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Protein

POU domain, class 3, transcription factor 1

Gene

POU3F1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Thought to be involved in early embryogenesis and neurogenesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi339 – 39860HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • RNA polymerase II transcription coactivator activity Source: Ensembl
  • sequence-specific DNA binding Source: MGI
  • sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiQ03052.

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 3, transcription factor 1
Alternative name(s):
Octamer-binding protein 6
Short name:
Oct-6
Octamer-binding transcription factor 6
Short name:
OTF-6
POU domain transcription factor SCIP
Gene namesi
Name:POU3F1
Synonyms:OCT6, OTF6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:9214. POU3F1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33538.

Polymorphism and mutation databases

BioMutaiPOU3F1.
DMDMi218512119.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 451451POU domain, class 3, transcription factor 1PRO_0000100720Add
BLAST

Proteomic databases

MaxQBiQ03052.
PaxDbiQ03052.
PRIDEiQ03052.

Expressioni

Tissue specificityi

Expressed in embryonal stem cells and in the developing brain.

Gene expression databases

BgeeiQ03052.
CleanExiHS_POU3F1.
GenevisibleiQ03052. HS.

Interactioni

Protein-protein interaction databases

BioGridi111449. 1 interaction.
DIPiDIP-277N.
STRINGi9606.ENSP00000362103.

Structurei

3D structure databases

ProteinModelPortaliQ03052.
SMRiQ03052. Positions 249-399.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini247 – 32175POU-specificPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 4519Ala-richAdd
BLAST
Compositional biasi59 – 242184Gly-richAdd
BLAST
Compositional biasi225 – 2284Poly-Ala
Compositional biasi418 – 4236Poly-Gly
Compositional biasi430 – 4356Poly-Pro
Compositional biasi439 – 4446Poly-His

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG261729.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000116303.
HOVERGENiHBG053120.
InParanoidiQ03052.
KOiK09365.
OMAiHPQWLPT.
OrthoDBiEOG7DJSMG.
PhylomeDBiQ03052.
TreeFamiTF316413.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. TF_POU_3.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03052-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTAQYLPR GPGGGAGGTG PLMHPDAAAA AAAAAAAERL HAGAAYREVQ
60 70 80 90 100
KLMHHEWLGA GAGHPVGLAH PQWLPTGGGG GGDWAGGPHL EHGKAGGGGT
110 120 130 140 150
GRADDGGGGG GFHARLVHQG AAHAGAAWAQ GSTAHHLGPA MSPSPGASGG
160 170 180 190 200
HQPQPLGLYA QAAYPGGGGG GLAGMLAAGG GGAGPGLHHA LHEDGHEAQL
210 220 230 240 250
EPSPPPHLGA HGHAHGHAHA GGLHAAAAHL HPGAGGGGSS VGEHSDEDAP
260 270 280 290 300
SSDDLEQFAK QFKQRRIKLG FTQADVGLAL GTLYGNVFSQ TTICRFEALQ
310 320 330 340 350
LSFKNMCKLK PLLNKWLEET DSSSGSPTNL DKIAAQGRKR KKRTSIEVGV
360 370 380 390 400
KGALESHFLK CPKPSAHEIT GLADSLQLEK EVVRVWFCNR RQKEKRMTPA
410 420 430 440 450
AGAGHPPMDD VYAPGELGPG GGGASPPSAP PPPPPAALHH HHHHTLPGSV

Q
Length:451
Mass (Da):45,496
Last modified:December 16, 2008 - v3
Checksum:i563217BD6A3D00CD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 282Missing in AAA59965 (PubMed:7909356).Curated
Sequence conflicti87 – 882GP → A in AAA59965 (PubMed:7909356).Curated
Sequence conflicti87 – 882GP → A in CAA79158 (PubMed:8451175).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26494 mRNA. Translation: AAA59965.1.
AL139158 Genomic DNA. Translation: CAI23136.1.
CH471059 Genomic DNA. Translation: EAX07298.1.
Z18284 mRNA. Translation: CAA79158.1.
CCDSiCCDS30679.1.
PIRiA56018.
RefSeqiNP_002690.3. NM_002699.3.
UniGeneiHs.1837.

Genome annotation databases

EnsembliENST00000373012; ENSP00000362103; ENSG00000185668.
GeneIDi5453.
KEGGihsa:5453.
UCSCiuc001ccp.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26494 mRNA. Translation: AAA59965.1.
AL139158 Genomic DNA. Translation: CAI23136.1.
CH471059 Genomic DNA. Translation: EAX07298.1.
Z18284 mRNA. Translation: CAA79158.1.
CCDSiCCDS30679.1.
PIRiA56018.
RefSeqiNP_002690.3. NM_002699.3.
UniGeneiHs.1837.

3D structure databases

ProteinModelPortaliQ03052.
SMRiQ03052. Positions 249-399.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111449. 1 interaction.
DIPiDIP-277N.
STRINGi9606.ENSP00000362103.

Polymorphism and mutation databases

BioMutaiPOU3F1.
DMDMi218512119.

Proteomic databases

MaxQBiQ03052.
PaxDbiQ03052.
PRIDEiQ03052.

Protocols and materials databases

DNASUi5453.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373012; ENSP00000362103; ENSG00000185668.
GeneIDi5453.
KEGGihsa:5453.
UCSCiuc001ccp.1. human.

Organism-specific databases

CTDi5453.
GeneCardsiGC01M038509.
H-InvDBHIX0028895.
HGNCiHGNC:9214. POU3F1.
MIMi602479. gene.
neXtProtiNX_Q03052.
PharmGKBiPA33538.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG261729.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000116303.
HOVERGENiHBG053120.
InParanoidiQ03052.
KOiK09365.
OMAiHPQWLPT.
OrthoDBiEOG7DJSMG.
PhylomeDBiQ03052.
TreeFamiTF316413.

Enzyme and pathway databases

SignaLinkiQ03052.

Miscellaneous databases

GeneWikiiPOU3F1.
GenomeRNAii5453.
NextBioi21105.
PROiQ03052.
SOURCEiSearch...

Gene expression databases

BgeeiQ03052.
CleanExiHS_POU3F1.
GenevisibleiQ03052. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. TF_POU_3.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia."
    Faus I., Hsu H.J., Fuchs E.
    Mol. Cell. Biol. 14:3263-3275(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The human Oct-6 POU transcription factor lacks the first 50 amino acids of its murine counterpart."
    Tobler A., Schreiber E., Fontana A.
    Nucleic Acids Res. 21:1043-1043(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-451.

Entry informationi

Entry nameiPO3F1_HUMAN
AccessioniPrimary (citable) accession number: Q03052
Secondary accession number(s): Q5TAG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 16, 2008
Last modified: July 22, 2015
This is version 147 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.