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Protein

Adenine deaminase

Gene

PA14_01830

Organism
Pseudomonas aeruginosa (strain UCBPP-PA14)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.UniRule annotation

Catalytic activityi

Adenine + H2O = hypoxanthine + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi14 – 141Zinc; catalyticUniRule annotation
Metal bindingi16 – 161Zinc; catalyticUniRule annotation
Metal bindingi194 – 1941Zinc; catalyticUniRule annotation
Active sitei197 – 1971Proton donorUniRule annotation
Sitei218 – 2181Important for catalytic activityUniRule annotation
Metal bindingi275 – 2751Zinc; catalyticUniRule annotation
Binding sitei276 – 2761SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciPAER208963:GI5K-151-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine deaminaseUniRule annotation (EC:3.5.4.2UniRule annotation)
Short name:
ADEUniRule annotation
Alternative name(s):
Adenine aminohydrolaseUniRule annotation
Short name:
AAHUniRule annotation
Gene namesi
Ordered Locus Names:PA14_01830
OrganismiPseudomonas aeruginosa (strain UCBPP-PA14)
Taxonomic identifieri208963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000653 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Adenine deaminasePRO_1000017678Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ02UT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218813.
KOiK01488.
OMAiDHGVRAI.

Family and domain databases

HAMAPiMF_01962. Adenine_deaminase. 1 hit.
InterProiIPR001365. A/AMP_deaminase_dom.
IPR028892. ADE.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01430. aden_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q02UT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYEWLNALPK AELHLHLEGT LEPELLFALA ERNRIALPWN DVETLRKAYA
60 70 80 90 100
FNNLQEFLDL YYAGADVLRT EQDFYDLTWA YLQKCKAQNV VHVEPFFDPQ
110 120 130 140 150
THTDRGIPFE VVLAGIRAAL QDGEKLLGIR HGLILSFLRH LSEEQAQKTL
160 170 180 190 200
DQALPFRDAF IAVGLDSSEV GHPPSKFQRV FDRARSEGFL TVAHAGEEGP
210 220 230 240 250
PEYIWEALDL LKVERIDHGV RAFEDERLMR RLIDEQIPLT VCPLSNTKLC
260 270 280 290 300
VFDDMSQHTI LDMLERGVKV TVNSDDPAYF GGYVTENFHA LQQSLGMTEE
310
QARRLAQNSL DARLVK
Length:316
Mass (Da):36,135
Last modified:November 14, 2006 - v1
Checksum:iFEEB18CED62CF184
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000438 Genomic DNA. Translation: ABJ15105.1.
RefSeqiWP_003083850.1. NC_008463.1.

Genome annotation databases

EnsemblBacteriaiABJ15105; ABJ15105; PA14_01830.
KEGGipau:PA14_01830.
PATRICi19846344. VBIPseAer79785_0157.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000438 Genomic DNA. Translation: ABJ15105.1.
RefSeqiWP_003083850.1. NC_008463.1.

3D structure databases

ProteinModelPortaliQ02UT0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ15105; ABJ15105; PA14_01830.
KEGGipau:PA14_01830.
PATRICi19846344. VBIPseAer79785_0157.

Phylogenomic databases

HOGENOMiHOG000218813.
KOiK01488.
OMAiDHGVRAI.

Enzyme and pathway databases

BioCyciPAER208963:GI5K-151-MONOMER.

Family and domain databases

HAMAPiMF_01962. Adenine_deaminase. 1 hit.
InterProiIPR001365. A/AMP_deaminase_dom.
IPR028892. ADE.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01430. aden_deam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADE_PSEAB
AccessioniPrimary (citable) accession number: Q02UT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: September 7, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.