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Protein

Cyclic nucleotide-gated olfactory channel

Gene

CNGA2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei521cAMPBy similarity1
Binding sitei536cAMPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi462 – 584cAMPBy similarityAdd BLAST123

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel

Keywords - Biological processi

Ion transport, Olfaction, Sensory transduction, Transport

Keywords - Ligandi

Calmodulin-binding, cAMP, cAMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic nucleotide-gated olfactory channel
Alternative name(s):
Cyclic nucleotide-gated cation channel 2
Cyclic nucleotide-gated channel alpha-2
Short name:
CNG channel alpha-2
Short name:
CNG-2
Short name:
CNG2
Gene namesi
Name:CNGA2
Synonyms:CNCG2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 140CytoplasmicSequence analysisAdd BLAST140
Transmembranei141 – 160Helical; Name=H1Sequence analysisAdd BLAST20
Topological domaini161 – 173ExtracellularSequence analysisAdd BLAST13
Transmembranei174 – 192Helical; Name=H2Sequence analysisAdd BLAST19
Topological domaini193 – 216CytoplasmicSequence analysisAdd BLAST24
Transmembranei217 – 236Helical; Name=H3Sequence analysisAdd BLAST20
Topological domaini237 – 274ExtracellularSequence analysisAdd BLAST38
Transmembranei275 – 297Helical; Name=H4Sequence analysisAdd BLAST23
Topological domaini298 – 349CytoplasmicSequence analysisAdd BLAST52
Transmembranei350 – 369Helical; Name=H5Sequence analysisAdd BLAST20
Topological domaini370 – 453ExtracellularSequence analysisAdd BLAST84
Transmembranei454 – 474Helical; Name=H6Sequence analysisAdd BLAST21
Topological domaini475 – 663CytoplasmicSequence analysisAdd BLAST189

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193111 – 663Cyclic nucleotide-gated olfactory channelAdd BLAST663

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi379N-linked (GlcNAc...)Curated1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ03041.
PRIDEiQ03041.

Expressioni

Tissue specificityi

Olfactory neurons.

Interactioni

Subunit structurei

Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide-gated (CNG) channel of olfactory sensory neurons (By similarity).By similarity

Protein-protein interaction databases

IntActiQ03041. 1 interactor.
MINTiMINT-7032993.
STRINGi9913.ENSBTAP00000027618.

Structurei

Secondary structure

1663
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi66 – 81Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SY9NMR-B60-85[»]
ProteinModelPortaliQ03041.
SMRiQ03041.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ03041.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili597 – 640By similarityAdd BLAST44

Domaini

The C-terminal coiled-coil domain mediates trimerization of CNGA subunits.By similarity

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0500. Eukaryota.
ENOG410YWWI. LUCA.
HOGENOMiHOG000007898.
HOVERGENiHBG000281.
InParanoidiQ03041.
KOiK04949.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR032406. CLZ_dom.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF16526. CLZ. 1 hit.
PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03041-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEKANGVKS SPANNHNHHA PPAIKASGKD DHRASSRPQS AAADDTSSEL
60 70 80 90 100
QQLAEMDAPQ QRRGGFRRIA RLVGVLREWA YRNFREEEPR PDSFLERFRG
110 120 130 140 150
PELHTVTTQQ GDGKGDKDGE GKGTKKKFEL FVLDPAGDWY YRWLFLIALP
160 170 180 190 200
VLYNWCLLVA RACFSDLQKG YYIVWLVLDY VSDVVYIADL FIRLRTGFLE
210 220 230 240 250
QGLLVKDTKK LRDNYIHTMQ FKLDVASIIP TDLIYFAVGI HNPEVRFNRL
260 270 280 290 300
LHFARMFEFF DRTETRTSYP NIFRISNLIL YILIIIHWNA CIYYAISKSI
310 320 330 340 350
GFGVDTWVYP NITDPEYGYL SREYIYCLYW STLTLTTIGE TPPPVKDEEY
360 370 380 390 400
LFVIFDFLIG VLIFATIVGN VGSMISNMNA TRAEFQAKID AVKHYMQFRK
410 420 430 440 450
VSKEMEAKVI RWFDYLWTNK KSVDEREVLK NLPAKLRAEI AINVHLSTLK
460 470 480 490 500
KVRIFQDCEA GLLVELVLKL RPQVFSPGDY ICRKGDIGKE MYIIKEGKLA
510 520 530 540 550
VVADDGVTQY ALLSAGSCFG EISILNIKGS KMGNRRTANI RSLGYSDLFC
560 570 580 590 600
LSKDDLMEAV TEYPDAKRVL EERGREILMK EGLLDENEVA ASMEVDVQEK
610 620 630 640 650
LEQLETNMDT LYTRFARLLA EYTGAQQKLK QRITVLETKM KQNNEDDSLS
660
DGMNSPEPPA EKP
Length:663
Mass (Da):76,014
Last modified:July 1, 1993 - v1
Checksum:iAB66D4F9203844EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55010 mRNA. Translation: CAA38754.1.
PIRiS11521.
RefSeqiNP_001001139.1. NM_001001139.2.
UniGeneiBt.28014.

Genome annotation databases

GeneIDi407172.
KEGGibta:407172.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55010 mRNA. Translation: CAA38754.1.
PIRiS11521.
RefSeqiNP_001001139.1. NM_001001139.2.
UniGeneiBt.28014.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SY9NMR-B60-85[»]
ProteinModelPortaliQ03041.
SMRiQ03041.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ03041. 1 interactor.
MINTiMINT-7032993.
STRINGi9913.ENSBTAP00000027618.

Proteomic databases

PaxDbiQ03041.
PRIDEiQ03041.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi407172.
KEGGibta:407172.

Organism-specific databases

CTDi1260.

Phylogenomic databases

eggNOGiKOG0500. Eukaryota.
ENOG410YWWI. LUCA.
HOGENOMiHOG000007898.
HOVERGENiHBG000281.
InParanoidiQ03041.
KOiK04949.

Miscellaneous databases

EvolutionaryTraceiQ03041.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR032406. CLZ_dom.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF16526. CLZ. 1 hit.
PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNGA2_BOVIN
AccessioniPrimary (citable) accession number: Q03041
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The olfactory channel is activated by both cAMP and cGMP at similar concentrations, whereas the cGMP-gated channel is much less sensitive to cAMP.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.