Q03001 (DYST_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dystonin

Alternative name(s):
230 kDa bullous pemphigoid antigen
230/240 kDa bullous pemphigoid antigen
Bullous pemphigoid antigen 1
Short name=BPA
Short name=Bullous pemphigoid antigen
Dystonia musculorum protein
Hemidesmosomal plaque protein

Gene names

Name:	DST
Synonyms:	BP230, BP240, BPAG1, DMH, DT, KIAA0728

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	7570 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Ref.7 Ref.20 Ref.23 Isoform 3: plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity. Ref.7 Ref.20 Ref.23 Isoform 6: required for bundling actin filaments around the nucleus By similarity. Ref.7 Ref.20 Ref.23 Isoform 7: regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Ref.7 Ref.20 Ref.23
Subunit structure	Homodimer. Isoform 1 interacts (via N-terminus) with PLEC (via N-terminus). Interacts with the neuronal intermediate filament protein, PRPH. Interacts with DES. Interacts with SYNE3 By similarity. Isoform 1 and isoform 6 can homodimerize (via N-terminus). Isoform 1 interacts (via N-terminus) with ACTN2. Isoform 1 interacts (via N-terminus) with PLEC (via N-terminus). Isoform 3 interacts (via N-terminus) with COL17A1 (via cytoplasmic region). Isoform 3 interacts (via N-terminus) with ITGB4 isoform beta-4a (via cytoplasmic region). Isoform 3 interacts (via N-terminus) with ERBB2IP (via C-terminus). Isoform 3 associates (via C-terminal) with KRT5-KRT14 (via rod region) intermadiate filaments of keratins. Interacts with MAPRE1; probably required for targeting to the growing microtubule plus ends. Interacts with TMIGD2. Ref.17 Ref.19 Ref.20 Ref.24 Ref.28
Subcellular location	Cytoplasm › cytoskeleton. Note: Associates with intermediate filaments, acin and microtubule cytoskeletons. Localizes to actin stress fibers and to actin-rich ruffling at the cortex of cells By similarity. Associated at the growing distal tip of microtubules. Ref.3 Ref.7 Ref.20 Ref.21 Ref.23 Ref.24 Isoform 1: Cytoplasm › cytoskeleton By similarity. Cytoplasm › myofibril › sarcomere › Z line. Cytoplasm › myofibril › sarcomere › H zone By similarity. Note: Localizes to microtubules and actin microfilaments throughout the cytoplasm and at focal contact attachments at the plasma membrane By similarity. Ref.3 Ref.7 Ref.20 Ref.21 Ref.23 Ref.24 Isoform 2: Cytoplasm › cytoskeleton By similarity. Note: Colocalizes both cortical and cytoplasmic actin filaments By similarity. Ref.3 Ref.7 Ref.20 Ref.21 Ref.23 Ref.24 Isoform 3: Cytoplasm › cytoskeleton. Cell junction › hemidesmosome. Note: Localizes to actin and intermediate filaments cytoskeletons By similarity. Colocalizes with the epidermal KRT5-KRT14 intermediate filaments network of keratins. Colocalizes with ITGB4 at the leading edge of migrating keratinocytes. Ref.3 Ref.7 Ref.20 Ref.21 Ref.23 Ref.24 Isoform 6: Nucleus By similarity. Nucleus envelope. Membrane; Single-pass membrane protein By similarity. Endoplasmic reticulum membrane; Single-pass membrane protein By similarity. Cytoplasm › cytoskeleton. Membrane; Single-pass membrane protein. Note: Localizes to actin and intermediate filaments cytoskeletons. Localizes to central actin stress fibers around the nucleus and is excluded form focal contact sites in myoblast cells. Translocates to the nucleus By similarity. Associates with actin cytoskeleton in sensory neurons. Ref.3 Ref.7 Ref.20 Ref.21 Ref.23 Ref.24 Isoform 7: Cytoplasm › cytoskeleton. Cell projection › axon. Membrane. Note: Associates with axonal microtubules and intermediate filaments, but not with actin cytoskeleton, in sensory neurons. Ref.3 Ref.7 Ref.20 Ref.21 Ref.23 Ref.24 Isoform 8: Cytoplasm › cytoskeleton By similarity. Cytoplasm › cell cortex By similarity. Cell membrane; Lipid-anchor By similarity Ref.3 Ref.7 Ref.20 Ref.21 Ref.23 Ref.24.
Tissue specificity	Isoform 1 is expressed in myoblasts (at protein level). Isoform 3 is expressed in the skin. Isoform 6 is expressed in the brain. Highly expressed in skeletal muscle and cultured keratinocytes. Ref.3 Ref.16 Ref.24
Domain	Its association with epidermal and simple keratins is dependent on the tertiary structure induced by heterodimerization of these intermedaite filaments proteins and most likely involves recognition sites located in the rod domain of these keratins. Ref.18 Ref.29 The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends. Ref.18 Ref.29
Involvement in disease	Hereditary sensory and autonomic neuropathy 6 (HSAN6) [MIM:614653]: A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN6 is a severe autosomal recessive disorder characterized by neonatal hypotonia, respiratory and feeding difficulties, lack of psychomotor development, and autonomic abnormalities including labile cardiovascular function, lack of corneal reflexes leading to corneal scarring, areflexia, and absent axonal flare response after intradermal histamine injection. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.1 Ref.27
Sequence similarities	Contains 1 actin-binding domain. Contains 2 CH (calponin-homology) domains. Contains 2 EF-hand domains. Contains 1 GAR domain. Contains 5 plectin repeats. Contains 1 SH3 domain. Contains 20 spectrin repeats.
Sequence caution	The sequence AAA35538.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the C-terminal part. The sequence AAA57185.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAB70870.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC04449.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC04848.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAI14341.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI14989.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI16609.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI16610.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI20330.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI20332.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI22044.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI22045.1 differs from that shown. Reason: Erroneous gene model prediction. Isoform 6: The sequence AAC50244.1 differs from that shown. Reason: Frameshift at position 51.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell junction Cell membrane Cell projection Cytoplasm Cytoskeleton Endoplasmic reticulum Intermediate filament Membrane Microtubule Nucleus
Coding sequence diversity	Alternative promoter usage Alternative splicing Polymorphism
Disease	Neuropathy
Domain	Coiled coil Repeat SH3 domain Transmembrane
Ligand	Actin-binding Calcium Metal-binding
Molecular function	Muscle protein
PTM	Isopeptide bond Lipoprotein Palmitate Phosphoprotein Ubl conjugation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axonogenesis Inferred from electronic annotation. Source: Compara cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW cell cycle arrest Inferred from electronic annotation. Source: InterPro cell motility Inferred from mutant phenotype Ref.23. Source: UniProtKB cytoplasmic microtubule organization Inferred from electronic annotation. Source: Compara hemidesmosome assembly Inferred from direct assay Ref.20. Source: UniProtKB integrin-mediated signaling pathway Non-traceable author statement Ref.19. Source: UniProtKB intermediate filament cytoskeleton organization Inferred from expression pattern Ref.3. Source: UniProtKB maintenance of cell polarity Inferred from mutant phenotype Ref.23. Source: UniProtKB microtubule cytoskeleton organization Inferred from direct assay Ref.7. Source: UniProtKB regulation of microtubule polymerization or depolymerization Inferred from electronic annotation. Source: Compara response to wounding Inferred from direct assay Ref.23. Source: UniProtKB retrograde axon cargo transport Inferred from electronic annotation. Source: Compara
Cellular_component	H zone Inferred from electronic annotation. Source: UniProtKB-SubCell Z disc Inferred from direct assay Ref.24. Source: UniProtKB actin cytoskeleton Inferred from direct assay Ref.7. Source: UniProtKB axon Inferred from electronic annotation. Source: UniProtKB-SubCell axon part Inferred from direct assay Ref.7. Source: UniProtKB basal plasma membrane Non-traceable author statement Ref.19. Source: UniProtKB basement membrane Traceable author statement Ref.13. Source: ProtInc cell cortex Inferred from electronic annotation. Source: UniProtKB-SubCell cell leading edge Inferred from direct assay Ref.23. Source: UniProtKB cytoplasmic membrane-bounded vesicle Inferred from direct assay PubMed 14581450. Source: MGI endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell hemidesmosome Inferred from direct assay Ref.20. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW intermediate filament cytoskeleton Inferred from direct assay Ref.7. Source: UniProtKB microtubule cytoskeleton Inferred from direct assay Ref.7. Source: UniProtKB microtubule plus end Inferred from direct assay Ref.29. Source: UniProtKB neurofilament cytoskeleton Inferred from electronic annotation. Source: Compara nuclear envelope Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay. Source: HPA
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro microtubule plus-end binding Inferred from direct assay Ref.29. Source: UniProtKB protein homodimerization activity Inferred from direct assay Ref.24. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
APPL1	Q9UKG1	3	EBI-310758,EBI-741243
DISC1	Q9NRI5	5	EBI-310758,EBI-529989
MAPRE1	Q15691	2	EBI-310758,EBI-1004115
OPTN	Q96CV9	2	EBI-310758,EBI-748974

Alternative products

This entry describes 8 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q03001-7)

Also known as: BPAG1-b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available. Derived from EST data.

Isoform 2 (identifier: Q03001-8)

Also known as: BPAG1-a; BPAG1eA; Dystonin-1; eA;

The sequence of this isoform differs from the canonical sequence as follows:
     1-381: MAGYLSPAAY...REKALRPEVE → MHSSSYSYRS...SFGSESFDGH
     1550-3635: Missing.
     7352-7375: Missing.
     7442-7442: K → KILHPLTRNYGKPWLTNSKMSTPCKAAECSDFPVPSAE

Isoform 3 (identifier: Q03001-3)

Also known as: BPAG1e; eBPAG1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-381: MAGYLSPAAY...REKALRPEVE → MHSSSYSYRS...SFGSESFDGH
     1433-1433: K → IKRCKETSEH...TGISSLYYSS
     1434-7570: Missing.

Note: Contains a phosphothreonine at position 1129. Contains a phosphoserine at position 1565 (By similarity).

Isoform 4 (identifier: Q03001-9)

Also known as: BPAG1eA; eB;

The sequence of this isoform differs from the canonical sequence as follows:
     1-381: MAGYLSPAAY...REKALRPEVE → MHSSSYSYRS...SFGSESFDGH
     3387-7570: Missing.

Note: Incomplete sequence.

Isoform 5 (identifier: Q03001-10)

The sequence of this isoform differs from the canonical sequence as follows:
     1-3753: Missing.
     4184-4200: GQVPLNSTALQDIISKN → DVGTGYCRSSEQYKCHE
     4201-7570: Missing.

Note: Incomplete sequence. No experimental confirmation available. Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 6 (identifier: Q03001-11)

Also known as: BPAG1n1; BPAG1n2; Dystonin-2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: MAGYLSPAAYLYVEEQEYLQAYEDVLERYK → MIAAAFLVLL...PAERAVLRIA
     47-7570: Missing.

Note: Incomplete sequence. Transmembrane protein (helical transmembrane domain from amino acid 18 to 38). Contains a phosphoserine at position 170.

Isoform 7 (identifier: Q03001-12)

Also known as: BPAG1n3;

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: MAGYLSPAAY...LIWTIILHFQ → MQHSIFSLKKKRCHSLYTSMSSVSKDTDGNE
     189-7570: Missing.

Note: Incomplete sequence.

Isoform 8 (identifier: Q03001-13)

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: MAGYLSPAAY...LIWTIILHFQ → MGNVCGCVRA...SVSKDTDGNE
     778-789: AYRAAMQTQWSW → VKLESVMVLVEY
     790-7570: Missing.

Note: Probably myristoylated on Gly-2 (By similarity). Probably S-palmitoylated on Cys-5 and Cys-7 (By similarity).

