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Protein

L-lactate dehydrogenase

Gene

lldD

Organism
Pseudomonas aeruginosa (strain UCBPP-PA14)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.UniRule annotation

Catalytic activityi

(S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.UniRule annotation

Cofactori

FMNUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei24SubstrateUniRule annotation1
Binding sitei106FMNUniRule annotation1
Binding sitei127FMNUniRule annotation1
Binding sitei129SubstrateUniRule annotation1
Binding sitei155FMNUniRule annotation1
Binding sitei164SubstrateUniRule annotation1
Binding sitei251FMNUniRule annotation1
Active sitei275Proton acceptorUniRule annotation1
Binding sitei278SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi306 – 330FMNUniRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFlavoprotein, FMN

Enzyme and pathway databases

BioCyciPAER208963:G1G74-5337-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.-.-UniRule annotation)
Gene namesi
Name:lldDUniRule annotation
Ordered Locus Names:PA14_63090
OrganismiPseudomonas aeruginosa (strain UCBPP-PA14)
Taxonomic identifieri208963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000653 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000689891 – 381L-lactate dehydrogenaseAdd BLAST381

Proteomic databases

PRIDEiQ02FQ1

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ02FQ1
SMRiQ02FQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 380FMN hydroxy acid dehydrogenaseUniRule annotationAdd BLAST380

Sequence similaritiesi

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000217464
KOiK00101
OMAiWHGRAWS

Family and domain databases

CDDicd02809 alpha_hydroxyacid_oxid_FMN, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01559 L_lact_dehydr, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR012133 Alpha-hydoxy_acid_DH_FMN
IPR000262 FMN-dep_DH
IPR037396 FMN_HAD
IPR008259 FMN_hydac_DH_AS
IPR020920 LldD
PfamiView protein in Pfam
PF01070 FMN_dh, 1 hit
PIRSFiPIRSF000138 Al-hdrx_acd_dh, 1 hit
PROSITEiView protein in PROSITE
PS00557 FMN_HYDROXY_ACID_DH_1, 1 hit
PS51349 FMN_HYDROXY_ACID_DH_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q02FQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIISASTDYR AAAQRKLPPF LFHYIDGGAY AEYTLRRNVE DLSAIALRQR
60 70 80 90 100
VLKNMSELSL ETRLFDETLA MPVALAPVGL TGMYARRGEV QAARAAAAKG
110 120 130 140 150
VPFTLSTVSV CPIEEVAPAI DRPMWFQLYV LKDRGFMRNA LERAKAAGVT
160 170 180 190 200
TLVFTVDMPV PGARYRDAHS GMSGPYAAPR RILQAMTHPA WAWDVGLLGK
210 220 230 240 250
PHDLGNISAY RGNPTGLEDY IGWLGANFDP SIAWKDLEWI REFWDGPMVI
260 270 280 290 300
KGILDPEDAR DAVKFGADGI VVSNHGGRQL DGVLSSARAL PAIADAVKGE
310 320 330 340 350
LAILADSGIR TGLDVVRMIA LGADSVLLGR AFVYALAAAG EAGVRNLLEL
360 370 380
IEKEMRVAMV LTGAKSIGEI SADSLVRELG A
Length:381
Mass (Da):41,106
Last modified:November 14, 2006 - v1
Checksum:iD9A557E62E29F958
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000438 Genomic DNA Translation: ABJ14154.1
RefSeqiWP_004365390.1, NC_008463.1

Genome annotation databases

EnsemblBacteriaiABJ14154; ABJ14154; PA14_63090
KEGGipau:PA14_63090

Similar proteinsi

Entry informationi

Entry nameiLLDD_PSEAB
AccessioniPrimary (citable) accession number: Q02FQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 14, 2006
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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