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Q02Y66 (PUR9_LACLS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:LACR_1605
OrganismLactococcus lactis subsp. cremoris (strain SK11) [Complete proteome] [HAMAP]
Taxonomic identifier272622 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

Protein attributes

Sequence length518 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 518518Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_1000018901

Sequences

Sequence LengthMass (Da)Tools
Q02Y66 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 0223F4472ED8AEA4

FASTA51857,140
        10         20         30         40         50         60 
MSKRALISVS DKEGIVEFAK KIQELGWEII STGGTKAVLD QEEIPNIAID EVTGFPEMMD 

        70         80         90        100        110        120 
GRVKTLHPLI HGALLGRRDL DSHMKSLAEH HISPIDLVVV NLYPFKETLL AGGSQAEMIE 

       130        140        150        160        170        180 
KIDIGGPSML RSAAKNHAAV TVVCDPMDYE KVEKELSADG ETSLELRQQL AAKVFRHTAS 

       190        200        210        220        230        240 
YDALIAQYLT EEFPVEDTKP EKLTLTYDLK QGMRYGENPQ QSADFYESGL PTTYSIAQSH 

       250        260        270        280        290        300 
QLHGKELSYN NVRDADAALQ IARDFDEPTV VALKHMNPCG IGTAKNIEQA WDYAYEADPV 

       310        320        330        340        350        360 
SIFGGIIVLN REVTEETAQK MSKIFLEIII APSYSKEALE ILSKKKNIRL LTVDFSKKEQ 

       370        380        390        400        410        420 
SEKEALVTGV LGGLLVQNQD VIVENPKEWT VATKVQPTDR QMEAMKFAWK AVKFVKSNGI 

       430        440        450        460        470        480 
IVTNDHQTLG VGPGQTNRVG SVKIALEATA DKDALLQENA VLGSDAFFPF ADNIDEIAKA 

       490        500        510 
GIKAIVQPGG SVRDQEVIEA CDKYGIAMVF TGLRHFRH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000425 Genomic DNA. Translation: ABJ73106.1.
RefSeqYP_809528.1. NC_008527.1.

3D structure databases

ProteinModelPortalQ02Y66.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272622.LACR_1605.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ73106; ABJ73106; LACR_1605.
GeneID4434476.
KEGGllc:LACR_1605.
PATRIC22290077. VBILacLac38071_1784.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMATAKNIEQ.
OrthoDBEOG6QCDFF.
ProtClustDBPRK00881.

Enzyme and pathway databases

BioCycLLAC272622:GJUG-1605-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_LACLS
AccessionPrimary (citable) accession number: Q02Y66
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: February 19, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways