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Q02BS4

- GCSPA_SOLUE

UniProt

Q02BS4 - GCSPA_SOLUE

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 1
Gene
gcvPA, Acid_0482
Organism
Solibacter usitatus (strain Ellin6076)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciSUSI234267:GHSK-485-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:Acid_0482
OrganismiSolibacter usitatus (strain Ellin6076)
Taxonomic identifieri234267 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaSolibacteresSolibacteralesSolibacteraceaeCandidatus Solibacter
ProteomesiUP000000671: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation
PRO_1000045676Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi234267.Acid_0482.

Structurei

3D structure databases

ProteinModelPortaliQ02BS4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q02BS4-1 [UniParc]FASTAAdd to Basket

« Hide

MRYLPKSESE RRQMLEACGV STPEELFAHL PDAVRLNRPL NLAPGISEYE    50
IVQYFRERAE QNANGYASFL GAGVYNHYRP VLVDTVVSRG EFLTSYTPYQ 100
AEIAQGTLTT IFEFQTMICQ LTGMDVANAS MYDGSTAVPE AAMMAVRATG 150
KGRVLISRTV HPEYREVLGT YAKHQGMPVQ EFGYVAESGG LDLEDLERKM 200
DDLTGAVIIQ TPNFFGIVEQ VKAAAEIAHK RGALLVVIFT EAVSLGLLEP 250
PADADIVAGE LQSFAISPSY GGPYAGIIAV KEKYIRQVPG RLVGQSLDSR 300
GNRAFCLTLS TREQHIRREK ATSNICTNQA LIALMATVFM TVYGKQGLRE 350
LAEQNLAKAH YLASKLKPRF TGKFFNEFVV RAEGQTPEEL NKQLLKKKII 400
GGLPLGRFYP ELADSYLVCA TEMTRRADMD ALVAATTAQP ATETVEVTA 449
Length:449
Mass (Da):49,372
Last modified:November 14, 2006 - v1
Checksum:iCDE1758C00BE2205
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000473 Genomic DNA. Translation: ABJ81492.1.
RefSeqiYP_821777.1. NC_008536.1.

Genome annotation databases

EnsemblBacteriaiABJ81492; ABJ81492; Acid_0482.
GeneIDi4431450.
KEGGisus:Acid_0482.
PATRICi32003010. VBICanSol30224_0505.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000473 Genomic DNA. Translation: ABJ81492.1 .
RefSeqi YP_821777.1. NC_008536.1.

3D structure databases

ProteinModelPortali Q02BS4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 234267.Acid_0482.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ81492 ; ABJ81492 ; Acid_0482 .
GeneIDi 4431450.
KEGGi sus:Acid_0482.
PATRICi 32003010. VBICanSol30224_0505.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci SUSI234267:GHSK-485-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ellin6076.

Entry informationi

Entry nameiGCSPA_SOLUE
AccessioniPrimary (citable) accession number: Q02BS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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