Q02WH3 (GALT_LACLS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galactose-1-phosphate uridylyltransferase
Short name=Gal-1-P uridylyltransferase
EC=2.7.7.12

Alternative name(s):
UDP-glucose--hexose-1-phosphate uridylyltransferase

Gene names

Name:	galT
Ordered Locus Names:	LACR_2243

Organism

Lactococcus lactis subsp. cremoris (strain SK11) [Complete proteome] [HAMAP]

Taxonomic identifier

272622 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose. HAMAP MF_00571
Pathway	Carbohydrate metabolism; galactose metabolism. HAMAP MF_00571
Subcellular location	Cytoplasm Potential HAMAP MF_00571.
Sequence similarities	Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Cellular component	Cytoplasm
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	galactose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	UDP-glucose:hexose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 493	493	Galactose-1-phosphate uridylyltransferase HAMAP MF_00571		PRO_1000025024

Sequences

	Sequence		Length	Mass (Da)
	Q02WH3 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: EFC0C7B04E24BBEE	FASTA	493	56,315
	10 20 30 40 50 60 MSIYQSIQDF ISLALQNGTI EPLDELYHRN QLLHFLGLND WAEVDKEVHE TNSLILMDQL 70 80 90 100 110 120 LAIANENNVI AKGQDEFYEA ALMNFMTPRP SKINHDFWEK YQASPDAATQ YFYELAQQVN 130 140 150 160 170 180 QVKTRDIARN IAFSHLTKYG KLEITINLSK PEKDPKAIAA AKLVKASSYP ACQLCLENEG 190 200 210 220 230 240 FYGLGNKPAR SNHRIIQVSI NGEDWGFQYS PYAYFNEHSI LLNAKHQPME INKRAFDNLL 250 260 270 280 290 300 GFLDKFPNYM IGSNADLPIV GGSILTHDHY QAGRHDFPMA KAELRETIEL AHFPEVSCGI 310 320 330 340 350 360 VNWPMSVLRL ASENQVELSK AADDFLKKWQ VYSDESLQIK AKSTDGTPHH TITPIARIRD 370 380 390 400 410 420 GKYELDLVLR DNNTNEKYPD GIFHPHPALH HIKKENIGLI EVMGLAILPA RLETELLEVE 430 440 450 460 470 480 RYLLNQDNQM NEIHKAWAEQ LKNEEHFTRE TVHATVQGAV GEVFEEVLKD AGVFKDTQEG 490 HEGFRKFIDF VNQ

References

[1]

"Comparative genomics of the lactic acid bacteria." Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V., Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M., Hawkins T. , Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A., Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R., O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T., Richardson P., Kozyavkin S., Weimer B.C., Mills D.A. Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006) [PubMed: 17030793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SK11.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000425 Genomic DNA. Translation: ABJ73699.1.
RefSeq	YP_811812.1. NC_008527.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q02WH3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4433861.
GenomeReviews	Gene locus LACR_2243 in contig CP000425_GR.
KEGG	llc:LACR_2243.
PATRIC	22291360. VBILacLac38071_2411.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4468.
HOGENOM	HBG337915.
OMA	HYFIGSN.
ProtClustDB	PRK05270.
Enzyme and pathway databases
BioCyc	LLAC272622:LACR_2243-MONOMER.
Family and domain databases
HAMAP	MF_00571. GalP_UDP_trans. [Tree]
InterPro	IPR000766. GalP_uridyl_Trfase_II. IPR023425. GalP_uridyl_Trfase_II_CS. IPR005850. GalP_Utransf_C. IPR005849. GalP_Utransf_N. [Graphical view]
KO	K00965.
Pfam	PF02744. GalP_UDP_tr_C. 1 hit. PF01087. GalP_UDP_transf. 1 hit. [Graphical view]
PIRSF	PIRSF006005. GalT_BS. 1 hit.
TIGRFAMs	TIGR01239. GalT_2. 1 hit.
PROSITE	PS01163. GAL_P_UDP_TRANSF_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GALT_LACLS

Accession

Primary (citable) accession number: Q02WH3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 14, 2006
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program