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Protein

Proteinase inhibitor

Gene

inh

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitor of the alkaline protease. It forms a non-covalent bond with the protease and may prevent its autocatalytic cleavage in the periplasm (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionMetalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-1275-MONOMER

Protein family/group databases

MEROPSiI38.002

Names & Taxonomyi

Protein namesi
Recommended name:
Proteinase inhibitor
Alternative name(s):
Aprin
Gene namesi
Name:inh
Synonyms:aprI
Ordered Locus Names:PA1250
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA1250

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000002671727 – 131Proteinase inhibitorAdd BLAST105

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ03026

Interactioni

Protein-protein interaction databases

MINTiQ03026
STRINGi208964.PA1250

Structurei

Secondary structure

1131
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi33 – 36Combined sources4
Beta strandi38 – 44Combined sources7
Beta strandi50 – 60Combined sources11
Turni61 – 64Combined sources4
Beta strandi65 – 71Combined sources7
Helixi72 – 77Combined sources6
Beta strandi79 – 81Combined sources3
Beta strandi85 – 89Combined sources5
Beta strandi92 – 96Combined sources5
Beta strandi98 – 100Combined sources3
Beta strandi102 – 110Combined sources9
Beta strandi113 – 117Combined sources5
Beta strandi119 – 121Combined sources3
Beta strandi123 – 128Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JIWX-ray1.74I26-131[»]
2RN4NMR-A26-131[»]
ProteinModelPortaliQ03026
SMRiQ03026
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ03026

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG41065N1 Bacteria
ENOG41123V0 LUCA
HOGENOMiHOG000247112
OMAiPAGWRPT

Family and domain databases

InterProiView protein in InterPro
IPR021140 Inh/Omp19
IPR003086 MPTase_inhib_I38
IPR022815 Prot_inh_I38
IPR016085 Protease_inh_b-brl_dom
PfamiView protein in Pfam
PF02974 Inh, 1 hit
PRINTSiPR01274 MPTASEINHBTR
ProDomiView protein in ProDom or Entries sharing at least one domain
PD015804 MPTase_inhib_I38, 1 hit
SUPFAMiSSF50882 SSF50882, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03026-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASAKLSRM VCLLCGFFST GISMASSLIL LSASDLAGQW TLQQDEAPAI
60 70 80 90 100
CHLELRDSEV AEASGYDLGG DTACLTRWLP SEPRAWRPTP AGIALLERGG
110 120 130
LTLMLLGRQG EGDYRVQKGD GGQLVLRRAT P
Length:131
Mass (Da):13,980
Last modified:October 1, 1993 - v1
Checksum:i8CE4A64ED10AA8CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64558 Genomic DNA Translation: CAA45859.1
AE004091 Genomic DNA Translation: AAG04639.1
PIRiS26700
RefSeqiNP_249941.1, NC_002516.2
WP_003082543.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG04639; AAG04639; PA1250
GeneIDi881261
KEGGipae:PA1250
PATRICifig|208964.12.peg.1298

Similar proteinsi

Entry informationi

Entry nameiINH_PSEAE
AccessioniPrimary (citable) accession number: Q03026
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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