Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q02BS4 (GCSPA_SOLUE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:Acid_0482
OrganismSolibacter usitatus (strain Ellin6076) [Complete proteome] [HAMAP]
Taxonomic identifier234267 [NCBI]
Taxonomic lineageBacteriaAcidobacteriaSolibacteresSolibacteralesSolibacteraceaeCandidatus Solibacter

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 449449Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000045676

Sequences

Sequence LengthMass (Da)Tools
Q02BS4 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: CDE1758C00BE2205

FASTA44949,372
        10         20         30         40         50         60 
MRYLPKSESE RRQMLEACGV STPEELFAHL PDAVRLNRPL NLAPGISEYE IVQYFRERAE 

        70         80         90        100        110        120 
QNANGYASFL GAGVYNHYRP VLVDTVVSRG EFLTSYTPYQ AEIAQGTLTT IFEFQTMICQ 

       130        140        150        160        170        180 
LTGMDVANAS MYDGSTAVPE AAMMAVRATG KGRVLISRTV HPEYREVLGT YAKHQGMPVQ 

       190        200        210        220        230        240 
EFGYVAESGG LDLEDLERKM DDLTGAVIIQ TPNFFGIVEQ VKAAAEIAHK RGALLVVIFT 

       250        260        270        280        290        300 
EAVSLGLLEP PADADIVAGE LQSFAISPSY GGPYAGIIAV KEKYIRQVPG RLVGQSLDSR 

       310        320        330        340        350        360 
GNRAFCLTLS TREQHIRREK ATSNICTNQA LIALMATVFM TVYGKQGLRE LAEQNLAKAH 

       370        380        390        400        410        420 
YLASKLKPRF TGKFFNEFVV RAEGQTPEEL NKQLLKKKII GGLPLGRFYP ELADSYLVCA 

       430        440 
TEMTRRADMD ALVAATTAQP ATETVEVTA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000473 Genomic DNA. Translation: ABJ81492.1.
RefSeqYP_821777.1. NC_008536.1.

3D structure databases

ProteinModelPortalQ02BS4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING234267.Acid_0482.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ81492; ABJ81492; Acid_0482.
GeneID4431450.
KEGGsus:Acid_0482.
PATRIC32003010. VBICanSol30224_0505.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMARLVGQTE.
OrthoDBEOG6XWV3B.

Enzyme and pathway databases

BioCycSUSI234267:GHSK-485-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_SOLUE
AccessionPrimary (citable) accession number: Q02BS4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families