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Q02DH2

- Q02DH2_PSEAB

UniProt

Q02DH2 - Q02DH2_PSEAB

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Protein
RNA polymerase-binding transcription factor DksA
Gene
dksA, PA14_73020
Organism
Pseudomonas aeruginosa (strain UCBPP-PA14)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei111 – 1111SulfateImported
Binding sitei115 – 1151SulfateImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri96 – 12025dksA C4-type By similarityUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. regulation of gene expression Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciPAER208963:GI5K-5944-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase-binding transcription factor DksAUniRule annotation
Gene namesi
Name:dksAUniRule annotation
Ordered Locus Names:PA14_73020Imported
OrganismiPseudomonas aeruginosa (strain UCBPP-PA14)Imported
Taxonomic identifieri208963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000653: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Interacts directly with the RNA polymerase By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi208963.PA14_73020.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IJJX-ray3.25A/B/C1-134[»]
ProteinModelPortaliQ02DH2.
SMRiQ02DH2. Positions 3-130.

Family & Domainsi

Sequence similaritiesi

Belongs to the DksA family.UniRule annotation
Contains 1 dksA C4-type zinc finger.UniRule annotation

Keywords - Domaini

Zinc-fingerUniRule annotation

Phylogenomic databases

eggNOGiCOG1734.
HOGENOMiHOG000178408.
KOiK06204.
OMAiRGEYGWC.
OrthoDBiEOG6JDWD6.

Family and domain databases

HAMAPiMF_00926. DksA.
InterProiIPR012784. DksA_RNA_pol-bd.
IPR000962. Znf_DskA_TraR.
[Graphical view]
PfamiPF01258. zf-dskA_traR. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02420. dksA. 1 hit.
PROSITEiPS51128. ZF_DKSA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02DH2-1 [UniParc]FASTAAdd to Basket

« Hide

MTEQELLAQP DAAYMDEAQQ DFFRDLLLRQ RQELQARIEG EFGELRDLER    50
PSDEADLASR EEQRQWQLRL LEREKKLLDK IDEALERLAR GDYGWCQETG 100
EPIGLRRLLL RPTATLCIEA KERQEKRERH VRHN 134
Length:134
Mass (Da):16,043
Last modified:November 14, 2006 - v1
Checksum:i88E8A7F687B692A0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000438 Genomic DNA. Translation: ABJ14923.1.
RefSeqiYP_794014.1. NC_008463.1.

Genome annotation databases

EnsemblBacteriaiABJ14923; ABJ14923; PA14_73020.
GeneIDi4385264.
KEGGipau:PA14_73020.
PATRICi19858165. VBIPseAer79785_5988.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000438 Genomic DNA. Translation: ABJ14923.1 .
RefSeqi YP_794014.1. NC_008463.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4IJJ X-ray 3.25 A/B/C 1-134 [» ]
ProteinModelPortali Q02DH2.
SMRi Q02DH2. Positions 3-130.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208963.PA14_73020.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ14923 ; ABJ14923 ; PA14_73020 .
GeneIDi 4385264.
KEGGi pau:PA14_73020.
PATRICi 19858165. VBIPseAer79785_5988.

Phylogenomic databases

eggNOGi COG1734.
HOGENOMi HOG000178408.
KOi K06204.
OMAi RGEYGWC.
OrthoDBi EOG6JDWD6.

Enzyme and pathway databases

BioCyci PAER208963:GI5K-5944-MONOMER.

Family and domain databases

HAMAPi MF_00926. DksA.
InterProi IPR012784. DksA_RNA_pol-bd.
IPR000962. Znf_DskA_TraR.
[Graphical view ]
Pfami PF01258. zf-dskA_traR. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02420. dksA. 1 hit.
PROSITEi PS51128. ZF_DKSA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UCBPP-PA14Imported.
  2. "DksA2, a zinc-independent structural analog of the transcription factor DksA."
    Furman R., Biswas T., Danhart E.M., Foster M.P., Tsodikov O.V., Artsimovitch I.
    FEBS Lett. 587:614-619(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS).

Entry informationi

Entry nameiQ02DH2_PSEAB
AccessioniPrimary (citable) accession number: Q02DH2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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