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 7570	7570	Dystonin		PRO_0000078138
Regions
	Domain	35 – 252	218	Actin-binding
	Domain	35 – 138	104	CH 1
	Domain	151 – 252	102	CH 2
	Repeat	701 – 797	97	Spectrin 1
	Domain	890 – 942	53	SH3
	Repeat	1584 – 1626	43	Plectin 1
	Repeat	1660 – 1703	44	Plectin 2
	Repeat	1774 – 1817	44	Plectin 3
	Repeat	1818 – 1855	38	Plectin 4
	Repeat	1856 – 1891	36	Plectin 5
	Repeat	3924 – 4000	77	Spectrin 2
	Repeat	4069 – 4153	85	Spectrin 3
	Repeat	4514 – 4622	109	Spectrin 4
	Repeat	4626 – 4731	106	Spectrin 5
	Repeat	4849 – 4952	104	Spectrin 6
	Repeat	5281 – 5389	109	Spectrin 7
	Repeat	5396 – 5497	102	Spectrin 8
	Repeat	5504 – 5606	103	Spectrin 9
	Repeat	5829 – 5933	105	Spectrin 10
	Repeat	5940 – 6042	103	Spectrin 11
	Repeat	6048 – 6154	107	Spectrin 12
	Repeat	6184 – 6264	81	Spectrin 13
	Repeat	6270 – 6373	104	Spectrin 14
	Repeat	6379 – 6481	103	Spectrin 15
	Repeat	6490 – 6592	103	Spectrin 16
	Repeat	6597 – 6700	104	Spectrin 17
	Repeat	6705 – 6811	107	Spectrin 18
	Repeat	6818 – 6918	101	Spectrin 19
	Repeat	6923 – 7026	104	Spectrin 20
	Domain	7197 – 7232	36	EF-hand 1
	Domain	7233 – 7268	36	EF-hand 2
	Domain	7273 – 7351	79	GAR
	Calcium binding	7210 – 7221	12	1 Potential
	Calcium binding	7246 – 7257	12	2 Potential
	Motif	1383 – 1389	7	Nuclear localization signal; in isoform 6 By similarity
	Motif	7550 – 7553	4	Microtubule tip localization signal
	Compositional bias	2394 – 2431	38	Asp-rich
	Compositional bias	2592 – 2599	8	Poly-Asp
Amino acid modifications
	Modified residue	2919	1	Phosphoserine Ref.26
	Modified residue	7364	1	Phosphoserine By similarity
	Modified residue	7432	1	Phosphoserine Ref.22
	Cross-link	5470		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Natural variations
	Alternative sequence	1 – 3753	3753	Missing in isoform 5.		VSP_041524
	Alternative sequence	1 – 381	381	MAGYL…RPEVE → MHSSSYSYRSSDSVFSNTTS TRTSLDSNENLLLVHCGPTL INSCISFGSESFDGH in isoform 2, isoform 3 and isoform 4.		VSP_041525
	Alternative sequence	1 – 138	138	MAGYL…ILHFQ → MQHSIFSLKKKRCHSLYTSM SSVSKDTDGNE in isoform 7.		VSP_041526
	Alternative sequence	1 – 138	138	MAGYL…ILHFQ → MGNVCGCVRAEKEEQYVDPA KTPLNPEKYSPGRKYFRRKP IKKTGGDKESVGANNENEGK KKSSSQPSKEQPAPLSRGLV QQESVTLNSALGDGIQQKKT EVVADSVKQKLLPSAVSSWS DCVNTSPAKDSETEVKVSEL DERISEKDSTPYCAKRKKHL DDVNTSEITFQEKTDVFSFR KAASLSSIPSGIERSLEKGG FPEDPPKSYSSIQEKQNTER FCPHATQHFQFKKKRCHSLY TSMSSVSKDTDGNE in isoform 8.		VSP_041527
	Alternative sequence	1 – 30	30	MAGYL…LERYK → MIAAAFLVLLRPYSIQCALF LLLLLLGTIATIVFFCCWHR KLQKGRHPMKSVFSGRSRSR DAVLRSHHFRSEGFRASPRH LRRRVAAAAAARLEEVKPVV EVHHQSEQETSVRKRRIKKS SRVQPEFYHSVQGASIRRPS SGNASYRCSMSSSADFSDED DFSQKSGSASPAPGDTLPWN LPKHERSKRKIQGGSVLDPA ERAVLRIA in isoform 6.		VSP_041528
	Alternative sequence	47 – 7570	7524	Missing in isoform 6.		VSP_041529
	Alternative sequence	189 – 7570	7382	Missing in isoform 7.		VSP_041530
	Alternative sequence	778 – 789	12	AYRAA…TQWSW → VKLESVMVLVEY in isoform 8.		VSP_041531
	Alternative sequence	790 – 7570	6781	Missing in isoform 8.		VSP_041532
	Alternative sequence	1433	1	K → IKRCKETSEHGAYSDLLQRQ KATVLENSKLTGKISELERM VAELKKQKSRVEEELPKVRE AAENELRKQQRNVEDISLQK IRAESEAKQYRRELETIVRE KEAAERELERVRQLTIEAEA KRAAVEENLLNFRNQLEENT FTRRTLEDHLKRKDLSLNDL EQQKNKLMEELRRKRDNEEE LLKLIKQMEKDLAFQKQVAE KQLKEKQKIELEARRKITEI QYTCRENALPVCPITQATSC RAVTGLQQEHDKQKAEELKQ QVDELTAANRKAEQDMRELT YELNALQLEKTSSEEKARLL KDKLDETNNTLRCLKLELER KDQAEKGYSQQLRELGRQLN QTTGKAEEAMQEASDLKKIK RNYQLELESLNHEKGKLQRE VDRITRAHAVAEKNIQHLNS QIHSFRDEKELERLQICQRK SDHLKEQFEKSHEQLLQNIK AEKENNDKIQRLNEELEKSN ECAEMLKQKVEELTRQNNET KLMMQRIQAESENIVLEKQT IQQRCEALKIQADGFKDQLR STNEHLHKQTKTEQDFQRKI KCLEEDLAKSQNLVSEFKQK CDQQNIIIQNTKKEVRNLNA ELNASKEEKRRGEQKVQLQQ AQVQELNNRLKKVQDELHLK TIEEQMTHRKMVLFQEESGK FKQSAEEFRKKMEKLMESKV ITENDISGIRLDFVSLQQEN SRAQENAKLCETNIKELERQ LQQYREQMQQGQHMEANHYQ KCQKLEDELIAQKREVENLK QKMDQQIKEHEHQLVLLQCE IQKKSTAKDCTFKPDFEMTV KECQHSGELSSRNTGHLHPT PRSPLLRWTQEPQPLEEKWQ HRVVEQIPKEVQFQPPGAPL EKEKSQQCYSEYFSQTSTEL QITFDETNPITRLSEIEKIR DQALNNSRPPVRYQDNACEM ELVKVLTPLEIAKNKQYDMH TEVTTLKQEKNPVPSAEEWM LEGCRASGGLKKGDFLKKGL EPETFQNFDGDHACSVRDDE FKFQGLRHTVTARQLVEAKL LDMRTIEQLRLGLKTVEEVQ KTLNKFLTKATSIAGLYLES TKEKISFASAAERIIIDKMV ALAFLEAQAATGFIIDPISG QTYSVEDAVLKGVVDPEFRI RLLEAEKAAVGYSYSSKTLS VFQAMENRMLDRQKGKHILE AQIASGGVIDPVRGIRVPPE IALQQGLLNNAILQFLHEPS SNTRVFPNPNNKQALYYSEL LRMCVFDVESQCFLFPFGER NISNLNVKKTHRISVVDTKT GSELTVYEAFQRNLIEKSIY LELSGQQYQWKEAMFFESYG HSSHMLTDTKTGLHFNINEA IEQGTIDKALVKKYQEGLIT LTELADSLLSRLVPKKDLHS PVAGYWLTASGERISVLKAS RRNLVDRITALRCLEAQVST GGIIDPLTGKKYRVAEALHR GLVDEGFAQQLRQCELVITG IGHPITNKMMSVVEAVNANI INKEMGIRCLEFQYLTGGLI EPQVHSRLSIEEALQVGIID VLIATKLKDQKSYVRNIICP QTKRKLTYKEALEKADFDFH TGLKLLEVSEPLMTGISSLY YSS in isoform 3.		VSP_041533
	Alternative sequence	1434 – 7570	6137	Missing in isoform 3.		VSP_041534
	Alternative sequence	1550 – 3635	2086	Missing in isoform 2.		VSP_041535
	Alternative sequence	3387 – 7570	4184	Missing in isoform 4.		VSP_041536
	Alternative sequence	4184 – 4200	17	GQVPL…IISKN → DVGTGYCRSSEQYKCHE in isoform 5.		VSP_041537
	Alternative sequence	4201 – 7570	3370	Missing in isoform 5.		VSP_041538
	Alternative sequence	7352 – 7375	24	Missing in isoform 2.		VSP_041539
	Alternative sequence	7442	1	K → KILHPLTRNYGKPWLTNSKM STPCKAAECSDFPVPSAE in isoform 2.		VSP_041540
	Natural variant	1319	1	N → K. Corresponds to variant rs35014998 [ dbSNP | Ensembl ].		VAR_063045
	Natural variant	2332	1	Q → R. Corresponds to variant rs16888053 [ dbSNP | Ensembl ].		VAR_063046
	Natural variant	3720	1	Q → R. Corresponds to variant rs4712138 [ dbSNP | Ensembl ].		VAR_063047
	Natural variant	5138	1	T → A. Ref.4 Corresponds to variant rs4715631 [ dbSNP | Ensembl ].		VAR_063048
Experimental info
	Mutagenesis	7548	1	K → Q: Loss of interaction with MAPRE1 and association with microtubule growing ends. Ref.29
	Mutagenesis	7550	1	S → A or N: Loss of association with microtubule growing ends. Ref.29
	Mutagenesis	7552	1	I → N: Loss of interaction with MAPRE1 and association with the growing microtubule plus ends; when associated with N-7553. Ref.29
	Mutagenesis	7553	1	P → N: Loss of interaction with MAPRE1 and association with the growing microtubule plus ends; when associated with N-7552. Ref.29
	Mutagenesis	7557	1	R → N: Loss of interaction with MAPRE1 and association with the growing microtubule plus ends.
	Mutagenesis	7558	1	K → N: Loss of interaction with MAPRE1 and association with the growing microtubule plus ends.
	Sequence conflict	573	1	P → A in BAH12207. Ref.4
	Sequence conflict	1177	1	V → G in M69225. Ref.1
	Sequence conflict	1177	1	V → G in AAL62061. Ref.3
	Sequence conflict	1177	1	V → G in AAL62062. Ref.3
	Sequence conflict	1363	1	K → E in AAL62061. Ref.3
	Sequence conflict	4703	1	R → H in BAC04449. Ref.4
	Sequence conflict	4935	1	N → S in BAC04449. Ref.4
	Sequence conflict	5030	1	E → G in AAL62061. Ref.3
	Sequence conflict	5177	1	Q → R in AAL62061. Ref.3
	Sequence conflict	5225	1	M → I in BAB70870. Ref.4
	Sequence conflict	5299	1	K → R in AAL62061. Ref.3
	Sequence conflict	5823	1	I → V in AAL62061. Ref.3
	Sequence conflict	5882	1	K → R in AAL62061. Ref.3
	Sequence conflict	5986	1	L → S in AAL62061. Ref.3
	Sequence conflict	6080	1	K → E in BAC04848. Ref.4
	Sequence conflict	6186	1	D → G in AAL62061. Ref.3
	Sequence conflict	6440	1	A → G in AAL62061. Ref.3
Isoform 3:
	Sequence conflict	1644	1	R → T in M69225. Ref.1
	Sequence conflict	2364	1	S → T in M69225. Ref.1
	Sequence conflict	2495	1	G → V in M69225. Ref.1
	Sequence conflict	2543	1	N → K in M69225. Ref.1
	Sequence conflict	2621	1	A → P in M69225. Ref.1
	Sequence conflict	1943	1	G → R in CAA41528. Ref.13
Isoform 6:
	Sequence conflict	48	1	P → L in AAC50244. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (BPAG1-b) [UniParc]. Last modified April 20, 2010. Version 4. Checksum: 1EA992E53D1C243E	FASTA	7,570	860,662
