Q02EZ9 (MSRA_PSEAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA
Short name=Protein-methionine-S-oxide reductase
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name=Peptide Met(O) reductase

Gene names

Name:	msrA
Ordered Locus Names:	PA14_66330

Organism

Pseudomonas aeruginosa (strain UCBPP-PA14) [Complete proteome] [HAMAP]

Taxonomic identifier

208963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 215	215	Peptide methionine sulfoxide reductase MsrA HAMAP MF_01401		PRO_1000068350
Sites
	Active site	58	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q02EZ9 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 2646C8E8D62B5CB6	FASTA	215	23,545
	10 20 30 40 50 60 MVLRSEILTK KSELPTPDQA LPGRESAMPV PEAHFVNGRP LTAPFPAGLQ QVLFGMGCFW 70 80 90 100 110 120 GAERRLWQQP GVWVTAVGYA GGYTPNPTYD EVCSGLTGHS EVVLVVYNPQ ETSFEQLLKV 130 140 150 160 170 180 FWEAHDPTQG MRQGGDIGTQ YRSVIYTFDA AQKAAAMASR ENFQAELAKA GYDRITTEIA 190 200 210 DVPPFYYAEA YHQQYLAKNP NGYCGLGGTG VCLPA

References

[1]

"Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial." Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S., Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L., Grills G., Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M. Genome Biol. 7:R90.1-R90.14(2006) [PubMed: 17038190] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UCBPP-PA14.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000438 Genomic DNA. Translation: ABJ14402.1.
RefSeq	YP_793487.1. NC_008463.1.
3D structure databases
ProteinModelPortal	Q02EZ9.
SMR	Q02EZ9. Positions 16-214.
ModBase	Search...
Protein-protein interaction databases
STRING	Q02EZ9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4385441.
GenomeReviews	Gene locus PA14_66330 in contig CP000438_GR.
KEGG	pau:PA14_66330.
NMPDR	fig|208963.3.peg.5224.
PATRIC	19857063. VBIPseAer79785_5443.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0225.
HOGENOM	HBG748152.
OMA	QETSFEQ.
ProtClustDB	CLSK869064.
Enzyme and pathway databases
BioCyc	PAER208963:PA14_66330-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA_PSEAB

Accession

Primary (citable) accession number: Q02EZ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 14, 2006
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program