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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Lactococcus lactis subsp. cremoris (strain SK11)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLLAC272622:GJUG-2323-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:LACR_2323
OrganismiLactococcus lactis subsp. cremoris (strain SK11)
Taxonomic identifieri272622 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000000240: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 564564Arginine--tRNA ligasePRO_1000018051Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi272622.LACR_2323.

Structurei

3D structure databases

ProteinModelPortaliQ02W95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi122 – 13211"HIGH" regionAdd
BLAST

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247211.
KOiK01887.
OMAiNPNGPLH.
OrthoDBiEOG6JB13C.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q02W95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEKQLVSQA LSAAIDGVLG VEQIAAIIEK PKSSDLGDLA FPAFQLAKTL
60 70 80 90 100
RKSPQIIAGE IAEKIDTKGF EKVIAVGPYV NFFLDKNATA SEVIREVLTE
110 120 130 140 150
GEHYGDANIG EGGNVPIDMS APNIAKPFSI GHLRSTVIGD SIAKIYEKLG
160 170 180 190 200
YQPIKINHLG DWGKQFGLLI TAYKKYGDEA TITANPIDEL LKLYVKINAE
210 220 230 240 250
AKEDPEVDEE GRQWFLKMEQ GDEEALRIWK WFSDVSLIEF NRIYGKLGVT
260 270 280 290 300
FDHFMGESFY SDKMDAIVED LENKNLLHES KGALIVDLEK YNLNPALIKK
310 320 330 340 350
TDGATLYITR DLATAAYRKK TFNFVKSLYV VGGEQTNHFK QLKAVLKEAG
360 370 380 390 400
YDWSDDMVHV PFGMVTQGGK KFSTRKGHVV KLEMALDEAV DRAEKQIEAK
410 420 430 440 450
NPNLENKEEV AKQVGVGAVK FYDLKTDRNN GYDFDLDEMV SFEGETGPYV
460 470 480 490 500
QYAHARIQSI LRKANRKVNI DNISLVVSDA EAWEIVKALK EFPNIVKRAA
510 520 530 540 550
DNYEPSIIAK YAISLAQAFN KYYAHVRILE DDAQLDGRLA LISATSIVLK
560
EALRLLGVAA PENM
Length:564
Mass (Da):62,917
Last modified:November 14, 2006 - v1
Checksum:iC0946F60F0850593
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000425 Genomic DNA. Translation: ABJ73777.1.
RefSeqiYP_811890.1. NC_008527.1.

Genome annotation databases

EnsemblBacteriaiABJ73777; ABJ73777; LACR_2323.
GeneIDi4434457.
KEGGillc:LACR_2323.
PATRICi22291516. VBILacLac38071_2489.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000425 Genomic DNA. Translation: ABJ73777.1.
RefSeqiYP_811890.1. NC_008527.1.

3D structure databases

ProteinModelPortaliQ02W95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272622.LACR_2323.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ73777; ABJ73777; LACR_2323.
GeneIDi4434457.
KEGGillc:LACR_2323.
PATRICi22291516. VBILacLac38071_2489.

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247211.
KOiK01887.
OMAiNPNGPLH.
OrthoDBiEOG6JB13C.

Enzyme and pathway databases

BioCyciLLAC272622:GJUG-2323-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SK11.

Entry informationi

Entry nameiSYR_LACLS
AccessioniPrimary (citable) accession number: Q02W95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: January 7, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.