	10 20 30 40 50 60 MAGYLSPAAY LYVEEQEYLQ AYEDVLERYK DERDKVQKKT FTKWINQHLM KVRKHVNDLY 70 80 90 100 110 120 EDLRDGHNLI SLLEVLSGDT LPREKGRMRF HRLQNVQIAL DYLKRRQVKL VNIRNDDITD 130 140 150 160 170 180 GNPKLTLGLI WTIILHFQIS DIHVTGESED MSAKERLLLW TQQATEGYAG IRCENFTTCW 190 200 210 220 230 240 RDGKLFNAII HKYRPDLIDM NTVAVQSNLA NLEHAFYVAE KIGVIRLLDP EDVDVSSPDE 250 260 270 280 290 300 KSVITYVSSL YDAFPKVPEG GEGIGANDVE VKWIEYQNMV NYLIQWIRHH VTTMSERTFP 310 320 330 340 350 360 NNPVELKALY NQYLQFKETE IPPKETEKSK IKRLYKLLEI WIEFGRIKLL QGYHPNDIEK 370 380 390 400 410 420 EWGKLIIAML EREKALRPEV ERLEMLQQIA NRVQRDSVIC EDKLILAGNA LQSDSKRLES 430 440 450 460 470 480 GVQFQNEAEI AGYILECENL LRQHVIDVQI LIDGKYYQAD QLVQRVAKLR DEIMALRNEC 490 500 510 520 530 540 SSVYSKGRIL TTEQTKLMIS GITQSLNSGF AQTLHPSLTS GLTQSLTPSL TSSSMTSGLS 550 560 570 580 590 600 SGMTSRLTPS VTPAYTPGFP SGLVPNFSSG VEPNSLQTLK LMQIRKPLLK SSLLDQNLTE 610 620 630 640 650 660 EEINMKFVQD LLNWVDEMQV QLDRTEWGSD LPSVESHLEN HKNVHRAIEE FESSLKEAKI 670 680 690 700 710 720 SEIQMTAPLK LTYAEKLHRL ESQYAKLLNT SRNQERHLDT LHNFVSRATN ELIWLNEKEE 730 740 750 760 770 780 EEVAYDWSER NTNIARKKDY HAELMRELDQ KEENIKSVQE IAEQLLLENH PARLTIEAYR 790 800 810 820 830 840 AAMQTQWSWI LQLCQCVEQH IKENTAYFEF FNDAKEATDY LRNLKDAIQR KYSCDRSSSI 850 860 870 880 890 900 HKLEDLVQES MEEKEELLQY KSTIANLMGK AKTIIQLKPR NSDCPLKTSI PIKAICDYRQ 910 920 930 940 950 960 IEITIYKDDE CVLANNSHRA KWKVISPTGN EAMVPSVCFT VPPPNKEAVD LANRIEQQYQ 970 980 990 1000 1010 1020 NVLTLWHESH INMKSVVSWH YLINEIDRIR ASNVASIKTM LPGEHQQVLS NLQSRFEDFL 1030 1040 1050 1060 1070 1080 EDSQESQVFS GSDITQLEKE VNVCKQYYQE LLKSAEREEQ EESVYNLYIS EVRNIRLRLE 1090 1100 1110 1120 1130 1140 NCEDRLIRQI RTPLERDDLH ESVFRITEQE KLKKELERLK DDLGTITNKC EEFFSQAAAS 1150 1160 1170 1180 1190 1200 SSVPTLRSEL NVVLQNMNQV YSMSSTYIDK LKTVNLVLKN TQAAEALVKL YETKLCEEEA 1210 1220 1230 1240 1250 1260 VIADKNNIEN LISTLKQWRS EVDEKRQVFH ALEDELQKAK AISDEMFKTY KERDLDFDWH 1270 1280 1290 1300 1310 1320 KEKADQLVER WQNVHVQIDN RLRDLEGIGK SLKYYRDTYH PLDDWIQQVE TTQRKIQENQ 1330 1340 1350 1360 1370 1380 PENSKTLATQ LNQQKMLVSE IEMKQSKMDE CQKYAEQYSA TVKDYELQTM TYRAMVDSQQ 1390 1400 1410 1420 1430 1440 KSPVKRRRMQ SSADLIIQEF MDLRTRYTAL VTLMTQYIKF AGDSLKRLEE EEKSLEEEKK 1450 1460 1470 1480 1490 1500 EHVEKAKELQ KWVSNISKTL KDAEKAGKPP FSKQKISSEE ISTKKEQLSE ALQTIQLFLA 1510 1520 1530 1540 1550 1560 KHGDKMTDEE RNELEKQVKT LQESYNLLFS ESLKQLQESQ TSGDVKVEEK LDKVIAGTID 1570 1580 1590 1600 1610 1620 QTTGEVLSVF QAVLRGLIDY DTGIRLLETQ LMISGLISPE LRKCFDLKDA KSHGLIDEQI 1630 1640 1650 1660 1670 1680 LCQLKELSKA KEIISAASPT TIPVLDALAQ SMITESMAIK VLEILLSTGS LVIPATGEQL 1690 1700 1710 1720 1730 1740 TLQKAFQQNL VSSALFSKVL ERQNMCKDLI DPCTSEKVSL IDMVQRSTLQ ENTGMWLLPV 1750 1760 1770 1780 1790 1800 RPQEGGRITL KCGRNISILR AAHEGLIDRE TMFRLLSAQL LSGGLINSNS GQRMTVEEAV 1810 1820 1830 1840 1850 1860 REGVIDRDTA SSILTYQVQT GGIIQSNPAK RLTVDEAVQC DLITSSSALL VLEAQRGYVG 1870 1880 1890 1900 1910 1920 LIWPHSGEIF PTSSSLQQEL ITNELAYKIL NGRQKIAALY IPESSQVIGL DAAKQLGIID 1930 1940 1950 1960 1970 1980 NNTASILKNI TLPDKMPDLG DLEACKNARR WLSFCKFQPS TVHDYRQEED VFDGEEPVTT 1990 2000 2010 2020 2030 2040 QTSEETKKLF LSYLMINSYM DANTGQRLLL YDGDLDEAVG MLLEGCHAEF DGNTAIKECL 2050 2060 2070 2080 2090 2100 DVLSSSGVFL NNASGREKDE CTATPSSFNK CHCGEPEHEE TPENRKCAID EEFNEMRNTV 2110 2120 2130 2140 2150 2160 INSEFSQSGK LASTISIDPK VNSSPSVCVP SLISYLTQTE LADISMLRSD SENILTNYEN 2170 2180 2190 2200 2210 2220 QSRVETNERA NECSHSKNIQ NFPSDLIENP IMKSKMSKFC GVNETENEDN TNRDSPIFDY 2230 2240 2250 2260 2270 2280 SPRLSALLSH DKLMHSQGSF NDTHTPESNG NKCEAPALSF SDKTMLSGQR IGEKFQDQFL 2290 2300 2310 2320 2330 2340 GIAAINISLP GEQYGQKSLN MISSNPQVQY HNDKYISNTS GEDEKTHPGF QQMPEDKEDE 2350 2360 2370 2380 2390 2400 SEIEEYSCAV TPGGDTDNAI VSLTCATPLL DETISASDYE TSLLNDQQNN TGTDTDSDDD 2410 2420 2430 2440 2450 2460 FYDTPLFEDD DHDSLLLDGD DRDCLHPEDY DTLQEENDET ASPADVFYDV SKENENSMVP 2470 2480 2490 2500 2510 2520 QGAPVGSLSV KNKAHCLQDF LMDVEKDELD SGEKIHLNPV GSDKVNGQSL ETGSERECTN 2530 2540 2550 2560 2570 2580 ILEGDESDSL TDYDIVGGKE SFTASLKFDD SGSWRGRKEE YVTGQEFHSD TDHLDSMQSE 2590 2600 2610 2620 2630 2640 ESYGDYIYDS NDQDDDDDDG IDEEGGGIRD ENGKPRCQNV AEDMDIQLCA SILNENSDEN 2650 2660 2670 2680 2690 2700 ENINTMILLD KMHSCSSLEK QQRVNVVQLA SPSENNLVTE KSNLPEYTTE IAGKSKENLL 2710 2720 2730 2740 2750 2760 NHEMVLKDVL PPIIKDTESE KTFGPASISH DNNNISSTSE LGTDLANTKV KLIQGSELPE 2770 2780 2790 2800 2810 2820 LTDSVKGKDE YFKNMTPKVD SSLDHIICTE PDLIGKPAEE SHLSLIASVT DKDPQGNGSD 2830 2840 2850 2860 2870 2880 LIKGRDGKSD ILIEDETSIQ KMYLGEGEVL VEGLVEEENR HLKLLPGKNT RDSFKLINSQ 2890 2900 2910 2920 2930 2940 FPFPQITNNE ELNQKGSLKK ATVTLKDEPN NLQIIVSKSP VQFENLEEIF DTSVSKEISD 2950 2960 2970 2980 2990 3000 DITSDITSWE GNTHFEESFT DGPEKELDLF TYLKHCAKNI KAKDVAKPNE DVPSHVLITA 3010 3020 3030 3040 3050 3060 PPMKEHLQLG VNNTKEKSTS TQKDSPLNDM IQSNDLCSKE SISGGGTEIS QFTPESIEAT 3070 3080 3090 3100 3110 3120 LSILSRKHVE DVGKNDFLQS ERCANGLGND NSSNTLNTDY SFLEINNKKE RIEQQLPKEQ 3130 3140 3150 3160 3170 3180 ALSPRSQEKE VQIPELSQVF VEDVKDILKS RLKEGHMNPQ EVEEPSACAD TKILIQNLIK 3190 3200 3210 3220 3230 3240 RITTSQLVNE ASTVPSDSQM SDSSGVSPMT NSSELKPESR DDPFCIGNLK SELLLNILKQ 3250 3260 3270 3280 3290 3300 DQHSQKITGV FELMRELTHM EYDLEKRGIT SKVLPLQLEN IFYKLLADGY SEKIEHVGDF 3310 3320 3330 3340 3350 3360 NQKACSTSEM MEEKPHILGD IKSKEGNYYS PNLETVKEIG LESSTVWAST LPRDEKLKDL 3370 3380 3390 3400 3410 3420 CNDFPSHLEC TSGSKEMASG DSSTEQFSSE LQQCLQHTEK MHEYLTLLQD MKPPLDNQES 3430 3440 3450 3460 3470 3480 LDNNLEALKN QLRQLETFEL GLAPIAVILR KDMKLAEEFL KSLPSDFPRG HVEELSISHQ 3490 3500 3510 3520 3530 3540 SLKTAFSSLS NVSSERTKQI MLAIDSEMSK LAVSHEEFLH KLKSFSDWVS EKSKSVKDIE 3550 3560 3570 3580 3590 3600 IVNVQDSEYV KKRLEFLKNV LKDLGHTKMQ LETTAFDVQF FISEYAQDLS PNQSKQLLRL 3610 3620 3630 3640 3650 3660 LNTTQKCFLD VQESVTTQVE RLETQLHLEQ DLDDQKIVAE RQQEYKEKLQ GICDLLTQTE 3670 3680 3690 3700 3710 3720 NRLIGHQEAF MIGDGTVELK KYQSKQEELQ KDMQGSAQAL AEVVKNTENF LKENGEKLSQ 3730 3740 3750 3760 3770 3780 EDKALIEQKL NEAKIKCEQL NLKAEQSKKE LDKVVTTAIK EETEKVAAVK QLEESKTKIE 3790 3800 3810 3820 3830 3840 NLLDWLSNVD KDSERAGTKH KQVIEQNGTH FQEGDGKSAI GEEDEVNGNL LETDVDGQVG 3850 3860 3870 3880 3890 3900 TTQENLNQQY QKVKAQHEKI ISQHQAVIIA TQSAQVLLEK QGQYLSPEEK EKLQKNMKEL 3910 3920 3930 3940 3950 3960 KVHYETALAE SEKKMKLTHS LQEELEKFDA DYTEFEHWLQ QSEQELENLE AGADDINGLM 3970 3980 3990 4000 4010 4020 TKLKRQKSFS EDVISHKGDL RYITISGNRV LEAAKSCSKR DGGKVDTSAT HREVQRKLDH 4030 4040 4050 4060 4070 4080 ATDRFRSLYS KCNVLGNNLK DLVDKYQHYE DASCGLLAGL QACEATASKH LSEPIAVDPK 4090 4100 4110 4120 4130 4140 NLQRQLEETK ALQGQISSQQ VAVEKLKKTA EVLLDARGSL LPAKNDIQKT LDDIVGRYED 4150 4160 4170 4180 4190 4200 LSKSVNERNE KLQITLTRSL SVQDGLDEML DWMGNVESSL KEQGQVPLNS TALQDIISKN 4210 4220 4230 4240 4250 4260 IMLEQDIAGR QSSINAMNEK VKKFMETTDP STASSLQAKM KDLSARFSEA SHKHKETLAK 4270 4280 4290 4300 4310 4320 MEELKTKVEL FENLSEKLQT FLETKTQALT EVDVPGKDVT ELSQYMQEST SEFLEHKKHL 4330 4340 4350 4360 4370 4380 EVLHSLLKEI SSHGLPSDKA LVLEKTNNLS KKFKEMEDTI KEKKEAVTSC QEQLDAFQVL 4390 4400 4410 4420 4430 4440 VKSLKSWIKE TTKKVPIVQP SFGAEDLGKS LEDTKKLQEK WSLKTPEIQK VNNSGISLCN 4450 4460 4470 4480 4490 4500 LISAVTTPAK AIAAVKSGGA VLNGEGTATN TEEFWANKGL TSIKKDMTDI SHGYEDLGLL 4510 4520 4530 4540 4550 4560 LKDKIAELNT KLSKLQKAQE ESSAMMQWLQ KMNKTATKWQ QTPAPTDTEA VKTQVEQNKS 4570 4580 4590 4600 4610 4620 FEAELKQNVN KVQELKDKLT ELLEENPDTP EAPRWKQMLT EIDSKWQELN QLTIDRQQKL 4630 4640 4650 4660 4670 4680 EESSNNLTQF QTVEAQLKQW LVEKELMVSV LGPLSIDPNM LNTQRQQVQI LLQEFATRKP 4690 4700 4710 4720 4730 4740 QYEQLTAAGQ GILSRPGEDP SLRGIVKEQL AAVTQKWDSL TGQLSDRCDW IDQAIVKSTQ 4750 4760 4770 4780 4790 4800 YQSLLRSLSD KLSDLDNKLS SSLAVSTHPD AMNQQLETAQ KMKQEIQQEK KQIKVAQALC 4810 4820 4830 4840 4850 4860 EDLSALVKEE YLKAELSRQL EGILKSFKDV EQKAENHVQH LQSACASSHQ FQQMSRDFQA 4870 4880 4890 4900 4910 4920 WLDTKKEEQN KSHPISAKLD VLESLIKDHK DFSKTLTAQS HMYEKTIAEG ENLLLKTQGS 4930 4940 4950 4960 4970 4980 EKAALQLQLN TIKTNWDTFN KQVKERENKL KESLEKALKY KEQVETLWPW IDKCQNNLEE 4990 5000 5010 5020 5030 5040 IKFCLDPAEG ENSIAKLKSL QKEMDQHFGM VELLNNTANS LLSVCEIDKE VVTDENKSLI 5050 5060 5070 5080 5090 5100 QKVDMVTEQL HSKKFCLENM TQKFKEFQEV SKESKRQLQC AKEQLDIHDS LGSQAYSNKY 5110 5120 5130 5140 5150 5160 LTMLQTQQKS LQALKHQVDL AKRLAQDLVV EASDSKGTSD VLLQVETIAQ EHSTLSQQVD 5170 5180 5190 5200 5210 5220 EKCSFLETKL QGIGHFQNTI REMFSQFAEF DDELDSMAPV GRDAETLQKQ KETIKAFLKK 5230 5240 5250 5260 5270 5280 LEALMASNDN ANKTCKMMLA TEETSPDLVG IKRDLEALSK QCNKLLDRAQ AREEQVEGTI 5290 5300 5310 5320 5330 5340 KRLEEFYSKL KEFSILLQKA EEHEESQGPV GMETETINQQ LNMFKVFQKE EIEPLQGKQQ 5350 5360 5370 5380 5390 5400 DVNWLGQGLI QSAAKSTSTQ GLEHDLDDVN ARWKTLNKKV AQRAAQLQEA LLHCGRFQDA 5410 5420 5430 5440 5450 5460 