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Q02ZS7

- FTHS_LACLS

UniProt

Q02ZS7 - FTHS_LACLS

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Lactococcus lactis subsp. cremoris (strain SK11)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLLAC272622:GJUG-1007-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:LACR_1007
    OrganismiLactococcus lactis subsp. cremoris (strain SK11)
    Taxonomic identifieri272622 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
    ProteomesiUP000000240: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 555555Formate--tetrahydrofolate ligasePRO_0000300526Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272622.LACR_1007.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02ZS7.
    SMRiQ02ZS7. Positions 4-553.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q02ZS7-1 [UniParc]FASTAAdd to Basket

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    MKTDIEIAQA AEIQPITKIA EKIGLSFDDI ELYGKYKAKI PLEVLEKFDE    50
    QTDGKLVLVT SINPTPAGEG KSTVTVGLAD AFARQDKNVM VALREPSLGP 100
    VMGIKGGAAG GGFAQVLPME DINLHFTGDI HAITTANNAI SAFLDNSLHQ 150
    GNPLNIDPRR IIWKRVLDLN DRALRHVTIG LGGPLNGVPR EDGFDITVAS 200
    EIMAVLCLAT SISDLKERLA RIVIAQNYDR KPVSVGDLGV QGAIAMLLKD 250
    ALKPNLVQTI EGTPALIHGG PFANIAHGCN SVLATKTALK LADIVITEAG 300
    FGADLGGEKF LDIKTRQLGK QPDAVVVVAT LRALKMHGGV DKKELTSENV 350
    EAVKKGFANL ERHIKNMQSY GLPVIVAINQ FASDTESEIS TLKELTEALG 400
    VSVSLTQVFA KGGEGGLDLA EKLSAMLQAK PDFRYLYELN QPLSVKLDKV 450
    VTEIYGGSKV NLSPKAKRQM REIEENGWNN LPVCMAKTQY SFSDQANLLA 500
    APEGFEVTVR ELIPKIGAGF IVALLGDVMT MPGLPKNPAA LKMDVTDDGK 550
    ISGLF 555
    Length:555
    Mass (Da):59,489
    Last modified:November 14, 2006 - v1
    Checksum:i53885E0E511816D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000425 Genomic DNA. Translation: ABJ72545.1.
    RefSeqiYP_808967.1. NC_008527.1.

    Genome annotation databases

    EnsemblBacteriaiABJ72545; ABJ72545; LACR_1007.
    GeneIDi4432775.
    KEGGillc:LACR_1007.
    PATRICi22288839. VBILacLac38071_1168.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000425 Genomic DNA. Translation: ABJ72545.1 .
    RefSeqi YP_808967.1. NC_008527.1.

    3D structure databases

    ProteinModelPortali Q02ZS7.
    SMRi Q02ZS7. Positions 4-553.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272622.LACR_1007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ72545 ; ABJ72545 ; LACR_1007 .
    GeneIDi 4432775.
    KEGGi llc:LACR_1007.
    PATRICi 22288839. VBILacLac38071_1168.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci LLAC272622:GJUG-1007-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SK11.

    Entry informationi

    Entry nameiFTHS_LACLS
    AccessioniPrimary (citable) accession number: Q02ZS7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3