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Q03026 (INH_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteinase inhibitor
Alternative name(s):
Aprin
Gene names
Name:inh
Synonyms:aprI
Ordered Locus Names:PA1250
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) [Reference proteome] [HAMAP]
Taxonomic identifier208964 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length131 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibitor of the alkaline protease. It forms a non-covalent bond with the protease and may prevent its autocatalytic cleavage in the periplasm By similarity.

Subcellular location

Periplasm.

Sequence similarities

Belongs to the protease inhibitor I38 family. [View classification]

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 By similarity
Chain27 – 131105Proteinase inhibitor
PRO_0000026717

Amino acid modifications

Disulfide bond51 ↔ 74 By similarity

Secondary structure

.......................... 131
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q03026 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 8CE4A64ED10AA8CD

FASTA13113,980
        10         20         30         40         50         60 
MSASAKLSRM VCLLCGFFST GISMASSLIL LSASDLAGQW TLQQDEAPAI CHLELRDSEV 

        70         80         90        100        110        120 
AEASGYDLGG DTACLTRWLP SEPRAWRPTP AGIALLERGG LTLMLLGRQG EGDYRVQKGD 

       130 
GGQLVLRRAT P 

« Hide

References

« Hide 'large scale' references
[1]"Sequence of a cluster of genes controlling synthesis and secretion of alkaline protease in Pseudomonas aeruginosa: relationships to other secretory pathways."
Duong F., Lazdunski A., Cami B., Murgier M.
Gene 121:47-54(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
[2]"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen."
Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. expand/collapse author list , Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.
Nature 406:959-964(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
[3]"Crystal structure of a complex between Pseudomonas aeruginosa alkaline protease and its cognate inhibitor: inhibition by a zinc-NH2 coordinative bond."
Hege T., Feltzer R.E., Gray R.D., Baumann U.
J. Biol. Chem. 276:35087-35092(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS) IN COMPLEX WITH PROTEASE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X64558 Genomic DNA. Translation: CAA45859.1.
AE004091 Genomic DNA. Translation: AAG04639.1.
PIRS26700.
RefSeqNP_249941.1. NC_002516.2.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1JIWX-ray1.74I26-131[»]
2RN4NMR-A26-131[»]
ProteinModelPortalQ03026.
SMRQ03026. Positions 26-131.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-204143.
STRING208964.PA1250.

Protein family/group databases

MEROPSI38.002.

Protocols and materials databases

DNASU881261.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG04639; AAG04639; PA1250.
GeneID881261.
KEGGpae:PA1250.
PATRIC19836824. VBIPseAer58763_1298.

Organism-specific databases

PseudoCAPPA1250.

Phylogenomic databases

eggNOGNOG47174.
HOGENOMHOG000247112.
OMAINANAIQ.
OrthoDBEOG69SKD8.

Family and domain databases

Gene3D2.40.128.10. 1 hit.
InterProIPR021140. Inh/Omp19.
IPR003086. MPTase_inhib_I38.
IPR022815. Prot_inh_I38.
IPR016085. Protease_inh_b-brl_dom.
[Graphical view]
PfamPF02974. Inh. 1 hit.
[Graphical view]
PRINTSPR01274. MPTASEINHBTR.
ProDomPD015804. MPTase_inhib_I38. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF50882. SSF50882. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ03026.

Entry information

Entry nameINH_PSEAE
AccessionPrimary (citable) accession number: Q03026
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 11, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references