LESLLSWMVD TEELVANQKP PSAEFKVVKA QIQEQKLLQR LLDDRKSTVE VIKREGEKIA 5470 5480 5490 5500 5510 5520 TTAEPADKVK ILKQLSLLDS RWEALLNKAE TRNRQLEGIS VVAQQFHETL EPLNEWLTTI 5530 5540 5550 5560 5570 5580 EKRLVNCEPI GTQASKLEEQ IAQHKALEDD IINHNKHLHQ AVSIGQSLKV LSSREDKDMV 5590 5600 5610 5620 5630 5640 QSKLDFSQVW YIEIQEKSHS RSELLQQALC NAKIFGEDEV ELMNWLNEVH DKLSKLSVQD 5650 5660 5670 5680 5690 5700 YSTEGLWKQQ SELRVLQEDI LLRKQNVDQA LLNGLELLKQ TTGDEVLIIQ DKLEAIKARY 5710 5720 5730 5740 5750 5760 KDITKLSTDV AKTLEQALQL ARRLHSTHEE LCTWLDKVEV ELLSYETQVL KGEEASQAQM 5770 5780 5790 5800 5810 5820 RPKELKKEAK NNKALLDSLN EVSSALLELV PWRAREGLEK MVAEDNERYR LVSDTITQKV 5830 5840 5850 5860 5870 5880 EEIDAAILRS QQFDQAADAE LSWITETEKK LMSLGDIRLE QDQTSAQLQV QKTFTMEILR 5890 5900 5910 5920 5930 5940 HKDIIDDLVK SGHKIMTACS EEEKQSMKKK LDKVLKNYDT ICQINSERYL QLERAQSLVN 5950 5960 5970 5980 5990 6000 QFWETYEELW PWLTETQSII SQLPAPALEY ETLRQQQEEH RQLRELIAEH KPHIDKMNKT 6010 6020 6030 6040 6050 6060 GPQLLELSPG EGFSIQEKYV AADTLYSQIK EDVKKRAVAL DEAISQSTQF HDKIDQILES 6070 6080 6090 6100 6110 6120 LERIVERLRQ PPSISAEVEK IKEQISENKN VSVDMEKLQP LYETLKQRGE EMIARSGGTD 6130 6140 6150 6160 6170 6180 KDISAKAVQD KLDQMVFIWE NIHTLVEERE AKLLDVMELA EKFWCDHMSL IVTIKDTQDF 6190 6200 6210 6220 6230 6240 IRDLEDPGID PSVVKQQQEA AETIREEIDG LQEELDIVIN LGSELIAACG EPDKPIVKKS 6250 6260 6270 6280 6290 6300 IDELNSAWDS LNKAWKDRID KLEEAMQAAV QYQDGLQAVF DWVDIAGGKL ASMSPIGTDL 6310 6320 6330 6340 6350 6360 ETVKQQIEEL KQFKSEAYQQ QIEMERLNHQ AELLLKKVTE ESDKHTVQDP LMELKLIWDS 6370 6380 6390 6400 6410 6420 LEERIINRQH KLEGALLALG QFQHALDELL AWLTHTEGLL SEQKPVGGDP KAIEIELAKH 6430 6440 6450 6460 6470 6480 HVLQNDVLAH QSTVEAVNKA GNDLIESSAG EEASNLQNKL EVLNQRWQNV LEKTEQRKQQ 6490 6500 6510 6520 6530 6540 LDGALRQAKG FHGEIEDLQQ WLTDTERHLL ASKPLGGLPE TAKEQLNVHM EVCAAFEAKE 6550 6560 6570 6580 6590 6600 ETYKSLMQKG QQMLARCPKS AETNIDQDIN NLKEKWESVE TKLNERKTKL EEALNLAMEF 6610 6620 6630 6640 6650 6660 HNSLQDFINW LTQAEQTLNV ASRPSLILDT VLFQIDEHKV FANEVNSHRE QIIELDKTGT 6670 6680 6690 6700 6710 6720 HLKYFSQKQD VVLIKNLLIS VQSRWEKVVQ RLVERGRSLD DARKRAKQFH EAWSKLMEWL 6730 6740 6750 6760 6770 6780 EESEKSLDSE LEIANDPDKI KTQLAQHKEF QKSLGAKHSV YDTTNRTGRS LKEKTSLADD 6790 6800 6810 6820 6830 6840 NLKLDDMLSE LRDKWDTICG KSVERQNKLE EALLFSGQFT DALQALIDWL YRVEPQLAED 6850 6860 6870 6880 6890 6900 QPVHGDIDLV MNLIDNHKAF QKELGKRTSS VQALKRSARE LIEGSRDDSS WVKVQMQELS 6910 6920 6930 6940 6950 6960 TRWETVCALS ISKQTRLEAA LRQAEEFHSV VHALLEWLAE AEQTLRFHGV LPDDEDALRT 6970 6980 6990 7000 7010 7020 LIDQHKEFMK KLEEKRAELN KATTMGDTVL AICHPDSITT IKHWITIIRA RFEEVLAWAK 7030 7040 7050 7060 7070 7080 QHQQRLASAL AGLIAKQELL EALLAWLQWA ETTLTDKDKE VIPQEIEEVK ALIAEHQTFM 7090 7100 7110 7120 7130 7140 EEMTRKQPDV DKVTKTYKRR AADPSSLQSH IPVLDKGRAG RKRFPASSLY PSGSQTQIET 7150 7160 7170 7180 7190 7200 KNPRVNLLVS KWQQVWLLAL ERRRKLNDAL DRLEELREFA NFDFDIWRKK YMRWMNHKKS 7210 7220 7230 7240 7250 7260 RVMDFFRRID KDQDGKITRQ EFIDGILSSK FPTSRLEMSA VADIFDRDGD GYIDYYEFVA 7270 7280 7290 7300 7310 7320 ALHPNKDAYK PITDADKIED EVTRQVAKCK CAKRFQVEQI GDNKYRFFLG NQFGDSQQLR 7330 7340 7350 7360 7370 7380 LVRILRSTVM VRVGGGWMAL DEFLVKNDPC RVHHHGSKML RSESNSSITT TQPTIAKGRT 7390 7400 7410 7420 7430 7440 NMELREKFIL ADGASQGMAA FRPRGRRSRP SSRGASPNRS TSVSSQAAQA ASPQVPATTT 7450 7460 7470 7480 7490 7500 PKGTPIQGSK LRLPGYLSGK GFHSGEDSGL ITTAAARVRT QFADSKKTPS RPGSRAGSKA 7510 7520 7530 7540 7550 7560 GSRASSRRGS DASDFDISEI QSVCSDVETV PQTHRPTPRA GSRPSTAKPS KIPTPQRKSP 7570 ASKLDKSSKR
	Isoform 2 (BPAG1-a) (BPAG1eA) (Dystonin-1) (eA) [UniParc]. Checksum: EF1B5C94E21ED130	FASTA	5,171	591,036
	10 20 30 40 50 60 MHSSSYSYRS SDSVFSNTTS TRTSLDSNEN LLLVHCGPTL INSCISFGSE SFDGHRLEML 70 80 90 100 110 120 QQIANRVQRD SVICEDKLIL AGNALQSDSK RLESGVQFQN EAEIAGYILE CENLLRQHVI 130 140 150 160 170 180 DVQILIDGKY YQADQLVQRV AKLRDEIMAL RNECSSVYSK GRILTTEQTK LMISGITQSL 190 200 210 220 230 240 NSGFAQTLHP SLTSGLTQSL TPSLTSSSMT SGLSSGMTSR LTPSVTPAYT PGFPSGLVPN 250 260 270 280 290 300 FSSGVEPNSL QTLKLMQIRK PLLKSSLLDQ NLTEEEINMK FVQDLLNWVD EMQVQLDRTE 310 320 330 340 350 360 WGSDLPSVES HLENHKNVHR AIEEFESSLK EAKISEIQMT APLKLTYAEK LHRLESQYAK 370 380 390 400 410 420 LLNTSRNQER HLDTLHNFVS RATNELIWLN EKEEEEVAYD WSERNTNIAR KKDYHAELMR 430 440 450 460 470 480 ELDQKEENIK SVQEIAEQLL LENHPARLTI EAYRAAMQTQ WSWILQLCQC VEQHIKENTA 490 500 510 520 530 540 YFEFFNDAKE ATDYLRNLKD AIQRKYSCDR SSSIHKLEDL VQESMEEKEE LLQYKSTIAN 550 560 570 580 590 600 LMGKAKTIIQ LKPRNSDCPL KTSIPIKAIC DYRQIEITIY KDDECVLANN SHRAKWKVIS 610 620 630 640 650 660 PTGNEAMVPS VCFTVPPPNK EAVDLANRIE QQYQNVLTLW HESHINMKSV VSWHYLINEI 670 680 690 700 710 720 DRIRASNVAS IKTMLPGEHQ QVLSNLQSRF EDFLEDSQES QVFSGSDITQ LEKEVNVCKQ 730 740 750 760 770 780 YYQELLKSAE REEQEESVYN LYISEVRNIR LRLENCEDRL IRQIRTPLER DDLHESVFRI 790 800 810 820 830 840 TEQEKLKKEL ERLKDDLGTI TNKCEEFFSQ AAASSSVPTL RSELNVVLQN MNQVYSMSST 850 860 870 880 890 900 YIDKLKTVNL VLKNTQAAEA LVKLYETKLC EEEAVIADKN NIENLISTLK QWRSEVDEKR 910 920 930 940 950 960 QVFHALEDEL QKAKAISDEM FKTYKERDLD FDWHKEKADQ LVERWQNVHV QIDNRLRDLE 970 980 990 1000 1010 1020 GIGKSLKYYR DTYHPLDDWI QQVETTQRKI QENQPENSKT LATQLNQQKM LVSEIEMKQS 1030 1040 1050 1060 1070 1080 KMDECQKYAE QYSATVKDYE LQTMTYRAMV DSQQKSPVKR RRMQSSADLI IQEFMDLRTR 1090 1100 1110 1120 1130 1140 YTALVTLMTQ YIKFAGDSLK RLEEEEKSLE EEKKEHVEKA KELQKWVSNI SKTLKDAEKA 1150 1160 1170 1180 1190 1200 GKPPFSKQKI SSEEISTKKE QLSEALQTIQ LFLAKHGDKM TDEERNELEK QVKTLQESYN 1210 1220 1230 1240 1250 1260 LLFSESLKQL QESQTSGDVK VEEKIVAERQ QEYKEKLQGI CDLLTQTENR LIGHQEAFMI 1270 1280 1290 1300 1310 1320 GDGTVELKKY QSKQEELQKD MQGSAQALAE VVKNTENFLK ENGEKLSQED KALIEQKLNE 1330 1340 1350 1360 1370 1380 AKIKCEQLNL KAEQSKKELD KVVTTAIKEE TEKVAAVKQL EESKTKIENL LDWLSNVDKD 1390 1400 1410 1420 1430 1440 SERAGTKHKQ VIEQNGTHFQ EGDGKSAIGE EDEVNGNLLE TDVDGQVGTT QENLNQQYQK 1450 1460 1470 1480 1490 1500 VKAQHEKIIS QHQAVIIATQ SAQVLLEKQG QYLSPEEKEK LQKNMKELKV HYETALAESE 1510 1520 1530 1540 1550 1560 KKMKLTHSLQ EELEKFDADY TEFEHWLQQS EQELENLEAG ADDINGLMTK LKRQKSFSED 1570 1580 1590 1600 1610 1620 VISHKGDLRY ITISGNRVLE AAKSCSKRDG GKVDTSATHR EVQRKLDHAT DRFRSLYSKC 1630 1640 1650 1660 1670 1680 NVLGNNLKDL VDKYQHYEDA SCGLLAGLQA CEATASKHLS EPIAVDPKNL QRQLEETKAL 1690 1700 1710 1720 1730 1740 QGQISSQQVA VEKLKKTAEV LLDARGSLLP AKNDIQKTLD DIVGRYEDLS KSVNERNEKL 1750 1760 1770 1780 1790 1800 QITLTRSLSV QDGLDEMLDW MGNVESSLKE QGQVPLNSTA LQDIISKNIM LEQDIAGRQS 1810 1820 1830 1840 1850 1860 SINAMNEKVK KFMETTDPST ASSLQAKMKD LSARFSEASH KHKETLAKME ELKTKVELFE 1870 1880 1890 1900 1910 1920 NLSEKLQTFL ETKTQALTEV DVPGKDVTEL SQYMQESTSE FLEHKKHLEV LHSLLKEISS 1930 1940 1950 1960 1970 1980 HGLPSDKALV LEKTNNLSKK FKEMEDTIKE KKEAVTSCQE QLDAFQVLVK SLKSWIKETT 1990 2000 2010 2020 2030 2040 KKVPIVQPSF GAEDLGKSLE DTKKLQEKWS LKTPEIQKVN NSGISLCNLI SAVTTPAKAI 2050 2060 2070 2080 2090 2100 AAVKSGGAVL NGEGTATNTE EFWANKGLTS IKKDMTDISH GYEDLGLLLK DKIAELNTKL 2110 2120 2130 2140 2150 2160 SKLQKAQEES SAMMQWLQKM NKTATKWQQT PAPTDTEAVK TQVEQNKSFE AELKQNVNKV 2170 2180 2190 2200 2210 2220 QELKDKLTEL LEENPDTPEA PRWKQMLTEI DSKWQELNQL TIDRQQKLEE SSNNLTQFQT 2230 2240 2250 2260 2270 2280 VEAQLKQWLV EKELMVSVLG PLSIDPNMLN TQRQQVQILL QEFATRKPQY EQLTAAGQGI 2290 2300 2310 2320 2330 2340 LSRPGEDPSL RGIVKEQLAA VTQKWDSLTG QLSDRCDWID QAIVKSTQYQ SLLRSLSDKL 2350 2360 2370 2380 2390 2400 SDLDNKLSSS LAVSTHPDAM NQQLETAQKM KQEIQQEKKQ IKVAQALCED LSALVKEEYL 2410 2420 2430 2440 2450 2460 KAELSRQLEG ILKSFKDVEQ KAENHVQHLQ SACASSHQFQ QMSRDFQAWL DTKKEEQNKS 2470 2480 2490 2500 2510 2520 HPISAKLDVL ESLIKDHKDF SKTLTAQSHM YEKTIAEGEN LLLKTQGSEK AALQLQLNTI 2530 2540 2550 2560 2570 2580 KTNWDTFNKQ VKERENKLKE SLEKALKYKE QVETLWPWID KCQNNLEEIK FCLDPAEGEN 2590 2600 2610 2620 2630 2640 SIAKLKSLQK EMDQHFGMVE LLNNTANSLL SVCEIDKEVV TDENKSLIQK VDMVTEQLHS 2650 2660 2670 2680 2690 2700 KKFCLENMTQ KFKEFQEVSK ESKRQLQCAK EQLDIHDSLG SQAYSNKYLT MLQTQQKSLQ 2710 2720 2730 2740 2750 2760 ALKHQVDLAK RLAQDLVVEA SDSKGTSDVL LQVETIAQEH STLSQQVDEK CSFLETKLQG 2770 2780 2790 2800 2810 2820 IGHFQNTIRE MFSQFAEFDD ELDSMAPVGR DAETLQKQKE TIKAFLKKLE ALMASNDNAN 2830 2840 2850 2860 2870 2880 KTCKMMLATE ETSPDLVGIK RDLEALSKQC NKLLDRAQAR EEQVEGTIKR LEEFYSKLKE 2890 2900 2910 2920 2930 2940 FSILLQKAEE HEESQGPVGM ETETINQQLN MFKVFQKEEI EPLQGKQQDV NWLGQGLIQS 2950 2960 2970 2980 2990 3000 