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Q02Y66

- PUR9_LACLS

UniProt

Q02Y66 - PUR9_LACLS

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Lactococcus lactis subsp. cremoris (strain SK11)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciLLAC272622:GJUG-1605-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:LACR_1605
OrganismiLactococcus lactis subsp. cremoris (strain SK11)
Taxonomic identifieri272622 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000000240: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Bifunctional purine biosynthesis protein PurHPRO_1000018901Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272622.LACR_1605.

Structurei

3D structure databases

ProteinModelPortaliQ02Y66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiCGVATGP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q02Y66-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKRALISVS DKEGIVEFAK KIQELGWEII STGGTKAVLD QEEIPNIAID
60 70 80 90 100
EVTGFPEMMD GRVKTLHPLI HGALLGRRDL DSHMKSLAEH HISPIDLVVV
110 120 130 140 150
NLYPFKETLL AGGSQAEMIE KIDIGGPSML RSAAKNHAAV TVVCDPMDYE
160 170 180 190 200
KVEKELSADG ETSLELRQQL AAKVFRHTAS YDALIAQYLT EEFPVEDTKP
210 220 230 240 250
EKLTLTYDLK QGMRYGENPQ QSADFYESGL PTTYSIAQSH QLHGKELSYN
260 270 280 290 300
NVRDADAALQ IARDFDEPTV VALKHMNPCG IGTAKNIEQA WDYAYEADPV
310 320 330 340 350
SIFGGIIVLN REVTEETAQK MSKIFLEIII APSYSKEALE ILSKKKNIRL
360 370 380 390 400
LTVDFSKKEQ SEKEALVTGV LGGLLVQNQD VIVENPKEWT VATKVQPTDR
410 420 430 440 450
QMEAMKFAWK AVKFVKSNGI IVTNDHQTLG VGPGQTNRVG SVKIALEATA
460 470 480 490 500
DKDALLQENA VLGSDAFFPF ADNIDEIAKA GIKAIVQPGG SVRDQEVIEA
510
CDKYGIAMVF TGLRHFRH
Length:518
Mass (Da):57,140
Last modified:November 14, 2006 - v1
Checksum:i0223F4472ED8AEA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000425 Genomic DNA. Translation: ABJ73106.1.
RefSeqiWP_011676465.1. NC_008527.1.
YP_809528.1. NC_008527.1.

Genome annotation databases

EnsemblBacteriaiABJ73106; ABJ73106; LACR_1605.
GeneIDi4434476.
KEGGillc:LACR_1605.
PATRICi22290077. VBILacLac38071_1784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000425 Genomic DNA. Translation: ABJ73106.1 .
RefSeqi WP_011676465.1. NC_008527.1.
YP_809528.1. NC_008527.1.

3D structure databases

ProteinModelPortali Q02Y66.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272622.LACR_1605.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ73106 ; ABJ73106 ; LACR_1605 .
GeneIDi 4434476.
KEGGi llc:LACR_1605.
PATRICi 22290077. VBILacLac38071_1784.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi CGVATGP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci LLAC272622:GJUG-1605-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SK11.

Entry informationi

Entry nameiPUR9_LACLS
AccessioniPrimary (citable) accession number: Q02Y66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: November 26, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3