Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alkaline protease secretion ATP-binding protein AprD

Gene

aprD

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the secretion of alkaline protease.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi366 – 373ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • protein secretion by the type I secretion system Source: InterPro
  • secretion Source: PseudoCAP
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Protein family/group databases

TCDBi3.A.1.110.4. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Alkaline protease secretion ATP-binding protein AprD
Gene namesi
Name:aprD
Ordered Locus Names:PA1246
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA1246.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei60 – 80HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei134 – 154HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei156 – 176HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei248 – 266HelicalPROSITE-ProRule annotationAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000919331 – 593Alkaline protease secretion ATP-binding protein AprDAdd BLAST593

Proteomic databases

PaxDbiQ03024.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA1246.

Structurei

3D structure databases

ProteinModelPortaliQ03024.
SMRiQ03024.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 301ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST279
Domaini332 – 567ABC transporterPROSITE-ProRule annotationAdd BLAST236

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108JJ6. Bacteria.
COG4618. LUCA.
HOGENOMiHOG000101575.
InParanoidiQ03024.
KOiK12536.
OMAiIIIMVCC.
PhylomeDBiQ03024.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR010128. ATPase_T1SS_PrtD.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24222:SF0. PTHR24222:SF0. 1 hit.
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR01842. type_I_sec_PrtD. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARLGSSVTN EIKQALAASR GALRSVAAFS GVINLLMLVP SLYMLQVYDR
60 70 80 90 100
VLSSANEVTL LMLTLMALGV FVFMGALEAL RSFVLVRVSE RFDGQLHGRI
110 120 130 140 150
YAAAFERNLR AGGQEASQAL HDLTTLRQFI TGQALFAFFD APWFPVYLLV
160 170 180 190 200
IFLFDPWLGL LSLVGALALM ALAWFNERAT RAPLAKAGEL SIKSGQLASN
210 220 230 240 250
NLRNAEVIEA MGMLGSMRGR WERLHQAFLD QQSLASERAA RINALSKYLR
260 270 280 290 300
IALQSLVLGL GAWLAVEGRI TPGMMIAGSI LMGRALGPID QLIGVWKQWG
310 320 330 340 350
AARDAYRRLS GLLDEFPARE RRMELPEPRG HLLLESLDAA PPGSEARTLR
360 370 380 390 400
GLTLAIPAGS VVGVIGPSGS GKSSLARVVL GIWPTLHGSV RLDGAEIRQY
410 420 430 440 450
ERETLGPRIG YLPQDIELFA GTVAENIARF GEVQADKVVE AARLAGVHEL
460 470 480 490 500
VLRLPQGYDT VLGVGGAGLS GGQRQRIALA RALYGAPTLV VLDEPNSNLD
510 520 530 540 550
DSGEQALLAA IQALKARGCT VLLITHRAGV LGCADRLLAL NAGQLHLYGE
560 570 580 590
RDQVLAALNN QRAASASQQR ADYRVAGYGA PQVVAAPRQG GVE
Length:593
Mass (Da):63,671
Last modified:October 1, 1993 - v1
Checksum:iCA3A817FBCC27318
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64558 Genomic DNA. Translation: CAA45855.1.
AE004091 Genomic DNA. Translation: AAG04635.1.
PIRiS26696.
RefSeqiNP_249937.1. NC_002516.2.
WP_003082539.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG04635; AAG04635; PA1246.
GeneIDi881263.
KEGGipae:PA1246.
PATRICi19836814. VBIPseAer58763_1293.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64558 Genomic DNA. Translation: CAA45855.1.
AE004091 Genomic DNA. Translation: AAG04635.1.
PIRiS26696.
RefSeqiNP_249937.1. NC_002516.2.
WP_003082539.1. NC_002516.2.

3D structure databases

ProteinModelPortaliQ03024.
SMRiQ03024.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA1246.

Protein family/group databases

TCDBi3.A.1.110.4. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiQ03024.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG04635; AAG04635; PA1246.
GeneIDi881263.
KEGGipae:PA1246.
PATRICi19836814. VBIPseAer58763_1293.

Organism-specific databases

PseudoCAPiPA1246.

Phylogenomic databases

eggNOGiENOG4108JJ6. Bacteria.
COG4618. LUCA.
HOGENOMiHOG000101575.
InParanoidiQ03024.
KOiK12536.
OMAiIIIMVCC.
PhylomeDBiQ03024.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR010128. ATPase_T1SS_PrtD.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24222:SF0. PTHR24222:SF0. 1 hit.
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR01842. type_I_sec_PrtD. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPRD_PSEAE
AccessioniPrimary (citable) accession number: Q03024
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.