Q02I47 (Q02I47_PSEAB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase 1 HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123

Alternative name(s):
Acetate--CoA ligase 1 HAMAP MF_01123
Acyl-activating enzyme 1 HAMAP MF_01123

Gene names

Name:	acsA EMBL ABJ10047.1
Synonyms:	acsA1 HAMAP MF_01123
Ordered Locus Names:	PA14_52800

Organism

Pseudomonas aeruginosa (strain UCBPP-PA14) [Complete proteome] [HAMAP]

Taxonomic identifier

208963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	651 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_01123 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01123
PTM	Acetylation HAMAP MF_01123
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	517	1	By similarity HAMAP MF_01123
Amino acid modifications
	Modified residue	609	1	N6-acetyllysine By similarity HAMAP MF_01123

Sequences

	Sequence		Length	Mass (Da)
	Q02I47 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 991802723539AD23	FASTA	651	71,763
	10 20 30 40 50 60 MSAASLYPVH PEAVARTFTD EATYKTMYQQ SVVNPDGFWR EQAQRIDWIK PFEKVKQTSF 70 80 90 100 110 120 DDHHVDIKWF ADGTLNVSHN CLDRHLAERG DQVAIIWEGD DPADHQEITY RQLHEQVCKF 130 140 150 160 170 180 ANALRGQDVH RGDVVTIYMP MIPEAVVAML ACTRIGAIHS VVFGGFSPEA LAGRIIDCKS 190 200 210 220 230 240 KVVITADEGV RGGKRTPLKA NVDDALTNPE TSSVQKIIVC KRTGAEIKWN QHRDVWYDDL 250 260 270 280 290 300 MKVAGSTCAP KEMGAEDPLF ILYTSGSTGK PKGVLHTTGG YLVYASLTHE RVFDYRPGEV 310 320 330 340 350 360 YWCTADIGWV TGHTYIVYGP LANGATTILF EGVPNYPDVT RVAKIIDKHK VNILYTAPTA 370 380 390 400 410 420 IRAMMAEGKA AVAGADGSSL RLLGSVGEPI NPEAWQWYYE TVGQSRCPIV DTWWQTETGA 430 440 450 460 470 480 CLMTPLPGAH AMKPGSAAKP FFGVVPALVD NLGNLIEGAA EGNLVILDSW PGQARTLFGD 490 500 510 520 530 540 HDRFVDTYFK TFKGMYFTGD GARRDEDGYY WITGRVDDVL NVSGHRMGTA EVESAMVAHP 550 560 570 580 590 600 KVAEAAVVGM QHDIKGQGIY VYVTLNSGVE PSEALRQELK QWVRREIGPI ATPDVIQWAP 610 620 630 640 650 GLPKTRSGKI MRRILRKIAA AEYDTLGDIS TLADPGVVQH LIETHRSMQA A

References

[1]

"Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial." Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S., Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L., Grills G., Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M. Genome Biol. 7:R90.1-R90.14(2006) [PubMed: 17038190] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000438 Genomic DNA. Translation: ABJ10047.1.
RefSeq	YP_792389.1. NC_008463.1.
3D structure databases
ProteinModelPortal	Q02I47.
SMR	Q02I47. Positions 16-647.
ModBase	Search...
Protein-protein interaction databases
STRING	Q02I47.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4385591.
GenomeReviews	Gene locus PA14_52800 in contig CP000438_GR.
KEGG	pau:PA14_52800.
PATRIC	19854812. VBIPseAer79785_4343.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0365.
HOGENOM	HBG547964.
OMA	DYWWHEE.
ProtClustDB	PRK00174.
Enzyme and pathway databases
BioCyc	PAER208963:PA14_52800-MONOMER.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q02I47_PSEAB

Accession

Primary (citable) accession number: Q02I47

Entry history

Integrated into UniProtKB/TrEMBL:	November 14, 2006
Last sequence update:	November 14, 2006
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)