Reviewed, UniProtKB/Swiss-Prot Q02V57 (HEM6_PSEAB)

Names and origin

Protein names

Recommended name:
    Coproporphyrinogen III oxidase, aerobic
      Short name=Coproporphyrinogenase
      Short name=Coprogen oxidase
    EC=1.3.3.3

Gene names

Name:	hemF
Ordered Locus Names:	PA14_00280

Organism

Pseudomonas aeruginosa (strain UCBPP-PA14) [Complete proteome] [HAMAP]

Taxonomic identifier

208963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Coproporphyrinogen-III + O(2) + 2 H(+) = protoporphyrinogen-IX + 2 CO(2) + 2 H(2)O.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen III (O2 route): step 1/1.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the aerobic coproporphyrinogen III oxidase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW porphyrin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	coproporphyrinogen oxidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 305	305	Coproporphyrinogen III oxidase, aerobic		PRO_1000019484

Sequences

	Sequence		Length	Mass (Da)
	Q02V57-1 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 240BD06FEA37EAE3	FASTA	305	34,806
	10 20 30 40 50 60 MTDRIAAVKT YLLDLQDRIC AALEAEDGKA RFAEDAWERP AGGGGRTRVI GDGALIEKGG 70 80 90 100 110 120 VNFSHVFGDS LPPSASAHRP ELAGRGFQAL GVSLVIHPEN PHVPTSHANV RFFCAEKEGE 130 140 150 160 170 180 EPVWWFGGGF DLTPYYAHEE DCVHWHRVAR DACAPFGADV YPRYKEWCDR YFHLKHRNEP 190 200 210 220 230 240 RGIGGLFFDD LNQWDFDTCF AFIRAIGDAY IDAYLPIVQR RKHTPFDERQ REFQAYRRGR 250 260 270 280 290 300 YVEFNLVFDR GTLFGLQSGG RTESILMSLP PQVRWGYDWK PEPGSEEARL TEYFLADRDW LAGQP

References

[1]

"Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial." Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S., Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L., Grills G., Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M. Genome Biol. 7:RESEARCH90.1-RESEARCH90.14(2006) [PubMed: 17038190] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000438 Genomic DNA. Translation: ABJ14980.1.
RefSeq	YP_788179.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4384742.
GenomeReviews	Gene locus PA14_00280 in contig CP000438_GR.
KEGG	pau:PA14_00280.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00333. [Tree]
InterPro	IPR001260. Coprogen_oxidas. [Graphical view]
Gene3D	G3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
PANTHER	PTHR10755. Coprogen_oxidas. 1 hit.
Pfam	PF01218. Coprogen_oxidas. 1 hit. [Graphical view]
PIRSF	PIRSF000166. Coproporphyri_ox. 1 hit.
PRINTS	PR00073. COPRGNOXDASE.
PROSITE	PS01021. COPROGEN_OXIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEM6_PSEAB

Accession

Primary (citable) accession number: Q02V57

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 14, 2006
Last modified:	November 4, 2008
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)