Q03030 (DCOA_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Oxaloacetate decarboxylase alpha chain
EC=4.1.1.3

Gene names

Name:	oadA1
Synonyms:	oadA
Ordered Locus Names:	STM0055
AND
Name:	oadA2
Ordered Locus Names:	STM3352

Organism

Salmonella typhimurium

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	591 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Lyase and sodium transporter.
Catalytic activity	Oxaloacetate = pyruvate + CO2.
Cofactor	Biotin.
Subunit structure	Composed of three chains (alpha, beta, and gamma).
Sequence similarities	Contains 1 biotinyl-binding domain.

Ontologies

Keywords
Biological process	Ion transport Sodium transport Transport
Ligand	Biotin Sodium
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	oxaloacetate decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 591	590	Oxaloacetate decarboxylase alpha chain		PRO_0000146834
Regions
	Domain	523 – 591	69	Biotinyl-binding
Amino acid modifications
	Modified residue	557	1	N6-biotinyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q03030 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: EE9CF9191E71D6BE	FASTA	591	63,207
	10 20 30 40 50 60 MTIAITDVVL RDAHQSLFAT RLRLDDMLPI AAALDDVGYG SLECWGGATF DACIRFLGED 70 80 90 100 110 120 PWLRLRELKK AMPKTPLQML LRGQNLLGYR HYADDVVERF VERAVKNGMD VFRVFDAMND 130 140 150 160 170 180 PRNMKAALQA VRSHGAHAQG TLSYTTSPAH TLQTWLDLTE QLLETGVDSI AIKDMSGILT 190 200 210 220 230 240 PMAAYELVSE IKKRFEVRLH LHCHATTGMA EMALLKAIEA GVDGVDTAIS SMSATYGHPA 250 260 270 280 290 300 TEALVATLAG TEHDTGLDIL KLENIAAYFR EVRKKYHAFE GQLKGYDSRI LVAQVPGGML 310 320 330 340 350 360 TNLESQLKQQ NAADKLDQVL AEIPRVREDL GFIPLVTPTS QIVGTQAVLN VLTGERYKTI 370 380 390 400 410 420 AKETAGILKG EYGHTPVPVN AALQARVLEG GAPVTCRPAD LLKPELAELE ADVRRQAQEK 430 440 450 460 470 480 GITLAGNAID DVLTVALFPQ IGLKFLENRN NPAAFEPLPQ AEAAQPVAKA EKPAASGIYT 490 500 510 520 530 540 VEVEGKAFVV KVSDGGDISQ LTAAVPAASS APVQAAAPAG AGTPVTAPLA GNIWKVIATE 550 560 570 580 590 GQTVAEGDVL LILEAMKMET EIRAAQAGTV RGIAVKSGDA VSVGDTLMTL A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence of the sodium ion pump oxaloacetate decarboxylase from Salmonella typhimurium." Woehlke G., Wifling K., Dimroth P. J. Biol. Chem. 267:22798-22803(1992) [PubMed: 1331067] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LT2.
[2]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M96434 Unassigned DNA. Translation: AAA02973.1. AE006468 Genomic DNA. Translation: AAL19019.1. AE006468 Genomic DNA. Translation: AAL22221.1.
PIR	B44465.
RefSeq	NP_459060.1. NC_003197.1. NP_462262.1. NC_003197.1.
3D structure databases
ProteinModelPortal	Q03030.
SMR	Q03030. Positions 3-449.
ModBase	Search...
Protein family/group databases
TCDB	3.B.1.1.1. Na+-transporting carboxylic acid decarboxylase (NaT-DC) family.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1251573. 1254875.
GenomeReviews	Gene locus STM0055 in contig AE006468_GR. Gene locus STM3352 in contig AE006468_GR.
KEGG	stm:STM0055. stm:STM3352.
PATRIC	32378375. VBISalEnt20916_0057.
Phylogenomic databases
HOGENOM	HBG717218.
OMA	ATLCITF.
ProtClustDB	PRK14040.
Enzyme and pathway databases
BioCyc	STYP99287:STM0055-MONOMER. STYP99287:STM3352-MONOMER.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001882. Biotin_BS. IPR000089. Biotin_lipoyl. IPR003379. Carboxylase_cons_dom. IPR005776. OadA. IPR000891. PYR_CT. IPR011053. Single_hybrid_motif. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01571.
Pfam	PF00364. Biotin_lipoyl. 1 hit. PF00682. HMGL-like. 1 hit. PF02436. PYC_OADA. 1 hit. [Graphical view]
SUPFAM	SSF51230. Hybrid_motif. 1 hit.
TIGRFAMs	TIGR01108. OadA. 1 hit.
PROSITE	PS00188. BIOTIN. 1 hit. PS50968. BIOTINYL_LIPOYL. 1 hit. PS50991. PYR_CT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCOA_SALTY

Accession

Primary (citable) accession number: Q03030

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program