AAKSTSTQGL EHDLDDVNAR WKTLNKKVAQ RAAQLQEALL HCGRFQDALE SLLSWMVDTE 3010 3020 3030 3040 3050 3060 ELVANQKPPS AEFKVVKAQI QEQKLLQRLL DDRKSTVEVI KREGEKIATT AEPADKVKIL 3070 3080 3090 3100 3110 3120 KQLSLLDSRW EALLNKAETR NRQLEGISVV AQQFHETLEP LNEWLTTIEK RLVNCEPIGT 3130 3140 3150 3160 3170 3180 QASKLEEQIA QHKALEDDII NHNKHLHQAV SIGQSLKVLS SREDKDMVQS KLDFSQVWYI 3190 3200 3210 3220 3230 3240 EIQEKSHSRS ELLQQALCNA KIFGEDEVEL MNWLNEVHDK LSKLSVQDYS TEGLWKQQSE 3250 3260 3270 3280 3290 3300 LRVLQEDILL RKQNVDQALL NGLELLKQTT GDEVLIIQDK LEAIKARYKD ITKLSTDVAK 3310 3320 3330 3340 3350 3360 TLEQALQLAR RLHSTHEELC TWLDKVEVEL LSYETQVLKG EEASQAQMRP KELKKEAKNN 3370 3380 3390 3400 3410 3420 KALLDSLNEV SSALLELVPW RAREGLEKMV AEDNERYRLV SDTITQKVEE IDAAILRSQQ 3430 3440 3450 3460 3470 3480 FDQAADAELS WITETEKKLM SLGDIRLEQD QTSAQLQVQK TFTMEILRHK DIIDDLVKSG 3490 3500 3510 3520 3530 3540 HKIMTACSEE EKQSMKKKLD KVLKNYDTIC QINSERYLQL ERAQSLVNQF WETYEELWPW 3550 3560 3570 3580 3590 3600 LTETQSIISQ LPAPALEYET LRQQQEEHRQ LRELIAEHKP HIDKMNKTGP QLLELSPGEG 3610 3620 3630 3640 3650 3660 FSIQEKYVAA DTLYSQIKED VKKRAVALDE AISQSTQFHD KIDQILESLE RIVERLRQPP 3670 3680 3690 3700 3710 3720 SISAEVEKIK EQISENKNVS VDMEKLQPLY ETLKQRGEEM IARSGGTDKD ISAKAVQDKL 3730 3740 3750 3760 3770 3780 DQMVFIWENI HTLVEEREAK LLDVMELAEK FWCDHMSLIV TIKDTQDFIR DLEDPGIDPS 3790 3800 3810 3820 3830 3840 VVKQQQEAAE TIREEIDGLQ EELDIVINLG SELIAACGEP DKPIVKKSID ELNSAWDSLN 3850 3860 3870 3880 3890 3900 KAWKDRIDKL EEAMQAAVQY QDGLQAVFDW VDIAGGKLAS MSPIGTDLET VKQQIEELKQ 3910 3920 3930 3940 3950 3960 FKSEAYQQQI EMERLNHQAE LLLKKVTEES DKHTVQDPLM ELKLIWDSLE ERIINRQHKL 3970 3980 3990 4000 4010 4020 EGALLALGQF QHALDELLAW LTHTEGLLSE QKPVGGDPKA IEIELAKHHV LQNDVLAHQS 4030 4040 4050 4060 4070 4080 TVEAVNKAGN DLIESSAGEE ASNLQNKLEV LNQRWQNVLE KTEQRKQQLD GALRQAKGFH 4090 4100 4110 4120 4130 4140 GEIEDLQQWL TDTERHLLAS KPLGGLPETA KEQLNVHMEV CAAFEAKEET YKSLMQKGQQ 4150 4160 4170 4180 4190 4200 MLARCPKSAE TNIDQDINNL KEKWESVETK LNERKTKLEE ALNLAMEFHN SLQDFINWLT 4210 4220 4230 4240 4250 4260 QAEQTLNVAS RPSLILDTVL FQIDEHKVFA NEVNSHREQI IELDKTGTHL KYFSQKQDVV 4270 4280 4290 4300 4310 4320 LIKNLLISVQ SRWEKVVQRL VERGRSLDDA RKRAKQFHEA WSKLMEWLEE SEKSLDSELE 4330 4340 4350 4360 4370 4380 IANDPDKIKT QLAQHKEFQK SLGAKHSVYD TTNRTGRSLK EKTSLADDNL KLDDMLSELR 4390 4400 4410 4420 4430 4440 DKWDTICGKS VERQNKLEEA LLFSGQFTDA LQALIDWLYR VEPQLAEDQP VHGDIDLVMN 4450 4460 4470 4480 4490 4500 LIDNHKAFQK ELGKRTSSVQ ALKRSARELI EGSRDDSSWV KVQMQELSTR WETVCALSIS 4510 4520 4530 4540 4550 4560 KQTRLEAALR QAEEFHSVVH ALLEWLAEAE QTLRFHGVLP DDEDALRTLI DQHKEFMKKL 4570 4580 4590 4600 4610 4620 EEKRAELNKA TTMGDTVLAI CHPDSITTIK HWITIIRARF EEVLAWAKQH QQRLASALAG 4630 4640 4650 4660 4670 4680 LIAKQELLEA LLAWLQWAET TLTDKDKEVI PQEIEEVKAL IAEHQTFMEE MTRKQPDVDK 4690 4700 4710 4720 4730 4740 VTKTYKRRAA DPSSLQSHIP VLDKGRAGRK RFPASSLYPS GSQTQIETKN PRVNLLVSKW 4750 4760 4770 4780 4790 4800 QQVWLLALER RRKLNDALDR LEELREFANF DFDIWRKKYM RWMNHKKSRV MDFFRRIDKD 4810 4820 4830 4840 4850 4860 QDGKITRQEF IDGILSSKFP TSRLEMSAVA DIFDRDGDGY IDYYEFVAAL HPNKDAYKPI 4870 4880 4890 4900 4910 4920 TDADKIEDEV TRQVAKCKCA KRFQVEQIGD NKYRFFLGNQ FGDSQQLRLV RILRSTVMVR 4930 4940 4950 4960 4970 4980 VGGGWMALDE FLVKNDPCRA KGRTNMELRE KFILADGASQ GMAAFRPRGR RSRPSSRGAS 4990 5000 5010 5020 5030 5040 PNRSTSVSSQ AAQAASPQVP ATTTPKILHP LTRNYGKPWL TNSKMSTPCK AAECSDFPVP 5050 5060 5070 5080 5090 5100 SAEGTPIQGS KLRLPGYLSG KGFHSGEDSG LITTAAARVR TQFADSKKTP SRPGSRAGSK 5110 5120 5130 5140 5150 5160 AGSRASSRRG SDASDFDISE IQSVCSDVET VPQTHRPTPR AGSRPSTAKP SKIPTPQRKS 5170 PASKLDKSSK R
	Isoform 3 (BPAG1e) (eBPAG1) [UniParc]. Checksum: 5D0C62D26120E069	FASTA	2,649	306,755
	10 20 30 40 50 60 MHSSSYSYRS SDSVFSNTTS TRTSLDSNEN LLLVHCGPTL INSCISFGSE SFDGHRLEML 70 80 90 100 110 120 QQIANRVQRD SVICEDKLIL AGNALQSDSK RLESGVQFQN EAEIAGYILE CENLLRQHVI 130 140 150 160 170 180 DVQILIDGKY YQADQLVQRV AKLRDEIMAL RNECSSVYSK GRILTTEQTK LMISGITQSL 190 200 210 220 230 240 NSGFAQTLHP SLTSGLTQSL TPSLTSSSMT SGLSSGMTSR LTPSVTPAYT PGFPSGLVPN 250 260 270 280 290 300 FSSGVEPNSL QTLKLMQIRK PLLKSSLLDQ NLTEEEINMK FVQDLLNWVD EMQVQLDRTE 310 320 330 340 350 360 WGSDLPSVES HLENHKNVHR AIEEFESSLK EAKISEIQMT APLKLTYAEK LHRLESQYAK 370 380 390 400 410 420 LLNTSRNQER HLDTLHNFVS RATNELIWLN EKEEEEVAYD WSERNTNIAR KKDYHAELMR 430 440 450 460 470 480 ELDQKEENIK SVQEIAEQLL LENHPARLTI EAYRAAMQTQ WSWILQLCQC VEQHIKENTA 490 500 510 520 530 540 YFEFFNDAKE ATDYLRNLKD AIQRKYSCDR SSSIHKLEDL VQESMEEKEE LLQYKSTIAN 550 560 570 580 590 600 LMGKAKTIIQ LKPRNSDCPL KTSIPIKAIC DYRQIEITIY KDDECVLANN SHRAKWKVIS 610 620 630 640 650 660 PTGNEAMVPS VCFTVPPPNK EAVDLANRIE QQYQNVLTLW HESHINMKSV VSWHYLINEI 670 680 690 700 710 720 DRIRASNVAS IKTMLPGEHQ QVLSNLQSRF EDFLEDSQES QVFSGSDITQ LEKEVNVCKQ 730 740 750 760 770 780 YYQELLKSAE REEQEESVYN LYISEVRNIR LRLENCEDRL IRQIRTPLER DDLHESVFRI 790 800 810 820 830 840 TEQEKLKKEL ERLKDDLGTI TNKCEEFFSQ AAASSSVPTL RSELNVVLQN MNQVYSMSST 850 860 870 880 890 900 YIDKLKTVNL VLKNTQAAEA LVKLYETKLC EEEAVIADKN NIENLISTLK QWRSEVDEKR 910 920 930 940 950 960 QVFHALEDEL QKAKAISDEM FKTYKERDLD FDWHKEKADQ LVERWQNVHV QIDNRLRDLE 970 980 990 1000 1010 1020 GIGKSLKYYR DTYHPLDDWI QQVETTQRKI QENQPENSKT LATQLNQQKM LVSEIEMKQS 1030 1040 1050 1060 1070 1080 KMDECQKYAE QYSATVKDYE LQTMTYRAMV DSQQKSPVKR RRMQSSADLI IQEFMDLRTR 1090 1100 1110 1120 1130 1140 YTALVTLMTQ YIKFAGDSLK RLEEEEIKRC KETSEHGAYS DLLQRQKATV LENSKLTGKI 1150 1160 1170 1180 1190 1200 SELERMVAEL KKQKSRVEEE LPKVREAAEN ELRKQQRNVE DISLQKIRAE SEAKQYRREL 1210 1220 1230 1240 1250 1260 ETIVREKEAA ERELERVRQL TIEAEAKRAA VEENLLNFRN QLEENTFTRR TLEDHLKRKD 1270 1280 1290 1300 1310 1320 LSLNDLEQQK NKLMEELRRK RDNEEELLKL IKQMEKDLAF QKQVAEKQLK EKQKIELEAR 1330 1340 1350 1360 1370 1380 RKITEIQYTC RENALPVCPI TQATSCRAVT GLQQEHDKQK AEELKQQVDE LTAANRKAEQ 1390 1400 1410 1420 1430 1440 DMRELTYELN ALQLEKTSSE EKARLLKDKL DETNNTLRCL KLELERKDQA EKGYSQQLRE 1450 1460 1470 1480 1490 1500 LGRQLNQTTG KAEEAMQEAS DLKKIKRNYQ LELESLNHEK GKLQREVDRI TRAHAVAEKN 1510 1520 1530 1540 1550 1560 IQHLNSQIHS FRDEKELERL QICQRKSDHL KEQFEKSHEQ LLQNIKAEKE NNDKIQRLNE 1570 1580 1590 1600 1610 1620 ELEKSNECAE MLKQKVEELT RQNNETKLMM QRIQAESENI VLEKQTIQQR CEALKIQADG 1630 1640 1650 1660 1670 1680 FKDQLRSTNE HLHKQTKTEQ DFQRKIKCLE EDLAKSQNLV SEFKQKCDQQ NIIIQNTKKE 1690 1700 1710 1720 1730 1740 VRNLNAELNA SKEEKRRGEQ KVQLQQAQVQ ELNNRLKKVQ DELHLKTIEE QMTHRKMVLF 1750 1760 1770 1780 1790 1800 QEESGKFKQS AEEFRKKMEK LMESKVITEN DISGIRLDFV SLQQENSRAQ ENAKLCETNI 1810 1820 1830 1840 1850 1860 KELERQLQQY REQMQQGQHM EANHYQKCQK LEDELIAQKR EVENLKQKMD QQIKEHEHQL 1870 1880 1890 1900 1910 1920 VLLQCEIQKK STAKDCTFKP DFEMTVKECQ HSGELSSRNT GHLHPTPRSP LLRWTQEPQP 1930 1940 1950 1960 1970 1980 LEEKWQHRVV EQIPKEVQFQ PPGAPLEKEK SQQCYSEYFS QTSTELQITF DETNPITRLS 1990 2000 2010 2020 2030 2040 EIEKIRDQAL NNSRPPVRYQ DNACEMELVK VLTPLEIAKN KQYDMHTEVT TLKQEKNPVP 2050 2060 2070 2080 2090 2100 SAEEWMLEGC RASGGLKKGD FLKKGLEPET FQNFDGDHAC SVRDDEFKFQ GLRHTVTARQ 2110 2120 2130 2140 2150 2160 LVEAKLLDMR TIEQLRLGLK TVEEVQKTLN KFLTKATSIA GLYLESTKEK ISFASAAERI 2170 2180 2190 2200 2210 2220 IIDKMVALAF LEAQAATGFI IDPISGQTYS VEDAVLKGVV DPEFRIRLLE AEKAAVGYSY 2230 2240 2250 2260 2270 2280 SSKTLSVFQA MENRMLDRQK GKHILEAQIA SGGVIDPVRG IRVPPEIALQ QGLLNNAILQ 2290 2300 2310 2320 2330 2340 FLHEPSSNTR VFPNPNNKQA LYYSELLRMC VFDVESQCFL FPFGERNISN LNVKKTHRIS 2350 2360 2370 2380 2390 2400 VVDTKTGSEL TVYEAFQRNL IEKSIYLELS GQQYQWKEAM FFESYGHSSH MLTDTKTGLH 2410 2420 2430 2440 2450 2460 FNINEAIEQG TIDKALVKKY QEGLITLTEL ADSLLSRLVP KKDLHSPVAG YWLTASGERI 2470 2480 2490 2500 2510 2520 SVLKASRRNL VDRITALRCL EAQVSTGGII DPLTGKKYRV AEALHRGLVD EGFAQQLRQC 2530 2540 2550 2560 2570 2580 ELVITGIGHP ITNKMMSVVE AVNANIINKE MGIRCLEFQY LTGGLIEPQV HSRLSIEEAL 2590 2600 2610 2620 2630 2640 QVGIIDVLIA TKLKDQKSYV RNIICPQTKR KLTYKEALEK ADFDFHTGLK LLEVSEPLMT GISSLYYSS
	Isoform 4 (BPAG1eA) (eB) [UniParc]. Checksum: 71C7175B93F7E1EC	FASTA	3,060	345,032
