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Protein

Thymidylate kinase

Gene

tmk

Organism
Pseudomonas aeruginosa (strain UCBPP-PA14)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPAER208963:GI5K-2085-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:PA14_25740
OrganismiPseudomonas aeruginosa (strain UCBPP-PA14)
Taxonomic identifieri208963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000653 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Thymidylate kinasePRO_1000023254Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ02PC5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229078.
KOiK00943.
OMAiGGIDIAE.
OrthoDBiEOG64JFSH.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q02PC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGLFVTLEG PEGAGKSTNR DYLAERLRER GIEVQLTREP GGTPLAERIR
60 70 80 90 100
ELLLAPGDEP MAADTELLLM FAARAQHIAG VIRPALARGA VVLCDRFTDA
110 120 130 140 150
TYAYQGGGRG LPEVRIAALE SFVQGDLRPD LTLVFDLPVE IGLARAAARG
160 170 180 190 200
RLDRFEQEDR RFFEAVRQTY LQRAAQAPER YQVLDAGLPL TEVQAGLDRL
210
LPNLLERLNG
Length:210
Mass (Da):23,137
Last modified:November 14, 2006 - v1
Checksum:i3A829ABC9526CAFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000438 Genomic DNA. Translation: ABJ12200.1.
RefSeqiWP_003138599.1. NC_008463.1.

Genome annotation databases

EnsemblBacteriaiABJ12200; ABJ12200; PA14_25740.
KEGGipau:PA14_25740.
PATRICi19850264. VBIPseAer79785_2091.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000438 Genomic DNA. Translation: ABJ12200.1.
RefSeqiWP_003138599.1. NC_008463.1.

3D structure databases

ProteinModelPortaliQ02PC5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ12200; ABJ12200; PA14_25740.
KEGGipau:PA14_25740.
PATRICi19850264. VBIPseAer79785_2091.

Phylogenomic databases

HOGENOMiHOG000229078.
KOiK00943.
OMAiGGIDIAE.
OrthoDBiEOG64JFSH.

Enzyme and pathway databases

BioCyciPAER208963:GI5K-2085-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UCBPP-PA14.

Entry informationi

Entry nameiKTHY_PSEAB
AccessioniPrimary (citable) accession number: Q02PC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: December 9, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.