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Protein

Uridine kinase

Gene

udk

Organism
Lactococcus lactis subsp. cremoris (strain SK11)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + uridine = ADP + UMP.UniRule annotation
ATP + cytidine = ADP + CMP.UniRule annotation

Pathwayi: CTP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes CTP from cytidine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Uridine kinase (udk)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway CTP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from cytidine, the pathway CTP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uridine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uridine kinase (udk)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uridine, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00574; UER00637.
UPA00579; UER00640.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine kinaseUniRule annotation (EC:2.7.1.48UniRule annotation)
Alternative name(s):
Cytidine monophosphokinaseUniRule annotation
Uridine monophosphokinaseUniRule annotation
Gene namesi
Name:udkUniRule annotation
Ordered Locus Names:LACR_1825
OrganismiLactococcus lactis subsp. cremoris (strain SK11)
Taxonomic identifieri272622 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000000240 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000178831 – 206Uridine kinaseAdd BLAST206

Structurei

3D structure databases

ProteinModelPortaliQ02XK6.
SMRiQ02XK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uridine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000262756.
KOiK00876.
OMAiTTLKPMH.

Family and domain databases

CDDicd02023. UMPK. 1 hit.
HAMAPiMF_00551. Uridine_kinase. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR006083. PRK/URK.
IPR000764. Uridine_kinase-like.
IPR026008. Uridine_kinase_.
PfamiView protein in Pfam
PF00485. PRK. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00235. udk. 1 hit.

Sequencei

Sequence statusi: Complete.

Q02XK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKTLIIGVT GGSASGKTSV SHAILETFSN ERIAMIEHDS YYKDQSHLTF
60 70 80 90 100
EERTKTNYDH PLAFDTDYLI AQLKELQYGR AVDIPIYDYA KHTRSQETYR
110 120 130 140 150
QEPVDVLIVE GILVLEDERL RDLMDIKIFV DTDDDVRIIR RIRRDIEERG
160 170 180 190 200
RTLDSVITQY LEAVKPMYHQ FIEPTKRYAD VIIPEGVSNT VGVDIITTKI

ASILND
Length:206
Mass (Da):23,754
Last modified:November 14, 2006 - v1
Checksum:i82E38F0521669EFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000425 Genomic DNA. Translation: ABJ73316.1.
RefSeqiWP_011676564.1. NC_008527.1.

Genome annotation databases

EnsemblBacteriaiABJ73316; ABJ73316; LACR_1825.
KEGGillc:LACR_1825.

Similar proteinsi

Entry informationi

Entry nameiURK_LACLS
AccessioniPrimary (citable) accession number: Q02XK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: August 30, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families