Q02UJ1 (Q02UJ1_PSEAB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase 2 HAMAP MF_00222
EC=1.1.1.25 HAMAP MF_00222

Gene names

Name:	aroE EMBL ABJ15193.1
Synonyms:	aroE2 HAMAP MF_00222
Ordered Locus Names:	PA14_03020

Organism

Pseudomonas aeruginosa (strain UCBPP-PA14) [Complete proteome] [HAMAP]

Taxonomic identifier

208963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family. HAMAP MF_00222

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00222
Ligand	NADP HAMAP MF_00222
Molecular function	Oxidoreductase HAMAP MF_00222 SAAS SAAS022893
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	135 – 139	5	NADP By similarity HAMAP MF_00222
Sites
	Active site	75	1	Proton acceptor By similarity HAMAP MF_00222

Sequences

	Sequence		Length	Mass (Da)
	Q02UJ1 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 6CC3CAE85790722E	FASTA	284	29,733
	10 20 30 40 50 60 MSAPRSVLAG LIGAGIQASR TPALHEREGD AQGIRYLYRL IDLDPLGKSA DDLEFLLAAA 70 80 90 100 110 120 SDLGFTGLNV TFPCKQAIIP LLDELSAEAR GIGAVNTVVL RDGRRIGHNT DCLGFAEGFR 130 140 150 160 170 180 RGLADAPRQR VVQMGAGGAG AAVAHALLAE GVERLVLFDV DPARAQALAD NLNQHFGAPR 190 200 210 220 230 240 ALAGSDLAGA LGDAQGLVNT TPVGMAKLPG MPVPAELLRA DLWVAEVIYF PLETELLRQA 250 260 270 280 RALGCRTLDG GTMAVFQAVK AFELFSGVEA DAARMQAHFA SLGD

References

[1]

"Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial." Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S., Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L., Grills G., Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M. Genome Biol. 7:R90.1-R90.14(2006) [PubMed: 17038190] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000438 Genomic DNA. Translation: ABJ15193.1.
RefSeq	YP_788395.1. NC_008463.1.
3D structure databases
ProteinModelPortal	Q02UJ1.
SMR	Q02UJ1. Positions 6-282.
ModBase	Search...
Protein-protein interaction databases
STRING	Q02UJ1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4383655.
GenomeReviews	Gene locus PA14_03020 in contig CP000438_GR.
KEGG	pau:PA14_03020.
NMPDR	fig|208963.3.peg.4477.
PATRIC	19846530. VBIPseAer79785_0250.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HBG553408.
OMA	HEHEGDA.
ProtClustDB	PRK12549.
Enzyme and pathway databases
BioCyc	PAER208963:PA14_03020-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q02UJ1_PSEAB

Accession

Primary (citable) accession number: Q02UJ1

Entry history

Integrated into UniProtKB/TrEMBL:	November 14, 2006
Last sequence update:	November 14, 2006
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)