         40         50         60 
MATTAQYLPR GPGGGAGGTG PLMHPDAAAA AAAAAAAERL HAGAAYREVQ KLMHHEWLGA 

        70         80         90        100        110        120 
GAGHPVGLAH PQWLPTGGGG GGDWAGGPHL EHGKAGGGGT GRADDGGGGG GFHARLVHQG 

       130        140        150        160        170        180 
AAHAGAAWAQ GSTAHHLGPA MSPSPGASGG HQPQPLGLYA QAAYPGGGGG GLAGMLAAGG 

       190        200        210        220        230        240 
GGAGPGLHHA LHEDGHEAQL EPSPPPHLGA HGHAHGHAHA GGLHAAAAHL HPGAGGGGSS 

       250        260        270        280        290        300 
VGEHSDEDAP SSDDLEQFAK QFKQRRIKLG FTQADVGLAL GTLYGNVFSQ TTICRFEALQ 

       310        320        330        340        350        360 
LSFKNMCKLK PLLNKWLEET DSSSGSPTNL DKIAAQGRKR KKRTSIEVGV KGALESHFLK 

       370        380        390        400        410        420 
CPKPSAHEIT GLADSLQLEK EVVRVWFCNR RQKEKRMTPA AGAGHPPMDD VYAPGELGPG 

       430        440        450 
GGGASPPSAP PPPPPAALHH HHHHTLPGSV Q 

« Hide

References

« Hide 'large scale' references
[1]"Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia."
Faus I., Hsu H.J., Fuchs E.
Mol. Cell. Biol. 14:3263-3275(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The human Oct-6 POU transcription factor lacks the first 50 amino acids of its murine counterpart."
Tobler A., Schreiber E., Fontana A.
Nucleic Acids Res. 21:1043-1043(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-451.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L26494 mRNA. Translation: AAA59965.1.
AL139158 Genomic DNA. Translation: CAI23136.1.
CH471059 Genomic DNA. Translation: EAX07298.1.
Z18284 mRNA. Translation: CAA79158.1.
PIRA56018.
RefSeqNP_002690.3. NM_002699.3.
UniGeneHs.1837.

3D structure databases

ProteinModelPortalQ03052.
SMRQ03052. Positions 249-399.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111449. 1 interaction.
DIPDIP-277N.
STRING9606.ENSP00000362103.

Polymorphism databases

DMDM218512119.

Proteomic databases

PaxDbQ03052.
PRIDEQ03052.

Protocols and materials databases

DNASU5453.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000373012; ENSP00000362103; ENSG00000185668.
GeneID5453.
KEGGhsa:5453.
UCSCuc001ccp.1. human.

Organism-specific databases

CTD5453.
GeneCardsGC01M038509.
H-InvDBHIX0028895.
HGNCHGNC:9214. POU3F1.
MIM602479. gene.
neXtProtNX_Q03052.
PharmGKBPA33538.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG261729.
HOGENOMHOG000116303.
HOVERGENHBG053120.
InParanoidQ03052.
KOK09365.
OMAKLMHHEW.
OrthoDBEOG7DJSMG.
PhylomeDBQ03052.
TreeFamTF316413.

Enzyme and pathway databases

SignaLinkQ03052.

Gene expression databases

BgeeQ03052.
CleanExHS_POU3F1.
GenevestigatorQ03052.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PIRSFPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPOU3F1.
GenomeRNAi5453.
NextBio21105.
PROQ03052.
SOURCESearch...

Entry information

Entry namePO3F1_HUMAN
AccessionPrimary (citable) accession number: Q03052
Secondary accession number(s): Q5TAG2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 16, 2008
Last modified: April 16, 2014
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM