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Q02ZS7 (FTHS_LACLS) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:LACR_1007
OrganismLactococcus lactis subsp. cremoris (strain SK11) [Complete proteome] [HAMAP]
Taxonomic identifier272622 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 555555Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000300526

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q02ZS7 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 53885E0E511816D1

FASTA55559,489
        10         20         30         40         50         60 
MKTDIEIAQA AEIQPITKIA EKIGLSFDDI ELYGKYKAKI PLEVLEKFDE QTDGKLVLVT 

        70         80         90        100        110        120 
SINPTPAGEG KSTVTVGLAD AFARQDKNVM VALREPSLGP VMGIKGGAAG GGFAQVLPME 

       130        140        150        160        170        180 
DINLHFTGDI HAITTANNAI SAFLDNSLHQ GNPLNIDPRR IIWKRVLDLN DRALRHVTIG 

       190        200        210        220        230        240 
LGGPLNGVPR EDGFDITVAS EIMAVLCLAT SISDLKERLA RIVIAQNYDR KPVSVGDLGV 

       250        260        270        280        290        300 
QGAIAMLLKD ALKPNLVQTI EGTPALIHGG PFANIAHGCN SVLATKTALK LADIVITEAG 

       310        320        330        340        350        360 
FGADLGGEKF LDIKTRQLGK QPDAVVVVAT LRALKMHGGV DKKELTSENV EAVKKGFANL 

       370        380        390        400        410        420 
ERHIKNMQSY GLPVIVAINQ FASDTESEIS TLKELTEALG VSVSLTQVFA KGGEGGLDLA 

       430        440        450        460        470        480 
EKLSAMLQAK PDFRYLYELN QPLSVKLDKV VTEIYGGSKV NLSPKAKRQM REIEENGWNN 

       490        500        510        520        530        540 
LPVCMAKTQY SFSDQANLLA APEGFEVTVR ELIPKIGAGF IVALLGDVMT MPGLPKNPAA 

       550 
LKMDVTDDGK ISGLF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000425 Genomic DNA. Translation: ABJ72545.1.
RefSeqYP_808967.1. NC_008527.1.

3D structure databases

ProteinModelPortalQ02ZS7.
SMRQ02ZS7. Positions 4-553.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272622.LACR_1007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ72545; ABJ72545; LACR_1007.
GeneID4432775.
KEGGllc:LACR_1007.
PATRIC22288839. VBILacLac38071_1168.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13505.

Enzyme and pathway databases

BioCycLLAC272622:GJUG-1007-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_LACLS
AccessionPrimary (citable) accession number: Q02ZS7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 14, 2006
Last modified: April 16, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways