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Q02I58 (Q02I58_PSEAB) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174
EC=1.2.1.71 HAMAP MF_01174
Alternative name(s):
Succinylglutamic semialdehyde dehydrogenase HAMAP MF_01174
Gene names
Name:aruD EMBL ABJ10058.1
Synonyms:astD HAMAP MF_01174
Ordered Locus Names:PA14_52670
OrganismPseudomonas aeruginosa (strain UCBPP-PA14) [Complete proteome] [HAMAP]
Taxonomic identifier208963 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length488 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174 SAAS SAAS017649

Catalytic activity

N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174 SAAS SAAS017649

Pathway

Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174 SAAS SAAS017649

Sequence similarities

Belongs to the aldehyde dehydrogenase family. AstD subfamily. HAMAP MF_01174

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding222 – 2276NAD By similarity HAMAP MF_01174

Sites

Active site2451 By similarity HAMAP MF_01174
Active site2791 By similarity HAMAP MF_01174

Sequences

Sequence LengthMass (Da)Tools
Q02I58 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: A66032807D582CE0

FASTA48851,537
        10         20         30         40         50         60 
MMSTHYIAGQ WLAGQGETLE SLDPVGQGVV WSGRGADAAQ VDAAVRAARE AFPAWARRPL 

        70         80         90        100        110        120 
EQRIELLERF AATLKSRADE LARAIGEETG KPLWESATEV TSMVNKVAIS VQAFRERTGE 

       130        140        150        160        170        180 
KSGPLADATA VLRHKPHGVV AVFGPYNFPG HLPNGHIVPA LLAGNCVVFK PSELTPKVAE 

       190        200        210        220        230        240 
LTLKAWIEAG LPAGVLNLVQ GGRETGVALA AHRGLDGLFF TGSSRTGNLL HSQFGGQPQK 

       250        260        270        280        290        300 
ILALEMGGNN PLVVEEVADL DAAVYTIIQS AFISAGQRCT CARRLLVPQG AWGDALLARL 

       310        320        330        340        350        360 
VAVSATLRVG RFDEQPAPFM GAVISLSAAE HLLKAQEHLI GKGAQPLLAM TQPIDGAALL 

       370        380        390        400        410        420 
TPGILDVSTV AERPDEEFFG PLLQVIRYSD FAAAIREANA TQYGLAAGLL SDSRERFEQF 

       430        440        450        460        470        480 
LVESRAGIVN WNKQLTGAAS SAPFGGIGAS GNHRPSAYYA ADYCAYPVAS LESPSVSLPA 


TLTPGISL

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References

[1]"Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial."
Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S., Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L., Grills G., Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M.
Genome Biol. 7:R90.1-R90.14(2006) [PubMed: 17038190] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000438 Genomic DNA. Translation: ABJ10058.1.
RefSeqYP_792378.1. NC_008463.1.

3D structure databases

ProteinModelPortalQ02I58.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ02I58.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4385602.
GenomeReviewsGene locus PA14_52670 in contig CP000438_GR.
KEGGpau:PA14_52670.
NMPDRfig|208963.3.peg.2529.
PATRIC19854790. VBIPseAer79785_4332.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHBG752218.
OMAMTQRDPR.
ProtClustDBPRK09457.

Enzyme and pathway databases

BioCycPAER208963:PA14_52670-MONOMER.

Family and domain databases

HAMAPMF_01174. Aldedh_AstD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR017649. SuccinylGlu_semiald_DH_AstD.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK06447.
PANTHERPTHR11699:SF24. PTHR11699:SF24. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR03240. Arg_catab_astD. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ02I58_PSEAB
AccessionPrimary (citable) accession number: Q02I58
Entry history
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: December 14, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info