Q02DM0 (DSBA_PSEAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thiol:disulfide interchange protein DsbA

Gene names

Name:	dsbA
Ordered Locus Names:	PA14_72450

Organism

Pseudomonas aeruginosa (strain UCBPP-PA14) [Complete proteome] [HAMAP]

Taxonomic identifier

208963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in disulfide-bond formation. Acts by transferring its disulfide bond to other proteins By similarity.
Subcellular location	Periplasm By similarity.
Sequence similarities	Belongs to the thioredoxin family. DsbA subfamily. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Redox-active center Signal
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 211	189	Thiol:disulfide interchange protein DsbA		PRO_0000271730
Regions
	Domain	23 – 203	181	Thioredoxin
Amino acid modifications
	Disulfide bond	56 ↔ 59		Redox-active Potential
Experimental info
	Sequence conflict	209	1	Missing Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q02DM0 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: A994F93CC8E8C9F6	FASTA	211	23,375
	10 20 30 40 50 60 MRNLILTAML AMASLFGMAA QADDYTAGKE YVELSSPVPV SQPGKIEVVE LFWYGCPHCY 70 80 90 100 110 120 AFEPTIVPWS EKLPADVHFV RLPALFGGIW NVHGQMFLTL ESMGVEHDVH NAVFEAIHKE 130 140 150 160 170 180 HKKLATPEEM ADFLAGKGVD KEKFLSTYNS FAIKGQMEKA KKLAMAYQVT GVPTMVVNGK 190 200 210 YRFDIGSAGG PEETLKLADY LIEKERAAAK K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors." Tan M.-W., Rahme L.G., Sternberg J.A., Tompkins R.G., Ausubel F.M. Proc. Natl. Acad. Sci. U.S.A. 96:2408-2413(1999) [PubMed: 10051655] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial." Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S., Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L., Grills G., Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M. Genome Biol. 7:R90.1-R90.14(2006) [PubMed: 17038190] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UCBPP-PA14.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF116282 Genomic DNA. Translation: AAD22452.1. CP000438 Genomic DNA. Translation: ABJ14875.1.
RefSeq	YP_793966.1. NC_008463.1.
3D structure databases
ProteinModelPortal	Q02DM0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q02DM0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4385158.
GenomeReviews	Gene locus PA14_72450 in contig CP000438_GR.
KEGG	pau:PA14_72450.
PATRIC	19858067. VBIPseAer79785_5939.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0526.
HOGENOM	HBG680642.
OMA	EVPKIKA.
ProtClustDB	CLSK869391.
Enzyme and pathway databases
BioCyc	PAER208963:PA14_72450-MONOMER.
Family and domain databases
InterPro	IPR001853. DSBA-like_thioredoxin_dom. IPR023205. Thiol:disulphide_interchange. IPR012336. Thioredoxin-like_fold. IPR017937. Thioredoxin_CS. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 2 hits.
KO	K03673.
Pfam	PF01323. DSBA. 1 hit. [Graphical view]
PIRSF	PIRSF001488. Tdi_protein. 1 hit.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DSBA_PSEAB

Accession

Primary (citable) accession number: Q02DM0
Secondary accession number(s): P95460

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	November 14, 2006
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program