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Protein

Oxaloacetate decarboxylase alpha chain

Gene

oadA1

more
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Lyase and sodium transporter.

Catalytic activityi

Oxaloacetate = pyruvate + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Biotin, Sodium

Protein family/group databases

TCDBi3.B.1.1.1. the na(+)-transporting carboxylic acid decarboxylase (nat-dc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxaloacetate decarboxylase alpha chain (EC:4.1.1.3)
Gene namesi
Name:oadA1
Synonyms:oadA
Ordered Locus Names:STM0055
AND
Name:oadA2
Ordered Locus Names:STM3352
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001468342 – 591Oxaloacetate decarboxylase alpha chainAdd BLAST590

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei557N6-biotinyllysinePROSITE-ProRule annotationBy similarity1

Proteomic databases

PaxDbiQ03030.

Interactioni

Subunit structurei

Composed of three chains (alpha, beta, and gamma).

Protein-protein interaction databases

STRINGi99287.STM3352.

Structurei

3D structure databases

ProteinModelPortaliQ03030.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 263Pyruvate carboxyltransferasePROSITE-ProRule annotationAdd BLAST261
Domaini518 – 591Biotinyl-bindingPROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Contains 1 biotinyl-binding domain.PROSITE-ProRule annotationCurated
Contains 1 pyruvate carboxyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4107QSA. Bacteria.
COG0511. LUCA.
COG5016. LUCA.
HOGENOMiHOG000231389.
KOiK01571.
OMAiPAVYTVE.
PhylomeDBiQ03030.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001882. Biotin_BS.
IPR000089. Biotin_lipoyl.
IPR003379. Carboxylase_cons_dom.
IPR005776. OadA.
IPR000891. PYR_CT.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00364. Biotin_lipoyl. 1 hit.
PF00682. HMGL-like. 1 hit.
PF02436. PYC_OADA. 1 hit.
[Graphical view]
SUPFAMiSSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01108. oadA. 1 hit.
PROSITEiPS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03030-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIAITDVVL RDAHQSLFAT RLRLDDMLPI AAALDDVGYG SLECWGGATF
60 70 80 90 100
DACIRFLGED PWLRLRELKK AMPKTPLQML LRGQNLLGYR HYADDVVERF
110 120 130 140 150
VERAVKNGMD VFRVFDAMND PRNMKAALQA VRSHGAHAQG TLSYTTSPAH
160 170 180 190 200
TLQTWLDLTE QLLETGVDSI AIKDMSGILT PMAAYELVSE IKKRFEVRLH
210 220 230 240 250
LHCHATTGMA EMALLKAIEA GVDGVDTAIS SMSATYGHPA TEALVATLAG
260 270 280 290 300
TEHDTGLDIL KLENIAAYFR EVRKKYHAFE GQLKGYDSRI LVAQVPGGML
310 320 330 340 350
TNLESQLKQQ NAADKLDQVL AEIPRVREDL GFIPLVTPTS QIVGTQAVLN
360 370 380 390 400
VLTGERYKTI AKETAGILKG EYGHTPVPVN AALQARVLEG GAPVTCRPAD
410 420 430 440 450
LLKPELAELE ADVRRQAQEK GITLAGNAID DVLTVALFPQ IGLKFLENRN
460 470 480 490 500
NPAAFEPLPQ AEAAQPVAKA EKPAASGIYT VEVEGKAFVV KVSDGGDISQ
510 520 530 540 550
LTAAVPAASS APVQAAAPAG AGTPVTAPLA GNIWKVIATE GQTVAEGDVL
560 570 580 590
LILEAMKMET EIRAAQAGTV RGIAVKSGDA VSVGDTLMTL A
Length:591
Mass (Da):63,207
Last modified:January 23, 2007 - v2
Checksum:iEE9CF9191E71D6BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96434 Unassigned DNA. Translation: AAA02973.1.
AE006468 Genomic DNA. Translation: AAL19019.1.
AE006468 Genomic DNA. Translation: AAL22221.1.
PIRiB44465.
RefSeqiNP_459060.1. NC_003197.1.
NP_462262.1. NC_003197.1.
WP_000150421.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL19019; AAL19019; STM0055.
AAL22221; AAL22221; STM3352.
GeneIDi1251573.
1254875.
KEGGistm:STM0055.
stm:STM3352.
PATRICi32378375. VBISalEnt20916_0057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96434 Unassigned DNA. Translation: AAA02973.1.
AE006468 Genomic DNA. Translation: AAL19019.1.
AE006468 Genomic DNA. Translation: AAL22221.1.
PIRiB44465.
RefSeqiNP_459060.1. NC_003197.1.
NP_462262.1. NC_003197.1.
WP_000150421.1. NC_003197.1.

3D structure databases

ProteinModelPortaliQ03030.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM3352.

Protein family/group databases

TCDBi3.B.1.1.1. the na(+)-transporting carboxylic acid decarboxylase (nat-dc) family.

Proteomic databases

PaxDbiQ03030.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL19019; AAL19019; STM0055.
AAL22221; AAL22221; STM3352.
GeneIDi1251573.
1254875.
KEGGistm:STM0055.
stm:STM3352.
PATRICi32378375. VBISalEnt20916_0057.

Phylogenomic databases

eggNOGiENOG4107QSA. Bacteria.
COG0511. LUCA.
COG5016. LUCA.
HOGENOMiHOG000231389.
KOiK01571.
OMAiPAVYTVE.
PhylomeDBiQ03030.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001882. Biotin_BS.
IPR000089. Biotin_lipoyl.
IPR003379. Carboxylase_cons_dom.
IPR005776. OadA.
IPR000891. PYR_CT.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00364. Biotin_lipoyl. 1 hit.
PF00682. HMGL-like. 1 hit.
PF02436. PYC_OADA. 1 hit.
[Graphical view]
SUPFAMiSSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01108. oadA. 1 hit.
PROSITEiPS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCOA_SALTY
AccessioniPrimary (citable) accession number: Q03030
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.