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Protein

POU domain, class 3, transcription factor 1

Gene

POU3F1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Thought to be involved in early embryogenesis and neurogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi339 – 398HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiQ03052
SIGNORiQ03052

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 3, transcription factor 1
Alternative name(s):
Octamer-binding protein 6
Short name:
Oct-6
Octamer-binding transcription factor 6
Short name:
OTF-6
POU domain transcription factor SCIP
Gene namesi
Name:POU3F1
Synonyms:OCT6, OTF6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000185668.6
HGNCiHGNC:9214 POU3F1
MIMi602479 gene
neXtProtiNX_Q03052

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5453
OpenTargetsiENSG00000185668
PharmGKBiPA33538

Polymorphism and mutation databases

BioMutaiPOU3F1
DMDMi218512119

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007201 – 451POU domain, class 3, transcription factor 1Add BLAST451

Proteomic databases

EPDiQ03052
MaxQBiQ03052
PaxDbiQ03052
PeptideAtlasiQ03052
PRIDEiQ03052

Expressioni

Tissue specificityi

Expressed in embryonal stem cells and in the developing brain.

Gene expression databases

BgeeiENSG00000185668
CleanExiHS_POU3F1
GenevisibleiQ03052 HS

Organism-specific databases

HPAiHPA055980
HPA073824

Interactioni

Protein-protein interaction databases

BioGridi111449, 1 interactor
DIPiDIP-277N
STRINGi9606.ENSP00000362103

Structurei

3D structure databases

ProteinModelPortaliQ03052
SMRiQ03052
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini247 – 321POU-specificPROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi27 – 45Ala-richAdd BLAST19
Compositional biasi59 – 242Gly-richAdd BLAST184
Compositional biasi225 – 228Poly-Ala4
Compositional biasi418 – 423Poly-Gly6
Compositional biasi430 – 435Poly-Pro6
Compositional biasi439 – 444Poly-His6

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG3802 Eukaryota
ENOG410XQ7X LUCA
GeneTreeiENSGT00760000118935
HOGENOMiHOG000116303
HOVERGENiHBG053120
InParanoidiQ03052
KOiK09365
OMAiMEDVYSQ
OrthoDBiEOG091G0U0S
PhylomeDBiQ03052
TreeFamiTF316413

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom
IPR016362 TF_POU_3
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00157 Pou, 1 hit
PIRSFiPIRSF002629 Transcription_factor_POU, 1 hit
PRINTSiPR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q03052-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTAQYLPR GPGGGAGGTG PLMHPDAAAA AAAAAAAERL HAGAAYREVQ
60 70 80 90 100
KLMHHEWLGA GAGHPVGLAH PQWLPTGGGG GGDWAGGPHL EHGKAGGGGT
110 120 130 140 150
GRADDGGGGG GFHARLVHQG AAHAGAAWAQ GSTAHHLGPA MSPSPGASGG
160 170 180 190 200
HQPQPLGLYA QAAYPGGGGG GLAGMLAAGG GGAGPGLHHA LHEDGHEAQL
210 220 230 240 250
EPSPPPHLGA HGHAHGHAHA GGLHAAAAHL HPGAGGGGSS VGEHSDEDAP
260 270 280 290 300
SSDDLEQFAK QFKQRRIKLG FTQADVGLAL GTLYGNVFSQ TTICRFEALQ
310 320 330 340 350
LSFKNMCKLK PLLNKWLEET DSSSGSPTNL DKIAAQGRKR KKRTSIEVGV
360 370 380 390 400
KGALESHFLK CPKPSAHEIT GLADSLQLEK EVVRVWFCNR RQKEKRMTPA
410 420 430 440 450
AGAGHPPMDD VYAPGELGPG GGGASPPSAP PPPPPAALHH HHHHTLPGSV

Q
Length:451
Mass (Da):45,496
Last modified:December 16, 2008 - v3
Checksum:i563217BD6A3D00CD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27 – 28Missing in AAA59965 (PubMed:7909356).Curated2
Sequence conflicti87 – 88GP → A in AAA59965 (PubMed:7909356).Curated2
Sequence conflicti87 – 88GP → A in CAA79158 (PubMed:8451175).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26494 mRNA Translation: AAA59965.1
AL139158 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07298.1
Z18284 mRNA Translation: CAA79158.1
CCDSiCCDS30679.1
PIRiA56018
RefSeqiNP_002690.3, NM_002699.3
UniGeneiHs.1837

Genome annotation databases

EnsembliENST00000373012; ENSP00000362103; ENSG00000185668
GeneIDi5453
KEGGihsa:5453
UCSCiuc001ccp.2 human

Similar proteinsi

Entry informationi

Entry nameiPO3F1_HUMAN
AccessioniPrimary (citable) accession number: Q03052
Secondary accession number(s): Q5TAG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 16, 2008
Last modified: May 23, 2018
This is version 165 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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