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Protein

Mitochondrial 2-oxodicarboxylate carrier 1

Gene

ODC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, 2-oxopimelate, oxaloacetate, citrate and malate. The main physiological role is probably to supply 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol where they are used in the biosynthesis of lysine and glutamate, respectively, and in lysine catabolism.

GO - Molecular functioni

GO - Biological processi

  • mitochondrial transport Source: SGD
  • translation Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-34033-MONOMER.
ReactomeiR-SCE-71064. Lysine catabolism.

Protein family/group databases

TCDBi2.A.29.2.8. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial 2-oxodicarboxylate carrier 1
Gene namesi
Name:ODC1
Ordered Locus Names:YPL134C
ORF Names:LPI11C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL134C.
SGDiS000006055. ODC1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei78 – 9720Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei126 – 14621Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei179 – 19921Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei219 – 23921Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei281 – 30121Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: SGD
  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Mitochondrial 2-oxodicarboxylate carrier 1PRO_0000090648Add
BLAST

Proteomic databases

MaxQBiQ03028.

Interactioni

Protein-protein interaction databases

BioGridi36047. 49 interactions.
DIPiDIP-8776N.
MINTiMINT-4505028.

Structurei

3D structure databases

ProteinModelPortaliQ03028.
SMRiQ03028. Positions 6-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati9 – 108100Solcar 1Add
BLAST
Repeati120 – 20485Solcar 2Add
BLAST
Repeati213 – 30088Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00730000111119.
HOGENOMiHOG000168307.
InParanoidiQ03028.
KOiK15110.
OMAiCIFQVRE.
OrthoDBiEOG092C3CGH.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03028-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSIDNRPLP FIYQFTAGAI AGVSELLVMY PLDVVKTRMQ LQVTTKGHPA
60 70 80 90 100
VVAAKAAVDH YTGVMDCLTK IVKKEGFSHL YKGITSPILM EAPKRAIKFS
110 120 130 140 150
GNDTFQTFYK KIFPTPNGEM TQKIAIYSGA SAGAVEAFVV APFELVKIRL
160 170 180 190 200
QDVNSQFKTP IEVVKNSVVK GGVLSLFNGL EATIWRHVLW NAGYFGIIFQ
210 220 230 240 250
IRKLLPAAKT STEKTRNDLI AGAIGGTVGC LLNTPFDVVK SRIQRSSGPL
260 270 280 290 300
RKYNWSLPSV LLVYREEGFK ALYKGFAPKV MRLAPGGGLL LVVFTNVMDF
310
FREVKYGKKQ
Length:310
Mass (Da):34,206
Last modified:November 1, 1996 - v1
Checksum:i8EB7D6231BC2BCEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43703 Genomic DNA. Translation: AAB68225.1.
BK006949 Genomic DNA. Translation: DAA11299.1.
PIRiS69050.
RefSeqiNP_015191.1. NM_001183948.1.

Genome annotation databases

EnsemblFungiiYPL134C; YPL134C; YPL134C.
GeneIDi855969.
KEGGisce:YPL134C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43703 Genomic DNA. Translation: AAB68225.1.
BK006949 Genomic DNA. Translation: DAA11299.1.
PIRiS69050.
RefSeqiNP_015191.1. NM_001183948.1.

3D structure databases

ProteinModelPortaliQ03028.
SMRiQ03028. Positions 6-297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36047. 49 interactions.
DIPiDIP-8776N.
MINTiMINT-4505028.

Protein family/group databases

TCDBi2.A.29.2.8. the mitochondrial carrier (mc) family.

Proteomic databases

MaxQBiQ03028.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL134C; YPL134C; YPL134C.
GeneIDi855969.
KEGGisce:YPL134C.

Organism-specific databases

EuPathDBiFungiDB:YPL134C.
SGDiS000006055. ODC1.

Phylogenomic databases

GeneTreeiENSGT00730000111119.
HOGENOMiHOG000168307.
InParanoidiQ03028.
KOiK15110.
OMAiCIFQVRE.
OrthoDBiEOG092C3CGH.

Enzyme and pathway databases

BioCyciYEAST:G3O-34033-MONOMER.
ReactomeiR-SCE-71064. Lysine catabolism.

Miscellaneous databases

PROiQ03028.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiODC1_YEAST
AccessioniPrimary (citable) accession number: Q03028
Secondary accession number(s): D6W3N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2840 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.