SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q03052

- PO3F1_HUMAN

UniProt

Q03052 - PO3F1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
POU domain, class 3, transcription factor 1
Gene
POU3F1, OCT6, OTF6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Thought to be involved in early embryogenesis and neurogenesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi339 – 39860Homeobox
Add
BLAST

GO - Molecular functioni

  1. RNA polymerase II transcription coactivator activity Source: Ensembl
  2. sequence-specific DNA binding Source: MGI
  3. sequence-specific DNA binding transcription factor activity Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. axon ensheathment Source: ProtInc
  2. forebrain development Source: Ensembl
  3. keratinocyte differentiation Source: Ensembl
  4. myelination in peripheral nervous system Source: Ensembl
  5. positive regulation of gene expression Source: UniProtKB
  6. positive regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiQ03052.

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 3, transcription factor 1
Alternative name(s):
Octamer-binding protein 6
Short name:
Oct-6
Octamer-binding transcription factor 6
Short name:
OTF-6
POU domain transcription factor SCIP
Gene namesi
Name:POU3F1
Synonyms:OCT6, OTF6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:9214. POU3F1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB
  2. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33538.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 451451POU domain, class 3, transcription factor 1
PRO_0000100720Add
BLAST

Proteomic databases

MaxQBiQ03052.
PaxDbiQ03052.
PRIDEiQ03052.

Expressioni

Tissue specificityi

Expressed in embryonal stem cells and in the developing brain.

Gene expression databases

BgeeiQ03052.
CleanExiHS_POU3F1.
GenevestigatoriQ03052.

Interactioni

Protein-protein interaction databases

BioGridi111449. 1 interaction.
DIPiDIP-277N.
STRINGi9606.ENSP00000362103.

Structurei

3D structure databases

ProteinModelPortaliQ03052.
SMRiQ03052. Positions 249-399.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini247 – 32175POU-specific
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 4519Ala-rich
Add
BLAST
Compositional biasi59 – 242184Gly-rich
Add
BLAST
Compositional biasi225 – 2284Poly-Ala
Compositional biasi418 – 4236Poly-Gly
Compositional biasi430 – 4356Poly-Pro
Compositional biasi439 – 4446Poly-His

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG261729.
HOGENOMiHOG000116303.
HOVERGENiHBG053120.
InParanoidiQ03052.
KOiK09365.
OMAiKLMHHEW.
OrthoDBiEOG7DJSMG.
PhylomeDBiQ03052.
TreeFamiTF316413.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03052-1 [UniParc]FASTAAdd to Basket

« Hide

MATTAQYLPR GPGGGAGGTG PLMHPDAAAA AAAAAAAERL HAGAAYREVQ    50
KLMHHEWLGA GAGHPVGLAH PQWLPTGGGG GGDWAGGPHL EHGKAGGGGT 100
GRADDGGGGG GFHARLVHQG AAHAGAAWAQ GSTAHHLGPA MSPSPGASGG 150
HQPQPLGLYA QAAYPGGGGG GLAGMLAAGG GGAGPGLHHA LHEDGHEAQL 200
EPSPPPHLGA HGHAHGHAHA GGLHAAAAHL HPGAGGGGSS VGEHSDEDAP 250
SSDDLEQFAK QFKQRRIKLG FTQADVGLAL GTLYGNVFSQ TTICRFEALQ 300
LSFKNMCKLK PLLNKWLEET DSSSGSPTNL DKIAAQGRKR KKRTSIEVGV 350
KGALESHFLK CPKPSAHEIT GLADSLQLEK EVVRVWFCNR RQKEKRMTPA 400
AGAGHPPMDD VYAPGELGPG GGGASPPSAP PPPPPAALHH HHHHTLPGSV 450
Q 451
Length:451
Mass (Da):45,496
Last modified:December 16, 2008 - v3
Checksum:i563217BD6A3D00CD
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 282Missing in AAA59965. 1 Publication
Sequence conflicti87 – 882GP → A in AAA59965. 1 Publication
Sequence conflicti87 – 882GP → A in CAA79158. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L26494 mRNA. Translation: AAA59965.1.
AL139158 Genomic DNA. Translation: CAI23136.1.
CH471059 Genomic DNA. Translation: EAX07298.1.
Z18284 mRNA. Translation: CAA79158.1.
CCDSiCCDS30679.1.
PIRiA56018.
RefSeqiNP_002690.3. NM_002699.3.
UniGeneiHs.1837.

Genome annotation databases

EnsembliENST00000373012; ENSP00000362103; ENSG00000185668.
GeneIDi5453.
KEGGihsa:5453.
UCSCiuc001ccp.1. human.

Polymorphism databases

DMDMi218512119.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L26494 mRNA. Translation: AAA59965.1 .
AL139158 Genomic DNA. Translation: CAI23136.1 .
CH471059 Genomic DNA. Translation: EAX07298.1 .
Z18284 mRNA. Translation: CAA79158.1 .
CCDSi CCDS30679.1.
PIRi A56018.
RefSeqi NP_002690.3. NM_002699.3.
UniGenei Hs.1837.

3D structure databases

ProteinModelPortali Q03052.
SMRi Q03052. Positions 249-399.
ModBasei Search...

Protein-protein interaction databases

BioGridi 111449. 1 interaction.
DIPi DIP-277N.
STRINGi 9606.ENSP00000362103.

Polymorphism databases

DMDMi 218512119.

Proteomic databases

MaxQBi Q03052.
PaxDbi Q03052.
PRIDEi Q03052.

Protocols and materials databases

DNASUi 5453.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373012 ; ENSP00000362103 ; ENSG00000185668 .
GeneIDi 5453.
KEGGi hsa:5453.
UCSCi uc001ccp.1. human.

Organism-specific databases

CTDi 5453.
GeneCardsi GC01M038509.
H-InvDB HIX0028895.
HGNCi HGNC:9214. POU3F1.
MIMi 602479. gene.
neXtProti NX_Q03052.
PharmGKBi PA33538.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG261729.
HOGENOMi HOG000116303.
HOVERGENi HBG053120.
InParanoidi Q03052.
KOi K09365.
OMAi KLMHHEW.
OrthoDBi EOG7DJSMG.
PhylomeDBi Q03052.
TreeFami TF316413.

Enzyme and pathway databases

SignaLinki Q03052.

Miscellaneous databases

GeneWikii POU3F1.
GenomeRNAii 5453.
NextBioi 21105.
PROi Q03052.
SOURCEi Search...

Gene expression databases

Bgeei Q03052.
CleanExi HS_POU3F1.
Genevestigatori Q03052.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PIRSFi PIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia."
    Faus I., Hsu H.J., Fuchs E.
    Mol. Cell. Biol. 14:3263-3275(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The human Oct-6 POU transcription factor lacks the first 50 amino acids of its murine counterpart."
    Tobler A., Schreiber E., Fontana A.
    Nucleic Acids Res. 21:1043-1043(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-451.

Entry informationi

Entry nameiPO3F1_HUMAN
AccessioniPrimary (citable) accession number: Q03052
Secondary accession number(s): Q5TAG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 16, 2008
Last modified: July 9, 2014
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi