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Q02RB5

- LPXB_PSEAB

UniProt

Q02RB5 - LPXB_PSEAB

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Pseudomonas aeruginosa (strain UCBPP-PA14)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciPAER208963:GI5K-1385-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:PA14_17220
    OrganismiPseudomonas aeruginosa (strain UCBPP-PA14)
    Taxonomic identifieri208963 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000000653: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 378378Lipid-A-disaccharide synthasePRO_1000049408Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi208963.PA14_17220.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02RB5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018004.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q02RB5-1 [UniParc]FASTAAdd to Basket

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    MADGLRVALV AGEASGDILG SGLMQALRAR HPDIEFIGVG GPRMEAEGLS    50
    SYFPMERLSV MGLVEVLGRL PELLRRRKRL IRTLIEARPD VMIGIDAPDF 100
    TLGVEHKLRQ AGLRTVHYVS PSVWAWRQKR VLKIREACDL MLALFPFEAR 150
    FYEEHGVPVR FVGHPLANTI PLQADRAAAR ARLGLPADGQ VVALMPGSRG 200
    GEVGKLGALF LDTAQRLLVE RPGLRFVLPC ASAARREQIE QMLQGREPLP 250
    LTLLDGASHE ALAACDAVLI ASGTATLEAL LYKRPMVVAY RVAGLTYRIL 300
    KRLVKSPYIS LPNLLAGRLL VPELIQDAAT PQALAATLSP LLDDGSQQVE 350
    FFDAIHRALR QDASAQAAEA VLQLVERR 378
    Length:378
    Mass (Da):41,280
    Last modified:November 14, 2006 - v1
    Checksum:i46CEEEA4863C68B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000438 Genomic DNA. Translation: ABJ12876.1.
    RefSeqiYP_789521.1. NC_008463.1.

    Genome annotation databases

    EnsemblBacteriaiABJ12876; ABJ12876; PA14_17220.
    GeneIDi4383256.
    KEGGipau:PA14_17220.
    PATRICi19848859. VBIPseAer79785_1401.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000438 Genomic DNA. Translation: ABJ12876.1 .
    RefSeqi YP_789521.1. NC_008463.1.

    3D structure databases

    ProteinModelPortali Q02RB5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208963.PA14_17220.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ12876 ; ABJ12876 ; PA14_17220 .
    GeneIDi 4383256.
    KEGGi pau:PA14_17220.
    PATRICi 19848859. VBIPseAer79785_1401.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018004.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci PAER208963:GI5K-1385-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UCBPP-PA14.

    Entry informationi

    Entry nameiLPXB_PSEAB
    AccessioniPrimary (citable) accession number: Q02RB5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3