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Q02V57 (HEM6_PSEAB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Coproporphyrinogen-III oxidase, aerobic
Short name=Coprogen oxidase
Short name=Coproporphyrinogenase
EC=1.3.3.3
Gene names
Name:hemF
Ordered Locus Names:PA14_00280
OrganismPseudomonas aeruginosa (strain UCBPP-PA14) [Complete proteome] [HAMAP]
Taxonomic identifier208963 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. HAMAP MF_00333

Catalytic activity

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. HAMAP MF_00333

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. HAMAP MF_00333

Subunit structure

Homodimer By similarity. HAMAP MF_00333

Subcellular location

Cytoplasm By similarity HAMAP MF_00333.

Sequence similarities

Belongs to the aerobic coproporphyrinogen-III oxidase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncoproporphyrinogen oxidase activity

Inferred from electronic annotation. Source: EC

protein homodimerization activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305Coproporphyrinogen-III oxidase, aerobic HAMAP MF_00333
PRO_1000019484

Regions

Region49 – 5810Important for dimerization By similarity
Region109 – 1113Substrate binding By similarity
Region241 – 27636Important for dimerization By similarity
Region259 – 2646Substrate binding By similarity

Sites

Active site1071Proton donor By similarity
Binding site931Substrate By similarity
Site1761Important for dimerization By similarity

Sequences

Sequence LengthMass (Da)Tools
Q02V57 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 240BD06FEA37EAE3

FASTA30534,806
        10         20         30         40         50         60 
MTDRIAAVKT YLLDLQDRIC AALEAEDGKA RFAEDAWERP AGGGGRTRVI GDGALIEKGG 

        70         80         90        100        110        120 
VNFSHVFGDS LPPSASAHRP ELAGRGFQAL GVSLVIHPEN PHVPTSHANV RFFCAEKEGE 

       130        140        150        160        170        180 
EPVWWFGGGF DLTPYYAHEE DCVHWHRVAR DACAPFGADV YPRYKEWCDR YFHLKHRNEP 

       190        200        210        220        230        240 
RGIGGLFFDD LNQWDFDTCF AFIRAIGDAY IDAYLPIVQR RKHTPFDERQ REFQAYRRGR 

       250        260        270        280        290        300 
YVEFNLVFDR GTLFGLQSGG RTESILMSLP PQVRWGYDWK PEPGSEEARL TEYFLADRDW 


LAGQP

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References

[1]"Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial."
Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S., Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L., Grills G., Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M.
Genome Biol. 7:R90.1-R90.14(2006) [PubMed: 17038190] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: UCBPP-PA14.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000438 Genomic DNA. Translation: ABJ14980.1.
RefSeqYP_788179.1. NC_008463.1.

3D structure databases

ProteinModelPortalQ02V57.
SMRQ02V57. Positions 1-301.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ02V57.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4384742.
GenomeReviewsGene locus PA14_00280 in contig CP000438_GR.
KEGGpau:PA14_00280.
PATRIC19846076. VBIPseAer79785_0023.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0408.
HOGENOMHBG631180.
OMAVKAYLLD.
ProtClustDBPRK05330.

Enzyme and pathway databases

BioCycPAER208963:PA14_00280-MONOMER.

Family and domain databases

HAMAPMF_00333. Coprogen_oxidas.
[Tree]
InterProIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
Gene3DG3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
KOK00228.
PANTHERPTHR10755. Coprogen_oxidas. 1 hit.
PfamPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PIRSFPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSPR00073. COPRGNOXDASE.
SUPFAMSSF102886. Coprogen_oxidas. 1 hit.
PROSITEPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEM6_PSEAB
AccessionPrimary (citable) accession number: Q02V57
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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