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Q02DH2

- Q02DH2_PSEAB

UniProt

Q02DH2 - Q02DH2_PSEAB

Protein

RNA polymerase-binding transcription factor DksA

Gene

dksA

Organism
Pseudomonas aeruginosa (strain UCBPP-PA14)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei111 – 1111SulfateImported
    Binding sitei115 – 1151SulfateImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri96 – 12025dksA C4-typeUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. regulation of gene expression Source: UniProtKB-HAMAP

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciPAER208963:GI5K-5944-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA polymerase-binding transcription factor DksAUniRule annotation
    Gene namesi
    Name:dksAUniRule annotation
    Ordered Locus Names:PA14_73020Imported
    OrganismiPseudomonas aeruginosa (strain UCBPP-PA14)Imported
    Taxonomic identifieri208963 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000000653: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Interacts directly with the RNA polymerase.UniRule annotation

    Protein-protein interaction databases

    STRINGi208963.PA14_73020.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4IJJX-ray3.25A/B/C1-134[»]
    ProteinModelPortaliQ02DH2.
    SMRiQ02DH2. Positions 3-130.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DksA family.UniRule annotation
    Contains 1 dksA C4-type zinc finger.UniRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri96 – 12025dksA C4-typeUniRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-fingerUniRule annotation

    Phylogenomic databases

    eggNOGiCOG1734.
    HOGENOMiHOG000178408.
    KOiK06204.
    OMAiRGEYGWC.
    OrthoDBiEOG6JDWD6.

    Family and domain databases

    HAMAPiMF_00926. DksA.
    InterProiIPR012784. DksA_RNA_pol-bd.
    IPR000962. Znf_DskA_TraR.
    [Graphical view]
    PfamiPF01258. zf-dskA_traR. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02420. dksA. 1 hit.
    PROSITEiPS51128. ZF_DKSA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q02DH2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEQELLAQP DAAYMDEAQQ DFFRDLLLRQ RQELQARIEG EFGELRDLER    50
    PSDEADLASR EEQRQWQLRL LEREKKLLDK IDEALERLAR GDYGWCQETG 100
    EPIGLRRLLL RPTATLCIEA KERQEKRERH VRHN 134
    Length:134
    Mass (Da):16,043
    Last modified:November 14, 2006 - v1
    Checksum:i88E8A7F687B692A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000438 Genomic DNA. Translation: ABJ14923.1.
    RefSeqiYP_794014.1. NC_008463.1.

    Genome annotation databases

    EnsemblBacteriaiABJ14923; ABJ14923; PA14_73020.
    GeneIDi4385264.
    KEGGipau:PA14_73020.
    PATRICi19858165. VBIPseAer79785_5988.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000438 Genomic DNA. Translation: ABJ14923.1 .
    RefSeqi YP_794014.1. NC_008463.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4IJJ X-ray 3.25 A/B/C 1-134 [» ]
    ProteinModelPortali Q02DH2.
    SMRi Q02DH2. Positions 3-130.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208963.PA14_73020.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ14923 ; ABJ14923 ; PA14_73020 .
    GeneIDi 4385264.
    KEGGi pau:PA14_73020.
    PATRICi 19858165. VBIPseAer79785_5988.

    Phylogenomic databases

    eggNOGi COG1734.
    HOGENOMi HOG000178408.
    KOi K06204.
    OMAi RGEYGWC.
    OrthoDBi EOG6JDWD6.

    Enzyme and pathway databases

    BioCyci PAER208963:GI5K-5944-MONOMER.

    Family and domain databases

    HAMAPi MF_00926. DksA.
    InterProi IPR012784. DksA_RNA_pol-bd.
    IPR000962. Znf_DskA_TraR.
    [Graphical view ]
    Pfami PF01258. zf-dskA_traR. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02420. dksA. 1 hit.
    PROSITEi PS51128. ZF_DKSA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UCBPP-PA14Imported.
    2. "DksA2, a zinc-independent structural analog of the transcription factor DksA."
      Furman R., Biswas T., Danhart E.M., Foster M.P., Tsodikov O.V., Artsimovitch I.
      FEBS Lett. 587:614-619(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS).

    Entry informationi

    Entry nameiQ02DH2_PSEAB
    AccessioniPrimary (citable) accession number: Q02DH2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 14, 2006
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3