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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Solibacter usitatus (strain Ellin6076)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciCSOL234267:G1G7G-497-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Acid_0482
OrganismiSolibacter usitatus (strain Ellin6076)
Taxonomic identifieri234267 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaSolibacteresSolibacteralesSolibacteraceaeCandidatus Solibacter
Proteomesi
  • UP000000671 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000456761 – 449Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST449

Proteomic databases

PRIDEiQ02BS4

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi234267.Acid_0482

Structurei

3D structure databases

ProteinModelPortaliQ02BS4
SMRiQ02BS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108JEM Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q02BS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYLPKSESE RRQMLEACGV STPEELFAHL PDAVRLNRPL NLAPGISEYE
60 70 80 90 100
IVQYFRERAE QNANGYASFL GAGVYNHYRP VLVDTVVSRG EFLTSYTPYQ
110 120 130 140 150
AEIAQGTLTT IFEFQTMICQ LTGMDVANAS MYDGSTAVPE AAMMAVRATG
160 170 180 190 200
KGRVLISRTV HPEYREVLGT YAKHQGMPVQ EFGYVAESGG LDLEDLERKM
210 220 230 240 250
DDLTGAVIIQ TPNFFGIVEQ VKAAAEIAHK RGALLVVIFT EAVSLGLLEP
260 270 280 290 300
PADADIVAGE LQSFAISPSY GGPYAGIIAV KEKYIRQVPG RLVGQSLDSR
310 320 330 340 350
GNRAFCLTLS TREQHIRREK ATSNICTNQA LIALMATVFM TVYGKQGLRE
360 370 380 390 400
LAEQNLAKAH YLASKLKPRF TGKFFNEFVV RAEGQTPEEL NKQLLKKKII
410 420 430 440
GGLPLGRFYP ELADSYLVCA TEMTRRADMD ALVAATTAQP ATETVEVTA
Length:449
Mass (Da):49,372
Last modified:November 14, 2006 - v1
Checksum:iCDE1758C00BE2205
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000473 Genomic DNA Translation: ABJ81492.1
RefSeqiWP_011682268.1, NC_008536.1

Genome annotation databases

EnsemblBacteriaiABJ81492; ABJ81492; Acid_0482
KEGGisus:Acid_0482

Similar proteinsi

Entry informationi

Entry nameiGCSPA_SOLUE
AccessioniPrimary (citable) accession number: Q02BS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: April 25, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health