Q03021 (RIO1_THEAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RIO-type serine/threonine-protein kinase Rio1
EC=2.7.11.1

Gene names

Name:	rio1
Ordered Locus Names:	Ta0396

Organism

Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) [Reference proteome] [HAMAP]

Taxonomic identifier

273075 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma › Thermoplasma acidophilum

Protein attributes

Sequence length	186 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

Ontologies

Keywords
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 186	186	RIO-type serine/threonine-protein kinase Rio1		PRO_0000213536
Sites
	Active site	124	1	Proton acceptor By similarity
	Metal binding	129	1	Magnesium By similarity
	Metal binding	140	1	Magnesium By similarity
	Binding site	15	1	ATP By similarity
	Binding site	129	1	ATP By similarity
	Binding site	140	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q03021 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 64E2FC7F0AF6C18A	FASTA	186	21,739
	10 20 30 40 50 60 MVFRAVSGKK FVAVKIFKMS TLKFMSIRKY IEGDQRFSKI RIDRNDIVPV WVRKEYTNLM 70 80 90 100 110 120 ALENAHVPAP KPIGFFKNIL VMSYIGTKSG PAPQLKDVEI DEGIYDQVID GMRRMYANRI 130 140 150 160 170 180 VHADLSEYNM LFHRKVYFID LAQAVDMDHP MAAEFLERDI VNVSNFFQKH GIETDPDKIR EYIKKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of the genes encoding the subunits H, B, A' and A'' of the DNA-dependent RNA polymerase and the initiator tRNA from Thermoplasma acidophilum." Klenk H.-P., Renner O., Schwass V., Zillig W. Nucleic Acids Res. 20:5226-5226(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.
[2]	"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum." Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W. Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X68198 Genomic DNA. Translation: CAA48285.1. AL445064 Genomic DNA. Translation: CAC11539.1.
PIR	S26727.
RefSeq	NP_393875.1. NC_002578.1.
3D structure databases
ProteinModelPortal	Q03021.
ModBase	Search...
Protein-protein interaction databases
STRING	273075.Ta0396m.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAC11539; CAC11539; CAC11539.
GeneID	1457005.
KEGG	tac:Ta0396m.
Phylogenomic databases
eggNOG	COG1718.
KO	K07178.
OMA	IGFFKNI.
ProtClustDB	CLSK227899.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR018934. RIO-like_kinase. IPR018935. RIO_kinase_CS. IPR008266. Tyr_kinase_AS. [Graphical view]
Pfam	PF01163. RIO1. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50011. PROTEIN_KINASE_DOM. False negative. PS01245. RIO1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RIO1_THEAC

Accession

Primary (citable) accession number: Q03021

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program