	10 20 30 40 50 60 MHSSSYSYRS SDSVFSNTTS TRTSLDSNEN LLLVHCGPTL INSCISFGSE SFDGHRLEML 70 80 90 100 110 120 QQIANRVQRD SVICEDKLIL AGNALQSDSK RLESGVQFQN EAEIAGYILE CENLLRQHVI 130 140 150 160 170 180 DVQILIDGKY YQADQLVQRV AKLRDEIMAL RNECSSVYSK GRILTTEQTK LMISGITQSL 190 200 210 220 230 240 NSGFAQTLHP SLTSGLTQSL TPSLTSSSMT SGLSSGMTSR LTPSVTPAYT PGFPSGLVPN 250 260 270 280 290 300 FSSGVEPNSL QTLKLMQIRK PLLKSSLLDQ NLTEEEINMK FVQDLLNWVD EMQVQLDRTE 310 320 330 340 350 360 WGSDLPSVES HLENHKNVHR AIEEFESSLK EAKISEIQMT APLKLTYAEK LHRLESQYAK 370 380 390 400 410 420 LLNTSRNQER HLDTLHNFVS RATNELIWLN EKEEEEVAYD WSERNTNIAR KKDYHAELMR 430 440 450 460 470 480 ELDQKEENIK SVQEIAEQLL LENHPARLTI EAYRAAMQTQ WSWILQLCQC VEQHIKENTA 490 500 510 520 530 540 YFEFFNDAKE ATDYLRNLKD AIQRKYSCDR SSSIHKLEDL VQESMEEKEE LLQYKSTIAN 550 560 570 580 590 600 LMGKAKTIIQ LKPRNSDCPL KTSIPIKAIC DYRQIEITIY KDDECVLANN SHRAKWKVIS 610 620 630 640 650 660 PTGNEAMVPS VCFTVPPPNK EAVDLANRIE QQYQNVLTLW HESHINMKSV VSWHYLINEI 670 680 690 700 710 720 DRIRASNVAS IKTMLPGEHQ QVLSNLQSRF EDFLEDSQES QVFSGSDITQ LEKEVNVCKQ 730 740 750 760 770 780 YYQELLKSAE REEQEESVYN LYISEVRNIR LRLENCEDRL IRQIRTPLER DDLHESVFRI 790 800 810 820 830 840 TEQEKLKKEL ERLKDDLGTI TNKCEEFFSQ AAASSSVPTL RSELNVVLQN MNQVYSMSST 850 860 870 880 890 900 YIDKLKTVNL VLKNTQAAEA LVKLYETKLC EEEAVIADKN NIENLISTLK QWRSEVDEKR 910 920 930 940 950 960 QVFHALEDEL QKAKAISDEM FKTYKERDLD FDWHKEKADQ LVERWQNVHV QIDNRLRDLE 970 980 990 1000 1010 1020 GIGKSLKYYR DTYHPLDDWI QQVETTQRKI QENQPENSKT LATQLNQQKM LVSEIEMKQS 1030 1040 1050 1060 1070 1080 KMDECQKYAE QYSATVKDYE LQTMTYRAMV DSQQKSPVKR RRMQSSADLI IQEFMDLRTR 1090 1100 1110 1120 1130 1140 YTALVTLMTQ YIKFAGDSLK RLEEEEKSLE EEKKEHVEKA KELQKWVSNI SKTLKDAEKA 1150 1160 1170 1180 1190 1200 GKPPFSKQKI SSEEISTKKE QLSEALQTIQ LFLAKHGDKM TDEERNELEK QVKTLQESYN 1210 1220 1230 1240 1250 1260 LLFSESLKQL QESQTSGDVK VEEKLDKVIA GTIDQTTGEV LSVFQAVLRG LIDYDTGIRL 1270 1280 1290 1300 1310 1320 LETQLMISGL ISPELRKCFD LKDAKSHGLI DEQILCQLKE LSKAKEIISA ASPTTIPVLD 1330 1340 1350 1360 1370 1380 ALAQSMITES MAIKVLEILL STGSLVIPAT GEQLTLQKAF QQNLVSSALF SKVLERQNMC 1390 1400 1410 1420 1430 1440 KDLIDPCTSE KVSLIDMVQR STLQENTGMW LLPVRPQEGG RITLKCGRNI SILRAAHEGL 1450 1460 1470 1480 1490 1500 IDRETMFRLL SAQLLSGGLI NSNSGQRMTV EEAVREGVID RDTASSILTY QVQTGGIIQS 1510 1520 1530 1540 1550 1560 NPAKRLTVDE AVQCDLITSS SALLVLEAQR GYVGLIWPHS GEIFPTSSSL QQELITNELA 1570 1580 1590 1600 1610 1620 YKILNGRQKI AALYIPESSQ VIGLDAAKQL GIIDNNTASI LKNITLPDKM PDLGDLEACK 1630 1640 1650 1660 1670 1680 NARRWLSFCK FQPSTVHDYR QEEDVFDGEE PVTTQTSEET KKLFLSYLMI NSYMDANTGQ 1690 1700 1710 1720 1730 1740 RLLLYDGDLD EAVGMLLEGC HAEFDGNTAI KECLDVLSSS GVFLNNASGR EKDECTATPS 1750 1760 1770 1780 1790 1800 SFNKCHCGEP EHEETPENRK CAIDEEFNEM RNTVINSEFS QSGKLASTIS IDPKVNSSPS 1810 1820 1830 1840 1850 1860 VCVPSLISYL TQTELADISM LRSDSENILT NYENQSRVET NERANECSHS KNIQNFPSDL 1870 1880 1890 1900 1910 1920 IENPIMKSKM SKFCGVNETE NEDNTNRDSP IFDYSPRLSA LLSHDKLMHS QGSFNDTHTP 1930 1940 1950 1960 1970 1980 ESNGNKCEAP ALSFSDKTML SGQRIGEKFQ DQFLGIAAIN ISLPGEQYGQ KSLNMISSNP 1990 2000 2010 2020 2030 2040 QVQYHNDKYI SNTSGEDEKT HPGFQQMPED KEDESEIEEY SCAVTPGGDT DNAIVSLTCA 2050 2060 2070 2080 2090 2100 TPLLDETISA SDYETSLLND QQNNTGTDTD SDDDFYDTPL FEDDDHDSLL LDGDDRDCLH 2110 2120 2130 2140 2150 2160 PEDYDTLQEE NDETASPADV FYDVSKENEN SMVPQGAPVG SLSVKNKAHC LQDFLMDVEK 2170 2180 2190 2200 2210 2220 DELDSGEKIH LNPVGSDKVN GQSLETGSER ECTNILEGDE SDSLTDYDIV GGKESFTASL 2230 2240 2250 2260 2270 2280 KFDDSGSWRG RKEEYVTGQE FHSDTDHLDS MQSEESYGDY IYDSNDQDDD DDDGIDEEGG 2290 2300 2310 2320 2330 2340 GIRDENGKPR CQNVAEDMDI QLCASILNEN SDENENINTM ILLDKMHSCS SLEKQQRVNV 2350 2360 2370 2380 2390 2400 VQLASPSENN LVTEKSNLPE YTTEIAGKSK ENLLNHEMVL KDVLPPIIKD TESEKTFGPA 2410 2420 2430 2440 2450 2460 SISHDNNNIS STSELGTDLA NTKVKLIQGS ELPELTDSVK GKDEYFKNMT PKVDSSLDHI 2470 2480 2490 2500 2510 2520 ICTEPDLIGK PAEESHLSLI ASVTDKDPQG NGSDLIKGRD GKSDILIEDE TSIQKMYLGE 2530 2540 2550 2560 2570 2580 GEVLVEGLVE EENRHLKLLP GKNTRDSFKL INSQFPFPQI TNNEELNQKG SLKKATVTLK 2590 2600 2610 2620 2630 2640 DEPNNLQIIV SKSPVQFENL EEIFDTSVSK EISDDITSDI TSWEGNTHFE ESFTDGPEKE 2650 2660 2670 2680 2690 2700 LDLFTYLKHC AKNIKAKDVA KPNEDVPSHV LITAPPMKEH LQLGVNNTKE KSTSTQKDSP 2710 2720 2730 2740 2750 2760 LNDMIQSNDL CSKESISGGG TEISQFTPES IEATLSILSR KHVEDVGKND FLQSERCANG 2770 2780 2790 2800 2810 2820 LGNDNSSNTL NTDYSFLEIN NKKERIEQQL PKEQALSPRS QEKEVQIPEL SQVFVEDVKD 2830 2840 2850 2860 2870 2880 ILKSRLKEGH MNPQEVEEPS ACADTKILIQ NLIKRITTSQ LVNEASTVPS DSQMSDSSGV 2890 2900 2910 2920 2930 2940 SPMTNSSELK PESRDDPFCI GNLKSELLLN ILKQDQHSQK ITGVFELMRE LTHMEYDLEK 2950 2960 2970 2980 2990 3000 RGITSKVLPL QLENIFYKLL ADGYSEKIEH VGDFNQKACS TSEMMEEKPH ILGDIKSKEG 3010 3020 3030 3040 3050 3060 NYYSPNLETV KEIGLESSTV WASTLPRDEK LKDLCNDFPS HLECTSGSKE MASGDSSTEQ
	Isoform 5 [UniParc]. Checksum: D462C85D9FA1C903	FASTA	447	50,373
	10 20 30 40 50 60 VVTTAIKEET EKVAAVKQLE ESKTKIENLL DWLSNVDKDS ERAGTKHKQV IEQNGTHFQE 70 80 90 100 110 120 GDGKSAIGEE DEVNGNLLET DVDGQVGTTQ ENLNQQYQKV KAQHEKIISQ HQAVIIATQS 130 140 150 160 170 180 AQVLLEKQGQ YLSPEEKEKL QKNMKELKVH YETALAESEK KMKLTHSLQE ELEKFDADYT 190 200 210 220 230 240 EFEHWLQQSE QELENLEAGA DDINGLMTKL KRQKSFSEDV ISHKGDLRYI TISGNRVLEA 250 260 270 280 290 300 AKSCSKRDGG KVDTSATHRE VQRKLDHATD RFRSLYSKCN VLGNNLKDLV DKYQHYEDAS 310 320 330 340 350 360 CGLLAGLQAC EATASKHLSE PIAVDPKNLQ RQLEETKALQ GQISSQQVAV EKLKKTAEVL 370 380 390 400 410 420 LDARGSLLPA KNDIQKTLDD IVGRYEDLSK SVNERNEKLQ ITLTRSLSVQ DGLDEMLDWM 430 440 GNVESSLKEQ DVGTGYCRSS EQYKCHE
	Isoform 6 (BPAG1n1) (BPAG1n2) (Dystonin-2) [UniParc]. Checksum: 9AD0D616AC22B94E	FASTA	224	25,379
	10 20 30 40 50 60 MIAAAFLVLL RPYSIQCALF LLLLLLGTIA TIVFFCCWHR KLQKGRHPMK SVFSGRSRSR 70 80 90 100 110 120 DAVLRSHHFR SEGFRASPRH LRRRVAAAAA ARLEEVKPVV EVHHQSEQET SVRKRRIKKS 130 140 150 160 170 180 SRVQPEFYHS VQGASIRRPS SGNASYRCSM SSSADFSDED DFSQKSGSAS PAPGDTLPWN 190 200 210 220 LPKHERSKRK IQGGSVLDPA ERAVLRIADE RDKVQKKTFT KWIN
	Isoform 7 (BPAG1n3) [UniParc]. Checksum: 8C50813157B4E7D3	FASTA	81	9,221
	10 20 30 40 50 60 MQHSIFSLKK KRCHSLYTSM SSVSKDTDGN EISDIHVTGE SEDMSAKERL LLWTQQATEG 70 80 YAGIRCENFT TCWRDGKLFN A
	Isoform 8 [UniParc]. Checksum: AB344F0B597C1961	FASTA	905	102,868
	10 20 30 40 50 60 MGNVCGCVRA EKEEQYVDPA KTPLNPEKYS PGRKYFRRKP IKKTGGDKES VGANNENEGK 70 80 90 100 110 120 KKSSSQPSKE QPAPLSRGLV QQESVTLNSA LGDGIQQKKT EVVADSVKQK LLPSAVSSWS 130 140 150 160 170 180 DCVNTSPAKD SETEVKVSEL DERISEKDST PYCAKRKKHL DDVNTSEITF QEKTDVFSFR 190 200 210 220 230 240 KAASLSSIPS GIERSLEKGG FPEDPPKSYS SIQEKQNTER FCPHATQHFQ FKKKRCHSLY 250 260 270 280 290 300 TSMSSVSKDT DGNEISDIHV TGESEDMSAK ERLLLWTQQA TEGYAGIRCE NFTTCWRDGK 310 320 330 340 350 360 LFNAIIHKYR PDLIDMNTVA VQSNLANLEH AFYVAEKIGV IRLLDPEDVD VSSPDEKSVI 370 380 390 400 410 420 TYVSSLYDAF PKVPEGGEGI GANDVEVKWI EYQNMVNYLI QWIRHHVTTM SERTFPNNPV 430 440 450 460 470 480 ELKALYNQYL QFKETEIPPK ETEKSKIKRL YKLLEIWIEF GRIKLLQGYH PNDIEKEWGK 490 500 510 520 530 540 LIIAMLEREK ALRPEVERLE MLQQIANRVQ RDSVICEDKL ILAGNALQSD SKRLESGVQF 550 560 570 580 590 600 QNEAEIAGYI LECENLLRQH VIDVQILIDG KYYQADQLVQ RVAKLRDEIM ALRNECSSVY 610 620 630 640 650 660 SKGRILTTEQ TKLMISGITQ SLNSGFAQTL HPSLTSGLTQ SLTPSLTSSS MTSGLSSGMT 670 680 690 700 710 720 SRLTPSVTPA YTPGFPSGLV PNFSSGVEPN SLQTLKLMQI RKPLLKSSLL DQNLTEEEIN 730 740 750 760 770 780 MKFVQDLLNW VDEMQVQLDR TEWGSDLPSV ESHLENHKNV HRAIEEFESS LKEAKISEIQ 790 800 810 820 830 840 MTAPLKLTYA EKLHRLESQY AKLLNTSRNQ ERHLDTLHNF VSRATNELIW LNEKEEEEVA 850 860 870 880 890 900 YDWSERNTNI ARKKDYHAEL MRELDQKEEN IKSVQEIAEQ LLLENHPARL TIEVKLESVM VLVEY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human bullous pemphigoid antigen (BPAG1). Amino acid sequences deduced from cloned cDNAs predict biologically important peptide segments and protein domains." Sawamura D., Li K., Chu M.-L., Uitto J. J. Biol. Chem. 266:17784-17790(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), DISEASE. Tissue: Keratinocyte.
[2]	"Cloning of the 5' mRNA for the 230-kD bullous pemphigoid antigen by rapid amplification of cDNA ends." Elgart G.W., Stanley J.R. J. Invest. Dermatol. 101:244-246(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Keratinocyte.
[3]	"Novel alternative splicings of BPAG1 (bullous pemphigoid antigen 1) including the domain structure closely related to MACF (microtubule actin cross-linking factor)." Okumura M., Yamakawa H., Ohara O., Owaribe K. J. Biol. Chem. 277:6682-6687(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [MRNA] OF 1-3386 (ISOFORM 4), SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Keratinocyte.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 8), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4114-6568 (ISOFORM 1), VARIANT ALA-5138. Tissue: Brain, Hippocampus, Placenta and Tongue.
