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Q02RB6

- LPXA_PSEAB

UniProt

Q02RB6 - LPXA_PSEAB

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Protein
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Gene
lpxA, PA14_17210
Organism
Pseudomonas aeruginosa (strain UCBPP-PA14)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciPAER208963:GI5K-1384-MONOMER.
UniPathwayiUPA00359; UER00477.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (EC:2.3.1.129)
Short name:
UDP-N-acetylglucosamine acyltransferase
Gene namesi
Name:lpxA
Ordered Locus Names:PA14_17210
OrganismiPseudomonas aeruginosa (strain UCBPP-PA14)
Taxonomic identifieri208963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000653: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferaseUniRule annotation
PRO_0000302585Add
BLAST

Interactioni

Subunit structurei

Homotrimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi208963.PA14_17210.

Structurei

3D structure databases

ProteinModelPortaliQ02RB6.
SMRiQ02RB6. Positions 2-258.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1043.
HOGENOMiHOG000294326.
KOiK00677.
OMAiDCQDKKY.
OrthoDBiEOG6F81P1.

Family and domain databases

Gene3Di1.20.1180.10. 1 hit.
HAMAPiMF_00387. LpxA.
InterProiIPR029098. Acetyltransf_C.
IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR010137. Lipid_A_LpxA.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamiPF13720. Acetyltransf_11. 1 hit.
PF00132. Hexapep. 2 hits.
[Graphical view]
PIRSFiPIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR01852. lipid_A_lpxA. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02RB6-1 [UniParc]FASTAAdd to Basket

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MSLIDPRAII DPSARLAADV QVGPWSIVGA EVEIGEGTVI GPHVVLKGPT    50
KIGKHNRIYQ FSSVGEDTPD LKYKGEPTRL VIGDHNVIRE GVTIHRGTVQ 100
DRAETTIGDH NLIMAYAHIG HDSVIGNHCI LVNNTALAGH VHVDDWAILS 150
GYTLVHQYCR IGAHSFSGMG SAIGKDVPAY VTVFGNPAEA RSMNFEGMRR 200
RGFSSEAIHA LRRAYKVVYR QGHTVEEALA ELAESAAQFP EVAVFRDSIQ 250
SATRGITR 258
Length:258
Mass (Da):28,010
Last modified:November 14, 2006 - v1
Checksum:iB40E9923058E259E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000438 Genomic DNA. Translation: ABJ12877.1.
RefSeqiYP_789520.1. NC_008463.1.

Genome annotation databases

EnsemblBacteriaiABJ12877; ABJ12877; PA14_17210.
GeneIDi4383257.
KEGGipau:PA14_17210.
PATRICi19848857. VBIPseAer79785_1400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000438 Genomic DNA. Translation: ABJ12877.1 .
RefSeqi YP_789520.1. NC_008463.1.

3D structure databases

ProteinModelPortali Q02RB6.
SMRi Q02RB6. Positions 2-258.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208963.PA14_17210.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ12877 ; ABJ12877 ; PA14_17210 .
GeneIDi 4383257.
KEGGi pau:PA14_17210.
PATRICi 19848857. VBIPseAer79785_1400.

Phylogenomic databases

eggNOGi COG1043.
HOGENOMi HOG000294326.
KOi K00677.
OMAi DCQDKKY.
OrthoDBi EOG6F81P1.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00477 .
BioCyci PAER208963:GI5K-1384-MONOMER.

Family and domain databases

Gene3Di 1.20.1180.10. 1 hit.
HAMAPi MF_00387. LpxA.
InterProi IPR029098. Acetyltransf_C.
IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR010137. Lipid_A_LpxA.
IPR011004. Trimer_LpxA-like.
[Graphical view ]
Pfami PF13720. Acetyltransf_11. 1 hit.
PF00132. Hexapep. 2 hits.
[Graphical view ]
PIRSFi PIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAMi SSF51161. SSF51161. 1 hit.
TIGRFAMsi TIGR01852. lipid_A_lpxA. 1 hit.
PROSITEi PS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UCBPP-PA14.

Entry informationi

Entry nameiLPXA_PSEAB
AccessioniPrimary (citable) accession number: Q02RB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 14, 2006
Last modified: June 11, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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