Q02XC2 (AROC_LACLS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	LACR_1916

Organism

Lactococcus lactis subsp. cremoris (strain SK11) [Complete proteome] [HAMAP]

Taxonomic identifier

272622 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	Chorismate synthase HAMAP MF_00300		PRO_1000022504

Sequences

	Sequence		Length	Mass (Da)
	Q02XC2 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 1DA4F9DF434B5A12	FASTA	388	42,783
	10 20 30 40 50 60 MRYFTAGESH GPRLTAIIEG VPAGLSLSAE DINIELKRRQ GGYGRGGRMK IESDQVEITS 70 80 90 100 110 120 GVRHGKTIGS PITLNVTNRD FKNWEQIMAA QDVEDKIKKQ RRLTKPRPGH ADLVGGMKYE 130 140 150 160 170 180 FEDLRNVLER SSARETTMRV AVGAVAKKLL HELEIEVANH VVNFGRREIS SPEHLSVQEI 190 200 210 220 230 240 RETAGRSDLS IFDESQAEDL RTYIDQIKKA GDTIGGIIET RVEGVPAGLG SYVQYDRKLD 250 260 270 280 290 300 AKIAGAVVSI NAFKGVEFGL GFEAGKRPGS QVMDEIIWSE NKGYTRSSNQ LGGFEGGMTN 310 320 330 340 350 360 GEQLIVRGVM KPIPTLYKPL MSIDTESHEP YKASVERSDP TALPAAGVVM ENVVATVVAQ 370 380 EICDKFNSDT INELKKALVD YKKRLSEY

References

[1]

"Comparative genomics of the lactic acid bacteria." Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V., Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M., Hawkins T. , Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A., Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R., O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T., Richardson P., Kozyavkin S., Weimer B.C., Mills D.A. Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006) [PubMed: 17030793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SK11.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000425 Genomic DNA. Translation: ABJ73400.1.
RefSeq	YP_811513.1. NC_008527.1.
3D structure databases
ProteinModelPortal	Q02XC2.
SMR	Q02XC2. Positions 1-388.
ModBase	Search...
Protein-protein interaction databases
STRING	Q02XC2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4432243.
GenomeReviews	Gene locus LACR_1916 in contig CP000425_GR.
KEGG	llc:LACR_1916.
PATRIC	22290699. VBILacLac38071_2092.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0082.
HOGENOM	HBG292336.
OMA	MLRWLTA.
ProtClustDB	PRK05382.
Enzyme and pathway databases
BioCyc	LLAC272622:LACR_1916-MONOMER.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_LACLS

Accession

Primary (citable) accession number: Q02XC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 14, 2006
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program