[5]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"Cloning and characterization of the neural isoforms of human dystonin." Brown A., Dalpe G., Mathieu M., Kothary R. Genomics 29:777-780(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-461 (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 1-46 (ISOFORM 6). Tissue: Fetal brain and Retina.
[7]	"Integrators of the cytoskeleton that stabilize microtubules." Yang Y., Bauer C., Strasser G., Wollman R., Julien J.P., Fuchs E. Cell 98:229-238(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-188 (ISOFORM 7), ALTERNATIVE SPLICING (ISOFORMS 6 AND 7), FUNCTION OF ISOFORMS 6 AND 7, SUBCELLULAR LOCATION (ISOFORMS 6 AND 7). Tissue: Fetal brain.
[8]	Geerts D., Sonnenberg A. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 208-308 (ISOFORM 1). Tissue: Pineal gland.
[9]	"Comparison of molecularly cloned bullous pemphigoid antigen to desmoplakin I confirms that they define a new family of cell adhesion junction plaque proteins." Tanaka T., Parry D.A.D., Klaus-Kovtun V., Steinert P.M., Stanley J.R. J. Biol. Chem. 266:12555-12559(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 881-7570 (ISOFORM 3). Tissue: Keratinocyte.
[10]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3754-7570 (ISOFORM 5). Tissue: Duodenum.
[11]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5947-7570 (ISOFORM 2). Tissue: Brain.
[12]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[13]	"Isolation of complementary DNA for bullous pemphigoid antigen by use of patients' autoantibodies." Stanley J.R., Tanaka T., Mueller S., Klaus-Kovtun V., Roop D. J. Clin. Invest. 82:1864-1870(1988) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Keratinocyte.
[14]	"The hemidesmosomal plaque. I. Characterization of a major constituent protein as a differentiation marker for certain forms of epithelia." Owaribe K., Kartenbeck J., Stumpp S., Magin T.M., Krieg T., Diaz L.A., Franke W.W. Differentiation 45:207-220(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[15]	"Identification of a second protein product of the gene encoding a human epidermal autoantigen." Hopkinson S.B., Jones J.C. Biochem. J. 300:851-857(1994) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 3).
[16]	"An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments." Yang Y., Dowling J., Yu Q.C., Kouklis P., Cleveland D.W., Fuchs E. Cell 86:655-665(1996) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORMS 3 AND 6), TISSUE SPECIFICITY.
[17]	"The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome." Hopkinson S.B., Jones J.C. Mol. Biol. Cell 11:277-286(2000) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORM 3), INTERACTION WITH COL17A1 AND ITGB4.
[18]	"Structural analysis of the predicted coiled-coil rod domain of the cytoplasmic bullous pemphigoid antigen (BPAG1). Empirical localization of the N-terminal globular domain-rod boundary." Tang H.-Y., Chaffotte A.-F., Thacher S.M. J. Biol. Chem. 271:9716-9722(1996) [PubMed] [Europe PMC] [Abstract] Cited for: DOMAINS.
[19]	"The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression." Favre B., Fontao L., Koster J., Shafaatian R., Jaunin F., Saurat J.-H., Sonnenberg A., Borradori L. J. Biol. Chem. 276:32427-32436(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ITGB4 AND ERBB2IP.
[20]	"Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly." Koster J., Geerts D., Favre B., Borradori L., Sonnenberg A. J. Cell Sci. 116:387-399(2003) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORM 3), FUNCTION OF ISOFORM 3, INTERACTION WITH COL17A1 AND ITGB4, SUBCELLULAR LOCATION (ISOFORM 3).
[21]	"Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus." Fontao L., Favre B., Riou S., Geerts D., Jaunin F., Saurat J.H., Green K.J., Sonnenberg A., Borradori L. Mol. Biol. Cell 14:1978-1992(2003) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORM 3), ASSOCIATION WITH KERATIN FILAMENTS, SUBCELLULAR LOCATION (ISOFORM 3).
[22]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7432, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[23]	"BPAG1e maintains keratinocyte polarity through beta4 integrin-mediated modulation of Rac1 and cofilin activities." Hamill K.J., Hopkinson S.B., DeBiase P., Jones J.C. Mol. Biol. Cell 20:2954-2962(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORM 3), FUNCTION OF ISOFORM 3, SUBCELLULAR LOCATION (ISOFORM 3).
[24]	"BPAG1 isoform-b: complex distribution pattern in striated and heart muscle and association with plectin and alpha-actinin." Steiner-Champliaud M.F., Schneider Y., Favre B., Paulhe F., Praetzel-Wunder S., Faulkner G., Konieczny P., Raith M., Wiche G., Adebola A., Liem R.K., Langbein L., Sonnenberg A., Fontao L., Borradori L. Exp. Cell Res. 316:297-313(2010) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORM 1), HOMODIMERIZATION, INTERACTION WITH ACTN2 AND PLEC, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[25]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[26]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2919, MASS SPECTROMETRY.
[27]	"Hereditary sensory autonomic neuropathy caused by a mutation in dystonin." Edvardson S., Cinnamon Y., Jalas C., Shaag A., Maayan C., Axelrod F.B., Elpeleg O. Ann. Neurol. 71:569-572(2012) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN HSAN6.
[28]	"Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis." Rahimi N., Rezazadeh K., Mahoney J.E., Hartsough E., Meyer R.D. Mol. Biol. Cell 23:1646-1656(2012) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TMIGD2.
[29]	"An EB1-binding motif acts as a microtubule tip localization signal." Honnappa S., Gouveia S.M., Weisbrich A., Damberger F.F., Bhavesh N.S., Jawhari H., Grigoriev I., van Rijssel F.J., Buey R.M., Lawera A., Jelesarov I., Winkler F.K., Wuthrich K., Akhmanova A., Steinmetz M.O. Cell 138:366-376(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 7541-7570 IN COMPLEX WITH MAPRE1, DOMAIN MICROTUBULE TIP LOCALIZATION SIGNAL, MUTAGENESIS OF LYS-7548; SER-7550; ILE-7552; PRO-7553 AND 7557-ARG-LYS-7558.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M69225 mRNA. No translation available.
L11690 mRNA. Translation: AAA52288.1.
AF400226 mRNA. Translation: AAL62061.1.
AF400227 mRNA. Translation: AAL62062.1.
AK055189 mRNA. Translation: BAB70870.1. Different initiation.
AK094883 mRNA. Translation: BAC04449.1. Different initiation.
AK096713 mRNA. Translation: BAC04848.1. Different initiation.
AK295864 mRNA. Translation: BAH12207.1.
AL049215 Genomic DNA. No translation available.
AL512422 , AL096710, AL137008, AL512448, AL590005 Genomic DNA. Translation: CAI14341.1. Sequence problems.
AL590005 , AL096710, AL137008, AL512422, AL512448 Genomic DNA. Translation: CAI14989.1. Sequence problems.
AL512448 , AL096710, AL137008, AL512422, AL590005 Genomic DNA. Translation: CAI16609.1. Sequence problems.
AL512448, AL096710, AL137008 Genomic DNA. Translation: CAI16610.1. Sequence problems.
AL137008 , AL096710, AL512422, AL512448, AL590005 Genomic DNA. Translation: CAI20330.1. Sequence problems.
AL137008, AL096710, AL512448 Genomic DNA. Translation: CAI20332.1. Sequence problems.
AL096710 , AL137008, AL512422, AL512448, AL590005 Genomic DNA. Translation: CAI22044.1. Sequence problems.
AL096710, AL137008, AL512448 Genomic DNA. Translation: CAI22045.1. Sequence problems.
AL096710 Genomic DNA. Translation: CAI22046.1.
AL096710 Genomic DNA. Translation: CAI22047.1.
U31850 mRNA. Translation: AAC50243.1.
U31851 mRNA. Translation: AAC50244.1. Frameshift.
AF165191 mRNA. Translation: AAD49334.1.
AY032900 mRNA. Translation: AAK63130.1.
AY032901 mRNA. Translation: AAK63131.1.
M63618 mRNA. Translation: AAA35606.1.
BC016991 mRNA. Translation: AAH16991.1.
AB018271 mRNA. Translation: BAA34448.2.
M22942 mRNA. Translation: AAA35538.1. Sequence problems.
X58677 mRNA. Translation: CAA41528.1.
U04850 Genomic DNA. Translation: AAA57184.1.
U04850 Genomic DNA. Translation: AAA57185.1. Sequence problems.

