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Q03026

- INH_PSEAE

UniProt

Q03026 - INH_PSEAE

Protein

Proteinase inhibitor

Gene

inh

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Inhibitor of the alkaline protease. It forms a non-covalent bond with the protease and may prevent its autocatalytic cleavage in the periplasm By similarity.By similarity

    GO - Molecular functioni

    1. metalloendopeptidase inhibitor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor

    Protein family/group databases

    MEROPSiI38.002.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteinase inhibitor
    Alternative name(s):
    Aprin
    Gene namesi
    Name:inh
    Synonyms:aprI
    Ordered Locus Names:PA1250
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA1250.

    Subcellular locationi

    GO - Cellular componenti

    1. outer membrane-bounded periplasmic space Source: InterPro

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626By similarityAdd
    BLAST
    Chaini27 – 131105Proteinase inhibitorPRO_0000026717Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi51 ↔ 74By similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-204143.
    STRINGi208964.PA1250.

    Structurei

    Secondary structure

    1
    131
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi33 – 364
    Beta strandi38 – 447
    Beta strandi50 – 6011
    Turni61 – 644
    Beta strandi65 – 717
    Helixi72 – 776
    Beta strandi79 – 813
    Beta strandi85 – 895
    Beta strandi92 – 965
    Beta strandi98 – 1003
    Beta strandi102 – 1109
    Beta strandi113 – 1175
    Beta strandi119 – 1213
    Beta strandi123 – 1286

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1JIWX-ray1.74I26-131[»]
    2RN4NMR-A26-131[»]
    ProteinModelPortaliQ03026.
    SMRiQ03026. Positions 26-131.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ03026.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47174.
    HOGENOMiHOG000247112.
    OMAiINANAIQ.
    OrthoDBiEOG69SKD8.

    Family and domain databases

    Gene3Di2.40.128.10. 1 hit.
    InterProiIPR021140. Inh/Omp19.
    IPR003086. MPTase_inhib_I38.
    IPR022815. Prot_inh_I38.
    IPR016085. Protease_inh_b-brl_dom.
    [Graphical view]
    PfamiPF02974. Inh. 1 hit.
    [Graphical view]
    PRINTSiPR01274. MPTASEINHBTR.
    ProDomiPD015804. MPTase_inhib_I38. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF50882. SSF50882. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q03026-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSASAKLSRM VCLLCGFFST GISMASSLIL LSASDLAGQW TLQQDEAPAI    50
    CHLELRDSEV AEASGYDLGG DTACLTRWLP SEPRAWRPTP AGIALLERGG 100
    LTLMLLGRQG EGDYRVQKGD GGQLVLRRAT P 131
    Length:131
    Mass (Da):13,980
    Last modified:October 1, 1993 - v1
    Checksum:i8CE4A64ED10AA8CD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64558 Genomic DNA. Translation: CAA45859.1.
    AE004091 Genomic DNA. Translation: AAG04639.1.
    PIRiS26700.
    RefSeqiNP_249941.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG04639; AAG04639; PA1250.
    GeneIDi881261.
    KEGGipae:PA1250.
    PATRICi19836824. VBIPseAer58763_1298.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64558 Genomic DNA. Translation: CAA45859.1 .
    AE004091 Genomic DNA. Translation: AAG04639.1 .
    PIRi S26700.
    RefSeqi NP_249941.1. NC_002516.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1JIW X-ray 1.74 I 26-131 [» ]
    2RN4 NMR - A 26-131 [» ]
    ProteinModelPortali Q03026.
    SMRi Q03026. Positions 26-131.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-204143.
    STRINGi 208964.PA1250.

    Protein family/group databases

    MEROPSi I38.002.

    Protocols and materials databases

    DNASUi 881261.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG04639 ; AAG04639 ; PA1250 .
    GeneIDi 881261.
    KEGGi pae:PA1250.
    PATRICi 19836824. VBIPseAer58763_1298.

    Organism-specific databases

    PseudoCAPi PA1250.

    Phylogenomic databases

    eggNOGi NOG47174.
    HOGENOMi HOG000247112.
    OMAi INANAIQ.
    OrthoDBi EOG69SKD8.

    Miscellaneous databases

    EvolutionaryTracei Q03026.

    Family and domain databases

    Gene3Di 2.40.128.10. 1 hit.
    InterProi IPR021140. Inh/Omp19.
    IPR003086. MPTase_inhib_I38.
    IPR022815. Prot_inh_I38.
    IPR016085. Protease_inh_b-brl_dom.
    [Graphical view ]
    Pfami PF02974. Inh. 1 hit.
    [Graphical view ]
    PRINTSi PR01274. MPTASEINHBTR.
    ProDomi PD015804. MPTase_inhib_I38. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF50882. SSF50882. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of a cluster of genes controlling synthesis and secretion of alkaline protease in Pseudomonas aeruginosa: relationships to other secretory pathways."
      Duong F., Lazdunski A., Cami B., Murgier M.
      Gene 121:47-54(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
    3. "Crystal structure of a complex between Pseudomonas aeruginosa alkaline protease and its cognate inhibitor: inhibition by a zinc-NH2 coordinative bond."
      Hege T., Feltzer R.E., Gray R.D., Baumann U.
      J. Biol. Chem. 276:35087-35092(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS) IN COMPLEX WITH PROTEASE.

    Entry informationi

    Entry nameiINH_PSEAE
    AccessioniPrimary (citable) accession number: Q03026
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3