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Protein

COMPASS component SPP1

Gene

SPP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.2 Publications

Miscellaneous

Present with 1680 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri22 – 72PHD-typePROSITE-ProRule annotationAdd BLAST51

GO - Molecular functioni

  • chromatin binding Source: SGD
  • metal ion binding Source: UniProtKB-KW
  • methylated histone binding Source: SGD

GO - Biological processi

  • chromatin silencing at telomere Source: SGD
  • histone H3-K4 methylation Source: SGD
  • regulation of meiotic DNA double-strand break formation Source: SGD
  • regulation of transcription, DNA-templated Source: SGD

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-34036-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
COMPASS component SPP1
Alternative name(s):
Complex proteins associated with SET1 protein SPP1
Set1C component SPP1
Suppressor of PRP protein 1
Gene namesi
Name:SPP1
Synonyms:CPS40, SAF41
Ordered Locus Names:YPL138C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL138C
SGDiS000006059 SPP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000593381 – 353COMPASS component SPP1Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei87PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ03012
PaxDbiQ03012
PRIDEiQ03012

PTM databases

iPTMnetiQ03012

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex which consists of SET12, BRE22, SPP12, SDC11, SHG11, SWD11, SWD21, and SWD31.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
REC107P216513EBI-32540,EBI-10742

GO - Molecular functioni

  • methylated histone binding Source: SGD

Protein-protein interaction databases

BioGridi36044, 146 interactors
DIPiDIP-2946N
IntActiQ03012, 12 interactors
MINTiQ03012
STRINGi4932.YPL138C

Structurei

3D structure databases

ProteinModelPortaliQ03012
SMRiQ03012
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi246 – 251Poly-Lys6

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri22 – 72PHD-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOGENOMiHOG000000990
InParanoidiQ03012
KOiK14960
OMAiEDVYCIC
OrthoDBiEOG092C1PYH

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR037869 Spp1
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR12321:SF97 PTHR12321:SF97, 2 hits
PfamiView protein in Pfam
PF00628 PHD, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q03012-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPQWCPPH STLKRNPTTG EDVYCICKRP DYGELMVGCD GCDDWFHFTC
60 70 80 90 100
LHIPEQFKDL VFSFYCPYCQ AGITGKNKDA IINGEGSLPK TLWKRKCRIS
110 120 130 140 150
DCYKPCLQDS KYCSEEHGRE FVNDIWSRLK TDEDRAVVKK MVEQTGHIDK
160 170 180 190 200
FKKFGQLDFI DNNIVVKTDD EKEIFDQIVV RDMTLKTLED DLQEVQEISL
210 220 230 240 250
PLFKKKLELL EVYLGWLDNV YTEMRKLDDD AASHVECGKE DSKGTKRKKK
260 270 280 290 300
KNSSRSRARK NICGYCSTYE RIPCSVEEFV RDFGSNEEAT KIHEVCTKWK
310 320 330 340 350
CNRHLDWVST NQEQYLQQID SLESMQERLQ HLIQARKKQL NIQYYEEILR

RGL
Length:353
Mass (Da):41,468
Last modified:November 1, 1996 - v1
Checksum:iF4B8DFE0CB358CA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43703 Genomic DNA Translation: AAB68222.1
BK006949 Genomic DNA Translation: DAA11296.1
PIRiS69047
RefSeqiNP_015187.1, NM_001183952.1

Genome annotation databases

EnsemblFungiiYPL138C; YPL138C; YPL138C
GeneIDi855965
KEGGisce:YPL138C

Similar proteinsi

Entry informationi

Entry nameiSPP1_YEAST
AccessioniPrimary (citable) accession number: Q03012
Secondary accession number(s): D6W3N0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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