SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q03026

- INH_PSEAE

UniProt

Q03026 - INH_PSEAE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Proteinase inhibitor
Gene
inh, aprI, PA1250
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibitor of the alkaline protease. It forms a non-covalent bond with the protease and may prevent its autocatalytic cleavage in the periplasm By similarity.

GO - Molecular functioni

  1. metalloendopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor

Protein family/group databases

MEROPSiI38.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteinase inhibitor
Alternative name(s):
Aprin
Gene namesi
Name:inh
Synonyms:aprI
Ordered Locus Names:PA1250
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA1250.

Subcellular locationi

GO - Cellular componenti

  1. outer membrane-bounded periplasmic space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 By similarity
Add
BLAST
Chaini27 – 131105Proteinase inhibitor
PRO_0000026717Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 74 By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

MINTiMINT-204143.
STRINGi208964.PA1250.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi33 – 364
Beta strandi38 – 447
Beta strandi50 – 6011
Turni61 – 644
Beta strandi65 – 717
Helixi72 – 776
Beta strandi79 – 813
Beta strandi85 – 895
Beta strandi92 – 965
Beta strandi98 – 1003
Beta strandi102 – 1109
Beta strandi113 – 1175
Beta strandi119 – 1213
Beta strandi123 – 1286

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JIWX-ray1.74I26-131[»]
2RN4NMR-A26-131[»]
ProteinModelPortaliQ03026.
SMRiQ03026. Positions 26-131.

Miscellaneous databases

EvolutionaryTraceiQ03026.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47174.
HOGENOMiHOG000247112.
OMAiINANAIQ.
OrthoDBiEOG69SKD8.

Family and domain databases

Gene3Di2.40.128.10. 1 hit.
InterProiIPR021140. Inh/Omp19.
IPR003086. MPTase_inhib_I38.
IPR022815. Prot_inh_I38.
IPR016085. Protease_inh_b-brl_dom.
[Graphical view]
PfamiPF02974. Inh. 1 hit.
[Graphical view]
PRINTSiPR01274. MPTASEINHBTR.
ProDomiPD015804. MPTase_inhib_I38. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50882. SSF50882. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03026-1 [UniParc]FASTAAdd to Basket

« Hide

MSASAKLSRM VCLLCGFFST GISMASSLIL LSASDLAGQW TLQQDEAPAI    50
CHLELRDSEV AEASGYDLGG DTACLTRWLP SEPRAWRPTP AGIALLERGG 100
LTLMLLGRQG EGDYRVQKGD GGQLVLRRAT P 131
Length:131
Mass (Da):13,980
Last modified:October 1, 1993 - v1
Checksum:i8CE4A64ED10AA8CD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64558 Genomic DNA. Translation: CAA45859.1.
AE004091 Genomic DNA. Translation: AAG04639.1.
PIRiS26700.
RefSeqiNP_249941.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG04639; AAG04639; PA1250.
GeneIDi881261.
KEGGipae:PA1250.
PATRICi19836824. VBIPseAer58763_1298.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64558 Genomic DNA. Translation: CAA45859.1 .
AE004091 Genomic DNA. Translation: AAG04639.1 .
PIRi S26700.
RefSeqi NP_249941.1. NC_002516.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JIW X-ray 1.74 I 26-131 [» ]
2RN4 NMR - A 26-131 [» ]
ProteinModelPortali Q03026.
SMRi Q03026. Positions 26-131.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-204143.
STRINGi 208964.PA1250.

Protein family/group databases

MEROPSi I38.002.

Protocols and materials databases

DNASUi 881261.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG04639 ; AAG04639 ; PA1250 .
GeneIDi 881261.
KEGGi pae:PA1250.
PATRICi 19836824. VBIPseAer58763_1298.

Organism-specific databases

PseudoCAPi PA1250.

Phylogenomic databases

eggNOGi NOG47174.
HOGENOMi HOG000247112.
OMAi INANAIQ.
OrthoDBi EOG69SKD8.

Miscellaneous databases

EvolutionaryTracei Q03026.

Family and domain databases

Gene3Di 2.40.128.10. 1 hit.
InterProi IPR021140. Inh/Omp19.
IPR003086. MPTase_inhib_I38.
IPR022815. Prot_inh_I38.
IPR016085. Protease_inh_b-brl_dom.
[Graphical view ]
Pfami PF02974. Inh. 1 hit.
[Graphical view ]
PRINTSi PR01274. MPTASEINHBTR.
ProDomi PD015804. MPTase_inhib_I38. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF50882. SSF50882. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of a cluster of genes controlling synthesis and secretion of alkaline protease in Pseudomonas aeruginosa: relationships to other secretory pathways."
    Duong F., Lazdunski A., Cami B., Murgier M.
    Gene 121:47-54(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
  3. "Crystal structure of a complex between Pseudomonas aeruginosa alkaline protease and its cognate inhibitor: inhibition by a zinc-NH2 coordinative bond."
    Hege T., Feltzer R.E., Gray R.D., Baumann U.
    J. Biol. Chem. 276:35087-35092(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS) IN COMPLEX WITH PROTEASE.

Entry informationi

Entry nameiINH_PSEAE
AccessioniPrimary (citable) accession number: Q03026
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 11, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi