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Q02R26 (ARND_PSEAB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD

EC=3.5.1.n3
Gene names
Name:arnD
Ordered Locus Names:PA14_18340
OrganismPseudomonas aeruginosa (strain UCBPP-PA14) [Complete proteome] [HAMAP]
Taxonomic identifier208963 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides By similarity. HAMAP-Rule MF_01870

Catalytic activity

4-deoxy-4-formamido-beta-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + formate. HAMAP-Rule MF_01870

Pathway

Glycolipid biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate: step 2/2. HAMAP-Rule MF_01870

Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP-Rule MF_01870

Sequence similarities

Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.

Contains 1 NodB homology domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD HAMAP-Rule MF_01870
PRO_0000383522

Regions

Domain2 – 260259NodB homology

Sequences

Sequence LengthMass (Da)Tools
Q02R26 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: CFE955C4565A0E27

FASTA29532,906
        10         20         30         40         50         60 
MIQAGLRIDV DTFRGTRDGV PRLLDLLDEA GLKATFFFSV GPDNMGRHLW RLARPAFFWK 

        70         80         90        100        110        120 
MLRSRAASLY GWDILLAGTA WPGKPIGREL GPLMRRTQAA GHEVGLHAWD HHAWQTHVGV 

       130        140        150        160        170        180 
WSAQQLGEQI RRGSDCLADI LGQPVRCSAA AGWRADGRVV EAKQPFGFRY NSDCRGRGAF 

       190        200        210        220        230        240 
RPRLADGSPG IPQVPVNLPT FDEVVGPGLP REAYNDFILE RFAAGRDNVY TIHAEVEGLL 

       250        260        270        280        290 
LAPAFRELLR RAERRGIRFR PLGELLPDDP RSLPLAELVR GRLAGREGWL GVRQP 

« Hide

References

[1]"Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial."
Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S., Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L., Grills G., Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M.
Genome Biol. 7:R90.1-R90.14(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: UCBPP-PA14.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000438 Genomic DNA. Translation: ABJ12789.1.
RefSeqYP_789610.1. NC_008463.1.

3D structure databases

ProteinModelPortalQ02R26.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING208963.PA14_18340.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ12789; ABJ12789; PA14_18340.
GeneID4381519.
KEGGpau:PA14_18340.
PATRIC19849045. VBIPseAer79785_1494.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0726.
HOGENOMHOG000261199.
KOK13014.
OMALHAWDHF.
OrthoDBEOG6423D0.
ProtClustDBPRK15394.

Enzyme and pathway databases

BioCycPAER208963:GI5K-1474-MONOMER.
UniPathwayUPA00030.
UPA00036; UER00496.

Family and domain databases

Gene3D3.20.20.370. 2 hits.
HAMAPMF_01870. ArnD.
InterProIPR023557. ArnD.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR002509. Polysac_deacetylase.
[Graphical view]
PfamPF01522. Polysacc_deac_1. 1 hit.
[Graphical view]
SUPFAMSSF88713. SSF88713. 2 hits.
PROSITEPS51677. NODB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARND_PSEAB
AccessionPrimary (citable) accession number: Q02R26
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: November 14, 2006
Last modified: February 19, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways