Reviewed, UniProtKB/Swiss-Prot Q02DZ0 (BETA_PSEAB)

Names and origin

Protein names

Recommended name:
    Choline dehydrogenase
      Short name=CHD
      Short name=CDH
    EC=1.1.99.1

Gene names

Name:	betA
Ordered Locus Names:	PA14_70940

Organism

Pseudomonas aeruginosa (strain UCBPP-PA14) [Complete proteome] [HAMAP]

Taxonomic identifier

208963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	561 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity.
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor.
Cofactor	FAD By similarity.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1.
Sequence similarities	Belongs to the GMC oxidoreductase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular alcohol metabolic process Inferred from electronic annotation. Source: InterPro glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro choline dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 561	561	Choline dehydrogenase		PRO_1000046567
Regions
	Nucleotide binding	6 – 35	30	FAD Probable
Sites
	Active site	475	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q02DZ0-1 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: B17C4E402673AAFB	FASTA	561	61,808
	10 20 30 40 50 60 MSQEFDYIII GAGSAGNVLA TRLTEDADVS VLLLEAGGPD YRFDFRTQMP AALAFPLQGR 70 80 90 100 110 120 RYNWAYETDP EPYMNNRRME CGRGKGLGGS SLINGMCYIR GNALDFDGWA KEPGLEDWSY 130 140 150 160 170 180 LDCLPYFRKA ETRDIGPNDY HGGDGPVSVT TPKAGNNPLF HAMVEAGVQA GYPRTDDLNG 190 200 210 220 230 240 YQQEGFGPMD RTVTPEGRRA ATGRGYLDQA RGRPNLTIVT HALSDRILFS GKRAIGVSYL 250 260 270 280 290 300 VGNGDNPATA HARREVLVCS GAIASPQLLQ RSGVGPAALL RDLDIPAVHD LPGVGANLQD 310 320 330 340 350 360 HLELYLQYAC KQPVSIYPAT KWWNQPAIGA QWLFLGKGLG ASNQFEAGGF IRTREAFEWP 370 380 390 400 410 420 NIQFHFLPVA INYNGSKGVQ EHGFQAHMGS MRSPSRGRIH LKSRDPRQHP SILFNYMSHE 430 440 450 460 470 480 QDWQEFRDGI RLTREIMNQP ALDPYRGREL SPGVNVQSDA ELDEFIRNHA ETAFHPSCSC 490 500 510 520 530 540 KMGSDDMAVV DGQGRVHGME GLRVVDASIM PLIITGNLNA TTIMMAEKIA DRIRGRQPLP 550 560 RSTAKYYVAG DAPVRGNPVR A

References

[1]

"Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial." Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S., Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L., Grills G., Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M. Genome Biol. 7:RESEARCH90.1-RESEARCH90.14(2006) [PubMed: 17038190] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000438 Genomic DNA. Translation: ABJ14755.1.
RefSeq	YP_793846.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4385076.
GenomeReviews	Gene locus PA14_70940 in contig CP000438_GR.
KEGG	pau:PA14_70940.
NMPDR	fig|208963.3.peg.4050.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00750. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. betA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. PS00624. GMC_OXRED_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETA_PSEAB

Accession

Primary (citable) accession number: Q02DZ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 14, 2006
Last modified:	November 25, 2008
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)