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Q03052

- PO3F1_HUMAN

UniProt

Q03052 - PO3F1_HUMAN

Protein

POU domain, class 3, transcription factor 1

Gene

POU3F1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 3 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Thought to be involved in early embryogenesis and neurogenesis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi339 – 39860HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II transcription coactivator activity Source: Ensembl
    2. sequence-specific DNA binding Source: MGI
    3. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. axon ensheathment Source: ProtInc
    2. forebrain development Source: Ensembl
    3. keratinocyte differentiation Source: Ensembl
    4. myelination in peripheral nervous system Source: Ensembl
    5. positive regulation of gene expression Source: UniProtKB
    6. positive regulation of transcription, DNA-templated Source: UniProtKB

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiQ03052.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 3, transcription factor 1
    Alternative name(s):
    Octamer-binding protein 6
    Short name:
    Oct-6
    Octamer-binding transcription factor 6
    Short name:
    OTF-6
    POU domain transcription factor SCIP
    Gene namesi
    Name:POU3F1
    Synonyms:OCT6, OTF6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:9214. POU3F1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB
    2. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33538.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 451451POU domain, class 3, transcription factor 1PRO_0000100720Add
    BLAST

    Proteomic databases

    MaxQBiQ03052.
    PaxDbiQ03052.
    PRIDEiQ03052.

    Expressioni

    Tissue specificityi

    Expressed in embryonal stem cells and in the developing brain.

    Gene expression databases

    BgeeiQ03052.
    CleanExiHS_POU3F1.
    GenevestigatoriQ03052.

    Interactioni

    Protein-protein interaction databases

    BioGridi111449. 1 interaction.
    DIPiDIP-277N.
    STRINGi9606.ENSP00000362103.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03052.
    SMRiQ03052. Positions 249-399.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini247 – 32175POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi27 – 4519Ala-richAdd
    BLAST
    Compositional biasi59 – 242184Gly-richAdd
    BLAST
    Compositional biasi225 – 2284Poly-Ala
    Compositional biasi418 – 4236Poly-Gly
    Compositional biasi430 – 4356Poly-Pro
    Compositional biasi439 – 4446Poly-His

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG261729.
    HOGENOMiHOG000116303.
    HOVERGENiHBG053120.
    InParanoidiQ03052.
    KOiK09365.
    OMAiKLMHHEW.
    OrthoDBiEOG7DJSMG.
    PhylomeDBiQ03052.
    TreeFamiTF316413.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q03052-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATTAQYLPR GPGGGAGGTG PLMHPDAAAA AAAAAAAERL HAGAAYREVQ    50
    KLMHHEWLGA GAGHPVGLAH PQWLPTGGGG GGDWAGGPHL EHGKAGGGGT 100
    GRADDGGGGG GFHARLVHQG AAHAGAAWAQ GSTAHHLGPA MSPSPGASGG 150
    HQPQPLGLYA QAAYPGGGGG GLAGMLAAGG GGAGPGLHHA LHEDGHEAQL 200
    EPSPPPHLGA HGHAHGHAHA GGLHAAAAHL HPGAGGGGSS VGEHSDEDAP 250
    SSDDLEQFAK QFKQRRIKLG FTQADVGLAL GTLYGNVFSQ TTICRFEALQ 300
    LSFKNMCKLK PLLNKWLEET DSSSGSPTNL DKIAAQGRKR KKRTSIEVGV 350
    KGALESHFLK CPKPSAHEIT GLADSLQLEK EVVRVWFCNR RQKEKRMTPA 400
    AGAGHPPMDD VYAPGELGPG GGGASPPSAP PPPPPAALHH HHHHTLPGSV 450
    Q 451
    Length:451
    Mass (Da):45,496
    Last modified:December 16, 2008 - v3
    Checksum:i563217BD6A3D00CD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 282Missing in AAA59965. (PubMed:7909356)Curated
    Sequence conflicti87 – 882GP → A in AAA59965. (PubMed:7909356)Curated
    Sequence conflicti87 – 882GP → A in CAA79158. (PubMed:8451175)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26494 mRNA. Translation: AAA59965.1.
    AL139158 Genomic DNA. Translation: CAI23136.1.
    CH471059 Genomic DNA. Translation: EAX07298.1.
    Z18284 mRNA. Translation: CAA79158.1.
    CCDSiCCDS30679.1.
    PIRiA56018.
    RefSeqiNP_002690.3. NM_002699.3.
    UniGeneiHs.1837.

    Genome annotation databases

    EnsembliENST00000373012; ENSP00000362103; ENSG00000185668.
    GeneIDi5453.
    KEGGihsa:5453.
    UCSCiuc001ccp.1. human.

    Polymorphism databases

    DMDMi218512119.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26494 mRNA. Translation: AAA59965.1 .
    AL139158 Genomic DNA. Translation: CAI23136.1 .
    CH471059 Genomic DNA. Translation: EAX07298.1 .
    Z18284 mRNA. Translation: CAA79158.1 .
    CCDSi CCDS30679.1.
    PIRi A56018.
    RefSeqi NP_002690.3. NM_002699.3.
    UniGenei Hs.1837.

    3D structure databases

    ProteinModelPortali Q03052.
    SMRi Q03052. Positions 249-399.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111449. 1 interaction.
    DIPi DIP-277N.
    STRINGi 9606.ENSP00000362103.

    Polymorphism databases

    DMDMi 218512119.

    Proteomic databases

    MaxQBi Q03052.
    PaxDbi Q03052.
    PRIDEi Q03052.

    Protocols and materials databases

    DNASUi 5453.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373012 ; ENSP00000362103 ; ENSG00000185668 .
    GeneIDi 5453.
    KEGGi hsa:5453.
    UCSCi uc001ccp.1. human.

    Organism-specific databases

    CTDi 5453.
    GeneCardsi GC01M038509.
    H-InvDB HIX0028895.
    HGNCi HGNC:9214. POU3F1.
    MIMi 602479. gene.
    neXtProti NX_Q03052.
    PharmGKBi PA33538.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG261729.
    HOGENOMi HOG000116303.
    HOVERGENi HBG053120.
    InParanoidi Q03052.
    KOi K09365.
    OMAi KLMHHEW.
    OrthoDBi EOG7DJSMG.
    PhylomeDBi Q03052.
    TreeFami TF316413.

    Enzyme and pathway databases

    SignaLinki Q03052.

    Miscellaneous databases

    GeneWikii POU3F1.
    GenomeRNAii 5453.
    NextBioi 21105.
    PROi Q03052.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q03052.
    CleanExi HS_POU3F1.
    Genevestigatori Q03052.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia."
      Faus I., Hsu H.J., Fuchs E.
      Mol. Cell. Biol. 14:3263-3275(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The human Oct-6 POU transcription factor lacks the first 50 amino acids of its murine counterpart."
      Tobler A., Schreiber E., Fontana A.
      Nucleic Acids Res. 21:1043-1043(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-451.

    Entry informationi

    Entry nameiPO3F1_HUMAN
    AccessioniPrimary (citable) accession number: Q03052
    Secondary accession number(s): Q5TAG2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 141 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3