IPI

IPI00142768.
IPI00217992.
IPI00642259.
IPI00816328.
IPI00956289.
IPI00979196.
IPI01018799.
IPI01018800.

PIR

A40937. I56317.

RefSeq

NP_001714.1. NM_001723.5.
NP_056363.2. NM_015548.4.

UniGene

Hs.604915.
Hs.669931.
Hs.728928.
Hs.735651.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3GJO	X-ray	2.50	E/F/G/H	7541-7570	[»]

ProteinModelPortal

Q03001.

SMR

Q03001. Positions 31-255, 583-795.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-33131N.

IntAct

Q03001. 24 interactions.

MINT

MINT-119936.

PTM databases

PhosphoSite

Q03001.

Polymorphism databases

DMDM

294862529.

Proteomic databases

PaxDb

Q03001.

PRIDE

Q03001.

Protocols and materials databases

DNASU

667.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000244364; ENSP00000244364; ENSG00000151914.
ENST00000370765; ENSP00000359801; ENSG00000151914.
ENST00000439203; ENSP00000404924; ENSG00000151914.

GeneID

667.

KEGG

hsa:667.

UCSC

uc003pcy.4. human.
uc003pdc.4. human.
uc003pde.2. human.
uc021zba.1. human.

Organism-specific databases

CTD

667.

GeneCards

GC06M056370.

H-InvDB

HIX0005976.
HIX0164999.

HGNC

HGNC:1090. DST.

HPA

HPA030200.

MIM

113810. gene.
614653. phenotype.

neXtProt

NX_Q03001.

Orphanet

89838. Autosomal recessive epidermolysis bullosa simplex.

PharmGKB

PA25399.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5069.

HOVERGEN

HBG031127.

InParanoid

Q8WXK8.

KO

K10382.

OMA

QQRNVED.

Enzyme and pathway databases

Reactome

REACT_111155. Cell-Cell communication.
REACT_118779. Extracellular matrix organization.

Gene expression databases

ArrayExpress

Q03001.

Bgee

Q03001.

CleanEx

HS_DST.

Genevestigator

Q03001.

GermOnline

ENSG00000151914. Homo sapiens.

Family and domain databases

Gene3D

1.10.238.10. 1 hit.
1.10.418.10. 2 hits.
3.30.920.20. 1 hit.

InterPro

IPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011992. EF-hand-like_dom.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR003108. GAS2_dom.
IPR001101. Plectin_repeat.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view]

Pfam

PF00307. CH. 2 hits.
PF13499. EF_hand_5. 1 hit.
PF02187. GAS2. 1 hit.
PF00681. Plectin. 5 hits.
PF00435. Spectrin. 19 hits.
[Graphical view]

SMART

SM00033. CH. 2 hits.
SM00054. EFh. 2 hits.
SM00243. GAS2. 1 hit.
SM00250. PLEC. 8 hits.
SM00150. SPEC. 32 hits.
[Graphical view]

SUPFAM

SSF47576. Calponin-homology. 1 hit.
SSF143575. SSF143575. 1 hit.

PROSITE

PS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS51460. GAR. 1 hit.
PS50002. SH3. False negative.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

DST. human.

EvolutionaryTrace

Q03001.

GenomeRNAi

667.

NextBio

2720.

SOURCE

Search...

Entry information

Entry name

DYST_HUMAN

Accession

Primary (citable) accession number: Q03001
Secondary accession number(s): B7Z3H1 , O94833, Q12825, Q13266, Q13267, Q13775, Q5TBT0, Q5TBT2, Q5TF23, Q5TF24, Q8N1T8, Q8N8J3, Q8WXK8, Q8WXK9, Q96AK9, Q96DQ5, Q96J76, Q96QT5, Q9H555, Q9UGD7, Q9UGD8, Q9UN10

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	April 20, 2010
Last modified:	May 1, 2013
This is version 150 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.