Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q02WZ5

- PNP_LACLS

UniProt

Q02WZ5 - PNP_LACLS

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Lactococcus lactis subsp. cremoris (strain SK11)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi490 – 4901MagnesiumUniRule annotation
    Metal bindingi496 – 4961MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciLLAC272622:GJUG-2047-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:LACR_2047
    OrganismiLactococcus lactis subsp. cremoris (strain SK11)
    Taxonomic identifieri272622 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
    ProteomesiUP000000240: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 769769Polyribonucleotide nucleotidyltransferasePRO_0000329689Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272622.LACR_2047.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02WZ5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini557 – 61660KHUniRule annotationAdd
    BLAST
    Domaini626 – 69469S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiPRWDWVA.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q02WZ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKETFSIEF AGRTLTVETG QVAKQANGAV VVRYGDTTVL TAATMGKMAT    50
    GDFFPLQVNY EEKMYAAGKF PGGFNKREAR PSTDATLTAR LIDRPIRPMF 100
    AEGFRNEVQV INTVLSYDEN ASGRVAAMFG SSLALAISDI PFDGPIAGVE 150
    VAYIDGKYVI NPTVAEKESS SLELSVAGNI NAINMVESGA KELSEEVMLG 200
    ALLAGHNAVK ELIEFQNEIV AKVGKEKAEV ELLHVDEDLK AEVIAAYNSD 250
    LQKAVQVEEK LAREAATKAV KEAIISVYSA KYENDENLSI ILRDLAEILE 300
    GMEHAEVRRL ITEDKIRPDG RKIDEIRPLD AEIDFTPRSI THGTGLFTRG 350
    QTQALSTLTL APMNEAQIID GLNDEYKKRF MHHYNFPQYS VGETGRYGAP 400
    GRREIGHGAL GERALEQVLP SLEEFPYAIR LVAEVLESNG SSSQASICAG 450
    TLALMAGGVP IKAPVAGIAM GLISDGTNYT VLTDIQGLED HFGDMDFKVA 500
    GTREGITALQ MDIKISGITP EILAEALAQA KTARFQILDV IEATIAQPRE 550
    ELAPSAPKID TIMIPVDKIK VVIGKGGEQI DKIIAETGVK IDIDDEGLCS 600
    IFSSDQSAID RAKEIIAELV REAKVGEVYE AKVVRIESFG AFVNLFGKQD 650
    AMVHISEMAW ARTAKVEDVM KLGDVVKVKI MKIDDKGRVD ASMRALVEKP 700
    EGYVEPERKP RERRDNKDRR NGNGFDRRNN DRNNHNNHNN NSGNHSFELR 750
    ERKSHVDHEF PELSTKKPE 769
    Length:769
    Mass (Da):84,304
    Last modified:November 14, 2006 - v1
    Checksum:i3AA5819C301CF7D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000425 Genomic DNA. Translation: ABJ73527.1.
    RefSeqiYP_811640.1. NC_008527.1.

    Genome annotation databases

    EnsemblBacteriaiABJ73527; ABJ73527; LACR_2047.
    GeneIDi4432421.
    KEGGillc:LACR_2047.
    PATRICi22290967. VBILacLac38071_2226.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000425 Genomic DNA. Translation: ABJ73527.1 .
    RefSeqi YP_811640.1. NC_008527.1.

    3D structure databases

    ProteinModelPortali Q02WZ5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272622.LACR_2047.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ73527 ; ABJ73527 ; LACR_2047 .
    GeneIDi 4432421.
    KEGGi llc:LACR_2047.
    PATRICi 22290967. VBILacLac38071_2226.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi PRWDWVA.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci LLAC272622:GJUG-2047-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SK11.

    Entry informationi

    Entry nameiPNP_LACLS
    AccessioniPrimary (citable) accession number: Q02WZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3