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Q02Y66

- PUR9_LACLS

UniProt

Q02Y66 - PUR9_LACLS

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, LACR_1605
Organism
Lactococcus lactis subsp. cremoris (strain SK11)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciLLAC272622:GJUG-1605-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:LACR_1605
OrganismiLactococcus lactis subsp. cremoris (strain SK11)
Taxonomic identifieri272622 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000000240: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000018901Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272622.LACR_1605.

Structurei

3D structure databases

ProteinModelPortaliQ02Y66.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiCGVATGP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q02Y66-1 [UniParc]FASTAAdd to Basket

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MSKRALISVS DKEGIVEFAK KIQELGWEII STGGTKAVLD QEEIPNIAID    50
EVTGFPEMMD GRVKTLHPLI HGALLGRRDL DSHMKSLAEH HISPIDLVVV 100
NLYPFKETLL AGGSQAEMIE KIDIGGPSML RSAAKNHAAV TVVCDPMDYE 150
KVEKELSADG ETSLELRQQL AAKVFRHTAS YDALIAQYLT EEFPVEDTKP 200
EKLTLTYDLK QGMRYGENPQ QSADFYESGL PTTYSIAQSH QLHGKELSYN 250
NVRDADAALQ IARDFDEPTV VALKHMNPCG IGTAKNIEQA WDYAYEADPV 300
SIFGGIIVLN REVTEETAQK MSKIFLEIII APSYSKEALE ILSKKKNIRL 350
LTVDFSKKEQ SEKEALVTGV LGGLLVQNQD VIVENPKEWT VATKVQPTDR 400
QMEAMKFAWK AVKFVKSNGI IVTNDHQTLG VGPGQTNRVG SVKIALEATA 450
DKDALLQENA VLGSDAFFPF ADNIDEIAKA GIKAIVQPGG SVRDQEVIEA 500
CDKYGIAMVF TGLRHFRH 518
Length:518
Mass (Da):57,140
Last modified:November 14, 2006 - v1
Checksum:i0223F4472ED8AEA4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000425 Genomic DNA. Translation: ABJ73106.1.
RefSeqiYP_809528.1. NC_008527.1.

Genome annotation databases

EnsemblBacteriaiABJ73106; ABJ73106; LACR_1605.
GeneIDi4434476.
KEGGillc:LACR_1605.
PATRICi22290077. VBILacLac38071_1784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000425 Genomic DNA. Translation: ABJ73106.1 .
RefSeqi YP_809528.1. NC_008527.1.

3D structure databases

ProteinModelPortali Q02Y66.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272622.LACR_1605.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ73106 ; ABJ73106 ; LACR_1605 .
GeneIDi 4434476.
KEGGi llc:LACR_1605.
PATRICi 22290077. VBILacLac38071_1784.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi CGVATGP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci LLAC272622:GJUG-1605-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SK11.

Entry informationi

Entry nameiPUR9_LACLS
AccessioniPrimary (citable) accession number: Q02Y66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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